Merops Switch to
Peptidases

Inhibitor

Family Clan Small-molecule
inhibitor SEARCHES BLAST
MEROPS

Other
information

Literature for inhibitor I12.001: Bowman-Birk inhibitor (Glycine-type) unit 1

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Inhibits

(Topics flags: S Structure, I Inhibitor, E Expression, V Review, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2023
  1. Ahmad,M.S., Akbar,Z. and Choudhary,M.I.
    Insight into the structural basis of the dual inhibitory mode of Lima bean (Phaseolus lunatus) serine protease inhibitor
    Proteins (2023) 91, 22-31. PubMed  Europe PubMed DOI
  2. Cheng,L., Wei,S., Liu,K., Zhao,X., Zhang,J. and Zhao,Y.
    Identification of the inducible activity in the promoter of the soybean BBI-DII gene exposed to abiotic stress or abscisic acid
    Physiol Mol Biol Plants (2023) 29, 947-957. PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2020
  3. Chen,Z., Chen,Y., Xue,Z., Gao,X., Jia,Y., Wang,Y., Lu,Y., Zhang,J., Zhang,M. and Chen,H.
    Insight into the inactivation mechanism of soybean Bowman-Birk trypsin inhibitor (BBTI) induced by epigallocatechin gallate and epigallocatechin: fluorescence, thermodynamics and docking studies
    Food Chem (2020) 303, 125380-125380. PubMed  Europe PubMed DOI  I
    4. 2013
  4. Hong,Y., Cai,X., Shao,B., Hong,J., Wang,S. and Rao,P.
    Isolation of a thermostable trypsin inhibitor with exploitable potential
    Eur Food Res Technol (2013) 237, 457-465. DOI
  5. Kumar,V. and Gowda,L.R.
    Production of horsegram (Dolichos biflorus) Bowman-Birk Inhibitor by an intein mediated protein purification system
    Protein Expr Purif (2013) 89, 16-24. PubMed  Europe PubMed DOI  E
  6. Kumar,V. and Gowda,L.R.
    The contribution of two disulfide bonds in the trypsin binding domain of horsegram (Dolichos biflorus) Bowman-Birk inhibitor to thermal stability and functionality
    Arch Biochem Biophys (2013) 537, 49-61. PubMed  Europe PubMed DOI
    7. 2012
  7. de Almeida Barros,B., da Silva,W.G., Moreira,M.A. and de Barros,E.G.
    In silico characterization and expression analysis of the multigene family encoding the Bowman-Birk protease inhibitor in soybean
    Mol Biol Rep (2012) 39, 327-334. PubMed  Europe PubMed DOI
  8. Safavi,F. and Rostami,A.
    Role of serine proteases in inflammation: Bowman-Birk protease inhibitor (BBI) as a potential therapy for autoimmune diseases
    Exp Mol Pathol (2012) 93, 428-433. PubMed  Europe PubMed DOI  U
  9. Tamburino,R., Severino,V., Sandomenico,A., Ruvo,M., Parente,A., Chambery,A. and Di Maro,A.
    De novo sequencing and characterization of a novel Bowman-Birk inhibitor from Lathyrus sativus L. seeds by electrospray mass spectrometry
    Mol Biosyst (2012) 8, 3232-3241. PubMed  Europe PubMed DOI
    10. 2011
  10. Muricken,D.G. and Gowda,L.R.
    Molecular engineering of a small trypsin inhibitor based on the binding loop of horsegram seed Bowman-Birk inhibitor
    J Enzyme Inhib Med Chem (2011) 26, 553-560. PubMed  Europe PubMed DOI
    11. 2010
  11. Qi,R.F., Liu,Z.X., Xu,S.Q., Zhang,L., Shao,X.X. and Chi,C.W.
    Small peptides derived from the Lys active fragment of the mung bean trypsin inhibitor are fully active against trypsin
