Literature for inhibitor I04.020: plasminogen activator inhibitor-1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Pharma

(Topics flags: S Structure, M Mutation, I Inhibitor, K Knockout, U Therapeutic, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2026

Kattner,A.A. From inhibition to regulation: serpins in health and disease Biomed J (2026) 49, 100950-100950. PubMed Europe PubMed DOI PMC EPMC

2025

Haynes,L.M., Holding,M.L., DiGiovanni,H.L., Siemieniak,D. and Ginsburg,D. High-throughput amino acid-level characterization of the interactions of plasminogen activator inhibitor-1 with variably divergent proteases Protein Sci (2025) 34, e70088-e70088. PubMed Europe PubMed DOI PMC EPMC
Haynes,L.M., Holding,M.L., Woodard,J., Siemieniak,D. and Ginsburg,D. Thermodynamics and selection of the plasminogen activator inhibitor-1 latency transition J Biol Chem (2025) , 110896-110896. PubMed Europe PubMed DOI
Wortley,J., Vu,J., Soogoor,N., Becerra,M. and Sathyamoorthy,M. A Contemporary Review of Plasminogen Activator Inhibitor Type 1: Structure, Function, Genetic Architecture, and Intracellular/Extracellular Roles TH Open (2025) 9, a26984219-a26984219. PubMed Europe PubMed DOI PMC EPMC

2024

Barrett,C.D., Moore,P.K., Moore,E.E., Moore,H.B., Chandler,J.G., Siddiqui,H., Maginot,E.R., Sauaia,A., Perez-Calatayud,A.A., Buesing,K., Wang,J., Davila-Chapa,C., Hershberger,D., Douglas,I., Pieracci,F.M. and Yaffe,M.B. Plasminogen Degradation by Neutrophil Elastase in Pleural Infection, Not High Plasminogen Activator Inhibitor-1 (PAI-1), is the Cause of Intrapleural Lytic Failure Chest (2024) PubMed Europe PubMed DOI
Gehlot,P., Brunnert,D., Kaushik,V., Yadav,A., Bage,S., Gaur,K., Saini,M., Ehrhardt,J., Manjunath,G.K., Kumar,A., Kasliwal,N., Sharma,A.K., Zygmunt,M. and Goyal,P. Unconventional localization of PAI-1 in PML bodies: A possible link with cellular growth of endothelial cells Biochem Biophys Rep (2024) 39, 101793-101793. PubMed Europe PubMed DOI PMC EPMC
Huang,Y.K., Cheng,W.C., Kuo,T.T., Yang,J.C., Wu,Y.C., Wu,H.H., Lo,C.C., Hsieh,C.Y., Wong,S.C., Lu,C.H., Wu,W.L., Liu,S.J., Li,Y.C., Lin,C.C., Shen,C.N., Hung,M.C., Lin,J.T., Yeh,C.C. and Sher,Y.P. Inhibition of ADAM9 promotes the selective degradation of KRAS and sensitizes pancreatic cancers to chemotherapy Nat Cancer (2024) 5, 400-419. PubMed Europe PubMed DOI
Vrzalova,A. and Vrzal,R. Orchestra of ligand-activated transcription factors in the molecular symphony of SERPINE 1 / PAI-1 gene regulation Biochimie (2024) PubMed Europe PubMed DOI V
Wang,X., Chen,L., Wen,B., Wang,L., Yang,F., Bao,J., Pan,X., Zhang,G., Ji,K. and Liu,H. Serpin family E member 1 enhances myometrium contractility by increasing ATP production during labor FASEB J (2024) 38, e23368-e23368. PubMed Europe PubMed DOI

2023

Alfieri,M., Meo,L. and Ragno,P. Posttranscriptional Regulation of the Plasminogen Activation System by Non-Coding RNA in Cancer Int J Mol Sci (2023) 24 PubMed Europe PubMed DOI PMC EPMC V
Chen,B.H., Lu,X.Q., Liang,X.H. and Wang,P. Serpin E1 mediates the induction of renal tubular degeneration and premature senescence upon diabetic insult Sci Rep (2023) 13, 16210-16210. PubMed Europe PubMed DOI PMC EPMC
Dai,W., Zhang,H., Lund,H., Zhang,Z., Castleberry,M., Rodriguez,M., Kuriakose,G., Gupta,S., Lewandowska,M., Powers,H.R., Valmiki,S., Zhu,J., Shapiro,A.D., Hussain,M.M., Lopez,J.A., Sorci-Thomas,M.G., Silverstein,R.L., Ginsberg,H.N., Sahoo,D., Tabas,I. and Zheng,Z. Intracellular tPA-PAI-1 interaction determines VLDL assembly in hepatocytes Science (2023) 381, eadh5207-eadh5207. PubMed Europe PubMed DOI PMC EPMC
Li,L., Li,F., Xu,Z., Li,L., Hu,H., Li,Y., Yu,S., Wang,M. and Gao,L. Identification and validation of SERPINE1 as a prognostic and immunological biomarker in pan-cancer and in ccRCC Front Pharmacol (2023) 14, 1213891-1213891. PubMed Europe PubMed DOI PMC EPMC
Mennesson,M. and Revest,J.M. Glucocorticoid-Responsive Tissue Plasminogen Activator (tPA) and Its Inhibitor Plasminogen Activator Inhibitor-1 (PAI-1): Relevance in Stress-Related Psychiatric Disorders Int J Mol Sci (2023) 24 PubMed Europe PubMed DOI PMC EPMC V
Rana,T., Jiang,C., Banerjee,S., Yi,N., Zmijewski,J.W., Liu,G. and Liu,R.M. PAI-1 Regulation of p53 Expression and Senescence in Type II Alveolar Epithelial Cells Cells (2023) 12 PubMed Europe PubMed DOI PMC EPMC
Wang,B., Gu,B., Zhang,T., Li,X., Wang,N., Ma,C., Xiang,L., Wang,Y., Gao,L., Yu,Y., Song,K., He,P., Wang,Y., Zhu,J. and Chen,H. Good or bad: Paradox of plasminogen activator inhibitor 1 (PAI-1) in digestive system tumors Cancer Lett (2023) 559, 216117-216117. PubMed Europe PubMed DOI V

