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Literature for inhibitor I14.001: hirudin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Inhibits

(Topics flags: S Structure, A Assay, P Specificity, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Liu,S.J., Cao,Y.L. and Zhang,C.
    Hirudin in the Treatment of Chronic Kidney Disease
    Molecules (2024) 29 PubMed  Europe PubMed DOI  PMC  EPMC  V
  2. Mo,L., Yang,C., Dai,Y., Liu,W., Gong,Y., Guo,Y., Zhu,Y., Cao,Y., Xiao,X., Du,S., Lu,S. and He,J.
    Novel drug delivery systems for hirudin-based product development and clinical applications
    Int J Biol Macromol (2024) 287, 138533-138533. PubMed  Europe PubMed DOI  V
  3. Yi,X., Liu,J., Zang,E., Tian,Y., Liu,J. and Shi,L.
    Exploring a Hirudin variant from nonhematophagous leeches: Unraveling full-length sequence, alternative splicing, function, and potential as a novel anticoagulant polypeptide
    J Ethnopharmacol (2024) 330, 118257-118257. PubMed  Europe PubMed DOI
    4. 2020
  4. Bian,Y., Zhang,Y. and Tian,Z.B.
    Effect of hirudin on serum matrix metalloproteinase-9 of acute cerebral infarction: A protocol of systematic review and meta-analysis
    Medicine (Baltimore) (2020) 99, e20533-e20533. PubMed  Europe PubMed DOI  PMC  EPMC
    5. 2019
  5. Cheng,B., Liu,F., Guo,Q., Lu,Y., Shi,H., Ding,A. and Xu,C.
    Identification and characterization of hirudin-HN, a new thrombin inhibitor, from the salivary glands of Hirudo nipponia
    PeerJ (2019) 7, e7716-e7716. PubMed  Europe PubMed DOI  PMC  EPMC
    6. 2018
  6. De Filippis,V., Acquasaliente,L., Pontarollo,G. and Peterle,D.
    Noncoded amino acids in protein engineering: structure-activity relationship studies of hirudin-thrombin interaction
    Biotechnol Appl Biochem (2018) 65, 69-80. PubMed  Europe PubMed DOI
    7. 2017
  7. Khan,H., Nadhman,A., Azam,S.S., Anees,M., Khan,I., Ullah,I., Sohail,M.F., Shahnaz,G. and Yasinzai,M.
    In-vitro antileishmanial potential of peptide drug hirudin
    Chem Biol Drug Des (2017) 89, 67-73. PubMed  Europe PubMed DOI
  8. Zhao,B., Zhang,Y., Huang,Y., Yu,J., Li,Y., Wang,Q., Ma,Y., Song,H.Y., Yu,M. and Mo,W.
    A novel hirudin derivative inhibiting thrombin without bleeding for subcutaneous injection
    Thromb Haemost (2017) 117, 44-56. PubMed  Europe PubMed DOI
    9. 2016
  9. Shabareesh,P. and Kaur,K.J.
    Structural and functional characterization of hirudin P6 derived novel bivalent thrombin inhibitors - studying the effect of linker length and glycosylation on their function
    Chem Biol Drug Des (2016) 88, 129-141. PubMed  Europe PubMed DOI
    10. 2015
  10. Liu,Y., Yang,J., Wang,J., Huang,Q., Yang,X. and Zhang,J.
    Test of hirudin activity by tracking the binding of hirudin to thrombin in the presence of BS3 cross-linking
    Blood Coagul Fibrinolysis (2015) 26, 823-826. PubMed  Europe PubMed DOI  A
  11. Sheffield,W.P., Eltringham-Smith,L.J., Gataiance,S. and Bhakta,V.
    A plasmin-activatable thrombin inhibitor reduces experimental thrombosis and assists experimental thrombolysis in murine models
