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Literature for inhibitor I11.001: ecotin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature

(Topics flags: S Structure, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2022
  1. Bagga,T., Sn,L., Sivaraman,J. and Shankar,S.<br>Sequence preference and scaffolding requirement for the inhibition of human neutrophil elastase by ecotin peptide<br>Protein Sci (2022) 31, 933-941. PubMed  Europe PubMed DOI
  2. Nagy,Z.A., Heja,D., Bencze,D., Kiss,B., Boros,E., Szakacs,D., Fodor,K., Wilmanns,M., Kocsis,A., Dobo,J., Gal,P., Harmat,V. and Pal,G.<br>Synergy of protease-binding sites within the ecotin homodimer is crucial for inhibition of MASP enzymes and for blocking lectin pathway activation<br>J Biol Chem (2022) 298, 101985-101985. PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2020
  3. Garcia,F.B., Cabral,A.D., Fuhlendorf,M.M., da Cruz,G.F., Dos Santos,J.V., Ferreira,G.C., de Rezende,B.R.C., Santana,C.M., Puzer,L., Sasaki,S.D., Garcia,W. and Speranca,M.A.<br>Functional and structural characterization of an ecotin-like serine protease inhibitor from Trypanosoma cruzi<br>Int J Biol Macromol (2020) 151, 459-466. PubMed  Europe PubMed DOI
  4. Jobichen,C., Prabhakar,M.T., Loh,S.N. and Sivaraman,J.<br>Structural Basis for the Inhibition Mechanism of Ecotin against Neutrophil Elastase by Targeting the Active Site and Secondary Binding Site<br>Biochemistry (2020) 59, 2788-2795. PubMed  Europe PubMed DOI
  5. Stanton,B.A., Hampton,T.H. and Ashare,A.<br>SARS-CoV-2 (COVID-19) and Cystic Fibrosis<br>Am J Physiol Lung Cell Mol Physiol (2020) 319, L408-L415. PubMed  Europe PubMed DOI
    6. 2019
  6. Nagy,Z.A., Szakacs,D., Boros,E., Heja,D., Vigh,E., Sandor,N., Jozsi,M., Oroszlan,G., Dobo,J., Gal,P. and Pal,G.<br>Ecotin, a microbial inhibitor of serine proteases, blocks multiple complement dependent and independent microbicidal activities of human serum<br>PLoS Pathog (2019) 15, e1008232-e1008232. PubMed  Europe PubMed DOI
    7. 2018
  7. Akermi,N., Mkaouar,H., Jeblaoui,A., Kriaa,A., Gargouri,A., Maguin,E. and Rhimi,M.<br>Relevant patented biotechnological applications of ecotin: an update<br>Recent Pat Biotechnol (2018) 12, 233-238. PubMed  Europe PubMed DOI  V
  8. Tseng,B.S., Reichhardt,C., Merrihew,G.E., Araujo-Hernandez,S.A., Harrison,J.J., Maccoss,M.J. and Parsek,M.R.<br>A biofilm matrix-associated protease inhibitor protects Pseudomonas aeruginosa from proteolytic attack<br>MBio (2018) 9 PubMed  Europe PubMed DOI  PMC  EPMC
    9. 2014
  9. Ireland,P.M., Marshall,L., Norville,I. and Sarkar-Tyson,M.<br>The serine protease inhibitor ecotin is required for full virulence of Burkholderia pseudomallei<br>Microb Pathog (2014) 67-68, 55-58. PubMed  Europe PubMed DOI
    10. 2013
  10. Gaboriaud,C., Gupta,R.K., Martin,L., Lacroix,M., Serre,L., Teillet,F., Arlaud,G.J., Rossi,V. and Thielens,N.M.<br>The serine protease domain of MASP-3: enzymatic properties and crystal structure in complex with ecotin<br>PLoS ONE (2013) 8, e67962-e67962. PubMed  Europe PubMed DOI  PMC  EPMC  S
    11. 2011
  11. Clark,E.A., Walker,N., Ford,D.C., Cooper,I.A., Oyston,P.C. and Acharya,K.R.<br>Molecular recognition of chymotrypsin by the serine protease inhibitor ecotin from Yersinia pestis<br>J Biol Chem (2011) 286, 24015-24022. PubMed  Europe PubMed DOI  S
    12. 2010
