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Literature for inhibitor I04.025: neuroserpin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature

(Topics flags: S Structure, M Mutation, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Liao,Y., Zhang,Q., Shi,Q., Liu,P., Zhong,P., Guo,L., Huang,Z., Peng,Y., Liu,W., Zhang,S., Adorjan,I., Fukuzaki,Y., Kawashita,E., Zhang,X.Q., Ma,N., Zhang,X., Molnar,Z. and Shi,L.<br>Neuroserpin alleviates cerebral ischemia-reperfusion injury by suppressing ischemia-induced endoplasmic reticulum stress<br>Neural Regen Res (2026) 21, 333-345. PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2023
  2. Chitranshi,N., Rajput,R., Godinez,A., Pushpitha,K., Mirzaei,M., Basavarajappa,D., Gupta,V., Sharma,S., You,Y., Galliciotti,G., Salekdeh,G.H., Baker,M.S., Graham,S.L. and Gupta,V.K.<br>Neuroserpin gene therapy inhibits retinal ganglion cell apoptosis and promotes functional preservation in glaucoma<br>Mol Ther (2023) 31, 2056-2076. PubMed  Europe PubMed DOI
    3. 2021
  3. D'Acunto,E., Fra,A., Visentin,C., Manno,M., Ricagno,S., Galliciotti,G. and Miranda,E.<br>Neuroserpin: structure, function, physiology and pathology<br>Cell Mol Life Sci (2021) PubMed  Europe PubMed DOI  V
  4. Fatima,S., Ansari,S., Bano,S., Ahamad,S., Ishqi,H.M., Tabish,M., Gupta,D., Rehman,S.U. and Jairajpuri,M.A.<br>Detection of truncated isoforms of human neuroserpin lacking the reactive center loop: Implications in noninhibitory role<br>IUBMB Life (2021) PubMed  Europe PubMed DOI
  5. Kement,D., Reumann,R., Schostak,K., Voss,H., Douceau,S., Dottermusch,M., Schweizer,M., Schluter,H., Vivien,D., Glatzel,M. and Galliciotti,G.<br>Neuroserpin Is Strongly Expressed in the Developing and Adult Mouse Neocortex but Its Absence Does Not Perturb Cortical Lamination and Synaptic Proteome<br>Front Neuroanat (2021) 15, 627896-627896. PubMed  Europe PubMed DOI  PMC  EPMC
    6. 2020
  6. Hermann,M., Reumann,R., Schostak,K., Kement,D., Gelderblom,M., Bernreuther,C., Frischknecht,R., Schipanski,A., Marik,S., Krasemann,S., Sepulveda-Falla,D., Schweizer,M., Magnus,T., Glatzel,M. and Galliciotti,G.<br>Deficits in developmental neurogenesis and dendritic spine maturation in mice lacking the serine protease inhibitor neuroserpin<br>Mol Cell Neurosci (2020) 102, 103420-103420. PubMed  Europe PubMed DOI  K
  7. Visentin,C., Broggini,L., Sala,B.M., Russo,R., Barbiroli,A., Santambrogio,C., Nonnis,S., Dubnovitsky,A., Bolognesi,M., Miranda,E., Achour,A. and Ricagno,S.<br>Glycosylation tunes neuroserpin physiological and pathological properties<br>Int J Mol Sci (2020) 21 PubMed  Europe PubMed DOI
    8. 2017
  8. Reumann,R., Vierk,R., Zhou,L., Gries,F., Kraus,V., Mienert,J., Romswinkel,E., Morellini,F., Ferrer,I., Nicolini,C., Fahnestock,M., Rune,G., Glatzel,M. and Galliciotti,G.<br>The serine protease inhibitor neuroserpin is required for normal synaptic plasticity and regulates learning and social behavior<br>Learn Mem (2017) 24, 650-659. PubMed  Europe PubMed DOI  PMC  EPMC
    9. 2016
  9. Ambadapadi,S., Munuswamy-Ramanujam,G., Zheng,D., Sullivan,C., Dai,E., Morshed,S., McFadden,B., Feldman,E., Pinard,M., McKenna,R., Tibbetts,S. and Lucas,A.<br>Reactive center loop (RCL) peptides derived from serpins display independent coagulation and immune modulating activities<br>J Biol Chem (2016) 291, 2874-2887. PubMed  Europe PubMed DOI
