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Literature for inhibitor I04.980: maspin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature

(Topics flags: S Structure, K Knockout, U Therapeutic, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Zeng,S., Zhang,J., Jiang,W. and Zeng,C.
    The paradoxical role of SERPINB5 in gastrointestinal cancers: oncogene or tumor suppressor?
    Mol Biol Rep52, 188-188. PubMed  Europe PubMed DOI  V
    2. 2022
  2. Sinha,K.K., Vinay,J., Parida,S., Singh,S.P. and Dixit,M.
    Association and functional significance of genetic variants present in regulatory elements of SERPINB5 gene in gallbladder cancer
    Gene808, 145989-145989. PubMed  Europe PubMed DOI
    3. 2020
  3. Khorsandi,L. and Farasat,M.
    Zinc oxide nanoparticles enhance expression of maspin in human breast cancer cells
    Environ Sci Pollut Res Int PubMed  Europe PubMed DOI
  4. Tang,S., Lian,X., Jiang,J., Cheng,H., Guo,J., Huang,C., Meng,H. and Li,X.
    Tumor Suppressive Maspin-Sensitized Prostate Cancer to Drug Treatment Through Negative Regulating Androgen Receptor Expression
    Front Cell Dev Biol8, 573820-573820. PubMed  Europe PubMed DOI  K
    5. 2019
  5. Lin,Y.H., Tsui,K.H., Chang,K.S., Hou,C.P., Feng,T.H. and Juang,H.H.
    Maspin is a PTEN-upregulated and p53-upregulated tumor suppressor gene and acts as an HDAC1 inhibitor in human bladder cancer
    Cancers (Basel)12, PubMed  Europe PubMed DOI
    6. 2016
  6. Al-Mamun,M., Ravenhill,L., Srisukkham,W., Hossain,A., Fall,C., Ellis,V. and Bass,R.
    Effects of noninhibitory serpin maspin on the actin cytoskeleton: a quantitative image modeling approach
    Microsc Microanal22, 394-409. PubMed  Europe PubMed DOI
    7. 2013
  7. Dzinic,S.H., Kaplun,A., Li,X., Bernardo,M., Meng,Y., Dean,I., Krass,D., Stemmer,P., Shin,N., Lonardo,F. and Sheng,S.
    Identification of an intrinsic determinant critical for maspin subcellular localization and function
    PLoS ONE8, e74502-e74502. PubMed  Europe PubMed DOI
  8. Khanaree,C., Chairatvit,K., Roytrakul,S. and Wongnoppavich,A.
    Reactive center loop moiety is essential for the maspin activity on cellular invasion and ubiquitin-proteasome level
    Oncol Res20, 427-435. PubMed  Europe PubMed DOI
  9. Mahajan,N., Shi,H.Y., Lukas,T.J. and Zhang,M.
    Tumor-suppressive maspin functions as a reactive oxygen species scavenger: importance of cysteine residues
    J Biol Chem288, 11611-11620. PubMed  Europe PubMed DOI
    10. 2012
  10. Bodenstine,T.M., Seftor,R.E., Khalkhali-Ellis,Z., Seftor,E.A., Pemberton,P.A. and Hendrix,M.J.
    Maspin: molecular mechanisms and therapeutic implications
    Cancer Metastasis Rev31, 529-551. PubMed  Europe PubMed DOI
    11. 2011
  11. Endsley,M.P., Hu,Y., Deng,Y., He,X., Warejcka,D.J., Twining,S.S., Gonias,S.L. and Zhang,M.
    Maspin, the molecular bridge between the plasminogen activator system and beta1 integrin that facilitates cell adhesion
    J Biol Chem286, 24599-24607. PubMed  Europe PubMed DOI
  12. Goulet,B., Kennette,W., Ablack,A., Postenka,C.O., Hague,M.N., Mymryk,J.S., Tuck,A.B., Giguere,V., Chambers,A.F. and Lewis,J.D.