2022

Kihn,K., Marchiori,E., Spagnolli,G., Boldrini,A., Terruzzi,L., Lawrence,D.A., Gershenson,A., Faccioli,P. and Wintrode,P.L. Long-range allostery mediates the regulation of plasminogen activator inhibitor-1 by cell adhesion factor vitronectin J Biol Chem (2022) 298, 102652-102652. PubMed Europe PubMed DOI PMC EPMC
Kim,W.T., Mun,J.Y., Baek,S.W., Kim,M.H., Yang,G.E., Jeong,M.S., Choi,S.Y., Han,J.Y., Kim,M.H. and Leem,S.H. Secretory SERPINE1 Expression Is Increased by Antiplatelet Therapy, Inducing MMP1 Expression and Increasing Colon Cancer Metastasis Int J Mol Sci (2022) 23 PubMed Europe PubMed DOI PMC EPMC
Liu,R.J., Xu,Z.P., Li,S.Y., Yu,J.J., Feng,N.H., Xu,B. and Chen,M. BAP1-Related ceRNA (NEAT1/miR-10a-5p/SERPINE1) Promotes Proliferation and Migration of Kidney Cancer Cells Front Oncol (2022) 12, 852515-852515. PubMed Europe PubMed DOI PMC EPMC K
Minemura,C., Asai,S., Koma,A., Kase-Kato,I., Tanaka,N., Kikkawa,N., Kasamatsu,A., Yokoe,H., Hanazawa,T., Uzawa,K. and Seki,N. Identification of Tumor-Suppressive miR-30e-3p Targets: Involvement of SERPINE1 in the Molecular Pathogenesis of Head and Neck Squamous Cell Carcinoma Int J Mol Sci (2022) 23 PubMed Europe PubMed DOI PMC EPMC
Pascini,T.V., Jeong,Y.J., Huang,W., Pala,Z.R., Sa,J.M., Wells,M.B., Kizito,C., Sweeney,B., Alves E Silva, Andrew,D.J., Jacobs-Lorena,M. and Vega-Rodriguez,J. Transgenic Anopheles mosquitoes expressing human PAI-1 impair malaria transmission Nat Commun (2022) 13, 2949-2949. PubMed Europe PubMed DOI PMC EPMC
Xu,C., Liu,X., Shen,J., Sun,Q., Guo,X., Yang,M. and Leng,J. Integrative identification of human serpin PAI-1 inhibitors from Dracaena dragon blood and molecular implications for inhibitor-induced PAI-1 allosterism Biotechnol Appl Biochem (2022) 69, 221-229. PubMed Europe PubMed DOI

2021

Chen,T.Y., Zhou,M., Lin,M.Q., Liang,S.T., Yan,Y., Wang,S.M., Fang,C.S., Li,D. and Ruan,Y. Research Progress on the SERPINE1 Protein and Chronic Inflammatory Diseases of the Upper Respiratory Tract: A Literature Review Int Arch Allergy Immunol (2021) , 1-6. PubMed Europe PubMed DOI
Ismail,A.A., Shaker,B.T. and Bajou,K. The Plasminogen-Activator Plasmin System in Physiological and Pathophysiological Angiogenesis Int J Mol Sci (2021) 23 PubMed Europe PubMed DOI PMC EPMC
Sillen,M. and Declerck,P.J. A Narrative Review on Plasminogen Activator Inhibitor-1 and Its (Patho)Physiological Role: To Target or Not to Target? Int J Mol Sci (2021) 22 PubMed Europe PubMed DOI PMC EPMC V
Song,L.T., Tada,H., Nishioka,T., Nemoto,E., Imamura,T., Potempa,J., Li,C.Y., Matsushita,K. and Sugawara,S. Porphyromonas gingivalis Gingipains-Mediated Degradation of Plasminogen Activator Inhibitor-1 Leads to Delayed Wound Healing Responses in Human Endothelial Cells J Innate Immun (2021) , 1-14. PubMed Europe PubMed DOI
Tziastoudi,M., Dardiotis,E., Pissas,G., Filippidis,G., Golfinopoulos,S., Siokas,V., Tachmitzi,S.V., Eleftheriadis,T., Hadjigeorgiou,G.M., Tsironi,E. and Stefanidis,I. Serpin Family E Member 1 Tag Single-Nucleotide Polymorphisms in Patients with Diabetic Nephropathy: An Association Study and Meta-Analysis Using a Genetic Model-Free Approach Genes (Basel) (2021) 12 PubMed Europe PubMed DOI PMC EPMC

