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Literature for inhibitor I04.046: myxoma virus serpin serp-1

Summary Alignment Sequences Sequence features Distribution Structure Literature Inhibits

(Topics flags: S Structure, U Therapeutic, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Welter,A.L., Palani,S., Machida,Y., Schellenberg,M.J. and Machida,Y.J.
    The viral serpin SPI-1 directly inhibits the host cell serine protease FAM111A
    J Biol Chem (2025) , 108175-108175. PubMed  Europe PubMed DOI
    2. 2023
  2. Varkoly,K., Beladi,R., Hamada,M., McFadden,G., Irving,J. and Lucas,A.R.
    Viral SERPINS-A Family of Highly Potent Immune-Modulating Therapeutic Proteins
    Biomolecules (2023) 13 PubMed  Europe PubMed DOI  PMC  EPMC  V
  3. Zhang,L., Li,Y.H., Kibler,K., Kraberger,S., Varsani,A., Turk,J., Elmadbouly,N., Aliskevich,E., Spaccarelli,L., Estifanos,B., Enow,J., Zanetti,I.R., Saldevar,N., Lim,E., Schlievert,J., Browder,K., Wilson,A., Juan,F.A., Pinteric,A., Garg,A., Monder,H., Saju,R., Gisriel,S., Jacobs,B., Karr,T.L., Florsheim,E.B., Kumar,V., Wallen,J., Rahman,M., McFadden,G., Hogue,B.G. and Lucas,A.R.
    Viral anti-inflammatory serpin reduces immuno-coagulopathic pathology in SARS-CoV-2 mouse models of infection
    EMBO Mol Med (2023) 15, e17376-e17376. PubMed  Europe PubMed DOI  PMC  EPMC
    4. 2021
  4. Yaron,J.R., Zhang,L., Burgin,M., Schutz,L.N., Awo,E.A., Keinan,S., McFadden,G., Ambadapadi,S., Guo,Q., Chen,H. and Lucas,A.R.
    Deriving Immune-Modulating Peptides from Viral Serine Protease Inhibitors (Serpins)
    Methods Mol Biol (2021) 2225, 107-123. PubMed  Europe PubMed DOI
  5. Zhuang,H., Han,S., Lu,L. and Reeves,W.H.
    Myxomavirus serpin alters macrophage function and prevents diffuse alveolar hemorrhage in pristane-induced lupus
    Clin Immunol (2021) 229, 108764-108764. PubMed  Europe PubMed DOI
    6. 2019
  6. Zhang,L., Yaron,J.R., Tafoya,A.M., Wallace,S.E., Kilbourne,J., Haydel,S., Rege,K., McFadden,G. and Lucas,A.R.
    A virus-derived immune modulating serpin accelerates wound closure with improved collagen remodeling
    J Clin Med (2019) 8 PubMed  Europe PubMed DOI  U
    7. 2018
  7. Mahon,B.P., Ambadapadi,S., Yaron,J.R., Lomelino,C.L., Pinard,M.A., Keinan,S., Kurnikov,I., Macaulay,C., Zhang,L., Reeves,W., McFadden,G., Tibbetts,S., McKenna,R. and Lucas,A.R.
    Crystal structure of cleaved Serp-1, a myxomavirus-derived immune modulating serpin: structural design of serpin reactive center loop peptides with improved therapeutic function
    Biochemistry (2018) 57, 1096-1107. PubMed  Europe PubMed DOI  S
  8. Rahman,M.M.
    Methods for identifying virus-derived serpins
    Methods Mol Biol (2018) 1826, 73-86. PubMed  Europe PubMed DOI
    9. 2016
  9. Ambadapadi,S., Munuswamy-Ramanujam,G., Zheng,D., Sullivan,C., Dai,E., Morshed,S., McFadden,B., Feldman,E., Pinard,M., McKenna,R., Tibbetts,S. and Lucas,A.
