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Literature for inhibitor I14.001: hirudin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature

(Topics flags: S Structure, A Assay, P Specificity, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Liu,S.J., Cao,Y.L. and Zhang,C.<br>Hirudin in the Treatment of Chronic Kidney Disease<br>Molecules (2024) 29 PubMed  Europe PubMed DOI  PMC  EPMC  V
  2. Mo,L., Yang,C., Dai,Y., Liu,W., Gong,Y., Guo,Y., Zhu,Y., Cao,Y., Xiao,X., Du,S., Lu,S. and He,J.<br>Novel drug delivery systems for hirudin-based product development and clinical applications<br>Int J Biol Macromol (2024) 287, 138533-138533. PubMed  Europe PubMed DOI  V
  3. Yi,X., Liu,J., Zang,E., Tian,Y., Liu,J. and Shi,L.<br>Exploring a Hirudin variant from nonhematophagous leeches: Unraveling full-length sequence, alternative splicing, function, and potential as a novel anticoagulant polypeptide<br>J Ethnopharmacol (2024) 330, 118257-118257. PubMed  Europe PubMed DOI
    4. 2020
  4. Bian,Y., Zhang,Y. and Tian,Z.B.<br>Effect of hirudin on serum matrix metalloproteinase-9 of acute cerebral infarction: A protocol of systematic review and meta-analysis<br>Medicine (Baltimore) (2020) 99, e20533-e20533. PubMed  Europe PubMed DOI  PMC  EPMC
    5. 2019
  5. Cheng,B., Liu,F., Guo,Q., Lu,Y., Shi,H., Ding,A. and Xu,C.<br>Identification and characterization of hirudin-HN, a new thrombin inhibitor, from the salivary glands of Hirudo nipponia<br>PeerJ (2019) 7, e7716-e7716. PubMed  Europe PubMed DOI  PMC  EPMC
    6. 2018
  6. De Filippis,V., Acquasaliente,L., Pontarollo,G. and Peterle,D.<br>Noncoded amino acids in protein engineering: structure-activity relationship studies of hirudin-thrombin interaction<br>Biotechnol Appl Biochem (2018) 65, 69-80. PubMed  Europe PubMed DOI
    7. 2017
  7. Khan,H., Nadhman,A., Azam,S.S., Anees,M., Khan,I., Ullah,I., Sohail,M.F., Shahnaz,G. and Yasinzai,M.<br>In-vitro antileishmanial potential of peptide drug hirudin<br>Chem Biol Drug Des (2017) 89, 67-73. PubMed  Europe PubMed DOI
  8. Zhao,B., Zhang,Y., Huang,Y., Yu,J., Li,Y., Wang,Q., Ma,Y., Song,H.Y., Yu,M. and Mo,W.<br>A novel hirudin derivative inhibiting thrombin without bleeding for subcutaneous injection<br>Thromb Haemost (2017) 117, 44-56. PubMed  Europe PubMed DOI
    9. 2016
  9. Shabareesh,P. and Kaur,K.J.<br>Structural and functional characterization of hirudin P6 derived novel bivalent thrombin inhibitors - studying the effect of linker length and glycosylation on their function<br>Chem Biol Drug Des (2016) 88, 129-141. PubMed  Europe PubMed DOI
    10. 2015
  10. Liu,Y., Yang,J., Wang,J., Huang,Q., Yang,X. and Zhang,J.<br>Test of hirudin activity by tracking the binding of hirudin to thrombin in the presence of BS3 cross-linking<br>Blood Coagul Fibrinolysis (2015) 26, 823-826. PubMed  Europe PubMed DOI  A
  11. Sheffield,W.P., Eltringham-Smith,L.J., Gataiance,S. and Bhakta,V.<br>A plasmin-activatable thrombin inhibitor reduces experimental thrombosis and assists experimental thrombolysis in murine models<br>J Thromb Thrombolysis (2015) 39, 443-451. PubMed  Europe PubMed DOI
    12. 2014
  12. Huang,Y., Zhang,Y., Zhao,B., Xu,Q., Zhou,X., Song,H., Yu,M. and Mo,W.<br>Structural basis of RGD-hirudin binding to thrombin: Tyr 3 and five C-terminal residues are crucial for inhibiting thrombin activity<br>BMC Struct Biol (2014) 14, 26-26. PubMed  Europe PubMed DOI
