Literature for inhibitor I07.004: macrocyclic squash trypsin inhibitor (Momordica cochinchinensis)

Summary Alignment Sequences Sequence features Distribution Structure Literature

(Topics flags: S Structure, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2020
  1. Mishra,M., Singh,V., Tellis,M.B., Joshi,R.S. and Singh,S.
    Repurposing the McoTI-II Rigid Molecular Scaffold in to Inhibitor of 'Papain Superfamily' Cysteine Proteases
    Pharmaceuticals (Basel)14, PubMed  Europe PubMed DOI
  2. 2019
  3. Jones,P.M., Mazzio,E., Soliman,K. and George,A.M.
    In silico investigation of the binding of MCoTI-II plant defense knottin to the gamma-NGF serine protease of the 7S nerve growth factor complex and biological activity of its NGF mimetic properties
    J Phys Chem B123, 9104-9110. PubMed  Europe PubMed DOI
  4. 2018
  5. Swedberg,J.E., Ghani,H.A., Harris,J.M., de Veer,S.J. and Craik,D.J.
    Potent, selective, and cell-penetrating inhibitors of kallikrein-related peptidase 4 based on the cyclic peptide MCoTI-II
    ACS Med Chem Lett9, 1258-1262. PubMed  Europe PubMed DOI
  6. 2016
  7. Jones,P.M. and George,A.M.
    Computational analysis of the MCoTI-II plant defence knottin reveals a novel intermediate conformation that facilitates trypsin binding
    Sci Rep6, 23174-23174. PubMed  Europe PubMed DOI  S
  8. Swedberg,J.E., Mahatmanto,T., Abdul Ghani,H., de Veer,S.J., Schroeder,C.I., Harris,J.M. and Craik,D.J.
    Substrate-guided design of selective FXIIa inhibitors based on the plant-derived Momordica cochinchinensis trypsin inhibitor-II (MCoTI-II) scaffold
    J Med Chem59, 7287-7292. PubMed  Europe PubMed DOI
  9. 2014
  10. Gray,K., Elghadban,S., Thongyoo,P., Owen,K.A., Szabo,R., Bugge,T.H., Tate,E.W., Leatherbarrow,R.J. and Ellis,V.
    Potent and specific inhibition of the biological activity of the type-II transmembrane serine protease matriptase by the cyclic microprotein MCoTI-II
    Thromb Haemost112, 402-411. PubMed  Europe PubMed DOI
  11. Reinwarth,M., Avrutina,O., Fabritz,S. and Kolmar,H.
    Fragmentation follows structure: top-down mass spectrometry elucidates the topology of engineered cystine-knot miniproteins
    PLoS ONE9, e108626-e108626. PubMed  Europe PubMed DOI
  12. 2013
  13. Daly,N.L., Thorstholm,L., Greenwood,K.P., King,G.J., Rosengren,K.J., Heras,B., Martin,J.L. and Craik,D.J.
    Structural insights into the role of the cyclic backbone in a squash trypsin inhibitor
    J Biol Chem288, 36141-36148. PubMed  Europe PubMed DOI
  14. Glotzbach,B., Reinwarth,M., Weber,N., Fabritz,S., Tomaszowski,M., Fittler,H., Christmann,A., Avrutina,O. and Kolmar,H.
    Combinatorial optimization of cystine-knot peptides towards high-affinity inhibitors of human matriptase-1
    PLoS ONE8, e76956-e76956. PubMed  Europe PubMed DOI
  15. Quimbar,P., Malik,U., Sommerhoff,C.P., Kaas,Q., Chan,L.Y., Huang,Y.H., Grundhuber,M., Dunse,K., Craik,D.J., Anderson,M.A. and Daly,N.L.
    High-affinity cyclic peptide matriptase inhibitors
    J Biol Chem288, 13885-13896. PubMed  Europe PubMed DOI
  16. 2012
  17. Arimatsu,P. and Sawangsook,O.
    Purification and characterization of trypsin inhibitor from Momordica cochinchinensis Spreng. seed and its effects to Spodoptera litura
