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Literature for inhibitor I07.004: macrocyclic squash trypsin inhibitor (Momordica cochinchinensis)

Summary Alignment Sequences Sequence features Distribution Structure Literature

(Topics flags: S Structure, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2020
  1. Mishra,M., Singh,V., Tellis,M.B., Joshi,R.S. and Singh,S.<br>Repurposing the McoTI-II Rigid Molecular Scaffold in to Inhibitor of 'Papain Superfamily' Cysteine Proteases<br>Pharmaceuticals (Basel) (2020) 14 PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2019
  2. Jones,P.M., Mazzio,E., Soliman,K. and George,A.M.<br>In silico investigation of the binding of MCoTI-II plant defense knottin to the gamma-NGF serine protease of the 7S nerve growth factor complex and biological activity of its NGF mimetic properties<br>J Phys Chem B (2019) 123, 9104-9110. PubMed  Europe PubMed DOI
    3. 2018
  3. Swedberg,J.E., Ghani,H.A., Harris,J.M., de Veer,S.J. and Craik,D.J.<br>Potent, selective, and cell-penetrating inhibitors of kallikrein-related peptidase 4 based on the cyclic peptide MCoTI-II<br>ACS Med Chem Lett (2018) 9, 1258-1262. PubMed  Europe PubMed DOI  PMC  EPMC
    4. 2016
  4. Jones,P.M. and George,A.M.<br>Computational analysis of the MCoTI-II plant defence knottin reveals a novel intermediate conformation that facilitates trypsin binding<br>Sci Rep (2016) 6, 23174-23174. PubMed  Europe PubMed DOI  PMC  EPMC  S
  5. Swedberg,J.E., Mahatmanto,T., Abdul Ghani,H., de Veer,S.J., Schroeder,C.I., Harris,J.M. and Craik,D.J.<br>Substrate-guided design of selective FXIIa inhibitors based on the plant-derived Momordica cochinchinensis trypsin inhibitor-II (MCoTI-II) scaffold<br>J Med Chem (2016) 59, 7287-7292. PubMed  Europe PubMed DOI
    6. 2014
  6. Gray,K., Elghadban,S., Thongyoo,P., Owen,K.A., Szabo,R., Bugge,T.H., Tate,E.W., Leatherbarrow,R.J. and Ellis,V.<br>Potent and specific inhibition of the biological activity of the type-II transmembrane serine protease matriptase by the cyclic microprotein MCoTI-II<br>Thromb Haemost (2014) 112, 402-411. PubMed  Europe PubMed DOI
  7. Reinwarth,M., Avrutina,O., Fabritz,S. and Kolmar,H.<br>Fragmentation follows structure: top-down mass spectrometry elucidates the topology of engineered cystine-knot miniproteins<br>PLoS ONE (2014) 9, e108626-e108626. PubMed  Europe PubMed DOI  PMC  EPMC
    8. 2013
  8. Daly,N.L., Thorstholm,L., Greenwood,K.P., King,G.J., Rosengren,K.J., Heras,B., Martin,J.L. and Craik,D.J.<br>Structural insights into the role of the cyclic backbone in a squash trypsin inhibitor<br>J Biol Chem (2013) 288, 36141-36148. PubMed  Europe PubMed DOI
  9. Glotzbach,B., Reinwarth,M., Weber,N., Fabritz,S., Tomaszowski,M., Fittler,H., Christmann,A., Avrutina,O. and Kolmar,H.<br>Combinatorial optimization of cystine-knot peptides towards high-affinity inhibitors of human matriptase-1<br>PLoS ONE (2013) 8, e76956-e76956. PubMed  Europe PubMed DOI  PMC  EPMC
  10. Quimbar,P., Malik,U., Sommerhoff,C.P., Kaas,Q., Chan,L.Y., Huang,Y.H., Grundhuber,M., Dunse,K., Craik,D.J., Anderson,M.A. and Daly,N.L.<br>High-affinity cyclic peptide matriptase inhibitors<br>J Biol Chem (2013) 288, 13885-13896. PubMed  Europe PubMed DOI
    11. 2012
  11. Arimatsu,P. and Sawangsook,O.<br>Purification and characterization of trypsin inhibitor from Momordica cochinchinensis Spreng. seed and its effects to Spodoptera litura<br>Asian J Plant Sci (2012) 11, 195-199. DOI