    13. 2013
  13. Kovach,I.M., Kakalis,L., Jordan,F. and Zhang,D.<br>Proton bridging in the interactions of thrombin with hirudin and its mimics<br>Biochemistry (2013) 52, 2472-2481. PubMed  Europe PubMed DOI  I
    14. 2012
  14. Hsieh,Y.S., Taleski,D., Wilkinson,B.L., Wijeyewickrema,L.C., Adams,T.E., Pike,R.N. and Payne,R.J.<br>Effect of O-glycosylation and tyrosine sulfation of leech-derived peptides on binding and inhibitory activity against thrombin<br>Chem Commun (Camb) (2012) 48, 1547-1549. PubMed  Europe PubMed DOI
    15. 2010
  15. Corral-Rodriguez,M.A., Macedo-Ribeiro,S., Pereira,P.J. and Fuentes-Prior,P.<br>Leech-derived thrombin inhibitors: from structures to mechanisms to clinical applications<br>J Med Chem (2010) 53, 3847-3861. PubMed  Europe PubMed DOI  S
    16. 2008
  16. Greinacher,A. and Warkentin,T.E.<br>The direct thrombin inhibitor hirudin<br>Thromb Haemost (2008) 99, 819-829. PubMed  Europe PubMed DOI  V
    17. 2007
  17. Liu,C.C., Brustad,E., Liu,W. and Schultz,P.G.<br>Crystal structure of a biosynthetic sulfo-hirudin complexed to thrombin<br>J Am Chem Soc (2007) 129, 10648-10649. PubMed  Europe PubMed DOI  PMC  EPMC  S
    18. 2006
  18. [YEAR:13-6-2006]Goulas,S., Gatos,D. and Barlos,K.<br>Convergent solid-phase synthesis of hirudin<br>J Pept Sci (13-6-2006) 12, 116-123. PubMed  Europe PubMed DOI
    19. 2005
  19. Meddahi,S., Bara,L., Fessi,H. and Samama,M.M.<br>Determination of prothombinase activation after adding human purified prothrombin to human clot: comparison of hirudin, an activated factor II inhibitor, with DX9065a, an activated factor X inhibitor, on clot-associated thrombin and on prothrombin activation<br>Blood Coagul Fibrinolysis (2005) 16, 125-133. PubMed  Europe PubMed  I
  20. [YEAR:27-5-2005]Mengwasser,K.E., Bush,L.A., Shih,P., Cantwell,A.M. and Di Cera,E.<br>Hirudin binding reveals key determinants of thrombin allostery<br>J Biol Chem (27-5-2005) 280, 26997-27003. PubMed  Europe PubMed DOI
    21. 2004
  21. De Filippis,V., De Boni,S., De Dea,E., Dalzoppo,D., Grandi,C. and Fontana,A.<br>Incorporation of the fluorescent amino acid 7-azatryptophan into the core domain 1-47 of hirudin as a probe of hirudin folding and thrombin recognition<br>Protein Sci (2004) 13, 1489-1502. PubMed  Europe PubMed DOI  PMC  EPMC
  22. Hanessian,S., Tremblay,M. and Petersen,J.F.<br>The N-acyloxyiminium ion aza-Prins route to octahydroindoles: total synthesis and structural confirmation of the antithrombotic marine natural product oscillarin<br>J Am Chem Soc (2004) 126, 6064-6071. PubMed  Europe PubMed DOI  S  I
  23. Wang,J., Zheng,H., Ou,X., Albertson,C.M., Fink,L.M., Herbert,J.M. and Hauer-Jensen,M.<br>Hirudin ameliorates intestinal radiation toxicity in the rat: support for thrombin inhibition as strategy to minimize side-effects after radiation therapy and as countermeasure against radiation exposure<br>J Thromb Haemost (2004) 2, 2027-2035. PubMed  Europe PubMed DOI
  24. Warkentin,T.E.<br>Bivalent direct thrombin inhibitors: hirudin and bivalirudin<br>Best Pract Res Clin Haematol (2004) 17, 105-125. PubMed  Europe PubMed DOI
  25. Zhou,W.B. and Zhang,Y.X.<br>Purification and identification of recombinant hirudin and its degradation products expressed in Pichia pastoris<br>Prep Biochem Biotechnol (2004) 34, 239-252. PubMed  Europe PubMed DOI  E
    26. 2003