  10. Carlson,K.S., Nguyen,L., Schwartz,K., Lawrence,D.A. and Schwartz,B.S.<br>Neuroserpin differentiates between forms of tissue type plasminogen activator via pH dependent deacylation<br>Front Cell Neurosci (2016) 10, 154-154. PubMed  Europe PubMed DOI  PMC  EPMC
    11. 2015
  11. Lee,T.W., Yang,A.S., Brittain,T. and Birch,N.P.<br>An analysis approach to identify specific functional sites in orthologous proteins using sequence and structural information: application to neuroserpin reveals regions that differentially regulate inhibitory activity<br>Proteins (2015) 83, 135-152. PubMed  Europe PubMed DOI
  12. Noto,R., Randazzo,L., Raccosta,S., Caccia,S., Moriconi,C., Miranda,E., Martorana,V. and Manno,M.<br>The stability and activity of human neuroserpin are modulated by a salt bridge that stabilises the reactive centre loop<br>Sci Rep (2015) 5, 13666-13666. PubMed  Europe PubMed DOI
    13. 2014
  13. Tsang,V.W., Young,D., During,M.J. and Birch,N.P.<br>AAV-Mediated overexpression of neuroserpin in the hippocampus decreases PSD-95 expression but does not affect hippocampal-dependent learning and memory<br>PLoS ONE (2014) 9, e91050-e91050. PubMed  Europe PubMed DOI  PMC  EPMC
    14. 2013
  14. Gelderblom,M., Neumann,M., Ludewig,P., Bernreuther,C., Krasemann,S., Arunachalam,P., Gerloff,C., Glatzel,M. and Magnus,T.<br>Deficiency in serine protease inhibitor neuroserpin exacerbates ischemic brain injury by increased postischemic inflammation<br>PLoS ONE (2013) 8, e63118-e63118. PubMed  Europe PubMed DOI  PMC  EPMC  K
    15. 2011
  15. Hagen,M.C., Murrell,J.R., Delisle,M.B., Andermann,E., Andermann,F., Guiot,M.C. and Ghetti,B.<br>Encephalopathy with neuroserpin inclusion bodies presenting as progressive myoclonus epilepsy and associated with a novel mutation in the proteinase inhibitor 12 gene<br>Brain Pathol (2011) 21, 575-582. PubMed  Europe PubMed DOI  M
    16. 2010
  16. Munuswamy-Ramanujam,G., Dai,E., Liu,L., Shnabel,M., Sun,Y.M., Bartee,M., Lomas,D.A. and Lucas,A.R.<br>Neuroserpin, a thrombolytic serine protease inhibitor (serpin), blocks transplant vasculopathy with associated modification of T-helper cell subsets<br>Thromb Haemost (2010) 103, 545-555. PubMed  Europe PubMed DOI
  17. Ricagno,S., Pezzullo,M., Barbiroli,A., Manno,M., Levantino,M., Santangelo,M.G., Bonomi,F. and Bolognesi,M.<br>Two latent and two hyperstable polymeric forms of human neuroserpin<br>Biophys J (2010) 99, 3402-3411. PubMed  Europe PubMed DOI  PMC  EPMC
  18. Srikeerthana,K. and De Causmaecker,P.<br>Comparative sequence and structural analyses of neuroserpin: the serine protease inhibitor family<br>[ISSN:ISBN:978-1-60558-722-6] (2010) DOI
    19. 2009
  19. Ricagno,S., Caccia,S., Sorrentino,G., Antonini,G. and Bolognesi,M.<br>Human neuroserpin: structure and time-dependent inhibition<br>J Mol Biol (2009) 388, 109-121. PubMed  Europe PubMed DOI  S
  20. Takehara,S., Onda,M., Zhang,J., Nishiyama,M., Yang,X., Mikami,B. and Lomas,D.A.<br>The 2.1-A crystal structure of native neuroserpin reveals unique structural elements that contribute to conformational instability<br>J Mol Biol (2009) 388, 11-20. PubMed  Europe PubMed DOI  S
