Merops Switch to
Peptidases

Inhibitor

Family Clan Small-molecule
inhibitor SEARCHES BLAST
MEROPS

Other
information

Literature for inhibitor I04.020: plasminogen activator inhibitor-1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Inhibits Pharma

(Topics flags: S Structure, M Mutation, I Inhibitor, K Knockout, U Therapeutic, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Kattner,A.A.
    From inhibition to regulation: serpins in health and disease
    Biomed J (2026) 49, 100950-100950. PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2025
  2. Haynes,L.M., Holding,M.L., DiGiovanni,H.L., Siemieniak,D. and Ginsburg,D.
    High-throughput amino acid-level characterization of the interactions of plasminogen activator inhibitor-1 with variably divergent proteases
    Protein Sci (2025) 34, e70088-e70088. PubMed  Europe PubMed DOI  PMC  EPMC
  3. Haynes,L.M., Holding,M.L., Woodard,J., Siemieniak,D. and Ginsburg,D.
    Thermodynamics and selection of the plasminogen activator inhibitor-1 latency transition
    J Biol Chem (2025) , 110896-110896. PubMed  Europe PubMed DOI
  4. Wortley,J., Vu,J., Soogoor,N., Becerra,M. and Sathyamoorthy,M.
    A Contemporary Review of Plasminogen Activator Inhibitor Type 1: Structure, Function, Genetic Architecture, and Intracellular/Extracellular Roles
    TH Open (2025) 9, a26984219-a26984219. PubMed  Europe PubMed DOI  PMC  EPMC
    5. 2024
  5. Barrett,C.D., Moore,P.K., Moore,E.E., Moore,H.B., Chandler,J.G., Siddiqui,H., Maginot,E.R., Sauaia,A., Perez-Calatayud,A.A., Buesing,K., Wang,J., Davila-Chapa,C., Hershberger,D., Douglas,I., Pieracci,F.M. and Yaffe,M.B.
    Plasminogen Degradation by Neutrophil Elastase in Pleural Infection, Not High Plasminogen Activator Inhibitor-1 (PAI-1), is the Cause of Intrapleural Lytic Failure
    Chest (2024) PubMed  Europe PubMed DOI
  6. Gehlot,P., Brunnert,D., Kaushik,V., Yadav,A., Bage,S., Gaur,K., Saini,M., Ehrhardt,J., Manjunath,G.K., Kumar,A., Kasliwal,N., Sharma,A.K., Zygmunt,M. and Goyal,P.
    Unconventional localization of PAI-1 in PML bodies: A possible link with cellular growth of endothelial cells
    Biochem Biophys Rep (2024) 39, 101793-101793. PubMed  Europe PubMed DOI  PMC  EPMC
  7. Huang,Y.K., Cheng,W.C., Kuo,T.T., Yang,J.C., Wu,Y.C., Wu,H.H., Lo,C.C., Hsieh,C.Y., Wong,S.C., Lu,C.H., Wu,W.L., Liu,S.J., Li,Y.C., Lin,C.C., Shen,C.N., Hung,M.C., Lin,J.T., Yeh,C.C. and Sher,Y.P.
    Inhibition of ADAM9 promotes the selective degradation of KRAS and sensitizes pancreatic cancers to chemotherapy
    Nat Cancer (2024) 5, 400-419. PubMed  Europe PubMed DOI
  8. Vrzalova,A. and Vrzal,R.
    Orchestra of ligand-activated transcription factors in the molecular symphony of SERPINE 1 / PAI-1 gene regulation
    Biochimie (2024) PubMed  Europe PubMed DOI  V
  9. Wang,X., Chen,L., Wen,B., Wang,L., Yang,F., Bao,J., Pan,X., Zhang,G., Ji,K. and Liu,H.
    Serpin family E member 1 enhances myometrium contractility by increasing ATP production during labor
    FASEB J (2024) 38, e23368-e23368. PubMed  Europe PubMed DOI
    10. 2023
  10. Alfieri,M., Meo,L. and Ragno,P.
    Posttranscriptional Regulation of the Plasminogen Activation System by Non-Coding RNA in Cancer
    Int J Mol Sci (2023) 24 PubMed  Europe PubMed DOI  PMC  EPMC  V
  11. Chen,B.H., Lu,X.Q., Liang,X.H. and Wang,P.
    Serpin E1 mediates the induction of renal tubular degeneration and premature senescence upon diabetic insult
    Sci Rep (2023) 13, 16210-16210. PubMed  Europe PubMed DOI  PMC  EPMC
  12. Dai,W., Zhang,H., Lund,H., Zhang,Z., Castleberry,M., Rodriguez,M., Kuriakose,G., Gupta,S., Lewandowska,M., Powers,H.R., Valmiki,S., Zhu,J., Shapiro,A.D., Hussain,M.M., Lopez,J.A., Sorci-Thomas,M.G., Silverstein,R.L., Ginsberg,H.N., Sahoo,D., Tabas,I. and Zheng,Z.
    Intracellular tPA-PAI-1 interaction determines VLDL assembly in hepatocytes
    Science (2023) 381, eadh5207-eadh5207. PubMed  Europe PubMed DOI  PMC  EPMC
  13. Li,L., Li,F., Xu,Z., Li,L., Hu,H., Li,Y., Yu,S., Wang,M. and Gao,L.
    Identification and validation of SERPINE1 as a prognostic and immunological biomarker in pan-cancer and in ccRCC
    Front Pharmacol (2023) 14, 1213891-1213891. PubMed  Europe PubMed DOI  PMC  EPMC
  14. Mennesson,M. and Revest,J.M.
    Glucocorticoid-Responsive Tissue Plasminogen Activator (tPA) and Its Inhibitor Plasminogen Activator Inhibitor-1 (PAI-1): Relevance in Stress-Related Psychiatric Disorders
    Int J Mol Sci (2023) 24 PubMed  Europe PubMed DOI  PMC  EPMC  V
  15. Rana,T., Jiang,C., Banerjee,S., Yi,N., Zmijewski,J.W., Liu,G. and Liu,R.M.
    PAI-1 Regulation of p53 Expression and Senescence in Type II Alveolar Epithelial Cells
    Cells (2023) 12 PubMed  Europe PubMed DOI  PMC  EPMC
  16. Wang,B., Gu,B., Zhang,T., Li,X., Wang,N., Ma,C., Xiang,L., Wang,Y., Gao,L., Yu,Y., Song,K., He,P., Wang,Y., Zhu,J. and Chen,H.
    Good or bad: Paradox of plasminogen activator inhibitor 1 (PAI-1) in digestive system tumors
    Cancer Lett (2023) 559, 216117-216117. PubMed  Europe PubMed DOI  V
    17. 2022
  17. Kihn,K., Marchiori,E., Spagnolli,G., Boldrini,A., Terruzzi,L., Lawrence,D.A., Gershenson,A., Faccioli,P. and Wintrode,P.L.