  26. [YEAR:25-3-2003]Lopez,M., Mende,K., Steinmetzer,T. and Nowak,G.<br>Cloning, purification and biochemical characterization of dipetarudin, a new chimeric thrombin inhibitor<br>J Chromatogr B Analyt Technol Biomed Life Sci (25-3-2003) 786, 73-80. PubMed  Europe PubMed DOI
  27. Peter,K., Gupta,A., Nordt,T., Bauer,S., Runge,M.S. and Bode,C.<br>Construction and in vitro testing of a novel fab-hirudin-based fusion protein that targets fibrin and inhibits thrombin in a factor Xa-dependent manner<br>J Cardiovasc Pharmacol (2003) 42, 237-244. PubMed  Europe PubMed DOI
  28. Wirsching,F., Keller,M., Hildmann,C., Riester,D. and Schwienhorst,A.<br>Directed evolution towards protease-resistant hirudin variants<br>Mol Genet Metab (2003) 80, 451-462. PubMed  Europe PubMed DOI
    29. 2002
  29. [YEAR:19-11-2002]De Filippis,V., Colombo,G., Russo,I., Spadari,B. and Fontana,A.<br>Probing the hirudin-thrombin interaction by incorporation of noncoded amino acids and molecular dynamics simulation<br>Biochemistry (19-11-2002) 41, 13556-13569. PubMed  Europe PubMed DOI
  30. Markwardt,F.<br>Hirudin as alternative anticoagulant - a historical review<br>Semin Thromb Hemost (2002) 28, 405-414. PubMed  Europe PubMed DOI
  31. Tan,S., Wu,W., Liu,J., Kong,Y., Pu,Y. and Yuan,R.<br>Efficient expression and secretion of recombinant hirudin III in E. coli using the L-asparaginase II signal sequence<br>Protein Expr Purif (2002) 25, 430-436. PubMed  Europe PubMed DOI  E
  32. [YEAR:1-5-2002]Weitz,J.I. and Crowther,M.<br>Direct thrombin inhibitors<br>Thromb Res (1-5-2002) 106, V275-V284. PubMed  Europe PubMed DOI
    33. 2001
  33. Bi,Q., Zhang,J., Huang,Y., Su,H., Zhou,X. and Zhu,S.<br>Construction, expression, and characterization of recombinant hirudin in Escherichia coli<br>Appl Biochem Biotechnol (2001) 95, 23-30. PubMed  Europe PubMed DOI
  34. [YEAR:13-3-2001]Greinacher,A. and Lubenow,N.<br>Recombinant hirudin in clinical practice: focus on lepirudin<br>Circulation (13-3-2001) 103, 1479-1484. PubMed  Europe PubMed
  35. Lahann,J., Pluster,W., Klee,D., Gattner,H.G. and Hocker,H.<br>Immobilization of the thrombin inhibitor r-hirudin conserving its biological activity<br>J Mater Sci Mater Med (2001) 12, 807-810. PubMed  Europe PubMed
  36. Menssen,H.D., Melber,K., Brandt,N. and Thiel,E.<br>The use of hirudin as universal anticoagulant in haematology, clinical chemistry and blood grouping<br>Clin Chem Lab Med (2001) 39, 1267-1277. PubMed  Europe PubMed DOI
  37. Sohn,J.H., Kang,H.A., Rao,K.J., Kim,C.H., Choi,E.S., Chung,B.H. and Rhee,S.K.<br>Current status of the anticoagulant hirudin: its biotechnological production and clinical practice<br>Appl Microbiol Biotechnol (2001) 57, 606-613. PubMed  Europe PubMed DOI
    38. 2000
  38. Gordon,M.B. and Beckman,J.A.<br>Successful anticoagulation with hirudin in a patient with mesenteric venous thrombosis and multiple coagulation abnormalities<br>Vasc Med (2000) 5, 159-162. PubMed  Europe PubMed
    39. 1998
  39. Conti,E., Rivetti,C., Wonacott,A. and Brick,P.<br>X-ray and spectrophotometric studies of the binding of proflavin to the S1 specificity pocket of human alpha-thrombin<br>FEBS Lett (1998) 425, 229-233. PubMed  Europe PubMed DOI  I
    40. 1997
  40. [YEAR:1-6-1997]Potzsch,B., Hund,S., Madlener,K., Unkrig,C. and Muller-Berghaus,G.<br>Monitoring of recombinant hirudin: assessment of a plasma-based ecarin clotting time assay<br>Thromb Res (1-6-1997) 86, 373-383. PubMed  Europe PubMed DOI  A  E
