Literature for inhibitor I04.021: protease nexin-1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature

(Topics flags: S Structure, M Mutation, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Chuang,H.W., Lin,L.H., Ji,D.D., Fu,T.Y., Lee,H.S., Yang,Y.F., Tseng,H.C. and Hsia,K.T.
    Serpin peptidase inhibitor, clade E, member 2 is associated with malignant progression and clinical prognosis in oral squamous cell carcinoma
    J Dent Sci19, 70-78. PubMed  Europe PubMed DOI  K
  2. Wu,S., Yang,Y., Zhang,M., Khan,A.U., Dai,J. and Ouyang,J.
    Serpin peptidase inhibitor, clade E, member 2 in physiology and pathology: recent advancements
    Front Mol Biosci11, 1334931-1334931. PubMed  Europe PubMed DOI  V
  3. 2020
  4. Aymonnier,K., Kawecki,C., Arocas,V., Boulaftali,Y. and Bouton,M.C.
    Serpins, New Therapeutic Targets for Hemophilia
    Thromb Haemost PubMed  Europe PubMed DOI  V
  5. Dokuni,R., Nagano,T., Jimbo,N., Sato,H., Kiriu,T., Yasuda,Y., Yamamoto,M., Tachihara,M., Kobayashi,K., Maniwa,Y. and Nishimura,Y.
    High expression level of serpin peptidase inhibitor clade E member 2 is associated with poor prognosis in lung adenocarcinoma
    Respir Res21, 331-331. PubMed  Europe PubMed DOI
  6. 2018
  7. Du,K., Zhou,Y., Chen,G., He,X. and Zhang,X.
    [Knockdown of serpin E2 inhibits proliferation, invasion and migration of colon cancer cells]
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi34, 1021-1026. PubMed  Europe PubMed
  8. Li,S.H., Hwu,Y.M., Lu,C.H., Lin,M.H., Yeh,L.Y. and Lee,R.K.
    Serine protease inhibitor SERPINE2 reversibly modulates murine sperm capacitation
    Int J Mol Sci19, PubMed  Europe PubMed DOI
  9. Xin,X., Ding,Y., Yang,Y., Fu,X., Zhou,J., McKee,C.M., Muschel,R.J., Gale,R.P., Apperley,J.F. and Xu,D.
    Protease nexin-1 prevents growth of human B cell lymphoma via inhibition of sonic hedgehog signaling
    Blood Cancer J8, 24-24. PubMed  Europe PubMed DOI
  10. 2016
  11. Francois,D., Venisse,L., Brouwers,E., Arocas,V., Declerck,P. and Bouton,M.-C.
    Selective neutralization of the serpin protease nexin-1 by a specific monoclonal antibody
    Br J Haematol172, 631-633. PubMed  Europe PubMed DOI
  12. 2015
  13. Arocas,V. and Bouton,M.-C.
    Protease nexin-1: a serpin involved in pathophysiology
    The Serpin Family: Proteins with Multiple Functions in Health and Disease179-196. DOI
  14. 2013
  15. Huntington,J.A.
    Thrombin inhibition by the serpins
    J Thromb Haemost11 Suppl 1, 254-264. PubMed  Europe PubMed DOI
  16. 2012
  17. Bouton,M.C., Boulaftali,Y., Richard,B., Arocas,V., Michel,J.B. and Jandrot-Perrus,M.
    Emerging role of serpinE2/protease nexin-1 in hemostasis and vascular biology
    Blood119, 2452-2457. PubMed  Europe PubMed DOI
  18. Li,W. and Huntington,J.A.
    Crystal structures of protease nexin-1 in complex with heparin and thrombin suggest a 2-step recognition mechanism
    Blood120, 459-467. PubMed  Europe PubMed DOI  S
  19. 2011
  20. Kukkonen,M.K., Tiili,E., Hamalainen,S., Vehmas,T., Oksa,P., Piirila,P. and Hirvonen,A.
    SERPINE2 haplotype as a risk factor for panlobular type of emphysema
    BMC Med Genet12, 157-157. PubMed  Europe PubMed DOI  M
  21. 2010
  22. Lino,M.M., Vaillant,C., Orolicki,S., Sticker,M., Kvajo,M. and Monard,D.
    Newly generated cells are increased in hippocampus of adult mice lacking a serine protease inhibitor
    BMC Neurosci11, 70-70. PubMed  Europe PubMed DOI  K
  23. Nagahara,A., Nakayama,M., Oka,D., Tsuchiya,M., Kawashima,A., Mukai,M., Nakai,Y., Takayama,H., Nishimura,K., Jo,Y., Nagai,A., Okuyama,A. and Nonomura,N.