    21. 2008
  21. Kumar,A. and Ragg,H.<br>Ancestry and evolution of a secretory pathway serpin<br>BMC Evol Biol (2008) 8, 250-250. PubMed  Europe PubMed DOI  PMC  EPMC
    22. 2007
  22. [YEAR:9-1-2007]Chen,P.Y., Chang,W.S., Chou,R.H., Lai,Y.K., Lin,S.C., Chi,C.Y. and Wu,C.W.<br>Two non-homologous brain diseases-related genes, SERPINI1 and PDCD10, are tightly linked by an asymmetric bidirectional promoter in an evolutionarily conserved manner<br>BMC Mol Biol (9-1-2007) 8, 2-2. PubMed  Europe PubMed DOI  PMC  EPMC
  23. Ishigami,S., Sandkvist,M., Tsui,F., Moore,E., Coleman,T.A. and Lawrence,D.A.<br>Identification of a novel targeting sequence for regulated secretion in the serine protease inhibitor neuroserpin<br>Biochem J (2007) 402, 25-34. PubMed  Europe PubMed DOI  PMC  EPMC
    24. 2006
  24. [YEAR:1-1-2006]Galliciotti,G. and Sonderegger,P.<br>Neuroserpin<br>Front Biosci (1-1-2006) 11, 33-45. PubMed  Europe PubMed DOI  V
  25. [YEAR:7-2-2006]Miranda,E. and Lomas,D.A.<br>Neuroserpin: a serpin to think about<br>Cell Mol Life Sci (7-2-2006) 63, 709-722. PubMed  Europe PubMed DOI  V
  26. Simonin,Y., Charron,Y., Sonderegger,P., Vassalli,J.D. and Kato,A.C.<br>An inhibitor of serine proteases, neuroserpin, acts as a neuroprotective agent in a mouse model of neurodegenerative disease<br>J Neurosci (2006) 26, 10614-10619. PubMed  Europe PubMed DOI
    27. 2004
  27. [YEAR:16-4-2004]Miranda,E., Romisch,K. and Lomas,D.A.<br>Mutants of neuroserpin that cause dementia accumulate as polymers within the endoplasmic reticulum<br>J Biol Chem (16-4-2004) 279, 28283-28291. PubMed  Europe PubMed DOI
  28. [YEAR:7-4-2004]Navarro-Yubero,C., Cuadrado,A., Sonderegger,P. and Munoz,A.<br>Neuroserpin is post-transcriptionally regulated by thyroid hormone<br>Brain Res Mol Brain Res (7-4-2004) 123, 56-65. PubMed  Europe PubMed DOI
  29. Yepes,M. and Lawrence,D.A.<br>Neuroserpin: a selective inhibitor of tissue-type plasminogen activator in the central nervous system<br>Thromb Haemost (2004) 91, 457-464. PubMed  Europe PubMed DOI
  30. Yepes,M. and Lawrence,D.A.<br>Tissue-type plasminogen activator and neuroserpin: a well-balanced act in the nervous system?<br>Trends Cardiovasc Med (2004) 14, 173-180. PubMed  Europe PubMed DOI
  31. Yepes,M. and Lawrence,D.A.<br>New functions for an old enzyme: nonhemostatic roles for tissue-type plasminogen activator in the central nervous system<br>Exp Biol Med (Maywood) (2004) 229, 1097-1104. PubMed  Europe PubMed
    32. 2003
  32. [YEAR:12-12-2003]Makarova,A., Mikhailenko,I., Bugge,T.H., List,K., Lawrence,D.A. and Strickland,D.K.<br>The low density lipoprotein receptor-related protein modulates protease activity in the brain by mediating the cellular internalization of both neuroserpin and neuroserpin-tissue-type plasminogen activator complexes<br>J Biol Chem (12-12-2003) 278, 50250-50258. PubMed  Europe PubMed DOI
    33. 2002
  33. [YEAR:6-12-2002]Barker-Carlson,K., Lawrence,D.A. and Schwartz,B.S.<br>Acyl-enzyme complexes between tissue-type plasminogen activator and neuroserpin are short-lived in vitro<br>J Biol Chem (6-12-2002) 277, 46852-46857. PubMed  Europe PubMed DOI