    41. 1996
  41. [YEAR:27-9-1996]Fischer,B.E., Schlokat,U., Mitterer,A., Savidis-Dacho,H., Grillberger,L., Reiter,M., Mundt,W., Dorner,F. and Eibl,J.<br>Rational design, recombinant preparation, and in vitro and in vivo characterization of human prothrombin-derived hirudin antagonists<br>J Biol Chem (27-9-1996) 271, 23737-23742. PubMed  Europe PubMed DOI
  42. Nicolini,F.A., Lee,P., Malycky,J.L., Lefkovits,J., Kottke-Marchant,K., Plow,E.F. and Topol,E.J.<br>Selective inhibition of factor Xa during thrombolytic therapy markedly improves coronary artery patency in a canine model of coronary thrombosis<br>Blood Coagul Fibrinolysis (1996) 7, 39-48. PubMed  Europe PubMed
    43. 1995
  43. Ascenzi,P., Amiconi,G., Bode,W., Bolognesi,M., Coletta,M. and Menegatti,E.<br>Proteinase inhibitors from the European medicinal leech Hirudo medicinalis: structural, functional and biomedical aspects<br>Mol Aspects Med (1995) 16, 215-313. PubMed  Europe PubMed DOI  V
    44. 1994
  44. Johnson,P.H.<br>Hirudin: clinical potential of a thrombin inhibitor<br>Annu Rev Med (1994) 45, 165-177. PubMed  Europe PubMed DOI
  45. [YEAR:5-4-1994]le Bonniec,B.F., Betz,A., Guinto,E.R., Esmon,C.T. and Stone,S.R.<br>Mapping of the thrombin des-ETW conformation by using site-directed mutants of hirudin. Evidence for the induction of nonlocal modifications by mutagenesis<br>Biochemistry (5-4-1994) 33, 3959-3966. PubMed  Europe PubMed
  46. Vindigni,A., De Filippis,V., Zanotti,G., Visco,C., Orsini,G. and Fontana,A.<br>Probing the structure of hirudin from Hirudinaria manillensis by limited proteolysis. Isolation, characterization and thrombin-inhibitory properties of N-terminal fragments<br>Eur J Biochem (1994) 226, 323-333. PubMed  Europe PubMed DOI  P
    47. 1993
  47. [YEAR:5-10-1993]Chatrenet,B. and Chang,J.Y.<br>The disulfide folding pathway of hirudin elucidated by stop/go folding experiments<br>J Biol Chem (5-10-1993) 268, 20988-20996. PubMed  Europe PubMed
  48. Priestle,J.P., Rahuel,J., Rink,H., Tones,M. and Grutter,M.G.<br>Changes in interactions in complexes of hirudin derivatives and human alpha-thrombin due to different crystal forms<br>Protein Sci (1993) 2, 1630-1642. PubMed  Europe PubMed DOI  PMC  EPMC
    49. 1992
  49. Bode,W. and Huber,R.<br>Natural protein proteinase inhibitors and their interaction with proteinases<br>Eur J Biochem (1992) 204, 433-451. PubMed  Europe PubMed
  50. Chang,J.Y. and Chatrenet,B.<br>The disulfide folding pathway of hirudin: A thrombin-specific inhibitor<br>J Protein Chem (1992) 11, 416-417. DOI
  51. [YEAR:5-12-1992]Knapp,A., Degenhardt,T. and Dodt,J.<br>Hirudisins. Hirudin-derived thrombin inhibitors with disintegrin activity<br>J Biol Chem (5-12-1992) 267, 24230-24234. PubMed  Europe PubMed
  52. Szyperski,T., Guntert,P., Stone,S.R., Tulinsky,A., Bode,W., Huber,R. and Wuthrich,K.<br>Impact of protein-protein contacts on the conformation of thrombin-bound hirudin studied by comparison with the nuclear magnetic resonance solution structure of hirudin(1-51)<br>J Mol Biol (1992) 228, 1206-1211. PubMed  Europe PubMed DOI
  53. Szyperski,T., Guntert,P., Stone,S.R. and Wuthrich,K.<br>Nuclear magnetic resonance solution structure of hirudin(1-51) and comparison with corresponding three-dimensional structures determined using the complete 65-residue hirudin polypeptide chain<br>J Mol Biol (1992) 228, 1193-1205. PubMed  Europe PubMed DOI  S
