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Literature for inhibitor I04.979: pigment epithelium derived factor

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature

(Topics flags: S Structure, A Assay, M Mutation, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Lyu,J., Wang,S., Chen,J., Yang,X., Gao,G. and Zhou,T.
    The comparison of pathogenic role and mechanism of Kallistatin and PEDF in tumors
    Biochim Biophys Acta Rev Cancer (2025) 1880, 189273-189273. PubMed  Europe PubMed DOI  V
    2. 2024
  2. Abooshahab,R., Al-Salami,H. and Dass,C.R.
    Synergy between PEDF and Doxorubicin in Breast Cancer Cells: Effects on Metastatic and Metabolic Pathways
    Int J Mol Sci (2024) 25 PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2023
  3. Singh,N., Hansdah,K., Bouzid,A., Ray,C.S., Desai,A., Panda,K.C., Choudhury,J.C., Tekari,A., Masmoudi,S. and Ramchander,P.V.
    Genetic variants and altered expression of SERPINF1 confer disease susceptibility in patients with otosclerosis
    J Hum Genet (2023) 68, 635-642. PubMed  Europe PubMed DOI
    4. 2022
  4. Qu,Q., Park,K., Zhou,K., Wassel,D., Farjo,R., Criswell,T., Ma,J.X. and Zhang,Y.
    Sustained therapeutic effect of an anti-inflammatory peptide encapsulated in nanoparticles on ocular vascular leakage in diabetic retinopathy
    Front Cell Dev Biol (2022) 10, 1049678-1049678. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Shahbazi,B., Arab,S.S., Mafakher,L., Azadmansh,K. and Teimoori-Toolabi,L.
    Computational assessment of pigment epithelium-derived factor as an anti-cancer protein during its interaction with the receptors
    J Biomol Struct Dyn (2022) , 1-17. PubMed  Europe PubMed DOI
    6. 2021
  6. Abooshahab,R., Al-Salami,H. and Dass,C.R.
    The increasing role of pigment epithelium-derived factor in metastasis: from biological importance to a promising target
    Biochem Pharmacol (2021) 193, 114787-114787. PubMed  Europe PubMed DOI  V
  7. Akiba,J., Yoshida,T., Sadashima,E., Murata,K., Matsui,T., Yamagishi,S.I., Kusano,H., Mihara,Y., Mizuochi,S., Kinjou,Y., Naito,Y., Hisaka,T., Sakai,H., Okuda,K., Nakashima,O. and Yano,H.
    The Expression of PEDF and its Putative Receptors in Hepatocellular Carcinoma and Background Liver Tissue
    Anticancer Res (2021) 41, 1203-1212. PubMed  Europe PubMed DOI
  8. Bagdadi,N., Sawaied,A., AbuMadighem,A., Lunenfeld,E. and Huleihel,M.
    The Expression Levels and Cellular Localization of Pigment Epithelium Derived Factor (PEDF) in Mouse Testis: Its Possible Involvement in the Differentiation of Spermatogonial Cells
    Int J Mol Sci (2021) 22 PubMed  Europe PubMed DOI  PMC  EPMC
    9. 2019
  9. Yamagishi,S.I., Koga,Y., Sotokawauchi,A., Hashizume,N., Fukahori,S., Matsui,T. and Yagi,M.
    Therapeutic potential of pigment epithelium-derived factor in cancer
    Curr Pharm Des (2019) 25, 313-324. PubMed  Europe PubMed DOI
    10. 2018
  10. Harries,R.L., Owen,S., Ruge,F., Morgan,M., Li,J., Zhang,Z., Harding,K.G., Torkington,J., Jiang,W.G. and Cai,J.
    Impact of pigment epithelium-derived factor on colorectal cancer in vitro and in vivo
    Oncotarget (2018) 9, 19192-19202. PubMed  Europe PubMed DOI  PMC  EPMC
  11. Jin,Z., Burrage,L.C., Jiang,M.M., Lee,Y.C., Bertin,T., Chen,Y., Tran,A., Gibbs,R.A., Jhangiani,S., Sutton,V.R., Rauch,F., Lee,B. and Jain,M.
    Whole-exome sequencing identifies an intronic cryptic splice site in SERPINF1 causing osteogenesis imperfecta Type VI
    JBMR Plus (2018) 2, 235-239. PubMed  Europe PubMed DOI  PMC  EPMC  M
  12. Yamagishi,S.I. and Matsui,T.
    Pigment epithelium-derived factor: a novel therapeutic target for cardiometabolic diseases and related complications
    Curr Med Chem (2018) 25, 1480-1500. PubMed  Europe PubMed DOI
    13. 2017
  13. He,X., Cheng,R., Park,K., Benyajati,S., Moiseyev,G., Sun,C., Olson,L.E., Yang,Y., Eby,B.K., Lau,K. and Ma,J.-X.
    Pigment epithelium-derived factor, a noninhibitory serine protease inhibitor, is renoprotective by inhibiting the Wnt pathway
    Kidney Int (2017) 91, 642-657. PubMed  Europe PubMed DOI
  14. Wang,J.Y., Liu,Y., Song,L.J., Lv,F., Xu,X.J., San,A., Wang,J., Yang,H.M., Yang,Z.Y., Jiang,Y., Wang,O., Xia,W.B., Xing,X.P. and Li,M.
    Novel mutations in SERPINF1 result in rare osteogenesis imperfecta type VI