    Long-range allostery mediates the regulation of plasminogen activator inhibitor-1 by cell adhesion factor vitronectin
    J Biol Chem (2022) 298, 102652-102652. PubMed  Europe PubMed DOI  PMC  EPMC
  18. Kim,W.T., Mun,J.Y., Baek,S.W., Kim,M.H., Yang,G.E., Jeong,M.S., Choi,S.Y., Han,J.Y., Kim,M.H. and Leem,S.H.
    Secretory SERPINE1 Expression Is Increased by Antiplatelet Therapy, Inducing MMP1 Expression and Increasing Colon Cancer Metastasis
    Int J Mol Sci (2022) 23 PubMed  Europe PubMed DOI  PMC  EPMC
  19. Liu,R.J., Xu,Z.P., Li,S.Y., Yu,J.J., Feng,N.H., Xu,B. and Chen,M.
    BAP1-Related ceRNA (NEAT1/miR-10a-5p/SERPINE1) Promotes Proliferation and Migration of Kidney Cancer Cells
    Front Oncol (2022) 12, 852515-852515. PubMed  Europe PubMed DOI  PMC  EPMC  K
  20. Minemura,C., Asai,S., Koma,A., Kase-Kato,I., Tanaka,N., Kikkawa,N., Kasamatsu,A., Yokoe,H., Hanazawa,T., Uzawa,K. and Seki,N.
    Identification of Tumor-Suppressive miR-30e-3p Targets: Involvement of SERPINE1 in the Molecular Pathogenesis of Head and Neck Squamous Cell Carcinoma
    Int J Mol Sci (2022) 23 PubMed  Europe PubMed DOI  PMC  EPMC
  21. Pascini,T.V., Jeong,Y.J., Huang,W., Pala,Z.R., Sa,J.M., Wells,M.B., Kizito,C., Sweeney,B., Alves E Silva, Andrew,D.J., Jacobs-Lorena,M. and Vega-Rodriguez,J.
    Transgenic Anopheles mosquitoes expressing human PAI-1 impair malaria transmission
    Nat Commun (2022) 13, 2949-2949. PubMed  Europe PubMed DOI  PMC  EPMC
  22. Xu,C., Liu,X., Shen,J., Sun,Q., Guo,X., Yang,M. and Leng,J.
    Integrative identification of human serpin PAI-1 inhibitors from Dracaena dragon blood and molecular implications for inhibitor-induced PAI-1 allosterism
    Biotechnol Appl Biochem (2022) 69, 221-229. PubMed  Europe PubMed DOI
    23. 2021
  23. Chen,T.Y., Zhou,M., Lin,M.Q., Liang,S.T., Yan,Y., Wang,S.M., Fang,C.S., Li,D. and Ruan,Y.
    Research Progress on the SERPINE1 Protein and Chronic Inflammatory Diseases of the Upper Respiratory Tract: A Literature Review
    Int Arch Allergy Immunol (2021) , 1-6. PubMed  Europe PubMed DOI
  24. Ismail,A.A., Shaker,B.T. and Bajou,K.
    The Plasminogen-Activator Plasmin System in Physiological and Pathophysiological Angiogenesis
    Int J Mol Sci (2021) 23 PubMed  Europe PubMed DOI  PMC  EPMC
  25. Sillen,M. and Declerck,P.J.
    A Narrative Review on Plasminogen Activator Inhibitor-1 and Its (Patho)Physiological Role: To Target or Not to Target?
    Int J Mol Sci (2021) 22 PubMed  Europe PubMed DOI  PMC  EPMC  V
  26. Song,L.T., Tada,H., Nishioka,T., Nemoto,E., Imamura,T., Potempa,J., Li,C.Y., Matsushita,K. and Sugawara,S.
    Porphyromonas gingivalis Gingipains-Mediated Degradation of Plasminogen Activator Inhibitor-1 Leads to Delayed Wound Healing Responses in Human Endothelial Cells
    J Innate Immun (2021) , 1-14. PubMed  Europe PubMed DOI
  27. Tziastoudi,M., Dardiotis,E., Pissas,G., Filippidis,G., Golfinopoulos,S., Siokas,V., Tachmitzi,S.V., Eleftheriadis,T., Hadjigeorgiou,G.M., Tsironi,E. and Stefanidis,I.
    Serpin Family E Member 1 Tag Single-Nucleotide Polymorphisms in Patients with Diabetic Nephropathy: An Association Study and Meta-Analysis Using a Genetic Model-Free Approach
    Genes (Basel) (2021) 12 PubMed  Europe PubMed DOI  PMC  EPMC
    28. 2020
  28. Chu,Y., Bucci,J.C. and Peterson,C.B.
    Dissecting molecular details and functional effects of the high-affinity copper binding site in plasminogen activator Inhibitor-1
    Protein Sci (2020) PubMed  Europe PubMed DOI
  29. Nougier,C., Benoit,R., Simon,M., Desmurs-Clavel,H., Marcotte,G., Argaud,L., David,J.S., Bonnet,A., Negrier,C. and Dargaud,Y.
    Hypofibrinolytic state and high thrombin generation may play a major role in SARS-COV2 associated thrombosis
    J Thromb Haemost (2020) PubMed  Europe PubMed DOI  PMC  EPMC
  30. Sanda,T., Yoshimura,M., Hyodo,K., Ishii,H. and Yamashita,T.
    Effects of Long-term Thrombin Inhibition (Dabigatran Etexilate) on Spontaneous Thrombolytic Activity during the Progression of Atherosclerosis in ApoE(-/-)-LDLR(-/-) Double-Knockout Mice
    Korean Circ J (2020) 50, 804-816. PubMed  Europe PubMed DOI  I
  31. Yang,B., Zhang,D., Qian,J. and Cheng,Y.
    Chelerythrine suppresses proliferation and metastasis of human prostate cancer cells via modulating MMP/TIMP/NF-kappaB system
    Mol Cell Biochem (2020) 474, 199-208. PubMed  Europe PubMed DOI
  32. Zhang,Q., Lei,L. and Jing,D.
    Knockdown of SERPINE1 reverses resistance of triplenegative breast cancer to paclitaxel via suppression of VEGFA
    Oncol Rep (2020) 44, 1875-1884. PubMed  Europe PubMed DOI  PMC  EPMC
    33. 2019
  33. Jendroszek,A., Madsen,J.B., Chana-Munoz,A., Dupont,D.M., Christensen,A., Panitz,F., Fuchtbauer,E.M., Lovell,S.C. and Jensen,J.K.
    Biochemical and structural analyses suggest that plasminogen activators coevolved with their cognate protein substrates and inhibitors
    J Biol Chem (2019) 294, 3794-3805. PubMed  Europe PubMed DOI
  34. Kubala,M.H. and DeClerck,Y.A.
    The plasminogen activator inhibitor-1 paradox in cancer: a mechanistic understanding
    Cancer Metastasis Rev (2019) 38, 483-492. PubMed  Europe PubMed DOI
  35. Peng,S., Xue,G., Chen,S., Chen,Z., Yuan,C., Li,J. and Huang,M.
    tPA Point mutation at autolysis loop enhances resistance to PAI-1 inhibition and catalytic activity
    Thromb Haemost (2019) 119, 77-86. PubMed  Europe PubMed DOI
  36. Reinke,A.A., Li,S.H., Warnock,M., Shaydakov,M.E., Guntaka,N.S., Su,E.J., Diaz,J.A., Emal,C.D. and Lawrence,D.A.
    Dual-reporter high-throughput screen for small-molecule in vivo inhibitors of plasminogen activator inhibitor type-1 yields a clinical lead candidate
    J Biol Chem (2019) 294, 1464-1477. PubMed  Europe PubMed DOI
    37. 2017
  37. Iwaki,T., Nagahashi,K., Takano,K., Suzuki-Inoue,K., Kanayama,N., Umemura,K. and Urano,T.
    Mutation in a highly conserved glycine residue in strand 5B of plasminogen activator inhibitor 1 causes polymerisation
    Thromb Haemost (2017) 117, 860-869. PubMed  Europe PubMed DOI  M
  38. Jendroszek,A., Sonnichsen,M.S., Munoz,A.C., Leyman,K., Christensen,A., Petersen,S.V., Wang,T., Bendixen,C., Panitz,F., Andreasen,P.A. and Jensen,J.K.