  12. Mylne,J.S., Chan,L.Y., Chanson,A.H., Daly,N.L., Schaefer,H., Bailey,T.L., Nguyencong,P., Cascales,L. and Craik,D.J.<br>Cyclic peptides arising by evolutionary parallelism via asparaginyl-endopeptidase-mediated biosynthesis<br>Plant Cell (2012) 24, 2765-2778. PubMed  Europe PubMed DOI
    13. 2010
  13. Puttamadappa,S.S., Jagadish,K., Shekhtman,A. and Camarero,J.A.<br>Backbone dynamics of cyclotide MCoTI-I free and complexed with trypsin<br>Angew Chem Int Ed Engl (2010) 49, 7030-7034. PubMed  Europe PubMed DOI
  14. Sommerhoff,C.P., Avrutina,O., Schmoldt,H.U., Gabrijelcic-Geiger,D., Diederichsen,U. and Kolmar,H.<br>Engineered cystine knot miniproteins as potent inhibitors of human mast cell tryptase beta<br>J Mol Biol (2010) 395, 167-175. PubMed  Europe PubMed DOI
    15. 2009
  15. Thongyoo,P., Bonomelli,C., Leatherbarrow,R.J. and Tate,E.W.<br>Potent inhibitors of beta-tryptase and human leukocyte elastase based on the MCoTI-II scaffold<br>J Med Chem (2009) 52, 6197-6200. PubMed  Europe PubMed DOI
    16. 2008
  16. Thongyoo,P., Roque-Rosell,N., Leatherbarrow,R.J. and Tate,E.W.<br>Chemical and biomimetic total syntheses of natural and engineered MCoTI cyclotides<br>Org Biomol Chem (2008) 6, 1462-1470. PubMed  Europe PubMed DOI
    17. 2006
  17. [YEAR:24-3-2006]Cemazar,M., Daly,N.L., Haggblad,S., Lo,K.P., Yulyaningsih,E. and Craik,D.J.<br>Knots in rings. The circular knotted protein Momordica cochinchinensis trypsin inhibitor-II folds via a stable two-disulfide intermediate<br>J Biol Chem (24-3-2006) 281, 8224-8232. PubMed  Europe PubMed DOI
  18. Niemann,H.H., Schmoldt,H.U., Wentzel,A., Kolmar,H. and Heinz,D.W.<br>Barnase fusion as a tool to determine the crystal structure of the small disulfide-rich protein McoEeTI<br>J Mol Biol (2006) 356, 1-8. PubMed  Europe PubMed DOI  S
  19. [YEAR:21-7-2006]Thongyoo,P., Tate,E.W. and Leatherbarrow,R.J.<br>Total synthesis of the macrocyclic cysteine knot microprotein MCoTI-II<br>Chem Commun (Camb) (21-7-2006) 2006, 2848-2850. PubMed  Europe PubMed DOI
    20. 2005
  20. Avrutina,O., Schmoldt,H.U., Gabrijelcic-Geiger,D., Le Nguyen,D., Sommerhoff,C.P., Diederichsen,U. and Kolmar,H.<br>Trypsin inhibition by macrocyclic and open-chain variants of the squash inhibitor MCoTI-II<br>Biol Chem (2005) 386, 1301-1306. PubMed  Europe PubMed DOI
    21. 2004
  21. Chiche,L., Heitz,A., Gelly,J.C., Gracy,J., Chau,P.T., Ha,P.T., Hernandez,J.F. and Le-Nguyen,D.<br>Squash inhibitors: from structural motifs to macrocyclic knottins<br>Curr Protein Pept Sci (2004) 5, 341-349. PubMed  Europe PubMed DOI  V
    22. 2001
  22. [YEAR:22-6-2001]Felizmenio-Quimio,M.E., Daly,N.L. and Craik,D.J.<br>Circular proteins in plants: solution structure of a novel macrocyclic trypsin inhibitor from Momordica cochinchinensis<br>J Biol Chem (22-6-2001) 276, 22875-22882. PubMed  Europe PubMed DOI  S
  23. [YEAR:10-7-2001]Heitz,A., Hernandez,J.F., Gagnon,J., Hong,T.T., Pham,T.T.C., Nguyen,T.M., Le Nguyen,D. and Chiche,L.<br>Solution structure of the squash trypsin inhibitor MCoTI-II. A new family for cyclic knottins<br>Biochemistry (10-7-2001) 40, 7973-7983. PubMed  Europe PubMed DOI  S
  24. Pearce,J.<br>Going round in circles to avoid proteolysis<br>Trends Biochem Sci (2001) 26, 282-282. PubMed  Europe PubMed
    25. 2000
  25. [YEAR:16-5-2000]Hernandez,J.F., Gagnon,J., Chiche,L., Nguyen,T.M., Andrieu,J.P., Heitz,A., Trinh,H.T., Pham,T.T. and Le Nguyen,D.<br>Squash trypsin inhibitors from Momordica cochinchinensis exhibit an atypical macrocyclic structure<br>Biochemistry (16-5-2000) 39, 5722-5730. PubMed  Europe PubMed DOI

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