    Nuclear localization of maspin is essential for its inhibition of tumor growth and metastasis
    Lab Invest91, 1181-1187. PubMed  Europe PubMed DOI
  13. Lei,K.F., Liu,B.Y., Wang,Y.F., Chen,X.H., Yu,B.Q., Guo,Y. and Zhu,Z.G.
    SerpinB5 interacts with KHDRBS3 and FBXO32 in gastric cancer cells
    Oncol Rep26, 1115-1120. PubMed  Europe PubMed DOI
  14. Luo,J., Shu,H., Ying,Y., Wu,W., Ji,T. and Zhong,L.
    [Mammary serine proteinase inhibitor subcellular expression in oral squamous cell carcinoma and its clinical significance]
    Zhonghua Kou Qiang Yi Xue Za Zhi46, 505-509. PubMed  Europe PubMed
    15. 2010
  15. Ravenhill,L., Wagstaff,L., Edwards,D.R., Ellis,V. and Bass,R.
    G-helix of maspin mediates effects on cell migration and adhesion
    J Biol Chem285, 36285-36292. PubMed  Europe PubMed DOI
  16. Teoh,S.S., Whisstock,J.C. and Bird,P.I.
    Maspin (serpinb5) is an obligate intracellular serpin
    J Biol Chem285, 10862-10869. PubMed  Europe PubMed DOI
  17. Yeom,S.Y., Jang,H.L., Lee,S.J., Kim,E., Son,H.J., Kim,B.G. and Park,C.
    Interaction of testisin with maspin and its impact on invasion and cell death resistance of cervical cancer cells
    FEBS Lett584, 1469-1475. PubMed  Europe PubMed DOI
    18. 2008
  18. Beltran,A.S., Sun,X., Lizardi,P.M. and Blancafort,P.
    Reprogramming epigenetic silencing: artificial transcription factors synergize with chromatin remodeling drugs to reactivate the tumor suppressor mammary serine protease inhibitor
    Mol Cancer Ther7, 1080-1090. PubMed  Europe PubMed DOI  U
  19. Findeisen,P., Rockel,M., Nees,M., Roder,C., Kienle,P., Von Knebel Doeberitz,M., Kalthoff,H. and Neumaier,M.
    Systematic identification and validation of candidate genes for detection of circulating tumor cells in peripheral blood specimens of colorectal cancer patients
    Int J Oncol33, 1001-1010. PubMed  Europe PubMed DOI
  20. Horswill,M.A., Narayan,M., Warejcka,D.J., Cirillo,L.A. and Twining,S.S.
    Epigenetic silencing of maspin expression occurs early in the conversion of keratocytes to fibroblasts
    Exp Eye Res86, 586-600. PubMed  Europe PubMed DOI
  21. Marioni,G., Giacomelli,L., D'Alessandro,E., Marchese-Ragona,R., Staffieri,C., Ferraro,S.M., Staffieri,A. and Blandamura,S.
    Nuclear localization of mammary serine protease inhibitor (MASPIN): is its impact on the prognosis in laryngeal carcinoma due to a proapoptotic effect?
    Am J Otolaryngol29, 156-162. PubMed  Europe PubMed DOI
    22. 2007
  22. Al-Ayyoubi,M., Schwartz,B.S. and Gettins,P.G.
    Maspin binds to urokinase-type and tissue-type plasminogen activator through exosite-exosite interactions
    J Biol Chem282, 19502-19509. PubMed  Europe PubMed DOI
  23. Denk,A.E., Bettstetter,M., Wild,P.J., Hoek,K., Bataille,F., Dietmaier,W. and Bosserhoff,A.K.
    Loss of maspin expression contributes to a more invasive potential in malignant melanoma
    Pigment Cell Res20, 112-119. PubMed  Europe PubMed DOI
  24. Li,X., Chen,D., Yin,S., Meng,Y., Yang,H., Landis-Piwowar,K.R., Li,Y., Sarkar,F.H., Reddy,G.P., Dou,Q.P. and Sheng,S.
    Maspin augments proteasome inhibitor-induced apoptosis in prostate cancer cells
    J Cell Physiol212, 298-306. PubMed  Europe PubMed DOI
  25. Tokuyama,R., Satomura,K., Maeda,E., Kudoh,K., Yamasaki,Y. and Nagayama,M.
    Maspin is involved in bone matrix maturation by enhancing the accumulation of latent TGF-beta