2020

Chu,Y., Bucci,J.C. and Peterson,C.B. Dissecting molecular details and functional effects of the high-affinity copper binding site in plasminogen activator Inhibitor-1 Protein Sci (2020) PubMed Europe PubMed DOI
Nougier,C., Benoit,R., Simon,M., Desmurs-Clavel,H., Marcotte,G., Argaud,L., David,J.S., Bonnet,A., Negrier,C. and Dargaud,Y. Hypofibrinolytic state and high thrombin generation may play a major role in SARS-COV2 associated thrombosis J Thromb Haemost (2020) PubMed Europe PubMed DOI PMC EPMC
Sanda,T., Yoshimura,M., Hyodo,K., Ishii,H. and Yamashita,T. Effects of Long-term Thrombin Inhibition (Dabigatran Etexilate) on Spontaneous Thrombolytic Activity during the Progression of Atherosclerosis in ApoE(-/-)-LDLR(-/-) Double-Knockout Mice Korean Circ J (2020) 50, 804-816. PubMed Europe PubMed DOI I
Yang,B., Zhang,D., Qian,J. and Cheng,Y. Chelerythrine suppresses proliferation and metastasis of human prostate cancer cells via modulating MMP/TIMP/NF-kappaB system Mol Cell Biochem (2020) 474, 199-208. PubMed Europe PubMed DOI
Zhang,Q., Lei,L. and Jing,D. Knockdown of SERPINE1 reverses resistance of triplenegative breast cancer to paclitaxel via suppression of VEGFA Oncol Rep (2020) 44, 1875-1884. PubMed Europe PubMed DOI PMC EPMC

2019

Jendroszek,A., Madsen,J.B., Chana-Munoz,A., Dupont,D.M., Christensen,A., Panitz,F., Fuchtbauer,E.M., Lovell,S.C. and Jensen,J.K. Biochemical and structural analyses suggest that plasminogen activators coevolved with their cognate protein substrates and inhibitors J Biol Chem (2019) 294, 3794-3805. PubMed Europe PubMed DOI
Kubala,M.H. and DeClerck,Y.A. The plasminogen activator inhibitor-1 paradox in cancer: a mechanistic understanding Cancer Metastasis Rev (2019) 38, 483-492. PubMed Europe PubMed DOI
Peng,S., Xue,G., Chen,S., Chen,Z., Yuan,C., Li,J. and Huang,M. tPA Point mutation at autolysis loop enhances resistance to PAI-1 inhibition and catalytic activity Thromb Haemost (2019) 119, 77-86. PubMed Europe PubMed DOI
Reinke,A.A., Li,S.H., Warnock,M., Shaydakov,M.E., Guntaka,N.S., Su,E.J., Diaz,J.A., Emal,C.D. and Lawrence,D.A. Dual-reporter high-throughput screen for small-molecule in vivo inhibitors of plasminogen activator inhibitor type-1 yields a clinical lead candidate J Biol Chem (2019) 294, 1464-1477. PubMed Europe PubMed DOI

2017

Iwaki,T., Nagahashi,K., Takano,K., Suzuki-Inoue,K., Kanayama,N., Umemura,K. and Urano,T. Mutation in a highly conserved glycine residue in strand 5B of plasminogen activator inhibitor 1 causes polymerisation Thromb Haemost (2017) 117, 860-869. PubMed Europe PubMed DOI M
Jendroszek,A., Sonnichsen,M.S., Munoz,A.C., Leyman,K., Christensen,A., Petersen,S.V., Wang,T., Bendixen,C., Panitz,F., Andreasen,P.A. and Jensen,J.K. Latency transition of plasminogen activator inhibitor type 1 is evolutionarily conserved Thromb Haemost (2017) 117 PubMed Europe PubMed DOI
Peng,S., Xue,G., Gong,L., Fang,C., Chen,J., Yuan,C., Chen,Z., Yao,L., Furie,B. and Huang,M. A long-acting PAI-1 inhibitor reduces thrombus formation Thromb Haemost (2017) 117, 1338-1347. PubMed Europe PubMed DOI