    J Thromb Thrombolysis (2015) 39, 443-451. PubMed  Europe PubMed DOI
    12. 2014
  12. Huang,Y., Zhang,Y., Zhao,B., Xu,Q., Zhou,X., Song,H., Yu,M. and Mo,W.
    Structural basis of RGD-hirudin binding to thrombin: Tyr 3 and five C-terminal residues are crucial for inhibiting thrombin activity
    BMC Struct Biol (2014) 14, 26-26. PubMed  Europe PubMed DOI
    13. 2013
  13. Kovach,I.M., Kakalis,L., Jordan,F. and Zhang,D.
    Proton bridging in the interactions of thrombin with hirudin and its mimics
    Biochemistry (2013) 52, 2472-2481. PubMed  Europe PubMed DOI  I
    14. 2012
  14. Hsieh,Y.S., Taleski,D., Wilkinson,B.L., Wijeyewickrema,L.C., Adams,T.E., Pike,R.N. and Payne,R.J.
    Effect of O-glycosylation and tyrosine sulfation of leech-derived peptides on binding and inhibitory activity against thrombin
    Chem Commun (Camb) (2012) 48, 1547-1549. PubMed  Europe PubMed DOI
    15. 2010
  15. Corral-Rodriguez,M.A., Macedo-Ribeiro,S., Pereira,P.J. and Fuentes-Prior,P.
    Leech-derived thrombin inhibitors: from structures to mechanisms to clinical applications
    J Med Chem (2010) 53, 3847-3861. PubMed  Europe PubMed DOI  S
    16. 2008
  16. Greinacher,A. and Warkentin,T.E.
    The direct thrombin inhibitor hirudin
    Thromb Haemost (2008) 99, 819-829. PubMed  Europe PubMed DOI  V
    17. 2007
  17. Liu,C.C., Brustad,E., Liu,W. and Schultz,P.G.
    Crystal structure of a biosynthetic sulfo-hirudin complexed to thrombin
    J Am Chem Soc (2007) 129, 10648-10649. PubMed  Europe PubMed DOI  PMC  EPMC  S
    18. 2006
  18. [YEAR:13-6-2006]Goulas,S., Gatos,D. and Barlos,K.
    Convergent solid-phase synthesis of hirudin
    J Pept Sci (13-6-2006) 12, 116-123. PubMed  Europe PubMed DOI
    19. 2005
  19. Meddahi,S., Bara,L., Fessi,H. and Samama,M.M.
    Determination of prothombinase activation after adding human purified prothrombin to human clot: comparison of hirudin, an activated factor II inhibitor, with DX9065a, an activated factor X inhibitor, on clot-associated thrombin and on prothrombin activation
    Blood Coagul Fibrinolysis (2005) 16, 125-133. PubMed  Europe PubMed  I
  20. [YEAR:27-5-2005]Mengwasser,K.E., Bush,L.A., Shih,P., Cantwell,A.M. and Di Cera,E.
    Hirudin binding reveals key determinants of thrombin allostery
    J Biol Chem (27-5-2005) 280, 26997-27003. PubMed  Europe PubMed DOI
    21. 2004
  21. De Filippis,V., De Boni,S., De Dea,E., Dalzoppo,D., Grandi,C. and Fontana,A.
    Incorporation of the fluorescent amino acid 7-azatryptophan into the core domain 1-47 of hirudin as a probe of hirudin folding and thrombin recognition
    Protein Sci (2004) 13, 1489-1502. PubMed  Europe PubMed DOI  PMC  EPMC
  22. Hanessian,S., Tremblay,M. and Petersen,J.F.
    The N-acyloxyiminium ion aza-Prins route to octahydroindoles: total synthesis and structural confirmation of the antithrombotic marine natural product oscillarin
    J Am Chem Soc (2004) 126, 6064-6071. PubMed  Europe PubMed DOI  S  I
  23. Wang,J., Zheng,H., Ou,X., Albertson,C.M., Fink,L.M., Herbert,J.M. and Hauer-Jensen,M.
    Hirudin ameliorates intestinal radiation toxicity in the rat: support for thrombin inhibition as strategy to minimize side-effects after radiation therapy and as countermeasure against radiation exposure
    J Thromb Haemost (2004) 2, 2027-2035. PubMed  Europe PubMed DOI
  24. Warkentin,T.E.
    Bivalent direct thrombin inhibitors: hirudin and bivalirudin
    Best Pract Res Clin Haematol (2004) 17, 105-125. PubMed  Europe PubMed DOI
  25. Zhou,W.B. and Zhang,Y.X.
    Purification and identification of recombinant hirudin and its degradation products expressed in Pichia pastoris
    Prep Biochem Biotechnol (2004) 34, 239-252. PubMed  Europe PubMed DOI  E
    26. 2003
  26. [YEAR:25-3-2003]Lopez,M., Mende,K., Steinmetzer,T. and Nowak,G.