  12. Sathler,P.C., Craik,C.S., Takeuchi,T., Zingali,R.B. and Castro,H.C.<br>Engineering ecotin for identifying proteins with a trypsin fold<br>Appl Biochem Biotechnol (2010) 160, 2355-2365. PubMed  Europe PubMed DOI  E
    13. 2009
  13. McCrudden,M.T., Ryan,L.A., Turkington,P. and Timson,D.J.<br>The contribution of key hydrophobic residues in ecotin to enzyme-inhibitor complex stability<br>J Enzyme Inhib Med Chem (2009) 24, 1207-1210. PubMed  Europe PubMed DOI
    14. 2006
  14. Castro,H.C., Monteiro,R.Q., Assafim,M., Loureiro,N.I., Craik,C. and Zingali,R.B.<br>Ecotin modulates thrombin activity through exosite-2 interactions<br>Int J Biochem Cell Biol (2006) 38, 1893-1900. PubMed  Europe PubMed DOI
    15. 2005
  15. [YEAR:15-11-2005]Jin,L., Pandey,P., Babine,R.E., Gorga,J.C., Seidl,K.J., Gelfand,E., Weaver,D.T., Abdel-Meguid,S.S. and Strickler,J.E.<br>Crystal structures of the FXIa catalytic domain in complex with ecotin mutants reveal substrate-like interactions<br>J Biol Chem (15-11-2005) 280, 4704-4712. PubMed  Europe PubMed DOI  S
    16. 2003
  16. Stoop,A.A. and Craik,C.S.<br>Engineering of a macromolecular scaffold to develop specific protease inhibitors<br>Nat Biotechnol (2003) 21, 1063-1068. PubMed  Europe PubMed DOI
  17. [YEAR:8-7-2003]Wang,S.X., Hur,E., Sousa,C.A., Brinen,L., Slivka,E.J. and Fletterick,R.J.<br>The extended interactions and Gla domain of blood coagulation factor Xa<br>Biochemistry (8-7-2003) 42, 7959-7966. PubMed  Europe PubMed DOI  S
    18. 2002
  18. [YEAR:19-7-2002]Laboissiere,M.C., Young,M.M., Pinho,R.G., Todd,S., Fletterick,R.J., Kuntz,I. and Craik,C.S.<br>Computer-assisted mutagenesis of ecotin to engineer its secondary binding site for urokinase inhibition<br>J Biol Chem (19-7-2002) 277, 26623-26631. PubMed  Europe PubMed DOI
    19. 2001
  19. [YEAR:18-5-2001]Eggers,C.T., Wang,S.X., Fletterick,R.J. and Craik,C.S.<br>The role of ecotin dimerization in protease inhibition<br>J Mol Biol (18-5-2001) 308, 975-991. PubMed  Europe PubMed DOI
  20. [YEAR:28-8-2001]Wang,S.X., Esmon,C.T. and Fletterick,R.J.<br>Crystal structure of thrombin-ecotin reveals conformational changes and extended interactions<br>Biochemistry (28-8-2001) 40, 10038-10046. PubMed  Europe PubMed DOI  S
    21. 2000
  21. [YEAR:16-6-2000]Gillmor,S.A., Takeuchi,T., Yang,S.Q., Craik,C.S. and Fletterick,R.J.<br>Compromise and accommodation in ecotin, a dimeric macromolecular inhibitor of serine proteases<br>J Mol Biol (16-6-2000) 299, 993-1003. PubMed  Europe PubMed DOI
    22. 1998
  22. [YEAR:19-6-1998]Yang,S.Q., Wang,C.I., Gillmor,S.A., Fletterick,R.J. and Craik,C.S.<br>Ecotin: a serine protease inhibitor with two distinct and interacting binding sites<br>J Mol Biol (19-6-1998) 279, 945-957. PubMed  Europe PubMed DOI
    23. 1997
  23. Perona,J.J., Tsu,C.A., Craik,C.S. and Fletterick,R.J.<br>Crystal structure of an ecotin-collagenase complex suggests a model for recognition and cleavage of the collagen triple helix<br>Biochemistry (1997) 36, 5381-5392. PubMed  Europe PubMed DOI  S
    24. 1996
  24. Pal,G., Szilagyi,L. and Graf,L.<br>Stable monomeric form of an originally dimeric serine proteinase inhibitor, ecotin, was constructed via site directed mutagenesis<br>FEBS Lett (1996) 385, 165-170. PubMed  Europe PubMed DOI