    Latency transition of plasminogen activator inhibitor type 1 is evolutionarily conserved
    Thromb Haemost (2017) 117 PubMed  Europe PubMed DOI
  39. Peng,S., Xue,G., Gong,L., Fang,C., Chen,J., Yuan,C., Chen,Z., Yao,L., Furie,B. and Huang,M.
    A long-acting PAI-1 inhibitor reduces thrombus formation
    Thromb Haemost (2017) 117, 1338-1347. PubMed  Europe PubMed DOI
    40. 2016
  40. Denorme,F., Wyseure,T., Peeters,M., Vandeputte,N., Gils,A., Deckmyn,H., Vanhoorelbeke,K., Declerck,P.J. and De Meyer,S.F.
    Inhibition of thrombin-activatable fibrinolysis inhibitor and plasminogen activator inhibitor-1 reduces ischemic brain damage in mice
    Stroke (2016) 47, 2419-2422. PubMed  Europe PubMed DOI
  41. Gettins,P.G. and Dolmer,K.
    The high affinity binding site on plasminogen activator inhibitor-1 (PAI-1) for the low density lipoprotein receptor-related protein (LRP1) is composed of four basic residues
    J Biol Chem (2016) 291, 800-812. PubMed  Europe PubMed DOI
  42. Gong,L., Liu,M., Zeng,T., Shi,X., Yuan,C., Andreasen,P.A. and Huang,M.
    Structural basis of specific inhibition of tissue-type plasminogen activator by plasminogen activators inhibitor-1
    Data Brief (2016) 6, 550-555. PubMed  Europe PubMed DOI  PMC  EPMC
  43. Gong,L., Proulle,V., Fang,C., Hong,Z., Lin,Z., Liu,M., Xue,G., Yuan,C., Lin,L., Furie,B., Flaumenhaft,R., Andreasen,P., Furie,B. and Huang,M.
    A specific plasminogen activator inhibitor-1 antagonist derived from inactivated urokinase
    J Cell Mol Med (2016) 20, 1851-1860. PubMed  Europe PubMed DOI
  44. Ji,Y., Weng,Z., Fish,P., Goyal,N., Luo,M., Myears,S.P., Strawn,T.L., Chandrasekar,B., Wu,J. and Fay,W.P.
    Pharmacological targeting of plasminogen activator inhibitor-1 decreases vascular smooth muscle cell migration and neointima formation
    Arterioscler Thromb Vasc Biol (2016) 36, 2167-2175. PubMed  Europe PubMed DOI
  45. Qureshi,T. and Peterson,C.B.
    Single fluorescence probes along the reactive center loop reveal site-specific changes during the latency transition of PAI-1
    Protein Sci (2016) 25, 487-498. PubMed  Europe PubMed DOI
    46. 2015
  46. Dittmann,M., Hoffmann,H.H., Scull,M.A., Gilmore,R.H., Bell,K.L., Ciancanelli,M., Wilson,S.J., Crotta,S., Yu,Y., Flatley,B., Xiao,J.W., Casanova,J.L., Wack,A., Bieniasz,P.D. and Rice,C.M.
    A serpin shapes the extracellular environment to prevent influenza A virus maturation
    Cell (2015) 160, 631-643. PubMed  Europe PubMed DOI
  47. Gong,L., Liu,M., Zeng,T., Shi,X., Yuan,C., Andreasen,P.A. and Huang,M.
    Crystal structure of the Michaelis complex between tissue-type plasminogen activator and plasminogen activators inhibitor-1
    J Biol Chem (2015) 290, 25795-25804. PubMed  Europe PubMed DOI  S
  48. Horvath,C.M.
    A serpin takes a bite out of the flu
    Cell Host Microbe (2015) 17, 283-284. PubMed  Europe PubMed DOI
    49. 2014
  49. Trelle,M.B., Madsen,J.B., Andreasen,P.A. and Jorgensen,T.J.
    Local transient unfolding of native state PAI-1 associated with serpin metastability
    Angew Chem Int Ed Engl (2014) 53, 9751-9754. PubMed  Europe PubMed DOI
    50. 2013
  50. Declerck,P.J. and Gils,A.
    Three Decades of Research on Plasminogen Activator Inhibitor-1: A Multifaceted Serpin
    Semin Thromb Hemost (2013) 39, 356-364. PubMed  Europe PubMed DOI  V
  51. Fortenberry,Y.M.
    Plasminogen activator inhibitor-1 inhibitors: a patent review (2006 - present)
    Expert Opin Ther Pat (2013) 23, 801-815. PubMed  Europe PubMed DOI  V
  52. Li,S.H., Reinke,A.A., Sanders,K.L., Emal,C.D., Whisstock,J.C., Stuckey,J.A. and Lawrence,D.A.
    Mechanistic characterization and crystal structure of a small molecule inactivator bound to plasminogen activator inhibitor-1
    Proc Natl Acad Sci U S A (2013) 110, E4941-E4949. PubMed  Europe PubMed DOI
    53. 2011
  53. Bernot,D., Stalin,J., Stocker,P., Bonardo,B., Scroyen,I., Alessi,M.C. and Peiretti,F.
    Plasminogen activator inhibitor 1 is an intracellular inhibitor of furin proprotein convertase
    J Cell Sci (2011) 124, 1224-1230. PubMed  Europe PubMed DOI
  54. Li,S.H. and Lawrence,D.A.
    Development of inhibitors of plasminogen activator inhibitor-1
    Methods Enzymol (2011) 501, 177-207. PubMed  Europe PubMed DOI  V
  55. Lin,Z., Jiang,L., Yuan,C., Jensen,J.K., Zhang,X., Luo,Z., Furie,B.C., Furie,B., Andreasen,P.A. and Huang,M.
    Structural basis for recognition of urokinase-type plasminogen activator by plasminogen activator inhibitor-1
    J Biol Chem (2011) 286, 7027-7032. PubMed  Europe PubMed DOI  PMC  EPMC
  56. Lobov,S. and Ranson,M.
    Molecular competition between plasminogen activator inhibitors type -1 and -2 for urokinase: implications for cellular proteolysis and adhesion in cancer
    Cancer Lett (2011) 303, 118-127. PubMed  Europe PubMed DOI
  57. Thompson,L.C., Goswami,S. and Peterson,C.B.
    Metals affect the structure and activity of human plasminogen activator inhibitor-1. II. Binding affinity and conformational changes
    Protein Sci (2011) 20, 366-378. PubMed  Europe PubMed DOI
    58. 2010
  58. Dewilde,M., Van De Craen,B., Compernolle,G., Madsen,J.B., Strelkov,S., Gils,A. and Declerck,P.J.
    Subtle structural differences between human and mouse PAI-1 reveal the basis for biochemical differences
    J Struct Biol (2010) 171, 95-101. PubMed  Europe PubMed DOI  S
  59. Hu,H., Zhao,Y., Xiao,Y., Zhang,R. and Song,H.
    Disruption of plasminogen activator inhibitor-1 gene enhances spontaneous enlargement of mouse airspace with increasing age
    Tohoku J Exp Med (2010) 222, 291-296. PubMed  Europe PubMed DOI  K
  60. Ju,H., Lim,B., Kim,M., Noh,S.M., Kim,W.H., Ihm,C., Choi,B.Y., Kim,Y.S. and Kang,C.
    SERPINE1 intron polymorphisms affecting gene expression are associated with diffuse-type gastric cancer susceptibility
    Cancer (2010) 116, 4248-4255. PubMed  Europe PubMed DOI  M
  61. Madsen,J.B., Dupont,D.M., Andersen,T.B., Nielsen,A.F., Sang,L., Brix,D.M., Jensen,J.K., Broos,T., Hendrickx,M.L., Christensen,A., Kjems,J. and Andreasen,P.A.