    Cloning, purification and biochemical characterization of dipetarudin, a new chimeric thrombin inhibitor
    J Chromatogr B Analyt Technol Biomed Life Sci (25-3-2003) 786, 73-80. PubMed  Europe PubMed DOI
  27. Peter,K., Gupta,A., Nordt,T., Bauer,S., Runge,M.S. and Bode,C.
    Construction and in vitro testing of a novel fab-hirudin-based fusion protein that targets fibrin and inhibits thrombin in a factor Xa-dependent manner
    J Cardiovasc Pharmacol (2003) 42, 237-244. PubMed  Europe PubMed DOI
  28. Wirsching,F., Keller,M., Hildmann,C., Riester,D. and Schwienhorst,A.
    Directed evolution towards protease-resistant hirudin variants
    Mol Genet Metab (2003) 80, 451-462. PubMed  Europe PubMed DOI
    29. 2002
  29. [YEAR:19-11-2002]De Filippis,V., Colombo,G., Russo,I., Spadari,B. and Fontana,A.
    Probing the hirudin-thrombin interaction by incorporation of noncoded amino acids and molecular dynamics simulation
    Biochemistry (19-11-2002) 41, 13556-13569. PubMed  Europe PubMed DOI
  30. Markwardt,F.
    Hirudin as alternative anticoagulant - a historical review
    Semin Thromb Hemost (2002) 28, 405-414. PubMed  Europe PubMed DOI
  31. Tan,S., Wu,W., Liu,J., Kong,Y., Pu,Y. and Yuan,R.
    Efficient expression and secretion of recombinant hirudin III in E. coli using the L-asparaginase II signal sequence
    Protein Expr Purif (2002) 25, 430-436. PubMed  Europe PubMed DOI  E
  32. [YEAR:1-5-2002]Weitz,J.I. and Crowther,M.
    Direct thrombin inhibitors
    Thromb Res (1-5-2002) 106, V275-V284. PubMed  Europe PubMed DOI
    33. 2001
  33. Bi,Q., Zhang,J., Huang,Y., Su,H., Zhou,X. and Zhu,S.
    Construction, expression, and characterization of recombinant hirudin in Escherichia coli
    Appl Biochem Biotechnol (2001) 95, 23-30. PubMed  Europe PubMed DOI
  34. [YEAR:13-3-2001]Greinacher,A. and Lubenow,N.
    Recombinant hirudin in clinical practice: focus on lepirudin
    Circulation (13-3-2001) 103, 1479-1484. PubMed  Europe PubMed
  35. Lahann,J., Pluster,W., Klee,D., Gattner,H.G. and Hocker,H.
    Immobilization of the thrombin inhibitor r-hirudin conserving its biological activity
    J Mater Sci Mater Med (2001) 12, 807-810. PubMed  Europe PubMed
  36. Menssen,H.D., Melber,K., Brandt,N. and Thiel,E.
    The use of hirudin as universal anticoagulant in haematology, clinical chemistry and blood grouping
    Clin Chem Lab Med (2001) 39, 1267-1277. PubMed  Europe PubMed DOI
  37. Sohn,J.H., Kang,H.A., Rao,K.J., Kim,C.H., Choi,E.S., Chung,B.H. and Rhee,S.K.
    Current status of the anticoagulant hirudin: its biotechnological production and clinical practice
    Appl Microbiol Biotechnol (2001) 57, 606-613. PubMed  Europe PubMed DOI
    38. 2000
  38. Gordon,M.B. and Beckman,J.A.
    Successful anticoagulation with hirudin in a patient with mesenteric venous thrombosis and multiple coagulation abnormalities
    Vasc Med (2000) 5, 159-162. PubMed  Europe PubMed
    39. 1998
  39. Conti,E., Rivetti,C., Wonacott,A. and Brick,P.
    X-ray and spectrophotometric studies of the binding of proflavin to the S1 specificity pocket of human alpha-thrombin
    FEBS Lett (1998) 425, 229-233. PubMed  Europe PubMed DOI  I
    40. 1997
  40. [YEAR:1-6-1997]Potzsch,B., Hund,S., Madlener,K., Unkrig,C. and Muller-Berghaus,G.