    Asian J Plant Sci11, 195-199. DOI
  18. Mylne,J.S., Chan,L.Y., Chanson,A.H., Daly,N.L., Schaefer,H., Bailey,T.L., Nguyencong,P., Cascales,L. and Craik,D.J.
    Cyclic peptides arising by evolutionary parallelism via asparaginyl-endopeptidase-mediated biosynthesis
    Plant Cell24, 2765-2778. PubMed  Europe PubMed DOI
  19. 2010
  20. Puttamadappa,S.S., Jagadish,K., Shekhtman,A. and Camarero,J.A.
    Backbone dynamics of cyclotide MCoTI-I free and complexed with trypsin
    Angew Chem Int Ed Engl49, 7030-7034. PubMed  Europe PubMed DOI
  21. Sommerhoff,C.P., Avrutina,O., Schmoldt,H.U., Gabrijelcic-Geiger,D., Diederichsen,U. and Kolmar,H.
    Engineered cystine knot miniproteins as potent inhibitors of human mast cell tryptase beta
    J Mol Biol395, 167-175. PubMed  Europe PubMed DOI
  22. 2009
  23. Thongyoo,P., Bonomelli,C., Leatherbarrow,R.J. and Tate,E.W.
    Potent inhibitors of beta-tryptase and human leukocyte elastase based on the MCoTI-II scaffold
    J Med Chem52, 6197-6200. PubMed  Europe PubMed DOI
  24. 2008
  25. Thongyoo,P., Roque-Rosell,N., Leatherbarrow,R.J. and Tate,E.W.
    Chemical and biomimetic total syntheses of natural and engineered MCoTI cyclotides
    Org Biomol Chem6, 1462-1470. PubMed  Europe PubMed DOI
  26. 2006
  27. [YEAR:24-3-2006]Cemazar,M., Daly,N.L., Haggblad,S., Lo,K.P., Yulyaningsih,E. and Craik,D.J.
    Knots in rings. The circular knotted protein Momordica cochinchinensis trypsin inhibitor-II folds via a stable two-disulfide intermediate
    J Biol Chem281, 8224-8232. PubMed  Europe PubMed DOI
  28. Niemann,H.H., Schmoldt,H.U., Wentzel,A., Kolmar,H. and Heinz,D.W.
    Barnase fusion as a tool to determine the crystal structure of the small disulfide-rich protein McoEeTI
    J Mol Biol356, 1-8. PubMed  Europe PubMed DOI  S
  29. [YEAR:21-7-2006]Thongyoo,P., Tate,E.W. and Leatherbarrow,R.J.
    Total synthesis of the macrocyclic cysteine knot microprotein MCoTI-II
    Chem Commun (Camb)2006, 2848-2850. PubMed  Europe PubMed DOI
  30. 2005
  31. Avrutina,O., Schmoldt,H.U., Gabrijelcic-Geiger,D., Le Nguyen,D., Sommerhoff,C.P., Diederichsen,U. and Kolmar,H.
    Trypsin inhibition by macrocyclic and open-chain variants of the squash inhibitor MCoTI-II
    Biol Chem386, 1301-1306. PubMed  Europe PubMed DOI
  32. 2004
  33. Chiche,L., Heitz,A., Gelly,J.C., Gracy,J., Chau,P.T., Ha,P.T., Hernandez,J.F. and Le-Nguyen,D.
    Squash inhibitors: from structural motifs to macrocyclic knottins
    Curr Protein Pept Sci5, 341-349. PubMed  Europe PubMed DOI  V
  34. 2001
  35. [YEAR:22-6-2001]Felizmenio-Quimio,M.E., Daly,N.L. and Craik,D.J.
    Circular proteins in plants: solution structure of a novel macrocyclic trypsin inhibitor from Momordica cochinchinensis
    J Biol Chem276, 22875-22882. PubMed  Europe PubMed DOI  S
  36. [YEAR:10-7-2001]Heitz,A., Hernandez,J.F., Gagnon,J., Hong,T.T., Pham,T.T.C., Nguyen,T.M., Le Nguyen,D. and Chiche,L.
    Solution structure of the squash trypsin inhibitor MCoTI-II. A new family for cyclic knottins
    Biochemistry40, 7973-7983. PubMed  Europe PubMed DOI  S
  37. Pearce,J.
    Going round in circles to avoid proteolysis
    Trends Biochem Sci26, 282-282. PubMed  Europe PubMed
  38. 2000
  39. [YEAR:16-5-2000]Hernandez,J.F., Gagnon,J., Chiche,L., Nguyen,T.M., Andrieu,J.P., Heitz,A., Trinh,H.T., Pham,T.T. and Le Nguyen,D.
    Squash trypsin inhibitors from Momordica cochinchinensis exhibit an atypical macrocyclic structure
    Biochemistry39, 5722-5730. PubMed  Europe PubMed DOI