    RNA Aptamers as conformational probes and regulatory agents for plasminogen activator inhibitor-1
    Biochemistry (2010) 49, 4103-4115. PubMed  Europe PubMed DOI
  62. Park,J., Seo,J.Y. and Ha,H.
    Plasminogen activator inhibitor-1 antisense oligodeoxynucleotides abrogate mesangial fibronectin accumulation
    Korean J Physiol Pharmacol (2010) 14, 385-390. PubMed  Europe PubMed DOI  PMC  EPMC  K
    63. 2009
  63. Dewilde,M., Strelkov,S.V., Rabijns,A. and Declerck,P.J.
    High quality structure of cleaved PAI-1-stab
    J Struct Biol (2009) 165, 126-132. PubMed  Europe PubMed DOI  S
  64. Dupont,D.M., Madsen,J.B., Kristensen,T., Bodker,J.S., Blouse,G.E., Wind,T. and Andreasen,P.A.
    Biochemical properties of plasminogen activator inhibitor-1
    Front Biosci (2009) 14, 1337-1361. PubMed  Europe PubMed  V
  65. Huang,Y., Border,W.A., Lawrence,D.A. and Noble,N.A.
    Mechanisms underlying the antifibrotic properties of noninhibitory PAI-1 (PAI-1R) in experimental nephritis
    Am J Physiol Renal Physiol (2009) 297, F1045-F1054. PubMed  Europe PubMed DOI  PMC  EPMC
  66. Tanaka,A., Suzuki,Y., Sugihara,K., Kanayama,N. and Urano,T.
    Inactivation of plasminogen activator inhibitor type 1 by activated factor XII plays a role in the enhancement of fibrinolysis by contact factors in-vitro
    Life Sci (2009) 85, 220-225. PubMed  Europe PubMed DOI
    67. 2008
  67. Bajou,K., Peng,H., Laug,W.E., Maillard,C., Noel,A., Foidart,J.M., Martial,J.A. and DeClerck,Y.A.
    Plasminogen activator inhibitor-1 protects endothelial cells from FasL-mediated apoptosis
    Cancer Cell (2008) 14, 324-334. PubMed  Europe PubMed DOI  PMC  EPMC
  68. Izuhara,Y., Takahashi,S., Nangaku,M., Takizawa,S., Ishida,H., Kurokawa,K., van Ypersele de Strihou,C., Hirayama,N. and Miyata,T.
    Inhibition of plasminogen activator inhibitor-1: its mechanism and effectiveness on coagulation and fibrosis
    Arterioscler Thromb Vasc Biol (2008) 28, 672-677. PubMed  Europe PubMed DOI
  69. Jensen,J.K. and Gettins,P.G.
    High-resolution structure of the stable plasminogen activator inhibitor type-1 variant 14-1B in its proteinase-cleaved form: a new tool for detailed interaction studies and modeling
    Protein Sci (2008) 17, 1844-1849. PubMed  Europe PubMed DOI  PMC  EPMC  S
  70. Komissarov,A.A., Andreasen,P.A., Declerck,P.J., Kamikubo,Y., Zhou,A. and Gruber,A.
    Redirection of the reaction between activated protein C and a serpin to the substrate pathway
    Thromb Res (2008) 122, 397-404. PubMed  Europe PubMed DOI
  71. Li,S.H., Gorlatova,N.V., Lawrence,D.A. and Schwartz,B.S.
    Structural differences between active forms of plasminogen activator inhibitor type 1 revealed by conformationally sensitive ligands
    J Biol Chem (2008) 283, 18147-18157. PubMed  Europe PubMed DOI  PMC  EPMC
    72. 2007
  72. Cale,J.M. and Lawrence,D.A.
    Structure-function relationships of plasminogen activator inhibitor-1 and its potential as a therapeutic agent
    Curr Drug Targets (2007) 8, 971-981. PubMed  Europe PubMed DOI  V  U
  73. Eren,M., Gleaves,L.A., Atkinson,J.B., King,L.E., Declerck,P.J. and Vaughan,D.E.
    Reactive site-dependent phenotypic alterations in plasminogen activator inhibitor-1 transgenic mice
    J Thromb Haemost (2007) 5, 1500-1508. PubMed  Europe PubMed DOI
  74. Wygrecka,M., Morty,R.E., Markart,P., Kanse,S.M., Andreasen,P.A., Wind,T., Guenther,A. and Preissner,K.T.
    Plasminogen activator inhibitor-1 is an inhibitor of factor VII-activating protease in patients with acute respiratory distress syndrome
    J Biol Chem (2007) 282, 21671-21682. PubMed  Europe PubMed DOI
  75. Yi,J.Y. and Im,H.
    Structural factors affecting the choice between latency transition and polymerization in inhibitory serpins
    Protein Sci (2007) 16, 833-841. PubMed  Europe PubMed DOI  PMC  EPMC
    76. 2006
  76. [YEAR:3-10-2006]Dupont,D.M., Blouse,G.E., Hansen,M., Mathiasen,L., Kjelgaard,S., Jensen,J.K., Christensen,A., Gils,A., Declerck,P.J., Andreasen,P.A. and Wind,T.
    Evidence for a pre-latent form of the serpin plasminogen activator inhibitor-1 with a detached beta-strand 1C
    J Biol Chem (3-10-2006) 281, 36071-36081. PubMed  Europe PubMed DOI
  77. Griffiths,S.L. and Grainger,D.J.
    Proposal of a novel diabetogenic mechanism involving the serpin PAI-1
    Bioessays (2006) 28, 629-641. PubMed  Europe PubMed DOI
    78. 2005
  78. Boudier,C., Gils,A., Declerck,P.J. and Bieth,J.G.
    The conversion of active to latent plasminogen activator inhibitor-1 is an energetically silent event
    Biophys J (2005) 88, 2848-2854. PubMed  Europe PubMed DOI  PMC  EPMC
  79. Dellas,C. and Loskutoff,D.J.
    Historical analysis of PAI-1 from its discovery to its potential role in cell motility and disease
    Thromb Haemost (2005) 93, 631-640. PubMed  Europe PubMed DOI  V
  80. [YEAR:15-11-2005]Hermans,P.W. and Hazelzet,J.A.
    Plasminogen activator inhibitor type 1 gene polymorphism and sepsis
    Clin Infect Dis (15-11-2005) 41 Suppl 7, S453-S458. PubMed  Europe PubMed DOI
  81. [YEAR:14-1-2005]Komissarov,A.A., Andreasen,P.A., Bodker,J.S., Declerck,P.J., Anagli,J.Y. and Shore,J.D.
    Additivity in effects of vitronectin and monoclonal antibodies against alpha-helix F of plasminogen activator inhibitor-1 on its reactions with target proteinases
    J Biol Chem (14-1-2005) 280, 1482-1489. PubMed  Europe PubMed DOI
  82. Na,Y.R. and Im,H.
    The length of the reactive center loop modulates the latency transition of plasminogen activator inhibitor-1
    Protein Sci (2005) 14, 55-63. PubMed  Europe PubMed DOI  PMC  EPMC
    83. 2004
  83. [YEAR:17-2-2004]Abbott,G.L., Blouse,G.E., Perron,M.J., Shore,J.D., Luck,L.A. and Szabo,A.G.