2016

Denorme,F., Wyseure,T., Peeters,M., Vandeputte,N., Gils,A., Deckmyn,H., Vanhoorelbeke,K., Declerck,P.J. and De Meyer,S.F. Inhibition of thrombin-activatable fibrinolysis inhibitor and plasminogen activator inhibitor-1 reduces ischemic brain damage in mice Stroke (2016) 47, 2419-2422. PubMed Europe PubMed DOI
Gettins,P.G. and Dolmer,K. The high affinity binding site on plasminogen activator inhibitor-1 (PAI-1) for the low density lipoprotein receptor-related protein (LRP1) is composed of four basic residues J Biol Chem (2016) 291, 800-812. PubMed Europe PubMed DOI
Gong,L., Liu,M., Zeng,T., Shi,X., Yuan,C., Andreasen,P.A. and Huang,M. Structural basis of specific inhibition of tissue-type plasminogen activator by plasminogen activators inhibitor-1 Data Brief (2016) 6, 550-555. PubMed Europe PubMed DOI PMC EPMC
Gong,L., Proulle,V., Fang,C., Hong,Z., Lin,Z., Liu,M., Xue,G., Yuan,C., Lin,L., Furie,B., Flaumenhaft,R., Andreasen,P., Furie,B. and Huang,M. A specific plasminogen activator inhibitor-1 antagonist derived from inactivated urokinase J Cell Mol Med (2016) 20, 1851-1860. PubMed Europe PubMed DOI
Ji,Y., Weng,Z., Fish,P., Goyal,N., Luo,M., Myears,S.P., Strawn,T.L., Chandrasekar,B., Wu,J. and Fay,W.P. Pharmacological targeting of plasminogen activator inhibitor-1 decreases vascular smooth muscle cell migration and neointima formation Arterioscler Thromb Vasc Biol (2016) 36, 2167-2175. PubMed Europe PubMed DOI
Qureshi,T. and Peterson,C.B. Single fluorescence probes along the reactive center loop reveal site-specific changes during the latency transition of PAI-1 Protein Sci (2016) 25, 487-498. PubMed Europe PubMed DOI

2015

Dittmann,M., Hoffmann,H.H., Scull,M.A., Gilmore,R.H., Bell,K.L., Ciancanelli,M., Wilson,S.J., Crotta,S., Yu,Y., Flatley,B., Xiao,J.W., Casanova,J.L., Wack,A., Bieniasz,P.D. and Rice,C.M. A serpin shapes the extracellular environment to prevent influenza A virus maturation Cell (2015) 160, 631-643. PubMed Europe PubMed DOI
Gong,L., Liu,M., Zeng,T., Shi,X., Yuan,C., Andreasen,P.A. and Huang,M. Crystal structure of the Michaelis complex between tissue-type plasminogen activator and plasminogen activators inhibitor-1 J Biol Chem (2015) 290, 25795-25804. PubMed Europe PubMed DOI S
Horvath,C.M. A serpin takes a bite out of the flu Cell Host Microbe (2015) 17, 283-284. PubMed Europe PubMed DOI

2014

Trelle,M.B., Madsen,J.B., Andreasen,P.A. and Jorgensen,T.J. Local transient unfolding of native state PAI-1 associated with serpin metastability Angew Chem Int Ed Engl (2014) 53, 9751-9754. PubMed Europe PubMed DOI

2013

Declerck,P.J. and Gils,A. Three Decades of Research on Plasminogen Activator Inhibitor-1: A Multifaceted Serpin Semin Thromb Hemost (2013) 39, 356-364. PubMed Europe PubMed DOI V
Fortenberry,Y.M. Plasminogen activator inhibitor-1 inhibitors: a patent review (2006 - present) Expert Opin Ther Pat (2013) 23, 801-815. PubMed Europe PubMed DOI V
Li,S.H., Reinke,A.A., Sanders,K.L., Emal,C.D., Whisstock,J.C., Stuckey,J.A. and Lawrence,D.A. Mechanistic characterization and crystal structure of a small molecule inactivator bound to plasminogen activator inhibitor-1 Proc Natl Acad Sci U S A (2013) 110, E4941-E4949. PubMed Europe PubMed DOI

2011

Bernot,D., Stalin,J., Stocker,P., Bonardo,B., Scroyen,I., Alessi,M.C. and Peiretti,F. Plasminogen activator inhibitor 1 is an intracellular inhibitor of furin proprotein convertase J Cell Sci (2011) 124, 1224-1230. PubMed Europe PubMed DOI
Li,S.H. and Lawrence,D.A. Development of inhibitors of plasminogen activator inhibitor-1 Methods Enzymol (2011) 501, 177-207. PubMed Europe PubMed DOI V
Lin,Z., Jiang,L., Yuan,C., Jensen,J.K., Zhang,X., Luo,Z., Furie,B.C., Furie,B., Andreasen,P.A. and Huang,M. Structural basis for recognition of urokinase-type plasminogen activator by plasminogen activator inhibitor-1 J Biol Chem (2011) 286, 7027-7032. PubMed Europe PubMed DOI PMC EPMC
Lobov,S. and Ranson,M. Molecular competition between plasminogen activator inhibitors type -1 and -2 for urokinase: implications for cellular proteolysis and adhesion in cancer Cancer Lett (2011) 303, 118-127. PubMed Europe PubMed DOI
Thompson,L.C., Goswami,S. and Peterson,C.B. Metals affect the structure and activity of human plasminogen activator inhibitor-1. II. Binding affinity and conformational changes Protein Sci (2011) 20, 366-378. PubMed Europe PubMed DOI

