Merops Switch to
Peptidases

Inhibitor

Family Clan Small-molecule
inhibitor SEARCHES BLAST
MEROPS

Other
information

Literature for inhibitor I04.028: CrmA viral serpin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature

(Topics flags: S Structure, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2023
  1. Varkoly,K., Beladi,R., Hamada,M., McFadden,G., Irving,J. and Lucas,A.R.
    Viral SERPINS-A Family of Highly Potent Immune-Modulating Therapeutic Proteins
    Biomolecules13, PubMed  Europe PubMed DOI  V
    2. 2019
  2. Bloomer,D.T., Kitevska-Ilioski,T., Pantaki-Eimany,D., Ji,Y., Miles,M.A., Heras,B. and Hawkins,C.J.
    CrmA orthologs from diverse poxviruses potently inhibit caspases-1 and -8, yet cleavage site mutagenesis frequently produces caspase-1-specific variants
    Biochem J476, 1335-1357. PubMed  Europe PubMed DOI
    3. 2018
  3. Rahman,M.M.
    Methods for identifying virus-derived serpins
    Methods Mol Biol1826, 73-86. PubMed  Europe PubMed DOI
    4. 2017
  4. Qin,Y., Li,M., Zhou,S.L., Yin,W., Bian,Z. and Shu,H.B.
    SPI-2/CrmA inhibits IFN-beta induction by targeting TBK1/IKKepsilon
    Sci Rep7, 10495-10495. PubMed  Europe PubMed DOI
    5. 2012
  5. Roth,S.J., Klopfleisch,R., Osterrieder,N. and Tischer,B.K.
    Cowpox virus serpin CrmA is necessary but not sufficient for the red pock phenotype on chicken chorioallantoic membranes
    Virus Res163, 254-261. PubMed  Europe PubMed DOI
    6. 2011
  6. Melo-Silva,C.R., Tscharke,D.C., Lobigs,M., Koskinen,A., Wong,Y.C., Buller,R.M., Mullbacher,A. and Regner,M.
    The ectromelia virus SPI-2 protein causes lethal mousepox by preventing NK cell responses
    J Virol85, 11170-11182. PubMed  Europe PubMed DOI
    7. 2007
  7. Swanson,R., Raghavendra,M.P., Zhang,W., Froelich,C., Gettins,P.G. and Olson,S.T.
    Serine and cysteine proteases are translocated to similar extents upon formation of covalent complexes with serpins. Fluorescence perturbation and fluorescence resonance energy transfer mapping of the protease binding site in CrmA complexes with granzyme B and caspase-1
    J Biol Chem282, 2305-2313. PubMed  Europe PubMed DOI
    8. 2006
  8. Dobo,J., Swanson,R., Salvesen,G.S., Olson,S.T. and Gettins,P.G.
    Cytokine response modifier A inhibition of initiator caspases results in covalent complex formation and dissociation of the caspase tetramer
    J Biol Chem281, 38781-38790. PubMed  Europe PubMed DOI
    9. 2005
  9. [YEAR:29-6-2005]Simonovic,M., Denault,J.B., Salvesen,G.S., Volz,K. and Gettins,P.G.
    Lack of involvement of strand s1'A of the viral serpin CrmA in anti-apoptotic or caspase-inhibitory functions
    Arch Biochem Biophys440, 1-9. PubMed  Europe PubMed DOI
  10. Tesch,L.D., Raghavendra,M.P., Bedsted-Faarvang,T., Gettins,P.G. and Olson,S.T.
    Specificity and reactive loop length requirements for crmA inhibition of serine proteases
    Protein Sci14, 533-542. PubMed  Europe PubMed DOI
    11. 2004
  11. Legrand,F.A., Verardi,P.H., Jones,L.A., Chan,K.S., Peng,Y. and Yilma,T.D.
    Induction of potent humoral and cell-mediated immune responses by attenuated vaccinia virus vectors with deleted serpin genes
    J Virol78, 2770-2779. PubMed  Europe PubMed DOI
    12. 2002
  12. Goswami,R., Kilkus,J., Scurlock,B. and Dawson,G.
    CrmA protects against apoptosis and ceramide formation in PC12 cells
    Neurochem Res27, 735-741. PubMed  Europe PubMed DOI  I
  13. [YEAR:1-9-2002]Ryan,C.A., Stennicke,H.R., Nava,V.E., Burch,J.B., Hardwick,J.M. and Salvesen,G.S.
    Inhibitor specificity of recombinant and endogenous caspase-9
    Biochem J366, 595-601. PubMed  Europe PubMed DOI  I