    19F NMR studies of plasminogen activator inhibitor-1
    Biochemistry (17-2-2004) 43, 1507-1519. PubMed  Europe PubMed DOI
  84. [YEAR:15-12-2004]Brogren,H., Karlsson,L., Andersson,M., Wang,L., Erlinge,D. and Jern,S.
    Platelets synthesize large amounts of active plasminogen activator inhibitor 1
    Blood (15-12-2004) 104, 3943-3948. PubMed  Europe PubMed DOI
  85. Cho,S.H., Ryu,C.H. and Oh,C.K.
    Plasminogen activator inhibitor-1 in the pathogenesis of asthma
    Exp Biol Med (Maywood) (2004) 229, 138-146. PubMed  Europe PubMed
  86. Crandall,D.L., Elokdah,H., Di,L., Hennan,J.K., Gorlatova,N.V. and Lawrence,D.A.
    Characterization and comparative evaluation of a structurally unique PAI-1 inhibitor exhibiting oral in-vivo efficacy
    J Thromb Haemost (2004) 2, 1422-1428. PubMed  Europe PubMed DOI
  87. Cullen,J.P., Nicholl,S.M., Sayeed,S., Sitzmann,J.V., Okada,S.S., Cahill,P.A. and Redmond,E.M.
    Plasminogen activator inhibitor-1 deficiency enhances flow-induced smooth muscle cell migration
    Thromb Res (2004) 114, 57-65. PubMed  Europe PubMed DOI  I
  88. Czekay,R.P. and Loskutoff,D.J.
    Unexpected role of plasminogen activator inhibitor 1 in cell adhesion and detachment
    Exp Biol Med (Maywood) (2004) 229, 1090-1096. PubMed  Europe PubMed
  89. [YEAR:27-8-2004]De Taeye,B., Gils,A., Vleugels,N., Rabijns,A. and Declerck,P.J.
    Comparative analysis of the proteinase specificity in wild-type and stabilized plasminogen activator inhibitor-1: evidence for contribution of intramolecular flexibility
    Biochem Biophys Res Commun (27-8-2004) 321, 746-751. PubMed  Europe PubMed DOI
  90. De Taeye,B., Gils,A. and Declerck,P.J.
    The story of the serpin plasminogen activator inhibitor 1: is there any need for another mutant?
    Thromb Haemost (2004) 92, 898-924. PubMed  Europe PubMed DOI  V
  91. [YEAR:7-5-2004]De Taeye,B., Compernolle,G. and Declerck,P.J.
    Site-directed targeting of plasminogen activator inhibitor-1 as an example for a novel approach in rational drug design
    J Biol Chem (7-5-2004) 279, 20447-20450. PubMed  Europe PubMed DOI
  92. [YEAR:1-7-2004]Elokdah,H., Abou-Gharbia,M., Hennan,J.K., McFarlane,G., Mugford,C.P., Krishnamurthy,G. and Crandall,D.L.
    Tiplaxtinin, a novel, orally efficacious inhibitor of plasminogen activator inhibitor-1: design, synthesis, and preclinical characterization
    J Med Chem (1-7-2004) 47, 3491-3494. PubMed  Europe PubMed DOI
  93. Gils,A. and Declerck,P.J.
    Plasminogen activator inhibitor-1
    Curr Med Chem (2004) 11, 2323-2334. PubMed  Europe PubMed
  94. [YEAR:5-7-2004]Gopalsamy,A., Kincaid,S.L., Ellingboe,J.W., Groeling,T.M., Antrilli,T.M., Krishnamurthy,G., Aulabaugh,A., Friedrichs,G.S. and Crandall,D.L.
    Design and synthesis of oxadiazolidinediones as inhibitors of plasminogen activator inhibitor-1
    Bioorg Med Chem Lett (5-7-2004) 14, 3477-3480. PubMed  Europe PubMed DOI
  95. Ibarra,C.A., Blouse,G.E., Christian,T.D. and Shore,J.D.
    The contribution of the exosite residues of plasminogen activator inhibitor-1 to proteinase inhibition
    J Biol Chem (2004) 279, 3643-3650. PubMed  Europe PubMed DOI
  96. [YEAR:2-1-2004]Jensen,J.K., Durand,M.K., Skeldal,S., Dupont,D.M., Bodker,J.S., Wind,T. and Andreasen,P.A.
    Construction of a plasminogen activator inhibitor-1 variant without measurable affinity to vitronectin but otherwise normal
    FEBS Lett (2-1-2004) 556, 175-179. PubMed  Europe PubMed DOI
  97. [YEAR:28-5-2004]Komissarov,A.A., Declerck,P.J. and Shore,J.D.
    Protonation state of a single histidine residue contributes significantly to the kinetics of the reaction of plasminogen activator inhibitor-1 with tissue-type plasminogen activator
    J Biol Chem (28-5-2004) 279, 23007-23013. PubMed  Europe PubMed DOI
  98. Lazar,M.H., Christensen,P.J., Du,M., Yu,B., Subbotina,N.M., Hanson,K.E., Hansen,J.M., White,E.S., Simon,R.H. and Sisson,T.H.
    Plasminogen activator inhibitor-1 impairs alveolar epithelial repair by binding to vitronectin
    Am J Respir Cell Mol Biol (2004) 31, 672-678. PubMed  Europe PubMed DOI
  99. [YEAR:15-12-2004]Liu,Q., Moller,U., Flugel,D. and Kietzmann,T.
    Induction of plasminogen activator inhibitor I gene expression by intracellular calcium via hypoxia-inducible factor-1
    Blood (15-12-2004) 104, 3993-4001. PubMed  Europe PubMed DOI
  100. [YEAR:10-12-2004]Lobov,S., Wilczynska,M., Bergstrom,F., Johansson,L.B. and Ny,T.
    Structural bases of the redox-dependent conformational switch in the serpin PAI-2
    J Mol Biol (10-12-2004) 344, 1359-1368. PubMed  Europe PubMed DOI
  101. Ma,L.J., Mao,S.L., Taylor,K.L., Kanjanabuch,T., Guan,Y., Zhang,Y., Brown,N.J., Swift,L.L., McGuinness,O.P., Wasserman,D.H., Vaughan,D.E. and Fogo,A.B.
    Prevention of obesity and insulin resistance in mice lacking plasminogen activator inhibitor 1
    Diabetes (2004) 53, 336-346. PubMed  Europe PubMed DOI  K
  102. Providence,K.M. and Higgins,P.J.
    PAI-1 expression is required for epithelial cell migration in two distinct phases of in vitro wound repair
    J Cell Physiol (2004) 200, 297-308. PubMed  Europe PubMed DOI
  103. [YEAR:6-5-2004]Stefansson,S., Yepes,M., Gorlatova,N., Day,D.E., Moore,E.G., Zabaleta,A., McMahon,G.A. and Lawrence,D.A.
    Mutants of plasminogen activator inhibitor-1 designed to inhibit neutrophil elastase and cathepsin G are more effective in vivo than their endogenous inhibitors
    J Biol Chem (6-5-2004) 279, 29981-29987. PubMed  Europe PubMed DOI
  104. Vergouwen,M.D., Frijns,C.J., Roos,Y.B., Rinkel,G.J., Baas,F. and Vermeulen,M.
    Plasminogen activator inhibitor-1 4G allele in the 4G/5G promoter polymorphism increases the occurrence of cerebral ischemia after aneurysmal subarachnoid hemorrhage
    Stroke (2004) 35, 1280-1283. PubMed  Europe PubMed DOI  M
  105. [YEAR:20-12-2004]Xiang,G., Schuster,M.D., Seki,T., Kocher,A.A., Eshghi,S., Boyle,A. and Itescu,S.