    Calcif Tissue Int (2017) 100, 55-66. PubMed  Europe PubMed DOI  M
    15. 2016
  15. Belkacemi,L. and Zhang,S.X.
    Anti-tumor effects of pigment epithelium-derived factor (PEDF): implication for cancer therapy. A mini-review
    J Exp Clin Cancer Res (2016) 35, 4-4. PubMed  Europe PubMed DOI  PMC  EPMC
  16. Ziff,J.L., Crompton,M., Powell,H.R., Lavy,J.A., Aldren,C.P., Steel,K.P., Saeed,S.R. and Dawson,S.J.
    Mutations and altered expression of SERPINF1 in patients with familial otosclerosis
    Hum Mol Genet (2016) 25, 2393-2403. PubMed  Europe PubMed DOI  M
    17. 2013
  17. Alcantara,M.B. and Dass,C.R.
    Regulation of MT1-MMP and MMP-2 by the serpin PEDF: a promising new target for metastatic cancer
    Cell Physiol Biochem (2013) 31, 487-494. PubMed  Europe PubMed DOI
    18. 2012
  18. Bohm,A., Ordelheide,A.M., Machann,J., Heni,M., Ketterer,C., Machicao,F., Schick,F., Stefan,N., Fritsche,A., Haring,H.U. and Staiger,H.
    Common genetic variation in the SERPINF1 locus determines overall adiposity, obesity-related insulin resistance, and circulating leptin levels
    PLoS ONE (2012) 7, e34035-e34035. PubMed  Europe PubMed DOI  PMC  EPMC  M
    19. 2011
  19. Cai,J., Wu,L., Qi,X., Li Calzi,S., Caballero,S., Shaw,L., Ruan,Q., Grant,M.B. and Boulton,M.E.
    PEDF regulates vascular permeability by a gamma-secretase-mediated pathway
    PLoS ONE (2011) 6, e21164-e21164. PubMed  Europe PubMed DOI  PMC  EPMC
  20. Homan,E.P., Rauch,F., Grafe,I., Lietman,C., Doll,J.A., Dawson,B., Bertin,T., Napierala,D., Morello,R., Gibbs,R., White,L., Miki,R., Cohn,D.H., Crawford,S., Travers,R., Glorieux,F.H. and Lee,B.
    Mutations in SERPINF1 cause osteogenesis imperfecta type VI
    J Bone Miner Res (2011) 26, 2798-2803. PubMed  Europe PubMed DOI  M
  21. Park,K., Lee,K., Zhang,B., Zhou,T., He,X., Gao,G., Murray,A.R. and Ma,J.X.
    Identification of a novel inhibitor of the canonical Wnt pathway
    Mol Cell Biol (2011) 31, 3038-3051. PubMed  Europe PubMed DOI
  22. Subramanian,P., Crawford,S.E. and Becerra,S.P.
    Assays for the antiangiogenic and neurotrophic serpin pigment epithelium-derived factor
    Methods Enzymol (2011) 499, 183-204. PubMed  Europe PubMed DOI  A
    23. 2010
  23. Kawaguchi,T., Yamagishi,S.I. and Sata,M.
    Structure-function relationships of PEDF
    Curr Mol Med (2010) 10, 302-311. PubMed  Europe PubMed DOI
  24. Yabe,T., Sanagi,T. and Yamada,H.
    The neuroprotective role of PEDF: implication for the therapy of neurological disorders
    Curr Mol Med (2010) 10, 259-266. PubMed  Europe PubMed DOI
  25. Yamagishi,S.I., Matsui,T., Kawaguchi,T. and Sata,M.
    Pathophysiological role of pigment epithelium-derived factor (PEDF) in hepatic disorders
    Curr Med Chem (2010) 17, 1995-2000. PubMed  Europe PubMed DOI
    26. 2009
  26. Crowe,S., Wu,L.E., Economou,C., Turpin,S.M., Matzaris,M., Hoehn,K.L., Hevener,A.L., James,D.E., Duh,E.J. and Watt,M.J.
    Pigment epithelium-derived factor contributes to insulin resistance in obesity
    Cell Metab (2009) 10, 40-47. PubMed  Europe PubMed DOI
  27. Filleur,S., Nelius,T., de Riese,W. and Kennedy,R.C.
    Characterization of PEDF: a multi-functional serpin family protein
    J Cell Biochem (2009) 106, 769-775. PubMed  Europe PubMed DOI  V
    28. 2006
  28. Xu,X., Zhang,S.S., Barnstable,C.J. and Tombran-Tink,J.
    Molecular phylogeny of the antiangiogenic and neurotrophic serpin, pigment epithelium derived factor in vertebrates
    BMC Genomics (2006) 7, 248-248. PubMed  Europe PubMed DOI  PMC  EPMC
    29. 2005
  29. [YEAR:1-9-2005]Tombran-Tink,J.
    The neuroprotective and angiogenesis inhibitory serpin, PEDF: new insights into phylogeny, function, and signaling
    Front Biosci (1-9-2005) 10, 2131-2149. PubMed  Europe PubMed
    30. 2001
  30. Simonovic,M., Gettins,P.G. and Volz,K.
    Crystal structure of human PEDF, a potent anti-angiogenic and neurite growth-promoting factor
    Proc Natl Acad Sci U S A (2001) 98, 11131-11135. PubMed  Europe PubMed DOI  PMC  EPMC  S
    31. 1999
  31. [YEAR:9-7-1999]Dawson,D.W., Volpert,O.V., Gillis,P., Crawford,S.E., Xu,H., Benedict,W. and Bouck,N.P.
    Pigment epithelium-derived factor: a potent inhibitor of angiogenesis
    Science (9-7-1999) 285, 245-248. PubMed  Europe PubMed DOI

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