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Literature for inhibitor I11.001: ecotin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature

(Topics flags: S Structure, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2022
  1. Bagga,T., Sn,L., Sivaraman,J. and Shankar,S.
    Sequence preference and scaffolding requirement for the inhibition of human neutrophil elastase by ecotin peptide
    Protein Sci31, 933-941. PubMed  Europe PubMed DOI
  2. Nagy,Z.A., Heja,D., Bencze,D., Kiss,B., Boros,E., Szakacs,D., Fodor,K., Wilmanns,M., Kocsis,A., Dobo,J., Gal,P., Harmat,V. and Pal,G.
    Synergy of protease-binding sites within the ecotin homodimer is crucial for inhibition of MASP enzymes and for blocking lectin pathway activation
    J Biol Chem298, 101985-101985. PubMed  Europe PubMed DOI
    3. 2020
  3. Garcia,F.B., Cabral,A.D., Fuhlendorf,M.M., da Cruz,G.F., Dos Santos,J.V., Ferreira,G.C., de Rezende,B.R.C., Santana,C.M., Puzer,L., Sasaki,S.D., Garcia,W. and Speranca,M.A.
    Functional and structural characterization of an ecotin-like serine protease inhibitor from Trypanosoma cruzi
    Int J Biol Macromol151, 459-466. PubMed  Europe PubMed DOI
  4. Jobichen,C., Prabhakar,M.T., Loh,S.N. and Sivaraman,J.
    Structural Basis for the Inhibition Mechanism of Ecotin against Neutrophil Elastase by Targeting the Active Site and Secondary Binding Site
    Biochemistry59, 2788-2795. PubMed  Europe PubMed DOI
  5. Stanton,B.A., Hampton,T.H. and Ashare,A.
    SARS-CoV-2 (COVID-19) and Cystic Fibrosis
    Am J Physiol Lung Cell Mol Physiol319, L408-L415. PubMed  Europe PubMed DOI
    6. 2019
  6. Nagy,Z.A., Szakacs,D., Boros,E., Heja,D., Vigh,E., Sandor,N., Jozsi,M., Oroszlan,G., Dobo,J., Gal,P. and Pal,G.
    Ecotin, a microbial inhibitor of serine proteases, blocks multiple complement dependent and independent microbicidal activities of human serum
    PLoS Pathog15, e1008232-e1008232. PubMed  Europe PubMed DOI
    7. 2018
  7. Akermi,N., Mkaouar,H., Jeblaoui,A., Kriaa,A., Gargouri,A., Maguin,E. and Rhimi,M.
    Relevant patented biotechnological applications of ecotin: an update
    Recent Pat Biotechnol12, 233-238. PubMed  Europe PubMed DOI  V
  8. Tseng,B.S., Reichhardt,C., Merrihew,G.E., Araujo-Hernandez,S.A., Harrison,J.J., Maccoss,M.J. and Parsek,M.R.
    A biofilm matrix-associated protease inhibitor protects Pseudomonas aeruginosa from proteolytic attack
    MBio9, PubMed  Europe PubMed DOI
    9. 2014
  9. Ireland,P.M., Marshall,L., Norville,I. and Sarkar-Tyson,M.
    The serine protease inhibitor ecotin is required for full virulence of Burkholderia pseudomallei
    Microb Pathog67-68, 55-58. PubMed  Europe PubMed DOI
    10. 2013
  10. Gaboriaud,C., Gupta,R.K., Martin,L., Lacroix,M., Serre,L., Teillet,F., Arlaud,G.J., Rossi,V. and Thielens,N.M.
    The serine protease domain of MASP-3: enzymatic properties and crystal structure in complex with ecotin
    PLoS ONE8, e67962-e67962. PubMed  Europe PubMed DOI  S
    11. 2011
  11. Clark,E.A., Walker,N., Ford,D.C., Cooper,I.A., Oyston,P.C. and Acharya,K.R.
    Molecular recognition of chymotrypsin by the serine protease inhibitor ecotin from Yersinia pestis