    Down-regulation of plasminogen activator inhibitor 1 expression promotes myocardial neovascularization by bone marrow progenitors
    J Exp Med (20-12-2004) 200, 1657-1666. PubMed  Europe PubMed DOI  PMC  EPMC  K
  106. [YEAR:9-2-2004]Ye,B., Chou,Y.L., Karanjawala,R., Lee,W., Lu,S.F., Shaw,K.J., Jones,S., Lentz,D., Liang,A., Tseng,J.L., Wu,Q. and Zhao,Z.
    Synthesis and biological evaluation of piperazine-based derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1)
    Bioorg Med Chem Lett (9-2-2004) 14, 761-765. PubMed  Europe PubMed DOI
  107. Zirlik,A., Leugers,A., Lohrmann,J., Ernst,S., Sobel,B.E., Bode,C. and Nordt,T.K.
    Direct attenuation of plasminogen activator inhibitor type-1 expression in human adipose tissue by thiazolidinediones
    Thromb Haemost (2004) 91, 674-682. PubMed  Europe PubMed DOI
    108. 2003
  108. [YEAR:15-4-2003]Behrendt,N., List,K., Andreasen,P.A. and Dano,K.
    The pro-urokinase plasminogen-activation system in the presence of serpin-type inhibitors and the urokinase receptor: rescue of activity through reciprocal pro-enzyme activation
    Biochem J (15-4-2003) 371, 277-287. PubMed  Europe PubMed DOI  PMC  EPMC
  109. [YEAR:28-10-2003]Blouse,G.E., Perron,M.J., Kvassman,J.O., Yunus,S., Thompson,J.H., Betts,R.L., Lutter,L.C. and Shore,J.D.
    Mutation of the highly conserved tryptophan in the serpin breach region alters the inhibitory mechanism of plasminogen activator inhibitor-1
    Biochemistry (28-10-2003) 42, 12260-12272. PubMed  Europe PubMed DOI
  110. Chuang-Tsai,S., Sisson,T.H., Hattori,N., Tsai,C.G., Subbotina,N.M., Hanson,K.E. and Simon,R.H.
    Reduction in fibrotic tissue formation in mice genetically deficient in plasminogen activator inhibitor-1
    Am J Pathol (2003) 163, 445-452. PubMed  Europe PubMed DOI  PMC  EPMC
  111. [YEAR:28-11-2003]Crandall,D.L., Hennan,J.K., Elokdah,H., Krishnamurthy,G., Antrilli,T.M., Bauer,J.S., Morgan,G.A. and Swillo,R.E.
    WAY-140312 reduces plasma PAI-1 while maintaining normal platelet aggregation
    Biochem Biophys Res Commun (28-11-2003) 311, 904-908. PubMed  Europe PubMed DOI
  112. [YEAR:27-6-2003]De Taeye,B., Compernolle,G., Dewilde,M., Biesemans,W. and Declerck,P.J.
    Immobilization of the distal hinge in the labile serpin plasminogen activator inhibitor 1: identification of a transition state with distinct conformational and functional properties
    J Biol Chem (27-6-2003) 278, 23899-23905. PubMed  Europe PubMed DOI
  113. [YEAR:1-8-2003]De Taeye,B., Verbeke,K., Compernolle,G., Biesemans,W., Gils,A. and Declerck,P.J.
    Structural determinants in the stability of the serpin/proteinase complex
    Biochem Biophys Res Commun (1-8-2003) 307, 529-534. PubMed  Europe PubMed DOI
  114. Dekker,R.J., Pannekoek,H. and Horrevoets,A.J.
    A steady-state competition model describes the modulating effects of thrombomodulin on thrombin inhibition by plasminogen activator inhibitor-1 in the absence and presence of vitronectin
    Eur J Biochem (2003) 270, 1942-1951. PubMed  Europe PubMed DOI
  115. [YEAR:1-8-2003]Einholm,A.P., Pedersen,K.E., Wind,T., Kulig,P., Overgaard,M.T., Jensen,J.K., Bodker,J.S., Christensen,A., Charlton,P. and Andreasen,P.A.
    Biochemical mechanism of action of a diketopiperazine inactivator of plasminogen activator inhibitor-1
    Biochem J (1-8-2003) 373, 723-732. PubMed  Europe PubMed DOI  PMC  EPMC
  116. Gils,A., Pedersen,K.E., Skottrup,P., Christensen,A., Naessens,D., Deinum,J., Enghild,J.J., Declerck,P.J. and Andreasen,P.A.
    Biochemical importance of glycosylation of plasminogen activator inhibitor-1
    Thromb Haemost (2003) 90, 206-217. PubMed  Europe PubMed DOI
  117. [YEAR:2-5-2003]Gorlatova,N.V., Elokdah,H., Fan,K., Crandall,D.L. and Lawrence,D.A.
    Mapping of a conformational epitope on plasminogen activator inhibitor-1 by random mutagenesis. Implications for serpin function
    J Biol Chem (2-5-2003) 278, 16329-16335. PubMed  Europe PubMed DOI
  118. Nakamura,T., Adachi,H., Hirai,Y., Satoh,A., Ohuchida,M. and Imaizumi,T.
    Association of plasminogen activator inhibitor-1 with insulin resistance in Japan where obesity is rare
    Metabolism (2003) 52, 226-229. PubMed  Europe PubMed DOI
  119. [YEAR:6-10-2003]Ye,B., Bauer,S., Buckman,B.O., Ghannam,A., Griedel,B.D., Khim,S.K., Lee,W., Sacchi,K.L., Shaw,K.J., Liang,A., Wu,Q. and Zhao,Z.
    Synthesis and biological evaluation of menthol-based derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1)
    Bioorg Med Chem Lett (6-10-2003) 13, 3361-3365. PubMed  Europe PubMed DOI
  120. Zhou,A., Huntington,J.A., Pannu,N.S., Carrell,R.W. and Read,R.J.
    How vitronectin binds PAI-1 to modulate fibrinolysis and cell migration
    Nat Struct Biol (2003) 10, 541-544. PubMed  Europe PubMed DOI  S
    121. 2002
  121. Backovic,M., Stratikos,E., Lawrence,D.A. and Gettins,P.G.
    Structural similarity of the covalent complexes formed between the serpin plasminogen activator inhibitor-1 and the arginine-specific proteinases trypsin, LMW u-PA, HMW u-PA, and t-PA: use of site-specific fluorescent probes of local environment
    Protein Sci (2002) 11, 1182-1191. PubMed  Europe PubMed DOI  PMC  EPMC
  122. Binder,B.R., Christ,G., Gruber,F., Grubic,N., Hufnagl,P., Krebs,M., Mihaly,J. and Prager,G.W.
    Plasminogen activator inhibitor 1: Physiological and pathophysiological roles
    News Physiol Sci (2002) 17, 56-61. PubMed  Europe PubMed
  123. [YEAR:8-10-2002]Blouse,G.E., Perron,M.J., Thompson,J.H., Day,D.E., Link,C.A. and Shore,J.D.
    A concerted structural transition in the plasminogen activator inhibitor-1 mechanism of inhibition
    Biochemistry (8-10-2002) 41, 11997-12009. PubMed  Europe PubMed DOI
  124. [YEAR:29-10-2002]Brodsky,S.V., Malinowski,K., Golightly,M., Jesty,J. and Goligorsky,M.S.
