Literature for inhibitor I04.078: serpina3n (Mus musculus)

Summary Gene structure Alignment Sequences Sequence features Distribution Structure Literature Inhibits

(Topics flags: I Inhibitor, U Therapeutic, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Liu,X., Li,G., Guo,Y., Li,R., Yi,S., Ding,S. and Wan,J.
    SerpinA3N inhibits mitochondrial complex I activity to prevent neuron ferroptosis following cerebral ischemic stroke
    Exp Neurol (2025) 392, 115370-115370. PubMed  Europe PubMed DOI
  2. 2024
  3. Latourte,A., Jaulerry,S., Combier,A., Cherifi,C., Jouan,Y., Grange,T., Daligault,J., Ea,H.K., Cohen-Solal,M., Hay,E. and Richette,P.
    SerpinA3N limits cartilage destruction in osteoarthritis by inhibiting macrophage-derived leucocyte elastase
    Ann Rheum Dis (2024) 83, 1781-1790. PubMed  Europe PubMed DOI
  4. 2023
  5. Li,F., Zhang,Y., Li,R., Li,Y., Ding,S., Zhou,J., Huang,T., Chen,C., Lu,B., Yu,W., Boltze,J., Li,P. and Wan,J.
    Neuronal Serpina3n is an endogenous protector against blood brain barrier damage following cerebral ischemic stroke
    J Cereb Blood Flow Metab (2023) 43, 241-257. PubMed  Europe PubMed DOI  PMC  EPMC
  6. 2021
  7. Ho,Y.T., Shimbo,T., Wijaya,E., Kitayama,T., Takaki,S., Ikegami,K., Miyashita,K., Ouchi,Y., Takaki,E., Yamamoto,R., Kaneda,Y. and Tamai,K.
    Longitudinal Single-Cell Transcriptomics Reveals a Role for Serpina3n-Mediated Resolution of Inflammation in a Mouse Colitis Model
    Cell Mol Gastroenterol Hepatol (2021) PubMed  Europe PubMed DOI
  8. 2020
  9. Aslam,M.S. and Yuan,L.
    Serpina3n: Potential drug and challenges, mini review
    J Drug Target (2020) 28, 368-378. PubMed  Europe PubMed DOI  V
  10. Gong,G.C., Song,S.R., Xu,X., Luo,Q., Han,Q., He,J.X. and Su,J.
    Serpina3n is closely associated with fibrotic procession and knockdown ameliorates bleomycin-induced pulmonary fibrosis
    Biochem Biophys Res Commun (2020) 532, 598-604. PubMed  Europe PubMed DOI
  11. 2015
  12. Haile,Y., Carmine-Simmen,K., Olechowski,C., Kerr,B., Bleackley,R.C. and Giuliani,F.
    Granzyme B-inhibitor serpina3n induces neuroprotection in vitro and in vivo
    J Neuroinflammation (2015) 12, 157-157. PubMed  Europe PubMed DOI  PMC  EPMC  U
  13. Marcet-Palacios,M., Ewen,C., Pittman,E., Duggan,B., Carmine-Simmen,K., Fahlman,R.P. and Bleackley,R.C.
    Design and characterization of a novel human granzyme B inhibitor
    Protein Eng Des Sel (2015) 28, 9-17. PubMed  Europe PubMed DOI
  14. Vicuna,L., Strochlic,D.E., Latremoliere,A., Bali,K.K., Simonetti,M., Husainie,D., Prokosch,S., Riva,P., Griffin,R.S., Njoo,C., Gehrig,S., Mall,M.A., Arnold,B., Devor,M., Woolf,C.J., Liberles,S.D., Costigan,M. and Kuner,R.
    The serine protease inhibitor serpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase
    Nat Med (2015) 21, 518-523. PubMed  Europe PubMed DOI  I
  15. Weyer,A.D. and Stucky,C.L.
    Repurposing a leukocyte elastase inhibitor for neuropathic pain
    Nat Med (2015) 21, 429-430. PubMed  Europe PubMed DOI  I
  16. 2011
  17. Ang,L.S., Boivin,W.A., Williams,S.J., Zhao,H., Abraham,T., Carmine-Simmen,K., McManus,B.M., Bleackley,R.C. and Granville,D.J.
    Serpina3n attenuates granzyme B-mediated decorin cleavage and rupture in a murine model of aortic aneurysm
    Cell Death Dis (2011) 2, e209-e209. PubMed  Europe PubMed DOI
  18. 2006
  19. [YEAR:15-10-2006]Sipione,S., Simmen,K.C., Lord,S.J., Motyka,B., Ewen,C., Shostak,I., Rayat,G.R., Dufour,J.M., Korbutt,G.S., Rajotte,R.V. and Bleackley,R.C.
    Identification of a novel human granzyme B inhibitor secreted by cultured sertoli cells
    J Immunol (15-10-2006) 177, 5051-5058. PubMed  Europe PubMed
  20. 2003
  21. Forsyth,S., Horvath,A. and Coughlin,P.
    A review and comparison of the murine alpha1-antitrypsin and alpha1-antichymotrypsin multigene clusters with the human clade A serpins
    Genomics (2003) 81, 336-345. PubMed  Europe PubMed DOI