    J Biol Chem286, 24015-24022. PubMed  Europe PubMed DOI  S
    12. 2010
  12. Sathler,P.C., Craik,C.S., Takeuchi,T., Zingali,R.B. and Castro,H.C.
    Engineering ecotin for identifying proteins with a trypsin fold
    Appl Biochem Biotechnol160, 2355-2365. PubMed  Europe PubMed DOI  E
    13. 2009
  13. McCrudden,M.T., Ryan,L.A., Turkington,P. and Timson,D.J.
    The contribution of key hydrophobic residues in ecotin to enzyme-inhibitor complex stability
    J Enzyme Inhib Med Chem24, 1207-1210. PubMed  Europe PubMed DOI
    14. 2006
  14. Castro,H.C., Monteiro,R.Q., Assafim,M., Loureiro,N.I., Craik,C. and Zingali,R.B.
    Ecotin modulates thrombin activity through exosite-2 interactions
    Int J Biochem Cell Biol38, 1893-1900. PubMed  Europe PubMed DOI
    15. 2005
  15. [YEAR:15-11-2005]Jin,L., Pandey,P., Babine,R.E., Gorga,J.C., Seidl,K.J., Gelfand,E., Weaver,D.T., Abdel-Meguid,S.S. and Strickler,J.E.
    Crystal structures of the FXIa catalytic domain in complex with ecotin mutants reveal substrate-like interactions
    J Biol Chem280, 4704-4712. PubMed  Europe PubMed DOI  S
    16. 2003
  16. Stoop,A.A. and Craik,C.S.
    Engineering of a macromolecular scaffold to develop specific protease inhibitors
    Nat Biotechnol21, 1063-1068. PubMed  Europe PubMed DOI
  17. [YEAR:8-7-2003]Wang,S.X., Hur,E., Sousa,C.A., Brinen,L., Slivka,E.J. and Fletterick,R.J.
    The extended interactions and Gla domain of blood coagulation factor Xa
    Biochemistry42, 7959-7966. PubMed  Europe PubMed DOI  S
    18. 2002
  18. [YEAR:19-7-2002]Laboissiere,M.C., Young,M.M., Pinho,R.G., Todd,S., Fletterick,R.J., Kuntz,I. and Craik,C.S.
    Computer-assisted mutagenesis of ecotin to engineer its secondary binding site for urokinase inhibition
    J Biol Chem277, 26623-26631. PubMed  Europe PubMed DOI
    19. 2001
  19. [YEAR:18-5-2001]Eggers,C.T., Wang,S.X., Fletterick,R.J. and Craik,C.S.
    The role of ecotin dimerization in protease inhibition
    J Mol Biol308, 975-991. PubMed  Europe PubMed DOI
  20. [YEAR:28-8-2001]Wang,S.X., Esmon,C.T. and Fletterick,R.J.
    Crystal structure of thrombin-ecotin reveals conformational changes and extended interactions
    Biochemistry40, 10038-10046. PubMed  Europe PubMed DOI  S
    21. 2000
  21. [YEAR:16-6-2000]Gillmor,S.A., Takeuchi,T., Yang,S.Q., Craik,C.S. and Fletterick,R.J.
    Compromise and accommodation in ecotin, a dimeric macromolecular inhibitor of serine proteases
    J Mol Biol299, 993-1003. PubMed  Europe PubMed DOI
    22. 1998
  22. [YEAR:19-6-1998]Yang,S.Q., Wang,C.I., Gillmor,S.A., Fletterick,R.J. and Craik,C.S.
    Ecotin: a serine protease inhibitor with two distinct and interacting binding sites
    J Mol Biol279, 945-957. PubMed  Europe PubMed DOI
    23. 1997
  23. Perona,J.J., Tsu,C.A., Craik,C.S. and Fletterick,R.J.
    Crystal structure of an ecotin-collagenase complex suggests a model for recognition and cleavage of the collagen triple helix
    Biochemistry36, 5381-5392. PubMed  Europe PubMed DOI  S
    24. 1996
  24. Pal,G., Szilagyi,L. and Graf,L.
    Stable monomeric form of an originally dimeric serine proteinase inhibitor, ecotin, was constructed via site directed mutagenesis