    Plasminogen activator inhibitor-1 promotes formation of endothelial microparticles with procoagulant potential
    Circulation (29-10-2002) 106, 2372-2378. PubMed  Europe PubMed DOI  K
  125. Eddy,A.A.
    Plasminogen activator inhibitor-1 and the kidney
    Am J Physiol Renal Physiol (2002) 283, F209-F220. PubMed  Europe PubMed DOI
  126. [YEAR:27-4-2002]Lahlou,A., Peraldi,M.N., Thervet,E., Flahault,A., Delarue,F., Soubrier,F., Rossert,J., Hertig,A. and Rondeau,E.
    Chronic graft dysfunction in renal transplant patients: potential role of plasminogen activator inhibitor type 1
    Transplantation (27-4-2002) 73, 1290-1295. PubMed  Europe PubMed  M
  127. Lee,J.H., Lee,K.H., Lee,J.H., Kim,S., Seol,M., Park,C.J., Chi,H.S., Kang,W., Kim,S.T., Kim,W.K. and Lee,J.S.
    Plasminogen activator inhibitor-1 is an independent diagnostic marker as well as severity predictor of hepatic veno-occlusive disease after allogeneic bone marrow transplantation in adults conditioned with busulphan and cyclophosphamide
    Br J Haematol (2002) 118, 1087-1094. PubMed  Europe PubMed DOI
  128. Luttun,A., Lupu,F., Storkebaum,E., Hoylaerts,M.F., Moons,L., Crawley,J., Bono,F., Poole,A.R., Tipping,P., Herbert,J.M., Collen,D. and Carmeliet,P.
    Lack of plasminogen activator inhibitor-1 promotes growth and abnormal matrix remodeling of advanced atherosclerotic plaques in apolipoprotein E-deficient mice
    Arterioscler Thromb Vasc Biol (2002) 22, 499-505. PubMed  Europe PubMed DOI
  129. Sisson,T.H., Hanson,K.E., Subbotina,N., Patwardhan,A., Hattori,N. and Simon,R.H.
    Inducible lung-specific urokinase expression reduces fibrosis and mortality after lung injury in mice
    Am J Physiol Lung Cell Mol Physiol (2002) 283, L1023-L1032. PubMed  Europe PubMed DOI
  130. Tsikouris,J.P., Suarez,J.A. and Meyerrose,G.E.
    Plasminogen activator inhibitor-1: physiologic role, regulation, and the influence of common pharmacologic agents
    J Clin Pharmacol (2002) 42, 1187-1199. PubMed  Europe PubMed DOI
  131. Van Ness,K., Chobaz-Peclat,V., Castellucci,M., So,A. and Busso,N.
    Plasminogen activator inhibitor type-1 deficiency attenuates murine antigen-induced arthritis
    Rheumatology (Oxford) (2002) 41, 136-141. PubMed  Europe PubMed
  132. Wind,T., Hansen,M., Jensen,J.K. and Andreasen,P.A.
    The molecular basis for anti-proteolytic and non-proteolytic functions of plasminogen activator inhibitor type-1: Roles of the reactive centre loop, the shutter region, the flexible joint region and the small serpin fragment
    Biol Chem (2002) 383, 21-36. PubMed  Europe PubMed DOI
  133. Wu,Q. and Zhao,Z.
    Inhibition of PAI-1: a new anti-thrombotic approach
    Curr Drug Targets Cardiovasc Haematol Disord (2002) 2, 27-42. PubMed  Europe PubMed DOI
  134. [YEAR:12-12-2002]Yamada,Y., Izawa,H., Ichihara,S., Takatsu,F., Ishihara,H., Hirayama,H., Sone,T., Tanaka,M. and Yokota,M.
    Prediction of the risk of myocardial infarction from polymorphisms in candidate genes
    N Engl J Med (12-12-2002) 347, 1916-1923. PubMed  Europe PubMed DOI  M
  135. [YEAR:22-1-2002]Yamamoto,K., Takeshita,K., Shimokawa,T., Yi,H., Isobe,K., Loskutoff,D.J. and Saito,H.
    Plasminogen activator inhibitor-1 is a major stress-regulated gene: implications for stress-induced thrombosis in aged individuals
    Proc Natl Acad Sci U S A (22-1-2002) 99, 890-895. PubMed  Europe PubMed DOI  PMC  EPMC
    136. 2001
  136. [YEAR:30-11-2001]Bijnens,A.P., Gils,A., Stassen,J.M., Komissarov,A.A., Knockaert,I., Brouwers,E., Shore,J.D. and Declerck,P.J.
    The distal hinge of the reactive site loop and its proximity: a target to modulate plasminogen activator inhibitor-1 activity
    J Biol Chem (30-11-2001) 276, 44912-44918. PubMed  Europe PubMed DOI
  137. Chan,J.C., Duszczyszyn,D.A., Castellino,F.J. and Ploplis,V.A.
    Accelerated skin wound healing in plasminogen activator inhibitor-1-deficient mice
    Am J Pathol (2001) 159, 1681-1688. PubMed  Europe PubMed DOI  PMC  EPMC
  138. [YEAR:14-8-2001]Kaikita,K., Fogo,A.B., Ma,L., Schoenhard,J.A., Brown,N.J. and Vaughan,D.E.
    Plasminogen activator inhibitor-1 deficiency prevents hypertension and vascular fibrosis in response to long-term nitric oxide synthase inhibition
    Circulation (14-8-2001) 104, 839-844. PubMed  Europe PubMed
  139. [YEAR:6-7-2001]Urano,T., Ihara,H., Umemura,K., Suzuki,Y., Oike,M., Akita,S., Tsukamoto,Y., Suzuki,I. and Takada,A.
    The profibrinolytic enzyme subtilisin NAT purified from Bacillus subtilis cleaves and inactivates plasminogen activator inhibitor type 1
    J Biol Chem (6-7-2001) 276, 24690-24696. PubMed  Europe PubMed DOI
    140. 2000
  140. [YEAR:3-3-2000]Bijnens,A.P., Gils,A., Knockaert,I., Stassen,J.M. and Declerck,P.J.
    Importance of the hinge region between alpha-helix F and the main part of serpins, based upon identification of the epitope of plasminogen activator inhibitor type 1 neutralizing antibodies
    J Biol Chem (3-3-2000) 275, 6375-6380. PubMed  Europe PubMed DOI
  141. Floridon,C., Nielsen,O., Holund,B., Sweep,F., Sunde,L., Thomsen,S.G. and Teisner,B.
    Does plasminogen activator inhibitor-1 (PAI-1) control trophoblast invasion? A study of fetal and maternal tissue in intrauterine, tubal and molar pregnancies
    Placenta (2000) 21, 754-762. PubMed  Europe PubMed DOI
  142. [YEAR:23-6-2000]Mangs,H., Sui,G.C. and Wiman,B.
    PAI-1 stability: the role of histidine residues
    FEBS Lett (23-6-2000) 475, 192-196. PubMed  Europe PubMed DOI
  143. Morange,P.E., Lijnen,H.R., Alessi,M.C., Kopp,F., Collen,D. and Juhan-Vague,I.
    Influence of PAI-1 on adipose tissue growth and metabolic parameters in a murine model of diet-induced obesity
    Arterioscler Thromb Vasc Biol (2000) 20, 1150-1154. PubMed  Europe PubMed
  144. Nar,H., Bauer,M., Stassen,J.M., Lang,D., Gils,A. and Declerck,P.J.
    Plasminogen activator inhibitor 1. Structure of the native serpin, comparison to its other conformers and implications for serpin inactivation
    J Mol Biol (2000) 297, 683-695. PubMed  Europe PubMed DOI  S
  145. Stout,T.J., Graham,H., Buckley,D.I. and Matthews,D.J.
    Structures of active and latent PAI-1: a possible stabilizing role for chloride ions
    Biochemistry (2000) 39, 8460-8469. PubMed  Europe PubMed DOI  S
    146. 1999
  146. [YEAR:5-5-1999]Mikolajczyk,S.D., Millar,L.S., Kumar,A. and Saedi,M.S.