    FEBS J (2010) 277, 224-232. PubMed  Europe PubMed DOI
    12. 2007
  12. Fernandez,J.H., Mello,M.O., Galgaro,L., Tanaka,A.S., Silva-Filho,M.C. and Neshich,G.
    Proteinase inhibition using small Bowman-Birk-type structures
    Genet Mol Res (2007) 6, 846-858. PubMed  Europe PubMed
    13. 2005
  13. Azzouz,H., Cherqui,A., Campan,E.D., Rahbe,Y., Duport,G., Jouanin,L., Kaiser,L. and Giordanengo,P.
    Effects of plant protease inhibitors, oryzacystatin I and soybean Bowman-Birk inhibitor, on the aphid Macrosiphum euphorbiae (Homoptera, Aphididae) and its parasitoid Aphelinus abdominalis (Hymenoptera, Aphelinidae)
    J Insect Physiol (2005) 51, 75-86. PubMed  Europe PubMed DOI
  14. Mao,Y., Lai,C., Vogtentanz,G., Schmidt,B., Day,T., Miller,J., Brandon,D.L. and Chen,D.
    Monoclonal antibodies against soybean Bowman-Birk inhibitor recognize the protease-reactive loops
    Protein J (2005) 24, 275-282. PubMed  Europe PubMed DOI
    15. 2003
  15. Barbosa,J.A., Teles,R.C., Forrer,V.P., Guimaraes,B.G., Medrano,F.J., Ventura,M.M. and Freitas,S.M.
    Crystallization, data collection and phasing of black-eyed pea trypsin/chymotrypsin inhibitor in complex with bovine beta-trypsin
    Acta Crystallogr D Biol Crystallogr (2003) 59, 1828-1830. PubMed  Europe PubMed DOI
  16. Debreczeni,J.E., Bunkoczi,G., Girmann,B. and Sheldrick,G.M.
    In-house phase determination of the lima bean trypsin inhibitor: a low-resolution sulfur-SAD case
    Acta Crystallogr D Biol Crystallogr (2003) 59, 393-395. PubMed  Europe PubMed DOI  S
    17. 2001
  17. Bell,H.A., Fitches,E.C., Down,R.E., Ford,L., Marris,G.C., Edwards,J.P., Gatehouse,J.A. and Gatehouse,A.M.
    Effect of dietary cowpea trypsin inhibitor (CpTI) on the growth and development of the tomato moth Lacanobia oleracea (Lepidoptera: Noctuidae) and on the success of the gregarious ectoparasitoid Eulophus pennicornis (Hymenoptera: Eulophidae)
    Pest Manag Sci (2001) 57, 57-65. PubMed  Europe PubMed DOI
    18. 1997
  18. Samudzi,C., Schroeder,S., Griffith,S., Chen,X. and Quinn,T.P.
    Crystallization and preliminary studies of lima bean trypsin inhibitor
    Proteins (1997) 27, 311-314. PubMed  Europe PubMed DOI
  19. [YEAR:5-12-1997]Sreerama,Y.N. and Gowda,L.R.
    Antigenic determinants and reactive sites of a trypsin/chymotrypsin double-headed inhibitor from horse gram (Dolichos biflorus)
    Biochim Biophys Acta (5-12-1997) 1343, 235-242. PubMed  Europe PubMed DOI
  20. Tanaka,A.S., Sampaio,M.U., Marangoni,S., de Oliveira,B., Novello,J.C., Oliva,M.L., Fink,E. and Sampaio,C.A.
    Purification and primary structure determination of a Bowman-Birk trypsin inhibitor from Torresea cearensis seeds
    Biol Chem (1997) 378, 273-281. PubMed  Europe PubMed
    21. 1996
  21. Birk,Y.
    Protein proteinase inhibitors in legume seeds - overview
    Arch Latinoam Nutr (1996) 44, 26S-30S. PubMed  Europe PubMed
  22. de Carvalho,P.G., Bloch,C., Jr., Morhy,L., da Silva,M.C., de Mello,L.V. and Neshich,G.
    Amino acid sequence of the Phaseolus vulgaris var. "fogo na serra" inhibitor and interactive surface modeling for the enzyme-inhibitor complex
    J Protein Chem (1996) 15, 591-598. PubMed  Europe PubMed
  23. Tanaka,A.S., Sampaio,M.U., Mentele,R., Auerswald,E.A. and Sampaio,C.A.
    Sequence of a new Bowman-Birk inhibitor from Torresea acreana seeds and comparison with Torresea cearensis trypsin inhibitor (TcTI2)
    J Protein Chem (1996) 15, 553-560. PubMed  Europe PubMed
  24. [YEAR:15-11-1996]Voss,R.H., Ermler,U., Essen,L.O., Wenzl,G., Kim,Y.M. and Flecker,P.