    FEBS Lett385, 165-170. PubMed  Europe PubMed DOI
  25. Shin,D.H., Song,H.K., Seong,I.S., Lee,C.S., Chung,C.H. and Suh,S.W.
    Crystal structure analyses of uncomplexed ecotin in two crystal forms: implications for its function and stability
    Protein Sci5, 2236-2247. PubMed  Europe PubMed DOI  S
    26. 1995
  26. Gillmor,S.A., McGrath,M.E. and Fletterick,R.J.
    Ecotin: A most adaptable protease inhibitor
    Perspect Drug Discov Design2, 475-482. DOI  V
  27. McGrath,M.E., Gillmor,S.A. and Fletterick,R.J.
    Ecotin: lessons on survival in a protease-filled world
    Protein Sci4, 141-148. PubMed  Europe PubMed DOI
  28. Ulmer,J.S., Lindquist,R.N., Dennis,M.S. and Lazarus,R.A.
    Ecotin is a potent inhibitor of the contact system proteases factor XIIa and plasma kallikrein
    FEBS Lett365, 159-163. PubMed  Europe PubMed DOI
  29. Wang,C.I., Yang,Q. and Craik,C.S.
    Isolation of a high affinity inhibitor of urokinase-type plasminogen activator by phage display of ecotin
    J Biol Chem270, 12250-12256. PubMed  Europe PubMed
    30. 1994
  30. McGrath,M.E., Erpel,T., Bystroff,C. and Fletterick,R.J.
    Macromolecular chelation as an improved mechanism of protease inhibition: structure of the ecotin-trypsin complex
    EMBO J13, 1502-1507. PubMed  Europe PubMed  S
  31. [YEAR:28-3-1994]Pal,G., Sprengel,G., Patthy,A. and Graf,L.
    Alteration of the specificity of ecotin, an E. coli serine proteinase inhibitor, by site directed mutagenesis
    FEBS Lett342, 57-60. PubMed  Europe PubMed DOI
  32. [YEAR:26-8-1994]Seong,I.S., Lee,H.R., Seol,J.H., Park,S.K., Lee,C.S., Suh,S.W., Hong,Y.M., Kang,M.S., Ha,D.B. and Chung,C.H.
    The P1 reactive site methionine residue of ecotin is not crucial for its specificity on target proteases. A potent inhibitor of pancreatic serine proteases from Escherichia coli
    J Biol Chem269, 21915-21918. PubMed  Europe PubMed
  33. [YEAR:5-4-1994]Seymour,J.L., Lindquist,R.N., Dennis,M.S., Moffat,B., Yansura,D., Reilly,D., Wessinger,M.E. and Lazarus,R.A.
    Ecotin is a potent anticoagulant and reversible tight-binding inhibitor of factor Xa
    Biochemistry33, 3949-3958. PubMed  Europe PubMed
    34. 1991
  34. Lee,H.R., Seo,J.H., Kim,O.M., Lee,C.S., Suh,S.W., Hong,Y.M., Tanaka,K., Ichihara,A., Ha,D.B. and Chung,C.H.
    Molecular cloning of the ecotin gene in Escherichia coli
    FEBS Lett287, 53-56. PubMed  Europe PubMed DOI
  35. McGrath,M.E., Erpel,T., Browner,M.F. and Fletterick,R.J.
    Expression of the protease inhibitor ecotin and its co-crystallization with trypsin
    J Mol Biol222, 139-142. PubMed  Europe PubMed DOI
  36. McGrath,M.E., Hines,W.M., Sakanari,J.A., Fletterick,R.J. and Craik,C.S.
    The sequence and reactive site of ecotin. A general inhibitor of pancreatic serine proteases from Escherichia coli
    J Biol Chem266, 6620-6625. PubMed  Europe PubMed
    37. 1986
  37. Braun,N.J. and Schnebli,H.P.
    A brief review of the biochemistry and pharmacology of eglin c, an elastase inhibitor
    Eur J Respir Dis Suppl146, 541-547. PubMed  Europe PubMed
    38. 1983
  38. [YEAR:25-9-1983]Chung,C.H., Ives,H.E., Almeda,S. and Goldberg,A.L.
    Purification from Escherichia coli of a periplasmic protein that is a potent inhibitor of pancreatic proteases
    J Biol Chem258, 11032-11038. PubMed  Europe PubMed

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