    SERPINE2 is a possible candidate promotor for lymph node metastasis in testicular cancer
    Biochem Biophys Res Commun391, 1641-1646. PubMed  Europe PubMed DOI
  24. 2009
  25. Fayard,B., Bianchi,F., Dey,J., Moreno,E., Djaffer,S., Hynes,N.E. and Monard,D.
    The serine protease inhibitor protease nexin-1 controls mammary cancer metastasis through LRP-1-mediated MMP-9 expression
    Cancer Res69, 5690-5698. PubMed  Europe PubMed DOI
  26. Koistinen,H., Koistinen,R., Zhang,W.M., Valmu,L. and Stenman,U.H.
    Nexin-1 inhibits the activity of human brain trypsin
    Neuroscience160, 97-102. PubMed  Europe PubMed DOI
  27. 2007
  28. Neesse,A., Wagner,M., Ellenrieder,V., Bachem,M., Gress,T.M. and Buchholz,M.
    Pancreatic stellate cells potentiate proinvasive effects of SERPINE2 expression in pancreatic cancer xenograft tumors
    Pancreatology7, 380-385. PubMed  Europe PubMed DOI
  29. 2006
  30. [YEAR:5-5-2006]Onuma,Y., Asashima,M. and Whitman,M.
    A serpin family gene, protease nexin-1 has an activity distinct from protease inhibition in early Xenopus embryos
    Mech Dev123, 463-471. PubMed  Europe PubMed DOI
  31. Richard,B., Pichon,S., Arocas,V., Venisse,L., Berrou,E., Bryckaert,M., Jandrot-Perrus,M. and Bouton,M.C.
    The serpin protease nexin-1 regulates vascular smooth muscle cell adhesion, spreading, migration and response to thrombin
    J Thromb Haemost4, 322-328. PubMed  Europe PubMed DOI
  32. 2004
  33. Richard,B., Arocas,V., Guillin,M.C., Michel,J.B., Jandrot-Perrus,M. and Bouton,M.C.
    Protease nexin-1: a cellular serpin down-regulated by thrombin in rat aortic smooth muscle cells
    J Cell Physiol201, 138-145. PubMed  Europe PubMed DOI
  34. 2003
  35. Bedard,J., Brule,S., Price,C.A., Silversides,D.W. and Lussier,J.G.
    Serine protease inhibitor-E2 (SERPINE2) is differentially expressed in granulosa cells of dominant follicle in cattle
    Mol Reprod Dev64, 152-165. PubMed  Europe PubMed DOI
  36. [YEAR:15-8-2003]Buchholz,M., Biebl,A., Neesse,A., Wagner,M., Iwamura,T., Leder,G., Adler,G. and Gress,T.M.
    SERPINE2 (protease nexin I) promotes extracellular matrix production and local invasion of pancreatic tumors in vivo
    Cancer Res63, 4945-4951. PubMed  Europe PubMed
  37. 2002
  38. [YEAR:6-12-2002]Crisp,R.J., Knauer,M.F. and Knauer,D.J.
    Protease nexin 1 is a potent urinary plasminogen activator inhibitor in the presence of collagen type IV
    J Biol Chem277, 47285-47291. PubMed  Europe PubMed DOI
  39. 2001
  40. [YEAR:13-3-2001]Murer,V., Spetz,J.F., Hengst,U., Altrogge,L.M., de Agostini,A. and Monard,D.
    Male fertility defects in mice lacking the serine protease inhibitor protease nexin-1
    Proc Natl Acad Sci U S A98, 3029-3033. PubMed  Europe PubMed DOI
  41. 2000
  42. [YEAR:1-12-2000]Knauer,D.J., Majumdar,D., Fong,P.C. and Knauer,M.F.
    SERPIN regulation of factor XIa. The novel observation that protease nexin 1 in the presence of heparin is a more potent inhibitor of factor XIa than C1 inhibitor
    J Biol Chem275, 37340-37346. PubMed  Europe PubMed DOI
  43. 1998
  44. [YEAR:20-11-1998]Myles,T., Church,F.C., Whinna,H.C., Monard,D. and Stone,S.R.
    Role of thrombin anion-binding exosite-I in the formation of thrombin-serpin complexes
    J Biol Chem273, 31203-31208. PubMed  Europe PubMed DOI
  45. 1997
  46. [YEAR:9-5-1997]Knauer,M.F., Hawley,S.B. and Knauer,D.J.
    Identification of a binding site in protease nexin I (PN1) required for the receptor mediated internalization of PN1-thrombin complexes
    J Biol Chem272, 12261-12264. PubMed  Europe PubMed DOI
  47. 1994
  48. Donovan,F.M., Vaughan,P.J. and Cunningham,D.D.
    Regulation of protease nexin-1 target protease specificity by collagen type IV
    J Biol Chem269, 17199-17205. PubMed  Europe PubMed
  49. 1984
  50. Knauer,D.J. and Cunningham,D.D.
    Protease nexins: cell-secreted proteins which regulate extracellular serine proteases
    Trends Biochem Sci9, 231-233. DOI
  51. 1983
  52. Knauer,D.J., Thompson,J.A. and Cunningham,D.D.
    Protease nexins: cell-secreted proteins that mediate the binding, internalization, and degradation of regulatory serine proteases
    J Cell Physiol117, 385-396. PubMed  Europe PubMed DOI