    Reactive center loop (RCL) peptides derived from serpins display independent coagulation and immune modulating activities
    J Biol Chem (2016) 291, 2874-2887. PubMed  Europe PubMed DOI
    10. 2014
  10. Brahn,E., Lee,S., Lucas,A., McFadden,G. and Macaulay,C.
    Suppression of collagen-induced arthritis with a serine proteinase inhibitor (serpin) derived from myxoma virus
    Clin Immunol (2014) 153, 254-263. PubMed  Europe PubMed DOI  U
    11. 2013
  11. Chen,H., Zheng,D., Abbott,J., Liu,L., Bartee,M.Y., Long,M., Davids,J., Williams,J., Feldmann,H., Strong,J., Grau,K.R., Tibbetts,S., Macaulay,C., McFadden,G., Thoburn,R., Lomas,D.A., Spinale,F.G., Virgin,H.W. and Lucas,A.
    Myxomavirus-derived serpin prolongs survival and reduces inflammation and hemorrhage in an unrelated lethal mouse viral infection
    Antimicrob Agents Chemother (2013) 57, 4114-4127. PubMed  Europe PubMed DOI
    12. 2011
  12. Chen,H., Zheng,D., Davids,J., Bartee,M.Y., Dai,E., Liu,L., Petrov,L., Macaulay,C., Thoburn,R., Sobel,E., Moyer,R., McFadden,G. and Lucas,A.
    Viral serpin therapeutics from concept to clinic
    Methods Enzymol (2011) 499, 301-329. PubMed  Europe PubMed DOI  U
    13. 2009
  13. Lucas,A., Liu,L., Dai,E., Bot,I., Viswanathan,K., Munuswamy-Ramunujam,G., Davids,J.A., Bartee,M.Y., Richardson,J., Christov,A., Wang,H., Macaulay,C., Poznansky,M., Zhong,R., Miller,L., Biessen,E., Richardson,M., Sullivan,C., Moyer,R., Hatton,M., Lomas,D.A. and McFadden,G.
    The serpin saga; development of a new class of virus derived anti-inflammatory protein immunotherapeutics
    Adv Exp Med Biol (2009) 666, 132-156. PubMed  Europe PubMed DOI  U
  14. Viswanathan,K., Richardson,J., Togonu-Bickersteth,B., Dai,E., Liu,L., Vatsya,P., Sun,Y.M., Yu,J., Munuswamy-Ramanujam,G., Baker,H. and Lucas,A.R.
    Myxoma viral serpin, Serp-1, inhibits human monocyte adhesion through regulation of actin-binding protein filamin B
    J Leukoc Biol (2009) 85, 418-426. PubMed  Europe PubMed DOI
    15. 2008
  15. Li,X., Schneider,H., Peters,A., Macaulay,C., King,E., Sun,Y., Liu,L., Dai,E., Davids,J.A., McFadden,G. and Lucas,A.
    Heparin alters viral serpin, serp-1, anti-thrombolytic activity to anti-thrombotic activity
    Open Biochem J (2008) 2, 6-15. PubMed  Europe PubMed DOI  PMC  EPMC
    16. 2007
  16. Richardson,M., Liu,L., Dunphy,L., Wong,D., Sun,Y., Viswanathan,K., Singh,G. and Lucas,A.
    Viral serpin, Serp-1, inhibits endogenous angiogenesis in the chicken chorioallantoic membrane model
    Cardiovasc Pathol (2007) 16, 191-202. PubMed  Europe PubMed DOI
    17. 2006
  17. [YEAR:27-3-2006]Bedard,E.L., Jiang,J., Arp,J., Qian,H., Wang,H., Guan,H., Liu,L., Parry,N., Kim,P., Garcia,B., Li,X., Macaulay,C., McFadden,G., Lucas,A. and Zhong,R.