    Monitoring of recombinant hirudin: assessment of a plasma-based ecarin clotting time assay
    Thromb Res (1-6-1997) 86, 373-383. PubMed  Europe PubMed DOI  A  E
    41. 1996
  41. [YEAR:27-9-1996]Fischer,B.E., Schlokat,U., Mitterer,A., Savidis-Dacho,H., Grillberger,L., Reiter,M., Mundt,W., Dorner,F. and Eibl,J.
    Rational design, recombinant preparation, and in vitro and in vivo characterization of human prothrombin-derived hirudin antagonists
    J Biol Chem (27-9-1996) 271, 23737-23742. PubMed  Europe PubMed DOI
  42. Nicolini,F.A., Lee,P., Malycky,J.L., Lefkovits,J., Kottke-Marchant,K., Plow,E.F. and Topol,E.J.
    Selective inhibition of factor Xa during thrombolytic therapy markedly improves coronary artery patency in a canine model of coronary thrombosis
    Blood Coagul Fibrinolysis (1996) 7, 39-48. PubMed  Europe PubMed
    43. 1995
  43. Ascenzi,P., Amiconi,G., Bode,W., Bolognesi,M., Coletta,M. and Menegatti,E.
    Proteinase inhibitors from the European medicinal leech Hirudo medicinalis: structural, functional and biomedical aspects
    Mol Aspects Med (1995) 16, 215-313. PubMed  Europe PubMed DOI  V
    44. 1994
  44. Johnson,P.H.
    Hirudin: clinical potential of a thrombin inhibitor
    Annu Rev Med (1994) 45, 165-177. PubMed  Europe PubMed DOI
  45. [YEAR:5-4-1994]le Bonniec,B.F., Betz,A., Guinto,E.R., Esmon,C.T. and Stone,S.R.
    Mapping of the thrombin des-ETW conformation by using site-directed mutants of hirudin. Evidence for the induction of nonlocal modifications by mutagenesis
    Biochemistry (5-4-1994) 33, 3959-3966. PubMed  Europe PubMed
  46. Vindigni,A., De Filippis,V., Zanotti,G., Visco,C., Orsini,G. and Fontana,A.
    Probing the structure of hirudin from Hirudinaria manillensis by limited proteolysis. Isolation, characterization and thrombin-inhibitory properties of N-terminal fragments
    Eur J Biochem (1994) 226, 323-333. PubMed  Europe PubMed DOI  P
    47. 1993
  47. [YEAR:5-10-1993]Chatrenet,B. and Chang,J.Y.
    The disulfide folding pathway of hirudin elucidated by stop/go folding experiments
    J Biol Chem (5-10-1993) 268, 20988-20996. PubMed  Europe PubMed
  48. Priestle,J.P., Rahuel,J., Rink,H., Tones,M. and Grutter,M.G.
    Changes in interactions in complexes of hirudin derivatives and human alpha-thrombin due to different crystal forms
    Protein Sci (1993) 2, 1630-1642. PubMed  Europe PubMed DOI  PMC  EPMC
    49. 1992
  49. Bode,W. and Huber,R.
    Natural protein proteinase inhibitors and their interaction with proteinases
    Eur J Biochem (1992) 204, 433-451. PubMed  Europe PubMed
  50. Chang,J.Y. and Chatrenet,B.
    The disulfide folding pathway of hirudin: A thrombin-specific inhibitor
    J Protein Chem (1992) 11, 416-417. DOI
  51. [YEAR:5-12-1992]Knapp,A., Degenhardt,T. and Dodt,J.