    J Bone Miner Res22, 1581-1591. PubMed  Europe PubMed DOI
  26. Yu,M., Zheng,H., Tsuneyama,K., Takahashi,H., Nomoto,K., Xu,H. and Takano,Y.
    Paradoxical expression of maspin in gastric carcinomas: correlation with carcinogenesis and progression
    Hum Pathol38, 1248-1255. PubMed  Europe PubMed DOI
    27. 2006
  27. Bailey,C.M., Khalkhali-Ellis,Z., Seftor,E.A. and Hendrix,M.J.
    Biological functions of maspin
    J Cell Physiol209, 617-624. PubMed  Europe PubMed DOI
  28. Chen,E.I. and Yates,J.R.
    Maspin and tumor metastasis
    IUBMB Life58, 25-29. PubMed  Europe PubMed DOI
  29. [YEAR:15-12-2006]Khalkhali-Ellis,Z.
    Maspin: the new frontier
    Clin Cancer Res12, 7279-7283. PubMed  Europe PubMed DOI  V
  30. [YEAR:10-9-2006]Lonardo,F., Li,X., Siddiq,F., Singh,R., Al-Abbadi,M., Pass,H.I. and Sheng,S.
    Maspin nuclear localization is linked to favorable morphological features in pulmonary adenocarcinoma
    Lung Cancer51, 31-39. PubMed  Europe PubMed DOI
  31. [YEAR:29-9-2006]Nakagawa,M., Katakura,H., Adachi,M., Takenaka,K., Yanagihara,K., Otake,Y., Wada,H. and Tanaka,F.
    Maspin expression and its clinical significance in non-small cell lung cancer
    Ann Surg Oncol13, 1517-1523. PubMed  Europe PubMed DOI
  32. Sheng,S.
    A role of novel serpin maspin in tumor progression: the divergence revealed through efforts to converge
    J Cell Physiol209, 631-635. PubMed  Europe PubMed DOI
  33. [YEAR:15-4-2006]Yin,S., Lockett,J., Meng,Y., Biliran,H., Jr., Blouse,G.E., Li,X., Reddy,N., Zhao,Z., Lin,X., Anagli,J., Cher,M.L. and Sheng,S.
    Maspin retards cell detachment via a novel interaction with the urokinase-type plasminogen activator/urokinase-type plasminogen activator receptor system
    Cancer Res66, 4173-4181. PubMed  Europe PubMed DOI
    34. 2005
  34. Boltze,C.
    Loss of maspin is a helpful prognosticator in colorectal cancer: a tissue microarray analysis
    Pathol Res Pract200, 783-790. PubMed  Europe PubMed DOI
  35. [YEAR:27-4-2005]Chen,E.I., Florens,L., Axelrod,F.T., Monosov,E., Barbas,C.F., III, Yates,J.R., III, Felding-Habermann,B. and Smith,J.W.
    Maspin alters the carcinoma proteome
    FASEB J19, 1123-1124. PubMed  Europe PubMed DOI
  36. [YEAR:30-9-2005]He,M.L., Jiang,A.L., Zhang,P.J., Hu,X.Y., Liu,Z.F., Yuan,H.Q. and Zhang,J.Y.
    Identification of androgen-responsive element ARE and Sp1 element in the maspin promoter
    Chin J Physiol48, 160-166. PubMed  Europe PubMed
  37. Hirai,K., Koizumi,K., Haraguchi,S., Hirata,T., Mikami,I., Fukushima,M., Yamagishi,S., Kawashima,T., Okada,D., Shimizu,K. and Kawamoto,M.
    Prognostic significance of the tumor suppressor gene maspin in non-small cell lung cancer
    Ann Thorac Surg79, 248-253. PubMed  Europe PubMed DOI
  38. Law,R.H., Irving,J.A., Buckle,A.M., Ruzyla,K., Buzza,M., Bashtannyk-Puhalovich,T.A., Beddoe,T.C., Nguyen,K., Worrall,D.M., Bottomley,S.P., Bird,P.I., Rossjohn,J. and Whisstock,J.C.
    The high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the G-helix
    J Biol Chem280, 22356-22364. PubMed  Europe PubMed DOI  S
    39. 2004
  39. [YEAR:22-10-2004]Al-Ayyoubi,M., Gettins,P.G. and Volz,K.