  25. Shin,D.H., Song,H.K., Seong,I.S., Lee,C.S., Chung,C.H. and Suh,S.W.<br>Crystal structure analyses of uncomplexed ecotin in two crystal forms: implications for its function and stability<br>Protein Sci (1996) 5, 2236-2247. PubMed  Europe PubMed DOI  PMC  EPMC  S
    26. 1995
  26. Gillmor,S.A., McGrath,M.E. and Fletterick,R.J.<br>Ecotin: A most adaptable protease inhibitor<br>Perspect Drug Discov Design (1995) 2, 475-482. DOI  V
  27. McGrath,M.E., Gillmor,S.A. and Fletterick,R.J.<br>Ecotin: lessons on survival in a protease-filled world<br>Protein Sci (1995) 4, 141-148. PubMed  Europe PubMed DOI  PMC  EPMC
  28. Ulmer,J.S., Lindquist,R.N., Dennis,M.S. and Lazarus,R.A.<br>Ecotin is a potent inhibitor of the contact system proteases factor XIIa and plasma kallikrein<br>FEBS Lett (1995) 365, 159-163. PubMed  Europe PubMed DOI
  29. Wang,C.I., Yang,Q. and Craik,C.S.<br>Isolation of a high affinity inhibitor of urokinase-type plasminogen activator by phage display of ecotin<br>J Biol Chem (1995) 270, 12250-12256. PubMed  Europe PubMed
    30. 1994
  30. McGrath,M.E., Erpel,T., Bystroff,C. and Fletterick,R.J.<br>Macromolecular chelation as an improved mechanism of protease inhibition: structure of the ecotin-trypsin complex<br>EMBO J (1994) 13, 1502-1507. PubMed  Europe PubMed  PMC  EPMC  S
  31. [YEAR:28-3-1994]Pal,G., Sprengel,G., Patthy,A. and Graf,L.<br>Alteration of the specificity of ecotin, an E. coli serine proteinase inhibitor, by site directed mutagenesis<br>FEBS Lett (28-3-1994) 342, 57-60. PubMed  Europe PubMed DOI
  32. [YEAR:26-8-1994]Seong,I.S., Lee,H.R., Seol,J.H., Park,S.K., Lee,C.S., Suh,S.W., Hong,Y.M., Kang,M.S., Ha,D.B. and Chung,C.H.<br>The P1 reactive site methionine residue of ecotin is not crucial for its specificity on target proteases. A potent inhibitor of pancreatic serine proteases from Escherichia coli<br>J Biol Chem (26-8-1994) 269, 21915-21918. PubMed  Europe PubMed
  33. [YEAR:5-4-1994]Seymour,J.L., Lindquist,R.N., Dennis,M.S., Moffat,B., Yansura,D., Reilly,D., Wessinger,M.E. and Lazarus,R.A.<br>Ecotin is a potent anticoagulant and reversible tight-binding inhibitor of factor Xa<br>Biochemistry (5-4-1994) 33, 3949-3958. PubMed  Europe PubMed
    34. 1991
  34. Lee,H.R., Seo,J.H., Kim,O.M., Lee,C.S., Suh,S.W., Hong,Y.M., Tanaka,K., Ichihara,A., Ha,D.B. and Chung,C.H.<br>Molecular cloning of the ecotin gene in Escherichia coli<br>FEBS Lett (1991) 287, 53-56. PubMed  Europe PubMed DOI
  35. McGrath,M.E., Hines,W.M., Sakanari,J.A., Fletterick,R.J. and Craik,C.S.<br>The sequence and reactive site of ecotin. A general inhibitor of pancreatic serine proteases from Escherichia coli<br>J Biol Chem (1991) 266, 6620-6625. PubMed  Europe PubMed
  36. McGrath,M.E., Erpel,T., Browner,M.F. and Fletterick,R.J.<br>Expression of the protease inhibitor ecotin and its co-crystallization with trypsin<br>J Mol Biol (1991) 222, 139-142. PubMed  Europe PubMed DOI
    37. 1986
  37. Braun,N.J. and Schnebli,H.P.<br>A brief review of the biochemistry and pharmacology of eglin c, an elastase inhibitor<br>Eur J Respir Dis Suppl (1986) 146, 541-547. PubMed  Europe PubMed
    38. 1983
  38. [YEAR:25-9-1983]Chung,C.H., Ives,H.E., Almeda,S. and Goldberg,A.L.<br>Purification from Escherichia coli of a periplasmic protein that is a potent inhibitor of pancreatic proteases<br>J Biol Chem (25-9-1983) 258, 11032-11038. PubMed  Europe PubMed

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