2010

Dewilde,M., Van De Craen,B., Compernolle,G., Madsen,J.B., Strelkov,S., Gils,A. and Declerck,P.J. Subtle structural differences between human and mouse PAI-1 reveal the basis for biochemical differences J Struct Biol (2010) 171, 95-101. PubMed Europe PubMed DOI S
Hu,H., Zhao,Y., Xiao,Y., Zhang,R. and Song,H. Disruption of plasminogen activator inhibitor-1 gene enhances spontaneous enlargement of mouse airspace with increasing age Tohoku J Exp Med (2010) 222, 291-296. PubMed Europe PubMed DOI K
Ju,H., Lim,B., Kim,M., Noh,S.M., Kim,W.H., Ihm,C., Choi,B.Y., Kim,Y.S. and Kang,C. SERPINE1 intron polymorphisms affecting gene expression are associated with diffuse-type gastric cancer susceptibility Cancer (2010) 116, 4248-4255. PubMed Europe PubMed DOI M
Madsen,J.B., Dupont,D.M., Andersen,T.B., Nielsen,A.F., Sang,L., Brix,D.M., Jensen,J.K., Broos,T., Hendrickx,M.L., Christensen,A., Kjems,J. and Andreasen,P.A. RNA Aptamers as conformational probes and regulatory agents for plasminogen activator inhibitor-1 Biochemistry (2010) 49, 4103-4115. PubMed Europe PubMed DOI
Park,J., Seo,J.Y. and Ha,H. Plasminogen activator inhibitor-1 antisense oligodeoxynucleotides abrogate mesangial fibronectin accumulation Korean J Physiol Pharmacol (2010) 14, 385-390. PubMed Europe PubMed DOI PMC EPMC K

2009

Dewilde,M., Strelkov,S.V., Rabijns,A. and Declerck,P.J. High quality structure of cleaved PAI-1-stab J Struct Biol (2009) 165, 126-132. PubMed Europe PubMed DOI S
Dupont,D.M., Madsen,J.B., Kristensen,T., Bodker,J.S., Blouse,G.E., Wind,T. and Andreasen,P.A. Biochemical properties of plasminogen activator inhibitor-1 Front Biosci (2009) 14, 1337-1361. PubMed Europe PubMed V
Huang,Y., Border,W.A., Lawrence,D.A. and Noble,N.A. Mechanisms underlying the antifibrotic properties of noninhibitory PAI-1 (PAI-1R) in experimental nephritis Am J Physiol Renal Physiol (2009) 297, F1045-F1054. PubMed Europe PubMed DOI PMC EPMC
Tanaka,A., Suzuki,Y., Sugihara,K., Kanayama,N. and Urano,T. Inactivation of plasminogen activator inhibitor type 1 by activated factor XII plays a role in the enhancement of fibrinolysis by contact factors in-vitro Life Sci (2009) 85, 220-225. PubMed Europe PubMed DOI

2008

Bajou,K., Peng,H., Laug,W.E., Maillard,C., Noel,A., Foidart,J.M., Martial,J.A. and DeClerck,Y.A. Plasminogen activator inhibitor-1 protects endothelial cells from FasL-mediated apoptosis Cancer Cell (2008) 14, 324-334. PubMed Europe PubMed DOI PMC EPMC
Izuhara,Y., Takahashi,S., Nangaku,M., Takizawa,S., Ishida,H., Kurokawa,K., van Ypersele de Strihou,C., Hirayama,N. and Miyata,T. Inhibition of plasminogen activator inhibitor-1: its mechanism and effectiveness on coagulation and fibrosis Arterioscler Thromb Vasc Biol (2008) 28, 672-677. PubMed Europe PubMed DOI
Jensen,J.K. and Gettins,P.G. High-resolution structure of the stable plasminogen activator inhibitor type-1 variant 14-1B in its proteinase-cleaved form: a new tool for detailed interaction studies and modeling Protein Sci (2008) 17, 1844-1849. PubMed Europe PubMed DOI PMC EPMC S
Komissarov,A.A., Andreasen,P.A., Declerck,P.J., Kamikubo,Y., Zhou,A. and Gruber,A. Redirection of the reaction between activated protein C and a serpin to the substrate pathway Thromb Res (2008) 122, 397-404. PubMed Europe PubMed DOI
Li,S.H., Gorlatova,N.V., Lawrence,D.A. and Schwartz,B.S. Structural differences between active forms of plasminogen activator inhibitor type 1 revealed by conformationally sensitive ligands J Biol Chem (2008) 283, 18147-18157. PubMed Europe PubMed DOI PMC EPMC

2007

Cale,J.M. and Lawrence,D.A. Structure-function relationships of plasminogen activator inhibitor-1 and its potential as a therapeutic agent Curr Drug Targets (2007) 8, 971-981. PubMed Europe PubMed DOI V U
Eren,M., Gleaves,L.A., Atkinson,J.B., King,L.E., Declerck,P.J. and Vaughan,D.E. Reactive site-dependent phenotypic alterations in plasminogen activator inhibitor-1 transgenic mice J Thromb Haemost (2007) 5, 1500-1508. PubMed Europe PubMed DOI
Wygrecka,M., Morty,R.E., Markart,P., Kanse,S.M., Andreasen,P.A., Wind,T., Guenther,A. and Preissner,K.T. Plasminogen activator inhibitor-1 is an inhibitor of factor VII-activating protease in patients with acute respiratory distress syndrome J Biol Chem (2007) 282, 21671-21682. PubMed Europe PubMed DOI
Yi,J.Y. and Im,H. Structural factors affecting the choice between latency transition and polymerization in inhibitory serpins Protein Sci (2007) 16, 833-841. PubMed Europe PubMed DOI PMC EPMC