  54. [YEAR:5-9-1992]Vitali,J., Martin,P.D., Malkowski,M.G., Robertson,W.D., Lazar,J.B., Winant,R.C., Johnson,P.H. and Edwards,B.F.<br>The structure of a complex of bovine alpha-thrombin and recombinant hirudin at 2.8-A resolution<br>J Biol Chem (5-9-1992) 267, 17670-17678. PubMed  Europe PubMed
    55. 1991
  55. [YEAR:15-6-1991]Chang,J.Y.<br>Stability of hirudin, a thrombin-specific inhibitor. The structure of alkaline-inactivated hirudin<br>J Biol Chem (15-6-1991) 266, 10839-10843. PubMed  Europe PubMed
  56. [YEAR:15-1-1991]Lazar,J.B., Winant,R.C. and Johnson,P.H.<br>Hirudin: amino-terminal residues play a major role in the interaction with thrombin<br>J Biol Chem (15-1-1991) 266, 685-688. PubMed  Europe PubMed
  57. Rydel,T.J., Tulinsky,A., Bode,W. and Huber,R.<br>Refined structure of the hirudin-thrombin complex<br>J Mol Biol (1991) 221, 583-601. PubMed  Europe PubMed DOI  S
  58. Skrzypczak-Jankun,E., Carperos,V.E., Ravichandran,K.G., Tulinsky,A., Westbrook,M. and Maraganore,J.M.<br>Structure of the hirugen and hirulog 1 complexes of alpha-thrombin<br>J Mol Biol (1991) 221, 1379-1393. PubMed  Europe PubMed  S
    59. 1990
  59. [YEAR:22-2-1990]Dennis,S., Wallace,A., Hofsteenge,J. and Stone,S.R.<br>Use of fragments of hirudin to investigate thrombin-hirudin interaction<br>Eur J Biochem (22-2-1990) 188, 61-66. PubMed  Europe PubMed
  60. Grutter,M.G., Priestle,J.P., Rahuel,J., Grossenbacher,H., Bode,W., Hofsteenge,J. and Stone,S.R.<br>Crystal structure of the thrombin-hirudin complex: a novel mode of serine protease inhibition<br>EMBO J (1990) 9, 2361-2365. PubMed  Europe PubMed  PMC  EPMC  S
  61. [YEAR:15-8-1990]Naski,M.C., Fenton,J.W., Maraganore,J.M., Olson,S.T. and Shafer,J.A.<br>The COOH-terminal domain of hirudin. An exosite-directed competitive inhibitor of the action of alpha-thrombin on fibrinogen<br>J Biol Chem (15-8-1990) 265, 13484-13489. PubMed  Europe PubMed
  62. [YEAR:15-6-1990]Prescott,S.M., Seeger,A.R., Zimmerman,G.A., McIntyre,T.M. and Maraganore,J.M.<br>Hirudin-based peptides block the inflammatory effects of thrombin on endothelial cells<br>J Biol Chem (15-6-1990) 265, 9614-9616. PubMed  Europe PubMed
  63. Rydel,T.J., Ravichandran,K.G., Tulinsky,A., Bode,W., Huber,R., Roitsch,C. and Fenton,J.W.<br>The structure of a complex of recombinant hirudin and human alpha-thrombin<br>Science (1990) 249, 277-280. PubMed  Europe PubMed  S
    64. 1989
  64. [YEAR:5-5-1989]Chang,J.Y.<br>The hirudin-binding site of human alpha-thrombin. Identification of lysyl residues which participate in the combining site of hirudin-thrombin complex<br>J Biol Chem (5-5-1989) 264, 7141-7146. PubMed  Europe PubMed
  65. Folkers,P.J., Clore,G.M., Driscoll,P.C., Dodt,J., Kohler,S. and Gronenborn,A.M.<br>Solution structure of recombinant hirudin and the Lys-47 --> Glu mutant: a nuclear magnetic resonance and hybrid distance geometry- dynamical simulated annealing study<br>Biochemistry (1989) 28, 2601-2617. PubMed  Europe PubMed  S
    66. 1987
  66. [YEAR:28-7-1987]Stone,S.R., Braun,P.J. and Hofsteenge,J.<br>Identification of regions of alpha-thrombin involved in its interaction with hirudin<br>Biochemistry (28-7-1987) 26, 4617-4624. PubMed  Europe PubMed
    67. 1986
  67. Seemuller,U., Dodt,J., Fink,E. and Fritz,H.<br>Proteinase inhibitors of the leech Hirudo medicinalis (hirudins, bdellins, eglins)<br> (1986) , 337-359.