    Hirudisins. Hirudin-derived thrombin inhibitors with disintegrin activity
    J Biol Chem (5-12-1992) 267, 24230-24234. PubMed  Europe PubMed
  52. Szyperski,T., Guntert,P., Stone,S.R., Tulinsky,A., Bode,W., Huber,R. and Wuthrich,K.
    Impact of protein-protein contacts on the conformation of thrombin-bound hirudin studied by comparison with the nuclear magnetic resonance solution structure of hirudin(1-51)
    J Mol Biol (1992) 228, 1206-1211. PubMed  Europe PubMed DOI
  53. Szyperski,T., Guntert,P., Stone,S.R. and Wuthrich,K.
    Nuclear magnetic resonance solution structure of hirudin(1-51) and comparison with corresponding three-dimensional structures determined using the complete 65-residue hirudin polypeptide chain
    J Mol Biol (1992) 228, 1193-1205. PubMed  Europe PubMed DOI  S
  54. [YEAR:5-9-1992]Vitali,J., Martin,P.D., Malkowski,M.G., Robertson,W.D., Lazar,J.B., Winant,R.C., Johnson,P.H. and Edwards,B.F.
    The structure of a complex of bovine alpha-thrombin and recombinant hirudin at 2.8-A resolution
    J Biol Chem (5-9-1992) 267, 17670-17678. PubMed  Europe PubMed
    55. 1991
  55. [YEAR:15-6-1991]Chang,J.Y.
    Stability of hirudin, a thrombin-specific inhibitor. The structure of alkaline-inactivated hirudin
    J Biol Chem (15-6-1991) 266, 10839-10843. PubMed  Europe PubMed
  56. [YEAR:15-1-1991]Lazar,J.B., Winant,R.C. and Johnson,P.H.
    Hirudin: amino-terminal residues play a major role in the interaction with thrombin
    J Biol Chem (15-1-1991) 266, 685-688. PubMed  Europe PubMed
  57. Rydel,T.J., Tulinsky,A., Bode,W. and Huber,R.
    Refined structure of the hirudin-thrombin complex
    J Mol Biol (1991) 221, 583-601. PubMed  Europe PubMed DOI  S
  58. Skrzypczak-Jankun,E., Carperos,V.E., Ravichandran,K.G., Tulinsky,A., Westbrook,M. and Maraganore,J.M.
    Structure of the hirugen and hirulog 1 complexes of alpha-thrombin
    J Mol Biol (1991) 221, 1379-1393. PubMed  Europe PubMed  S
    59. 1990
  59. [YEAR:22-2-1990]Dennis,S., Wallace,A., Hofsteenge,J. and Stone,S.R.
    Use of fragments of hirudin to investigate thrombin-hirudin interaction
    Eur J Biochem (22-2-1990) 188, 61-66. PubMed  Europe PubMed
  60. Grutter,M.G., Priestle,J.P., Rahuel,J., Grossenbacher,H., Bode,W., Hofsteenge,J. and Stone,S.R.
    Crystal structure of the thrombin-hirudin complex: a novel mode of serine protease inhibition
    EMBO J (1990) 9, 2361-2365. PubMed  Europe PubMed  PMC  EPMC  S
  61. [YEAR:15-8-1990]Naski,M.C., Fenton,J.W., Maraganore,J.M., Olson,S.T. and Shafer,J.A.
    The COOH-terminal domain of hirudin. An exosite-directed competitive inhibitor of the action of alpha-thrombin on fibrinogen
    J Biol Chem (15-8-1990) 265, 13484-13489. PubMed  Europe PubMed
  62. [YEAR:15-6-1990]Prescott,S.M., Seeger,A.R., Zimmerman,G.A., McIntyre,T.M. and Maraganore,J.M.
    Hirudin-based peptides block the inflammatory effects of thrombin on endothelial cells
    J Biol Chem (15-6-1990) 265, 9614-9616. PubMed  Europe PubMed
  63. Rydel,T.J., Ravichandran,K.G., Tulinsky,A., Bode,W., Huber,R., Roitsch,C. and Fenton,J.W.
    The structure of a complex of recombinant hirudin and human alpha-thrombin
    Science (1990) 249, 277-280. PubMed  Europe PubMed  S
    64. 1989
  64. [YEAR:5-5-1989]Chang,J.Y.
