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Literature for inhibitor I04.021: protease nexin-1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature

(Topics flags: S Structure, M Mutation, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Idir,L., Yu,J., Bonnin,P., Richard,B., Loyau,S., Boulaftali,Y., Bouton,M.C. and Arocas,V.
    SerpinE2 deficiency exacerbates glomerular Injury in diabetic nephropathy through dysregulated angiogenesis and inflammatory responses
    Am J Physiol Renal Physiol (2025) PubMed  Europe PubMed DOI
    2. 2024
  2. Chuang,H.W., Lin,L.H., Ji,D.D., Fu,T.Y., Lee,H.S., Yang,Y.F., Tseng,H.C. and Hsia,K.T.
    Serpin peptidase inhibitor, clade E, member 2 is associated with malignant progression and clinical prognosis in oral squamous cell carcinoma
    J Dent Sci (2024) 19, 70-78. PubMed  Europe PubMed DOI  PMC  EPMC  K
  3. Wu,S., Yang,Y., Zhang,M., Khan,A.U., Dai,J. and Ouyang,J.
    Serpin peptidase inhibitor, clade E, member 2 in physiology and pathology: recent advancements
    Front Mol Biosci (2024) 11, 1334931-1334931. PubMed  Europe PubMed DOI  PMC  EPMC  V
    4. 2021
  4. Selbonne,S., Madjene,C., Salmon,B., Boulaftali,Y., Bouton,M.C. and Arocas,V.
    Protease nexin-1 deficiency increases mouse hindlimb neovascularisation following ischemia and accelerates femoral artery perfusion
    Sci Rep (2021) 11, 13412-13412. PubMed  Europe PubMed DOI  PMC  EPMC
    5. 2020
  5. Aymonnier,K., Kawecki,C., Arocas,V., Boulaftali,Y. and Bouton,M.C.
    Serpins, New Therapeutic Targets for Hemophilia
    Thromb Haemost (2020) PubMed  Europe PubMed DOI  V
  6. Dokuni,R., Nagano,T., Jimbo,N., Sato,H., Kiriu,T., Yasuda,Y., Yamamoto,M., Tachihara,M., Kobayashi,K., Maniwa,Y. and Nishimura,Y.
    High expression level of serpin peptidase inhibitor clade E member 2 is associated with poor prognosis in lung adenocarcinoma
    Respir Res (2020) 21, 331-331. PubMed  Europe PubMed DOI  PMC  EPMC
    7. 2018
  7. Du,K., Zhou,Y., Chen,G., He,X. and Zhang,X.
    [Knockdown of serpin E2 inhibits proliferation, invasion and migration of colon cancer cells]
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi (2018) 34, 1021-1026. PubMed  Europe PubMed
  8. Li,S.H., Hwu,Y.M., Lu,C.H., Lin,M.H., Yeh,L.Y. and Lee,R.K.
    Serine protease inhibitor SERPINE2 reversibly modulates murine sperm capacitation
    Int J Mol Sci (2018) 19 PubMed  Europe PubMed DOI
  9. Xin,X., Ding,Y., Yang,Y., Fu,X., Zhou,J., McKee,C.M., Muschel,R.J., Gale,R.P., Apperley,J.F. and Xu,D.
    Protease nexin-1 prevents growth of human B cell lymphoma via inhibition of sonic hedgehog signaling
    Blood Cancer J (2018) 8, 24-24. PubMed  Europe PubMed DOI  PMC  EPMC
    10. 2016
  10. Francois,D., Venisse,L., Brouwers,E., Arocas,V., Declerck,P. and Bouton,M.-C.
    Selective neutralization of the serpin protease nexin-1 by a specific monoclonal antibody
    Br J Haematol (2016) 172, 631-633. PubMed  Europe PubMed DOI
    11. 2015
  11. Arocas,V. and Bouton,M.-C.
    Protease nexin-1: a serpin involved in pathophysiology
    The Serpin Family: Proteins with Multiple Functions in Health and Disease (2015) , 179-196. DOI
    12. 2013
  12. Huntington,J.A.
    Thrombin inhibition by the serpins
    J Thromb Haemost (2013) 11 Suppl 1, 254-264. PubMed  Europe PubMed DOI
    13. 2012
  13. Bouton,M.C., Boulaftali,Y., Richard,B., Arocas,V., Michel,J.B. and Jandrot-Perrus,M.
    Emerging role of serpinE2/protease nexin-1 in hemostasis and vascular biology
    Blood (2012) 119, 2452-2457. PubMed  Europe PubMed DOI
  14. Li,W. and Huntington,J.A.
    Crystal structures of protease nexin-1 in complex with heparin and thrombin suggest a 2-step recognition mechanism
    Blood (2012) 120, 459-467. PubMed  Europe PubMed DOI  S
    15. 2011
  15. Kukkonen,M.K., Tiili,E., Hamalainen,S., Vehmas,T., Oksa,P., Piirila,P. and Hirvonen,A.
    SERPINE2 haplotype as a risk factor for panlobular type of emphysema
    BMC Med Genet (2011) 12, 157-157. PubMed  Europe PubMed DOI  M
    16. 2010
  16. Lino,M.M., Vaillant,C., Orolicki,S., Sticker,M., Kvajo,M. and Monard,D.
    Newly generated cells are increased in hippocampus of adult mice lacking a serine protease inhibitor
    BMC Neurosci (2010) 11, 70-70. PubMed  Europe PubMed DOI  K
  17. Nagahara,A., Nakayama,M., Oka,D., Tsuchiya,M., Kawashima,A., Mukai,M., Nakai,Y., Takayama,H., Nishimura,K., Jo,Y., Nagai,A., Okuyama,A. and Nonomura,N.