2006

[YEAR:3-10-2006]Dupont,D.M., Blouse,G.E., Hansen,M., Mathiasen,L., Kjelgaard,S., Jensen,J.K., Christensen,A., Gils,A., Declerck,P.J., Andreasen,P.A. and Wind,T. Evidence for a pre-latent form of the serpin plasminogen activator inhibitor-1 with a detached beta-strand 1C J Biol Chem (3-10-2006) 281, 36071-36081. PubMed Europe PubMed DOI
Griffiths,S.L. and Grainger,D.J. Proposal of a novel diabetogenic mechanism involving the serpin PAI-1 Bioessays (2006) 28, 629-641. PubMed Europe PubMed DOI

2005

Boudier,C., Gils,A., Declerck,P.J. and Bieth,J.G. The conversion of active to latent plasminogen activator inhibitor-1 is an energetically silent event Biophys J (2005) 88, 2848-2854. PubMed Europe PubMed DOI PMC EPMC
Dellas,C. and Loskutoff,D.J. Historical analysis of PAI-1 from its discovery to its potential role in cell motility and disease Thromb Haemost (2005) 93, 631-640. PubMed Europe PubMed DOI V
[YEAR:15-11-2005]Hermans,P.W. and Hazelzet,J.A. Plasminogen activator inhibitor type 1 gene polymorphism and sepsis Clin Infect Dis (15-11-2005) 41 Suppl 7, S453-S458. PubMed Europe PubMed DOI
[YEAR:14-1-2005]Komissarov,A.A., Andreasen,P.A., Bodker,J.S., Declerck,P.J., Anagli,J.Y. and Shore,J.D. Additivity in effects of vitronectin and monoclonal antibodies against alpha-helix F of plasminogen activator inhibitor-1 on its reactions with target proteinases J Biol Chem (14-1-2005) 280, 1482-1489. PubMed Europe PubMed DOI
Na,Y.R. and Im,H. The length of the reactive center loop modulates the latency transition of plasminogen activator inhibitor-1 Protein Sci (2005) 14, 55-63. PubMed Europe PubMed DOI PMC EPMC