    68. 1983
  68. [YEAR:1-6-1983]Baskova,I.P., Cherkesova,D.U. and Mosolov,V.V.<br>Hirudin from leech heads and whole leeches and "pseudo-hirudin" from leech bodies<br>Thromb Res (1-6-1983) 30, 459-467. PubMed  Europe PubMed
  69. [YEAR:12-12-1983]Chang,J.Y.<br>The functional domain of hirudin, a thrombin-specific inhibitor<br>FEBS Lett (12-12-1983) 164, 307-313. PubMed  Europe PubMed DOI
    70. 1982
  70. [YEAR:28-6-1982]Markwardt,F., Hauptmann,J., Nowak,G., Klessen,C. and Walsmann,P.<br>Pharmacological studies on the antithrombotic action of hirudin in experimental animals<br>Thromb Haemost (28-6-1982) 47, 226-229. PubMed  Europe PubMed
    71. 1980
  71. [YEAR:1-8-1980]Ishikawa,A., Hafter,R., Seemuller,U., Gokel,J.M. and Graeff,H.<br>The effect of hirudin on endotoxin induced disseminated intravascular coagulation (DIC)<br>Thromb Res (1-8-1980) 19, 351-358. PubMed  Europe PubMed
  72. Nowak,G. and Markwardt,F.<br>Influence of hirudin on endotoxin-induced disseminated intravascular coagulation (DIC) in weaned pigs<br>Exp Pathol (Jena) (1980) 18, 438-443. PubMed  Europe PubMed
    73. 1976
  73. Bagdy,D., Barabas,E., Graf,L., Petersen,T.E. and Magnusson,S.<br>Hirudin<br>Methods Enzymol (1976) 45, 669-678. PubMed  Europe PubMed DOI  V
    74. 1967
  74. Markwardt,F. and Walsmann,P.<br>[Purification and analysis of the thrombin inhibitor hirudin]<br>Hoppe Seylers Z Physiol Chem (1967) 348, 1381-1386. PubMed  Europe PubMed
    75. 1958
  75. Markwardt,F.<br>[Experiments on the pharmacological characterization of hirudin.]<br>Naunyn Schmiedebergs Arch Exp Pathol Pharmakol (1958) 234, 516-529. PubMed  Europe PubMed DOI
    76. 1957
  76. Markwardt,F.<br>[Isolation and chemical characterization of hirudin]<br>Hoppe Seylers Z Physiol Chem (1957) 308, 147-156. PubMed  Europe PubMed
  77. Markwardt,F.<br>[Determination of thrombin by titration with hirudin]<br>Arch Pharm Ber Dtsch Pharm Ges (1957) 290, 280-285. PubMed  Europe PubMed
  78. Markwardt,F.<br>[Experiments on the reaction mechanisms of hirudin]<br>Naunyn Schmiedebergs Arch Exp Pathol Pharmakol (1957) 232, 343-345. PubMed  Europe PubMed DOI
    79. 1956
  79. Markwardt,F.<br>Die antagonistische Wirkung des Hirudins gegen Thrombin in vivo<br>Naturwissenschaften (1956) 43, 111- DOI

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