    SERPINE2 is a possible candidate promotor for lymph node metastasis in testicular cancer
    Biochem Biophys Res Commun (2010) 391, 1641-1646. PubMed  Europe PubMed DOI
    18. 2009
  18. Fayard,B., Bianchi,F., Dey,J., Moreno,E., Djaffer,S., Hynes,N.E. and Monard,D.
    The serine protease inhibitor protease nexin-1 controls mammary cancer metastasis through LRP-1-mediated MMP-9 expression
    Cancer Res (2009) 69, 5690-5698. PubMed  Europe PubMed DOI
  19. Koistinen,H., Koistinen,R., Zhang,W.M., Valmu,L. and Stenman,U.H.
    Nexin-1 inhibits the activity of human brain trypsin
    Neuroscience (2009) 160, 97-102. PubMed  Europe PubMed DOI
    20. 2007
  20. Neesse,A., Wagner,M., Ellenrieder,V., Bachem,M., Gress,T.M. and Buchholz,M.
    Pancreatic stellate cells potentiate proinvasive effects of SERPINE2 expression in pancreatic cancer xenograft tumors
    Pancreatology (2007) 7, 380-385. PubMed  Europe PubMed DOI
    21. 2006
  21. [YEAR:5-5-2006]Onuma,Y., Asashima,M. and Whitman,M.
    A serpin family gene, protease nexin-1 has an activity distinct from protease inhibition in early Xenopus embryos
    Mech Dev (5-5-2006) 123, 463-471. PubMed  Europe PubMed DOI
  22. Richard,B., Pichon,S., Arocas,V., Venisse,L., Berrou,E., Bryckaert,M., Jandrot-Perrus,M. and Bouton,M.C.
    The serpin protease nexin-1 regulates vascular smooth muscle cell adhesion, spreading, migration and response to thrombin
    J Thromb Haemost (2006) 4, 322-328. PubMed  Europe PubMed DOI
    23. 2004
  23. Richard,B., Arocas,V., Guillin,M.C., Michel,J.B., Jandrot-Perrus,M. and Bouton,M.C.
    Protease nexin-1: a cellular serpin down-regulated by thrombin in rat aortic smooth muscle cells
    J Cell Physiol (2004) 201, 138-145. PubMed  Europe PubMed DOI
    24. 2003
  24. Bedard,J., Brule,S., Price,C.A., Silversides,D.W. and Lussier,J.G.
    Serine protease inhibitor-E2 (SERPINE2) is differentially expressed in granulosa cells of dominant follicle in cattle
    Mol Reprod Dev (2003) 64, 152-165. PubMed  Europe PubMed DOI
  25. [YEAR:15-8-2003]Buchholz,M., Biebl,A., Neesse,A., Wagner,M., Iwamura,T., Leder,G., Adler,G. and Gress,T.M.
    SERPINE2 (protease nexin I) promotes extracellular matrix production and local invasion of pancreatic tumors in vivo
    Cancer Res (15-8-2003) 63, 4945-4951. PubMed  Europe PubMed
    26. 2002
  26. [YEAR:6-12-2002]Crisp,R.J., Knauer,M.F. and Knauer,D.J.
    Protease nexin 1 is a potent urinary plasminogen activator inhibitor in the presence of collagen type IV
    J Biol Chem (6-12-2002) 277, 47285-47291. PubMed  Europe PubMed DOI
    27. 2001
  27. [YEAR:13-3-2001]Murer,V., Spetz,J.F., Hengst,U., Altrogge,L.M., de Agostini,A. and Monard,D.
    Male fertility defects in mice lacking the serine protease inhibitor protease nexin-1
    Proc Natl Acad Sci U S A (13-3-2001) 98, 3029-3033. PubMed  Europe PubMed DOI  PMC  EPMC
    28. 2000
  28. [YEAR:1-12-2000]Knauer,D.J., Majumdar,D., Fong,P.C. and Knauer,M.F.
    SERPIN regulation of factor XIa. The novel observation that protease nexin 1 in the presence of heparin is a more potent inhibitor of factor XIa than C1 inhibitor
    J Biol Chem (1-12-2000) 275, 37340-37346. PubMed  Europe PubMed DOI
    29. 1998
  29. [YEAR:20-11-1998]Myles,T., Church,F.C., Whinna,H.C., Monard,D. and Stone,S.R.
    Role of thrombin anion-binding exosite-I in the formation of thrombin-serpin complexes
    J Biol Chem (20-11-1998) 273, 31203-31208. PubMed  Europe PubMed DOI
    30. 1997
  30. [YEAR:9-5-1997]Knauer,M.F., Hawley,S.B. and Knauer,D.J.
    Identification of a binding site in protease nexin I (PN1) required for the receptor mediated internalization of PN1-thrombin complexes
    J Biol Chem (9-5-1997) 272, 12261-12264. PubMed  Europe PubMed DOI
    31. 1994
  31. Donovan,F.M., Vaughan,P.J. and Cunningham,D.D.
    Regulation of protease nexin-1 target protease specificity by collagen type IV
    J Biol Chem (1994) 269, 17199-17205. PubMed  Europe PubMed
    32. 1984
  32. Knauer,D.J. and Cunningham,D.D.
    Protease nexins: cell-secreted proteins which regulate extracellular serine proteases
    Trends Biochem Sci (1984) 9, 231-233. DOI
    33. 1983
  33. Knauer,D.J., Thompson,J.A. and Cunningham,D.D.
    Protease nexins: cell-secreted proteins that mediate the binding, internalization, and degradation of regulatory serine proteases
    J Cell Physiol (1983) 117, 385-396. PubMed  Europe PubMed DOI

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