2004

[YEAR:17-2-2004]Abbott,G.L., Blouse,G.E., Perron,M.J., Shore,J.D., Luck,L.A. and Szabo,A.G. 19F NMR studies of plasminogen activator inhibitor-1 Biochemistry (17-2-2004) 43, 1507-1519. PubMed Europe PubMed DOI
[YEAR:15-12-2004]Brogren,H., Karlsson,L., Andersson,M., Wang,L., Erlinge,D. and Jern,S. Platelets synthesize large amounts of active plasminogen activator inhibitor 1 Blood (15-12-2004) 104, 3943-3948. PubMed Europe PubMed DOI
Cho,S.H., Ryu,C.H. and Oh,C.K. Plasminogen activator inhibitor-1 in the pathogenesis of asthma Exp Biol Med (Maywood) (2004) 229, 138-146. PubMed Europe PubMed
Crandall,D.L., Elokdah,H., Di,L., Hennan,J.K., Gorlatova,N.V. and Lawrence,D.A. Characterization and comparative evaluation of a structurally unique PAI-1 inhibitor exhibiting oral in-vivo efficacy J Thromb Haemost (2004) 2, 1422-1428. PubMed Europe PubMed DOI
Cullen,J.P., Nicholl,S.M., Sayeed,S., Sitzmann,J.V., Okada,S.S., Cahill,P.A. and Redmond,E.M. Plasminogen activator inhibitor-1 deficiency enhances flow-induced smooth muscle cell migration Thromb Res (2004) 114, 57-65. PubMed Europe PubMed DOI I
Czekay,R.P. and Loskutoff,D.J. Unexpected role of plasminogen activator inhibitor 1 in cell adhesion and detachment Exp Biol Med (Maywood) (2004) 229, 1090-1096. PubMed Europe PubMed
[YEAR:27-8-2004]De Taeye,B., Gils,A., Vleugels,N., Rabijns,A. and Declerck,P.J. Comparative analysis of the proteinase specificity in wild-type and stabilized plasminogen activator inhibitor-1: evidence for contribution of intramolecular flexibility Biochem Biophys Res Commun (27-8-2004) 321, 746-751. PubMed Europe PubMed DOI
De Taeye,B., Gils,A. and Declerck,P.J. The story of the serpin plasminogen activator inhibitor 1: is there any need for another mutant? Thromb Haemost (2004) 92, 898-924. PubMed Europe PubMed DOI V
[YEAR:7-5-2004]De Taeye,B., Compernolle,G. and Declerck,P.J. Site-directed targeting of plasminogen activator inhibitor-1 as an example for a novel approach in rational drug design J Biol Chem (7-5-2004) 279, 20447-20450. PubMed Europe PubMed DOI
[YEAR:1-7-2004]Elokdah,H., Abou-Gharbia,M., Hennan,J.K., McFarlane,G., Mugford,C.P., Krishnamurthy,G. and Crandall,D.L. Tiplaxtinin, a novel, orally efficacious inhibitor of plasminogen activator inhibitor-1: design, synthesis, and preclinical characterization J Med Chem (1-7-2004) 47, 3491-3494. PubMed Europe PubMed DOI
Gils,A. and Declerck,P.J. Plasminogen activator inhibitor-1 Curr Med Chem (2004) 11, 2323-2334. PubMed Europe PubMed
[YEAR:5-7-2004]Gopalsamy,A., Kincaid,S.L., Ellingboe,J.W., Groeling,T.M., Antrilli,T.M., Krishnamurthy,G., Aulabaugh,A., Friedrichs,G.S. and Crandall,D.L. Design and synthesis of oxadiazolidinediones as inhibitors of plasminogen activator inhibitor-1 Bioorg Med Chem Lett (5-7-2004) 14, 3477-3480. PubMed Europe PubMed DOI
Ibarra,C.A., Blouse,G.E., Christian,T.D. and Shore,J.D. The contribution of the exosite residues of plasminogen activator inhibitor-1 to proteinase inhibition J Biol Chem (2004) 279, 3643-3650. PubMed Europe PubMed DOI
[YEAR:2-1-2004]Jensen,J.K., Durand,M.K., Skeldal,S., Dupont,D.M., Bodker,J.S., Wind,T. and Andreasen,P.A. Construction of a plasminogen activator inhibitor-1 variant without measurable affinity to vitronectin but otherwise normal FEBS Lett (2-1-2004) 556, 175-179. PubMed Europe PubMed DOI
[YEAR:28-5-2004]Komissarov,A.A., Declerck,P.J. and Shore,J.D. Protonation state of a single histidine residue contributes significantly to the kinetics of the reaction of plasminogen activator inhibitor-1 with tissue-type plasminogen activator J Biol Chem (28-5-2004) 279, 23007-23013. PubMed Europe PubMed DOI
Lazar,M.H., Christensen,P.J., Du,M., Yu,B., Subbotina,N.M., Hanson,K.E., Hansen,J.M., White,E.S., Simon,R.H. and Sisson,T.H. Plasminogen activator inhibitor-1 impairs alveolar epithelial repair by binding to vitronectin Am J Respir Cell Mol Biol (2004) 31, 672-678. PubMed Europe PubMed DOI
[YEAR:15-12-2004]Liu,Q., Moller,U., Flugel,D. and Kietzmann,T. Induction of plasminogen activator inhibitor I gene expression by intracellular calcium via hypoxia-inducible factor-1 Blood (15-12-2004) 104, 3993-4001. PubMed Europe PubMed DOI
[YEAR:10-12-2004]Lobov,S., Wilczynska,M., Bergstrom,F., Johansson,L.B. and Ny,T. Structural bases of the redox-dependent conformational switch in the serpin PAI-2 J Mol Biol (10-12-2004) 344, 1359-1368. PubMed Europe PubMed DOI
Ma,L.J., Mao,S.L., Taylor,K.L., Kanjanabuch,T., Guan,Y., Zhang,Y., Brown,N.J., Swift,L.L., McGuinness,O.P., Wasserman,D.H., Vaughan,D.E. and Fogo,A.B. Prevention of obesity and insulin resistance in mice lacking plasminogen activator inhibitor 1 Diabetes (2004) 53, 336-346. PubMed Europe PubMed DOI K
Providence,K.M. and Higgins,P.J. PAI-1 expression is required for epithelial cell migration in two distinct phases of in vitro wound repair J Cell Physiol (2004) 200, 297-308. PubMed Europe PubMed DOI
[YEAR:6-5-2004]Stefansson,S., Yepes,M., Gorlatova,N., Day,D.E., Moore,E.G., Zabaleta,A., McMahon,G.A. and Lawrence,D.A. Mutants of plasminogen activator inhibitor-1 designed to inhibit neutrophil elastase and cathepsin G are more effective in vivo than their endogenous inhibitors J Biol Chem (6-5-2004) 279, 29981-29987. PubMed Europe PubMed DOI
Vergouwen,M.D., Frijns,C.J., Roos,Y.B., Rinkel,G.J., Baas,F. and Vermeulen,M. Plasminogen activator inhibitor-1 4G allele in the 4G/5G promoter polymorphism increases the occurrence of cerebral ischemia after aneurysmal subarachnoid hemorrhage Stroke (2004) 35, 1280-1283. PubMed Europe PubMed DOI M
[YEAR:20-12-2004]Xiang,G., Schuster,M.D., Seki,T., Kocher,A.A., Eshghi,S., Boyle,A. and Itescu,S. Down-regulation of plasminogen activator inhibitor 1 expression promotes myocardial neovascularization by bone marrow progenitors J Exp Med (20-12-2004) 200, 1657-1666. PubMed Europe PubMed DOI PMC EPMC K
[YEAR:9-2-2004]Ye,B., Chou,Y.L., Karanjawala,R., Lee,W., Lu,S.F., Shaw,K.J., Jones,S., Lentz,D., Liang,A., Tseng,J.L., Wu,Q. and Zhao,Z. Synthesis and biological evaluation of piperazine-based derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) Bioorg Med Chem Lett (9-2-2004) 14, 761-765. PubMed Europe PubMed DOI
Zirlik,A., Leugers,A., Lohrmann,J., Ernst,S., Sobel,B.E., Bode,C. and Nordt,T.K. Direct attenuation of plasminogen activator inhibitor type-1 expression in human adipose tissue by thiazolidinediones Thromb Haemost (2004) 91, 674-682. PubMed Europe PubMed DOI