    The hirudin-binding site of human alpha-thrombin. Identification of lysyl residues which participate in the combining site of hirudin-thrombin complex
    J Biol Chem (5-5-1989) 264, 7141-7146. PubMed  Europe PubMed
  65. Folkers,P.J., Clore,G.M., Driscoll,P.C., Dodt,J., Kohler,S. and Gronenborn,A.M.
    Solution structure of recombinant hirudin and the Lys-47 --> Glu mutant: a nuclear magnetic resonance and hybrid distance geometry- dynamical simulated annealing study
    Biochemistry (1989) 28, 2601-2617. PubMed  Europe PubMed  S
    66. 1987
  66. [YEAR:28-7-1987]Stone,S.R., Braun,P.J. and Hofsteenge,J.
    Identification of regions of alpha-thrombin involved in its interaction with hirudin
    Biochemistry (28-7-1987) 26, 4617-4624. PubMed  Europe PubMed
    67. 1986
  67. Seemuller,U., Dodt,J., Fink,E. and Fritz,H.
    Proteinase inhibitors of the leech Hirudo medicinalis (hirudins, bdellins, eglins)
     (1986) , 337-359.
    68. 1983
  68. [YEAR:1-6-1983]Baskova,I.P., Cherkesova,D.U. and Mosolov,V.V.
    Hirudin from leech heads and whole leeches and "pseudo-hirudin" from leech bodies
    Thromb Res (1-6-1983) 30, 459-467. PubMed  Europe PubMed
  69. [YEAR:12-12-1983]Chang,J.Y.
    The functional domain of hirudin, a thrombin-specific inhibitor
    FEBS Lett (12-12-1983) 164, 307-313. PubMed  Europe PubMed DOI
    70. 1982
  70. [YEAR:28-6-1982]Markwardt,F., Hauptmann,J., Nowak,G., Klessen,C. and Walsmann,P.
    Pharmacological studies on the antithrombotic action of hirudin in experimental animals
    Thromb Haemost (28-6-1982) 47, 226-229. PubMed  Europe PubMed
    71. 1980
  71. [YEAR:1-8-1980]Ishikawa,A., Hafter,R., Seemuller,U., Gokel,J.M. and Graeff,H.
    The effect of hirudin on endotoxin induced disseminated intravascular coagulation (DIC)
    Thromb Res (1-8-1980) 19, 351-358. PubMed  Europe PubMed
  72. Nowak,G. and Markwardt,F.
    Influence of hirudin on endotoxin-induced disseminated intravascular coagulation (DIC) in weaned pigs
    Exp Pathol (Jena) (1980) 18, 438-443. PubMed  Europe PubMed
    73. 1976
  73. Bagdy,D., Barabas,E., Graf,L., Petersen,T.E. and Magnusson,S.
    Hirudin
    Methods Enzymol (1976) 45, 669-678. PubMed  Europe PubMed DOI  V
    74. 1967
  74. Markwardt,F. and Walsmann,P.
    [Purification and analysis of the thrombin inhibitor hirudin]
    Hoppe Seylers Z Physiol Chem (1967) 348, 1381-1386. PubMed  Europe PubMed
    75. 1958
  75. Markwardt,F.
    [Experiments on the pharmacological characterization of hirudin.]
    Naunyn Schmiedebergs Arch Exp Pathol Pharmakol (1958) 234, 516-529. PubMed  Europe PubMed DOI
    76. 1957
  76. Markwardt,F.
    [Isolation and chemical characterization of hirudin]
    Hoppe Seylers Z Physiol Chem (1957) 308, 147-156. PubMed  Europe PubMed
  77. Markwardt,F.
    [Determination of thrombin by titration with hirudin]
    Arch Pharm Ber Dtsch Pharm Ges (1957) 290, 280-285. PubMed  Europe PubMed
  78. Markwardt,F.
    [Experiments on the reaction mechanisms of hirudin]
    Naunyn Schmiedebergs Arch Exp Pathol Pharmakol (1957) 232, 343-345. PubMed  Europe PubMed DOI
    79. 1956
  79. Markwardt,F.
    Die antagonistische Wirkung des Hirudins gegen Thrombin in vivo
    Naturwissenschaften (1956) 43, 111- DOI

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