    Crystal structure of human maspin, a serpin with antitumor properties: reactive center loop of maspin is exposed but constrained
    J Biol Chem279, 55540-55544. PubMed  Europe PubMed DOI  S
  40. Ito,R., Nakayama,H., Yoshida,K., Oda,N. and Yasui,W.
    Loss of maspin expression is associated with development and progression of gastric carcinoma with p53 abnormality
    Oncol Rep12, 985-990. PubMed  Europe PubMed
  41. [YEAR:15-1-2004]Khalkhali-Ellis,Z., Christian,A.L., Kirschmann,D.A., Edwards,E.M., Rezaie-Thompson,M., Vasef,M.A., Gruman,L.M., Seftor,R.E., Norwood,L.E. and Hendrix,M.J.
    Regulating the tumor suppressor gene maspin in breast cancer cells: a potential mechanism for the anticancer properties of tamoxifen
    Clin Cancer Res10, 449-454. PubMed  Europe PubMed DOI
  42. [YEAR:1-3-2004]Liu,J., Yin,S., Reddy,N., Spencer,C. and Sheng,S.
    Bax mediates the apoptosis-sensitizing effect of maspin
    Cancer Res64, 1703-1711. PubMed  Europe PubMed DOI
  43. Murakami,J., Asaumi,J., Maki,Y., Tsujigiwa,H., Kuroda,M., Nagai,N., Yanagi,Y., Inoue,T., Kawasaki,S., Tanaka,N., Matsubara,N. and Kishi,K.
    Effects of demethylating agent 5-aza-2(')-deoxycytidine and histone deacetylase inhibitor FR901228 on maspin gene expression in oral cancer cell lines
    Oral Oncol40, 597-603. PubMed  Europe PubMed DOI
  44. [YEAR:1-5-2004]Nickoloff,B.J., Lingen,M.W., Chang,B.D., Shen,M., Swift,M., Curry,J., Bacon,P., Bodner,B. and Roninson,I.B.
    Tumor suppressor maspin is up-regulated during keratinocyte senescence, exerting a paracrine antiangiogenic activity
    Cancer Res64, 2956-2961. PubMed  Europe PubMed DOI
  45. Wada,K., Maesawa,C., Akasaka,T. and Masuda,T.
    Aberrant expression of the maspin gene associated with epigenetic modification in melanoma cells
    J Invest Dermatol122, 805-811. PubMed  Europe PubMed DOI
    46. 2002
  46. [YEAR:6-12-2002]Bass,R., Fernandez,A.M. and Ellis,V.
    Maspin inhibits cell migration in the absence of protease inhibitory activity
    J Biol Chem277, 46845-46848. PubMed  Europe PubMed DOI
  47. [YEAR:13-6-2002]Jiang,N., Meng,Y., Zhang,S., Mensah-Osman,E. and Sheng,S.
    Maspin sensitizes breast carcinoma cells to induced apoptosis
    Oncogene21, 4089-4098. PubMed  Europe PubMed DOI
    48. 2000
  48. Maass,N., Hojo,T., Zhang,M., Sager,R., Jonat,W. and Nagasaki,K.
    Maspin - a novel protease inhibitor with tumor-suppressing activity in breast cancer
    Acta Oncol39, 931-934. PubMed  Europe PubMed DOI
  49. [YEAR:1-9-2000]McGowen,R., Biliran,H., Jr., Sager,R. and Sheng,S.
    The surface of prostate carcinoma DU145 cells mediates the inhibition of urokinase-type plasminogen activator by maspin
    Cancer Res60, 4771-4778. PubMed  Europe PubMed
    50. 1995
  50. Pemberton,P.A., Wong,D.T., Gibson,H.L., Kiefer,M.C., Fitzpatrick,P.A., Sager,R. and Barr,P.J.
    The tumor suppressor maspin does not undergo the stressed to relaxed transition or inhibit trypsin-like serine proteases. Evidence that maspin is not a protease inhibitory serpin
    J Biol Chem270, 15832-15837. PubMed  Europe PubMed DOI
    51. 1994
  51. [YEAR:28-1-1994]Zou,Z., Anisowicz,A., Hendrix,M.J., Thor,A., Neveu,M., Sheng,S., Rafidi,K., Seftor,E. and Sager,R.
    Maspin, a serpin with tumor-suppressing activity in human mammary epithelial cells
    Science263, 526-529. PubMed  Europe PubMed

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