    Crystal structure of the bifunctional soybean Bowman-Birk inhibitor at 0.28-nm resolution. Structural peculiarities in a folded protein conformation
    Eur J Biochem (15-11-1996) 242, 122-131. PubMed  Europe PubMed  S
    25. 1995
  25. Ramasarma,P.R., Rao,A.G. and Rao,D.R.
    Role of disulfide linkages in structure and activity of proteinase inhibitor from horsegram (Dolichos biflorus)
    Biochim Biophys Acta (1995) 1248, 35-42. PubMed  Europe PubMed DOI
    26. 1994
  26. [YEAR:7-1-1994]Prakash,B., Murthy,M.R., Sreerama,Y.N., Sarma,P.R. and Rao,D.R.
    Crystallization and preliminary X-ray diffraction studies on a trypsin/chymotrypsin double-headed inhibitor from horse gram
    J Mol Biol (7-1-1994) 235, 364-366. PubMed  Europe PubMed
  27. Terada,S., Fujimura,S. and Kimoto,E.
    Amino acid sequences of double-headed proteinase inhibitors from the seeds of Canavalia lineata
    Biosci Biotechnol Biochem (1994) 58, 376-379. PubMed  Europe PubMed DOI
  28. Terada,S., Fujimura,S., Kino,S. and Kimoto,E.
    Purification and characterization of three proteinase inhibitors from Canavalia lineata seeds
    Biosci Biotechnol Biochem (1994) 58, 371-375. PubMed  Europe PubMed DOI
    29. 1993
  29. Lin,G., Bode,W., Huber,R., Chi,C. and Engh,R.A.
    The 0.25-nm X-ray structure of the Bowman-Birk-type inhibitor from mung bean in ternary complex with porcine trypsin
    Eur J Biochem (1993) 212, 549-555. PubMed  Europe PubMed  S
    30. 1992
  30. Werner,M.H. and Wemmer,D.E.
    Three-dimensional structure of soybean trypsin/chymotrypsin Bowman-Birk inhibitor in solution
    Biochemistry (1992) 31, 999-1010. PubMed  Europe PubMed  S
    31. 1991
  31. Tashiro,M., Hirata,C., Asao,T. and Takahashi,K.
    Purification, characterization, and amino acid sequence of foxtail millet trypsin inhibitor III
    Agric Biol Chem (1991) 55, 419-426. DOI
  32. Werner,M.H. and Wemmer,D.E.
    1H assignments and secondary structure determination of the soybean trypsin/chymotrypsin Bowman-Birk inhibitor
    Biochemistry (1991) 30, 3356-3364. PubMed  Europe PubMed  S
  33. Werner,M.H. and Wemmer,D.E.
    Erratum: 1H Assignments and secondary structure determination of the soybean trypsin/chymotrypsin Bowman-Birk inhibitor (Biochemistry, Volume 30, Number 14, April 9, 1991, pages 3356- 3364)
    Biochemistry (1991) 30, 10362-10362.  S
    34. 1986
  34. Nordlund,T.M., Liu,X.Y. and Sommer,J.H.
    Fluorescence polarization decay of tyrosine in lima bean trypsin inhibitor
    Proc Natl Acad Sci U S A (1986) 83, 8977-8981. PubMed  Europe PubMed  PMC  EPMC
    35. 1985
  35. Birk,Y.
    The Bowman-Birk inhibitor. Trypsin- and chymotrypsin-inhibitor from soybeans
    Int J Pept Protein Res (1985) 25, 113-131. PubMed  Europe PubMed  V
  36. Ishikawa,C., Watanabe,K., Sakata,N., Nakagaki,C., Nakamura,S. and Takahashi,K.
    Azuki bean (Vigna angularis) protease inhibitors: isolation and amino acid sequences
    J Biochem (1985) 97, 55-70. PubMed  Europe PubMed
  37. Smirnoff,P., Ramachandran,J. and Birk,Y.
    Preparation of photoreactive derivatives of trypsin-chymotrypsin inhibitors from soybeans and chick peas by selective modification of lysine residues
    Int J Pept Protein Res (1985) 26, 274-278. PubMed  Europe PubMed
  38. Yavelow,J., Collins,M., Birk,Y., Troll,W. and Kennedy,A.R.
    Nanomolar concentrations of Bowman-Birk soybean protease inhibitor suppress x-ray-induced transformation in vitro
    Proc Natl Acad Sci U S A (1985) 82, 5395-5399. PubMed  Europe PubMed  PMC  EPMC
    39. 1984
  39. Tan,F.L., Shi,Q.L., Wang,L.X. and Qi,Z.W.
    Studies on the mung bean trypsin inhibitor - reduction and reoxidation of the disulfide bonds of the Lys active fragment
    Sci Sin [B] (1984) 27, 918-925. PubMed  Europe PubMed
    40. 1983
  40. Tanaka,Y., Tsunogae,Y., Hayakawa,Y., Tanaka,I., Yamane,T., Ashida,T., Ishikawa,C., Watanabe,K., Nakamura,S. and Takahashi,K.