    14. 2001
  14. [YEAR:15-7-2001]Snipas,S.J., Stennicke,H.R., Riedl,S., Potempa,J., Travis,J., Barrett,A.J. and Salvesen,G.S.
    Inhibition of distant caspase homologues by natural caspase inhibitors
    Biochem J357, 575-580. PubMed  Europe PubMed DOI
    15. 2000
  15. [YEAR:15-7-2000]Renatus,M., Zhou,Q., Stennicke,H.R., Snipas,S.J., Turk,D., Bankston,L.A., Liddington,R.C. and Salvesen,G.S.
    Crystal structure of the apoptotic suppressor CrmA in its cleaved form
    Structure8, 789-797. PubMed  Europe PubMed DOI  S
  16. Simonovic,M., Gettins,P.G.W. and Volz,K.
    Crystal structure of viral serpin crmA provides insights into its mechanism of cysteine proteinase inhibition
    Protein Sci9, 1423-1427. PubMed  Europe PubMed DOI  S
  17. Zhou,Q. and Salvesen,G.S.
    Viral caspase inhibitors CrmA and p35
    Methods Enzymol322, 143-154. PubMed  Europe PubMed  V
    18. 1997
  18. Kettle,S., Alcami,A., Khanna,A., Ehret,R., Jassoy,C. and Smith,G.L.
    Vaccinia virus serpin B13R (SPI-2) inhibits interleukin-1beta-converting enzyme and protects virus-infected cells from TNF- and Fas-mediated apoptosis, but does not prevent IL-1beta-induced fever
    J Gen Virol78, 677-685. PubMed  Europe PubMed
  19. [YEAR:21-3-1997]Zhou,Q., Snipas,S., Orth,K., Muzio,M., Dixit,V.M. and Salvesen,G.S.
    Target protease specificity of the viral serpin CrmA. Analysis of five caspases
    J Biol Chem272, 7797-7800. PubMed  Europe PubMed DOI
    20. 1996
  20. Martin,S.J., Amarante-Mendes,G.P., Shi,L., Chuang,T.H., Casiano,C.A., O'Brien,G.A., Fitzgerald,P., Tan,E.M., Bokoch,G.M., Greenberg,A.H. and Green,D.R.
    The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/CED-3 family protease,CPP32, via a novel two- step mechanism
    EMBO J15, 2407-2416. PubMed  Europe PubMed
    21. 1995
  21. [YEAR:1-3-1995]Howard,A.D., Palyha,O.C., Griffin,P.R., Peterson,E.P., Lenny,A.B., Ding,G.J., Pickup,D.J., Thornberry,N.A., Schmidt,J.A. and Tocci,M.J.
    Human IL-1 beta processing and secretion in recombinant baculovirus-infected Sf9 cells is blocked by the cowpox virus serpin crmA
    J Immunol154, 2321-2332. PubMed  Europe PubMed
  22. Miura,M., Friedlander,R.M. and Yuan,J.
    Tumor necrosis factor-induced apoptosis is mediated by a CrmA-sensitive cell death pathway
    Proc Natl Acad Sci U S A92, 8318-8322. PubMed  Europe PubMed DOI
  23. Quan,L.T., Caputo,A., Bleackley,R.C., Pickup,D.J. and Salvesen,G.S.
    Granzyme B is inhibited by the cowpox virus serpin cytokine response modifier A
    J Biol Chem270, 10377-10379. PubMed  Europe PubMed DOI
  24. Tewari,M., Quan,L.T., O'Rourke,K., Desnoyers,S., Zeng,Z., Beidler,D.R., Poirier,G.G., Salvesen,G.S. and Dixit,V.M.
    Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase
    Cell81, 801-809. PubMed  Europe PubMed
    25. 1994
  25. [YEAR:29-7-1994]Komiyama,T., Ray,C.A., Pickup,D.J., Howard,A.D., Thornberry,N.A., Peterson,E.P. and Salvesen,G.
    Inhibition of interleukin-1 beta converting enzyme by the cowpox virus serpin CrmA. An example of cross-class inhibition
    J Biol Chem269, 19331-19337. PubMed  Europe PubMed
    26. 1992
  26. [YEAR:15-5-1992]Ray,C.A., Black,R.A., Kronheim,S.R., Greenstreet,T.A., Sleath,P.R., Salvesen,G.S. and Pickup,D.J.
    Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme
    Cell69, 597-604. PubMed  Europe PubMed DOI
    27. 1990
  27. Jin,Q., Jin,D.Y. and Hou,Y.D.
    The vaccinia virus HindIII K fragment encodes a novel protein belonging to the serpin superfamily
    Sci China B33, 453-459. PubMed  Europe PubMed

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use