  34. [YEAR:10-5-2002]Belorgey,D., Crowther,D.C., Mahadeva,R. and Lomas,D.A.<br>Mutant neuroserpin (S49P) that causes familial encephalopathy with neuroserpin inclusion bodies is a poor proteinase inhibitor and readily forms polymers in vitro<br>J Biol Chem (10-5-2002) 277, 17367-17373. PubMed  Europe PubMed DOI
  35. [YEAR:29-6-2002]Davis,R.L., Shrimpton,A.E., Carrell,R.W., Lomas,D.A., Gerhard,L., Baumann,B., Lawrence,D.A., Yepes,M., Kim,T.S., Ghetti,B., Piccardo,P., Takao,M., Lacbawan,F., Muenke,M., Sifers,R.N., Bradshaw,C.B., Kent,P.F., Collins,G.H., Larocca,D. and Holohan,P.D.<br>Association between conformational mutations in neuroserpin and onset and severity of dementia<br>Lancet (29-6-2002) 359, 2242-2247. PubMed  Europe PubMed DOI
  36. Lomas,D.A. and Carrell,R.W.<br>Serpinopathies and the conformational dementias<br>Nat Rev Genet (2002) 3, 759-768. PubMed  Europe PubMed DOI
  37. Lomas,D.A., Lourbakos,A., Cumming,S.A. and Belorgey,D.<br>Hypersensitive mousetraps, alpha1-antitrypsin deficiency and dementia<br>Biochem Soc Trans (2002) 30, 89-92. PubMed  Europe PubMed
  38. Parmar,P.K., Coates,L.C., Pearson,J.F., Hill,R.M. and Birch,N.P.<br>Neuroserpin regulates neurite outgrowth in nerve growth factor-treated PC12 cells<br>J Neurochem (2002) 82, 1406-1415. PubMed  Europe PubMed DOI
  39. Yepes,M., Sandkvist,M., Coleman,T.A., Moore,E., Wu,J.Y., Mitola,D., Bugge,T.H. and Lawrence,D.A.<br>Regulation of seizure spreading by neuroserpin and tissue-type plasminogen activator is plasminogen-independent<br>J Clin Invest (2002) 109, 1571-1578. PubMed  Europe PubMed DOI  PMC  EPMC
  40. [YEAR:6-8-2002]Zhang,Z., Zhang,L., Yepes,M., Jiang,Q., Li,Q., Arniego,P., Coleman,T.A., Lawrence,D.A. and Chopp,M.<br>Adjuvant treatment with neuroserpin increases the therapeutic window for tissue-type plasminogen activator administration in a rat model of embolic stroke<br>Circulation (6-8-2002) 106, 740-745. PubMed  Europe PubMed DOI
    41. 2001
  41. [YEAR:7-9-2001]Briand,C., Kozlov,S.V., Sonderegger,P. and Grutter,M.G.<br>Crystal structure of neuroserpin: a neuronal serpin involved in a conformational disease<br>FEBS Lett (7-9-2001) 505, 18-22. PubMed  Europe PubMed DOI  S
    42. 1998
  42. [YEAR:23-1-1998]Osterwalder,T., Cinelli,P., Baici,A., Pennella,A., Krueger,S.R., Schrimpf,S.P., Meins,M. and Sonderegger,P.<br>The axonally secreted serine proteinase inhibitor, neuroserpin, inhibits plasminogen activators and plasmin but not thrombin<br>J Biol Chem (23-1-1998) 273, 2312-2321. PubMed  Europe PubMed DOI
    43. 1997
  43. [YEAR:26-12-1997]Hastings,G.A., Coleman,T.A., Haudenschild,C.C., Stefansson,S., Smith,E.P., Barthlow,R., Cherry,S., Sandkvist,M. and Lawrence,D.A.<br>Neuroserpin, a brain-associated inhibitor of tissue plasminogen activator is localized primarily in neurons. Implications for the regulation of motor learning and neuronal survival<br>J Biol Chem (26-12-1997) 272, 33062-33067. PubMed  Europe PubMed DOI
    44. 1996
  44. [YEAR:17-6-1996]Osterwalder,T., Contartese,J., Stoeckli,E.T., Kuhn,T.B. and Sonderegger,P.<br>Neuroserpin, an axonally secreted serine protease inhibitor<br>EMBO J (17-6-1996) 15, 2944-2953. PubMed  Europe PubMed  PMC  EPMC

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