    Prevention of chronic renal allograft rejection by SERP-1 protein
    Transplantation (27-3-2006) 81, 908-914. PubMed  Europe PubMed DOI
  18. [YEAR:9-1-2006]Dai,E., Viswanathan,K., Sun,Y.M., Li,X., Liu,L.Y., Togonu-Bickersteth,B., Richardson,J., Macaulay,C., Nash,P., Turner,P., Nazarian,S.H., Moyer,R., McFadden,G. and Lucas,A.R.
    Identification of myxomaviral serpin reactive site loop sequences that regulate innate immune responses
    J Biol Chem (9-1-2006) 281, 8041-8050. PubMed  Europe PubMed DOI
  19. [YEAR:1-1-2006]Richardson,J., Viswanathan,K. and Lucas,A.
    Serpins, the vasculature, and viral therapeutics
    Front Biosci (1-1-2006) 11, 1042-1056. PubMed  Europe PubMed  V
  20. Viswanathan,K., Liu,L., Vaziri,S., Dai,E., Richardson,J., Togonu-Bickersteth,B., Vatsya,P., Christov,A. and Lucas,A.R.
    Myxoma viral serpin, Serp-1, a unique interceptor of coagulation and innate immune pathways
    Thromb Haemost (2006) 95, 499-510. PubMed  Europe PubMed DOI
    21. 2005
  21. Luttge,B.G. and Moyer,R.W.
    Suppressors of a host range mutation in the rabbitpox virus serpin SPI-1 map to proteins essential for viral DNA replication
    J Virol (2005) 79, 9168-9179. PubMed  Europe PubMed DOI  PMC  EPMC
    22. 2003
  22. [YEAR:5-9-2003]Bot,I., von der Thusen,J.H., Donners,M.M., Lucas,A., Fekkes,M.L., de Jager,S.C., Kuiper,J., Daemen,M.J., van Berkel,T.J., Heeneman,S. and Biessen,E.A.
    Serine protease inhibitor Serp-1 strongly impairs atherosclerotic lesion formation and induces a stable plaque phenotype in ApoE-/-mice
    Circ Res (5-9-2003) 93, 464-471. PubMed  Europe PubMed DOI
  23. [YEAR:16-5-2003]Dai,E., Guan,H., Liu,L., Little,S., McFadden,G., Vaziri,S., Cao,H., Ivanova,I.A., Bocksch,L. and Lucas,A.
    Serp-1, a viral anti-inflammatory serpin, regulates cellular serine proteinase and serpin responses to vascular injury
    J Biol Chem (16-5-2003) 278, 18563-18572. PubMed  Europe PubMed DOI
    24. 2000
  24. Hatton,M.W.C., Ross,B., Southward,S.M.R. and Lucas,A.
    Metabolism and distribution of the virus-encoded serine proteinase inhibitor SERP-1 in healthy rabbits
    Metabolism (2000) 49, 1449-1452. PubMed  Europe PubMed DOI
  25. [YEAR:5-7-2000]Wang,Y.X., Turner,P.C., Ness,T.L., Moon,K.B., Schoeb,T.R. and Moyer,R.W.
    The cowpox virus SPI-3 and myxoma virus SERP1 serpins are not functionally interchangeable despite their similar proteinase inhibition profiles in vitro
    Virology (5-7-2000) 272, 281-292. PubMed  Europe PubMed DOI
    26. 1996
  26. Lucas,A., Liu,L., Macen,J., Nash,P., Dai,E., Stewart,M., Graham,K., Etches,W., Boshkov,L., Nation,P.N., Humen,D., Hobman,M.L. and McFadden,G.
    Virus-encoded serine proteinase inhibitor SERP-1 inhibits atherosclerotic plaque development after balloon angioplasty
    Circulation (1996) 94, 2890-2900. PubMed  Europe PubMed
    27. 1993
  27. Lomas,D.A., Evans,D.L., Upton,C., McFadden,G. and Carrell,R.W.
    Inhibition of plasmin, urokinase, tissue plasminogen activator, and C1s by a myxoma virus serine proteinase inhibitor
    J Biol Chem (1993) 268, 516-521. PubMed  Europe PubMed

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