    Preliminary crystallographic study of Bowman-Birk protease inhibitor (adzuki bean) and its complex with trypsin
    J Biochem (1983) 94, 611-613. PubMed  Europe PubMed
    41. 1982
  41. Tan,F. and Chi,C.W.
    Active domains in mung bean trypsin inhibitor
    Sci Sin [B] (1982) 25, 160-167.
    42. 1981
  42. Kiyohara,T., Yokota,K., Masaki,Y., Matsui,O., Iwasaki,T. and Yoshikawa,M.
    The amino acid sequences of proteinase inhibitors I-A and I-A' from adzuki beans
    J Biochem (1981) 90, 721-728. PubMed  Europe PubMed
    43. 1980
  43. Birk,Y., Jibson,M.D. and Bewley,T.A.
    Circular dichroism spectra of cleavage fragments of soybean trypsin-chymotrypsin inhibitor
    Int J Pept Protein Res (1980) 15, 193-199. PubMed  Europe PubMed
  44. [YEAR:30-9-1980]Ohtaki,Y., Kiyohara,T., Iwasaki,T. and Yoshikawa,M.
    Temporary site in the anti-tryptic fragment from adzuki-bean proteinase inhibitor II
    Biochem Biophys Res Commun (30-9-1980) 96, 719-724. PubMed  Europe PubMed
  45. Yoshikawa,M., Kiyohara,T., Iwasaki,T., Kawata,M., Ohtaki,Y. and Nakao,C.
    Isolation and some properties of two fragments with inhibitory activity obtained from adzuki bean proteinase inhibitor by peptic digestion
    J Biochem (1980) 87, 619-627. PubMed  Europe PubMed
    46. 1979
  46. [YEAR:1-3-1979]Ishikawa,C., Nakamura,S., Watanabe,K. and Takahashi,K.
    The amino acid sequence of adzuki bean proteinase inhibitor I
    FEBS Lett (1-3-1979) 99, 97-100. PubMed  Europe PubMed
  47. [YEAR:10-6-1979]Wei,C.H., Basu,S.P. and Einstein,J.R.
    Preliminary crystallographic data for Bowman-Birk inhibitor from soybean seeds
    J Biol Chem (10-6-1979) 254, 4892-4894. PubMed  Europe PubMed
  48. Yoshikawa,M., Kiyohara,T., Iwasaki,T., Ishii,Y. and Kimura,N.
    Amino acid sequences of proteinase inhibitors II and II' from adzuki beans
    Agric Biol Chem (1979) 43, 787-796. DOI
    49. 1978
  49. Chrispeels,M.J. and Baumgartner,B.
    Trypsin inhibitor in mung bean cotyledons. Purification, characteristics, subcellular localization and metabolism
    Plant Physiol (1978) 61, 617-623. PubMed  Europe PubMed  PMC  EPMC
  50. Odani,S. and Ikenaka,T.
    Studies on soybean trypsin inhibitors, XII. Linear sequences of two soybean double-headed trypsin inhibitors, D-II and E-I
    J Biochem (1978) 83, 737-745. PubMed  Europe PubMed
    51. 1977
  51. Odani,S. and Ikenaka,T.
    Studies on soybean trypsin inhibitors. XI. Complete amino acid sequence of a soybean trypsin-chymotrypsin-elastase inhibitor, C-II
    J Biochem (1977) 82, 1523-1531. PubMed  Europe PubMed
  52. Odani,S. and Ikenaka,T.
    Studies on soybean trypsin inhibitors. X. Isolation and partial characterization of four soybean double-headed proteinase inhibitors
    J Biochem (1977) 82, 1513-1522. PubMed  Europe PubMed
    53. 1976
  53. Birk,Y.
    Lima bean trypsin inhibitors
    Methods Enzymol (1976) 45, 707-709. PubMed  Europe PubMed DOI
  54. Birk,Y.
    Trypsin and chymotrypsin inhibitors from soybeans
    Methods Enzymol (1976) 45, 700-707. PubMed  Europe PubMed DOI
  55. Odani,S. and Ikenaka,T.
    The amino acid sequences of two soybean double headed proteinase inhibitors and evolutionary consideration on the legume proteinase inhibitors
    J Biochem (1976) 80, 641-643. PubMed  Europe PubMed
    56. 1975
  56. [YEAR:10-6-1975]Wilson,K.A. and Laskowski,M., Sr.