    Prostatic human kallikrein 2 inactivates and complexes with plasminogen activator inhibitor-1
    Int J Cancer (5-5-1999) 81, 438-442. PubMed  Europe PubMed DOI
  147. [YEAR:2-11-1999]Rezaie,A.R.
    Role of exosites 1 and 2 in thrombin reaction with plasminogen activator inhibitor-1 in the absence and presence of cofactors
    Biochemistry (2-11-1999) 38, 14592-14599. PubMed  Europe PubMed DOI
  148. Sharp,A.M., Stein,P.E., Pannu,N.S., Carrell,R.W., Berkenpas,M.B., Ginsburg,D., Lawrence,D.A. and Read,R.J.
    The active conformation of plasminogen activator inhibitor 1, a target for drugs to control fibrinolysis and cell adhesion
    Structure (1999) 7, 111-118. PubMed  Europe PubMed DOI  S
  149. [YEAR:15-6-1999]Zhu,Y., Carmeliet,P. and Fay,W.P.
    Plasminogen activator inhibitor-1 is a major determinant of arterial thrombolysis resistance
    Circulation (15-6-1999) 99, 3050-3055. PubMed  Europe PubMed
    150. 1998
  150. [YEAR:17-3-1998]Farrehi,P.M., Ozaki,C.K., Carmeliet,P. and Fay,W.P.
    Regulation of arterial thrombolysis by plasminogen activator inhibitor-1 in mice
    Circulation (17-3-1998) 97, 1002-1008. PubMed  Europe PubMed
  151. Xue,Y., Bjorquist,P., Inghardt,T., Linschoten,M., Musil,D., Sjolin,L. and Deinum,J.
    Interfering with the inhibitory mechanism of serpins: crystal structure of a complex formed between cleaved plasminogen activator inhibitor type 1 and a reactive-centre loop peptide
    Structure (1998) 6, 627-636. PubMed  Europe PubMed  S
    152. 1997
  152. [YEAR:4-11-1997]Carmeliet,P., Moons,L., Lijnen,R., Janssens,S., Lupu,F., Collen,D. and Gerard,R.D.
    Inhibitory role of plasminogen activator inhibitor-1 in arterial wound healing and neointima formation: a gene targeting and gene transfer study in mice
    Circulation (4-11-1997) 96, 3180-3191. PubMed  Europe PubMed
  153. [YEAR:15-4-1997]Carmeliet,P., Moons,L., Dewerchin,M., Mackman,N., Luther,T., Breier,G., Ploplis,V., Muller,M., Nagy,A., Plow,E., Gerard,R., Edgington,T., Risau,W. and Collen,D.
    Insights in vessel development and vascular disorders using targeted inactivation and transfer of vascular endothelial growth factor, the tissue factor receptor, and the plasminogen system
    Ann N Y Acad Sci (15-4-1997) 811, 191-206. PubMed  Europe PubMed DOI
    154. 1996
  154. [YEAR:1-6-1996]Eitzman,D.T., Krauss,J.C., Shen,T., Cui,J. and Ginsburg
    Lack of plasminogen activator inhibitor-1 effect in a transgenic mouse model of metastatic melanoma
    Blood (1-6-1996) 87, 4718-4722. PubMed  Europe PubMed
  155. Gils,A., Knockaert,I. and Declerck,P.J.
    Substrate behavior of plasminogen activator inhibitor-1 is not associated with a lack of insertion of the reactive site loop
    Biochemistry (1996) 35, 7474-7481. PubMed  Europe PubMed DOI
    156. 1995
  156. Aertgeerts,K., De Bondt,H.L., De Ranter,C.J. and Declerck,P.J.
    Mechanisms contributing to the conformational and functional flexibility of plasminogen activator inhibitor-1
    Nat Struct Biol (1995) 2, 891-897. PubMed  Europe PubMed
  157. Fa,M., Karolin,J., Aleshkov,S., Strandberg,L., Johansson,L.B. and Ny,T.
    Time-resolved polarized fluorescence spectroscopy studies of plasminogen activator inhibitor type 1: conformational changes of the reactive center upon interactions with target proteases, vitronectin and heparin
    Biochemistry (1995) 34, 13833-13840. PubMed  Europe PubMed
  158. Steven,F.S., Anees,M. and Booth,N.A.
    Selectivity of the plasminogen activator inhibitor (PAI-1) for the iso enzyme of guanidinobenzoatase on the surface of colonic carcinoma cells
    Anticancer Res (1995) 15, 205-210. PubMed  Europe PubMed
  159. Tucker,H.M., Mottonen,J., Goldsmith,E.J. and Gerard,R.D.
    Engineering of plasminogen activator inhibitor-1 to reduce the rate of latency transition
    Nat Struct Biol (1995) 2, 442-445. PubMed  Europe PubMed
    160. 1994
  160. Bjorquist,P., Brohlin,M., Ehnebom,J., Ericsson,M., Kristiansen,C., Pohl,G. and Deinum,J.
    Plasminogen activator inhibitor type-1 interacts exclusively with the proteinase domain of tissue plasminogen activator
    Biochim Biophys Acta (1994) 1209, 191-202. PubMed  Europe PubMed
    161. 1993
  161. Carmeliet,P., Stassen,J.M., Schoonjans,L., Ream,B., van den Oord,J.J., De Mol,M., Mulligan,R.C. and Collen,D.
    Plasminogen activator inhibitor-1 gene-deficient mice. II. Effects on hemostasis, thrombosis, and thrombolysis
    J Clin Invest (1993) 92, 2756-2760. PubMed  Europe PubMed DOI  PMC  EPMC  K
  162. Carmeliet,P., Kieckens,L., Schoonjans,L., Ream,B., van Nuffelen,A., Prendergast,G., Cole,M., Bronson,R., Collen,D. and Mulligan,R.C.
    Plasminogen activator inhibitor-1 gene-deficient mice. I. Generation by homologous recombination and characterization
    J Clin Invest (1993) 92, 2746-2755. PubMed  Europe PubMed DOI  PMC  EPMC  K
    163. 1992
  163. Mottonen,J., Strand,A., Symersky,J., Sweet,R.M., Danley,D.E., Geoghegan,K.F., Gerard,R.D. and Goldsmith,E.J.
    Structural basis of latency in plasminogen activator inhibitor-1
    Nature (1992) 355, 270-273. PubMed  Europe PubMed DOI  S
    164. 1990
  164. Andreasen,P.A., Georg,B., Lund,L.R., Riccio,A. and Stacey,S.N.
    Plasminogen activator inhibitors: hormonally regulated serpins
    Mol Cell Endocrinol (1990) 68, 1-19. PubMed  Europe PubMed DOI
    165. 1977
  165. [YEAR:15-8-1977]Wiman,B. and Collen,D.
    Purification and characterization of human antiplasmin, the fast-acting plasmin inhibitor in plasma
    Eur J Biochem (15-8-1977) 78, 19-26. PubMed  Europe PubMed

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2026 EBI
Terms of use