    The partial amino acid sequence of trypsin inhibitor II from garden bean, Phaseolus vulgaris, with location of the trypsin and elastase-reactive sites
    J Biol Chem (10-6-1975) 250, 4261-4267. PubMed  Europe PubMed
  57. Yoshida,C. and Yoshikawa,M.
    Purification and characterization of proteinase inhibitors from adzuki beans (Phaseolus angularis)
    J Biochem (1975) 78, 935-945. PubMed  Europe PubMed
    58. 1973
  58. [YEAR:27-3-1973]Krahn,J. and Stevens,F.C.
    Peptide-bond hydrolysis equilibria in the antitrypsin site of lima bean protease inhibitor
    Biochemistry (27-3-1973) 12, 1330-1335. PubMed  Europe PubMed
  59. [YEAR:15-12-1973]Steiner,R.F., Horan,C. and Lunasin,A.
    The interaction of guanidinated lima bean inhibitor with trypsin
    FEBS Lett (15-12-1973) 38, 106-111. PubMed  Europe PubMed DOI
  60. Stevens,F.C. and Doskoch,E.
    Lima bean protease inhibitor: reduction and reoxidation of the disulfide bonds and their reactivity in the trypsin-inhibitor complex
    Can J Biochem (1973) 51, 1021-1028. PubMed  Europe PubMed
  61. Weder,J.K.P.
    Cleavage of a trypsin chymotrypsin inhibitor from Phaseolus vulgaris in active fragments
    Z Lebensm Unters Forsch (1973) 153, 83-86. DOI
  62. [YEAR:10-2-1973]Wilson,K.A. and Laskowski,M., Sr.
    Isolation of three isoinhibitors of trypsin from garden bean, Phaseolus vulgaris, having either lysine or arginine at the reactive site
    J Biol Chem (10-2-1973) 248, 756-762. PubMed  Europe PubMed
    63. 1972
  63. [YEAR:9-5-1972]Krahn,J. and Stevens,F.C.
    Antitrypsin site of lima bean protease inhibitor
    Biochemistry (9-5-1972) 11, 1804-1808. PubMed  Europe PubMed
  64. Odani,S. and Ikenaka,T.
    Studies on soybean trypsin inhibitors. IV. Complete amino acid sequence and the anti-proteinase sites of Bowman-Birk soybean proteinase inhibitor
    J Biochem (1972) 71, 839-848. PubMed  Europe PubMed
    65. 1970
  65. [YEAR:23-6-1970]Krahn,J. and Stevens,F.C.
    Lima bean trypsin inhibitor. Limited proteolysis by trypsin and chymotrypsin
    Biochemistry (23-6-1970) 9, 2646-2652. PubMed  Europe PubMed
    66. 1967
  66. [YEAR:25-11-1967]Haynes,R. and Feeney,R.E.
    Fractionation and properties of trypsin and chymotrypsin inhibitors from lima beans
    J Biol Chem (25-11-1967) 242, 5378-5385. PubMed  Europe PubMed
    67. 1965
  67. Chu,H.M., Lo,S.S., Jen,M.H., Chi,C.W. and Tsao,T.C.
    The relationship between trypsin inhibitors A and B from mung bean (Phaseolus aureus Roxb.) and some chemical characteristics of the inhibitors
    Sci Sin (1965) 14, 1454-1463. PubMed  Europe PubMed
  68. Chu,H.M. and Chi,C.W.
    The isolation and crystallization of two trypsin inhibitors of low molecular weight from mung bean (Phaseolus aureus Roxb.)
    Sci Sin (1965) 14, 1441-1453. PubMed  Europe PubMed
    69. 1963
  69. Birk,Y., Gertler,A. and Khalef,S.
    A pure trypsin inhibitor from soya beans
    Biochem J (1963) 87, 281-284. PubMed  Europe PubMed  PMC  EPMC

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2026 EBI
Terms of use