2003

[YEAR:15-4-2003]Behrendt,N., List,K., Andreasen,P.A. and Dano,K. The pro-urokinase plasminogen-activation system in the presence of serpin-type inhibitors and the urokinase receptor: rescue of activity through reciprocal pro-enzyme activation Biochem J (15-4-2003) 371, 277-287. PubMed Europe PubMed DOI PMC EPMC
[YEAR:28-10-2003]Blouse,G.E., Perron,M.J., Kvassman,J.O., Yunus,S., Thompson,J.H., Betts,R.L., Lutter,L.C. and Shore,J.D. Mutation of the highly conserved tryptophan in the serpin breach region alters the inhibitory mechanism of plasminogen activator inhibitor-1 Biochemistry (28-10-2003) 42, 12260-12272. PubMed Europe PubMed DOI
Chuang-Tsai,S., Sisson,T.H., Hattori,N., Tsai,C.G., Subbotina,N.M., Hanson,K.E. and Simon,R.H. Reduction in fibrotic tissue formation in mice genetically deficient in plasminogen activator inhibitor-1 Am J Pathol (2003) 163, 445-452. PubMed Europe PubMed DOI PMC EPMC
[YEAR:28-11-2003]Crandall,D.L., Hennan,J.K., Elokdah,H., Krishnamurthy,G., Antrilli,T.M., Bauer,J.S., Morgan,G.A. and Swillo,R.E. WAY-140312 reduces plasma PAI-1 while maintaining normal platelet aggregation Biochem Biophys Res Commun (28-11-2003) 311, 904-908. PubMed Europe PubMed DOI
[YEAR:27-6-2003]De Taeye,B., Compernolle,G., Dewilde,M., Biesemans,W. and Declerck,P.J. Immobilization of the distal hinge in the labile serpin plasminogen activator inhibitor 1: identification of a transition state with distinct conformational and functional properties J Biol Chem (27-6-2003) 278, 23899-23905. PubMed Europe PubMed DOI
[YEAR:1-8-2003]De Taeye,B., Verbeke,K., Compernolle,G., Biesemans,W., Gils,A. and Declerck,P.J. Structural determinants in the stability of the serpin/proteinase complex Biochem Biophys Res Commun (1-8-2003) 307, 529-534. PubMed Europe PubMed DOI
Dekker,R.J., Pannekoek,H. and Horrevoets,A.J. A steady-state competition model describes the modulating effects of thrombomodulin on thrombin inhibition by plasminogen activator inhibitor-1 in the absence and presence of vitronectin Eur J Biochem (2003) 270, 1942-1951. PubMed Europe PubMed DOI
[YEAR:1-8-2003]Einholm,A.P., Pedersen,K.E., Wind,T., Kulig,P., Overgaard,M.T., Jensen,J.K., Bodker,J.S., Christensen,A., Charlton,P. and Andreasen,P.A. Biochemical mechanism of action of a diketopiperazine inactivator of plasminogen activator inhibitor-1 Biochem J (1-8-2003) 373, 723-732. PubMed Europe PubMed DOI PMC EPMC
Gils,A., Pedersen,K.E., Skottrup,P., Christensen,A., Naessens,D., Deinum,J., Enghild,J.J., Declerck,P.J. and Andreasen,P.A. Biochemical importance of glycosylation of plasminogen activator inhibitor-1 Thromb Haemost (2003) 90, 206-217. PubMed Europe PubMed DOI
[YEAR:2-5-2003]Gorlatova,N.V., Elokdah,H., Fan,K., Crandall,D.L. and Lawrence,D.A. Mapping of a conformational epitope on plasminogen activator inhibitor-1 by random mutagenesis. Implications for serpin function J Biol Chem (2-5-2003) 278, 16329-16335. PubMed Europe PubMed DOI
Nakamura,T., Adachi,H., Hirai,Y., Satoh,A., Ohuchida,M. and Imaizumi,T. Association of plasminogen activator inhibitor-1 with insulin resistance in Japan where obesity is rare Metabolism (2003) 52, 226-229. PubMed Europe PubMed DOI
[YEAR:6-10-2003]Ye,B., Bauer,S., Buckman,B.O., Ghannam,A., Griedel,B.D., Khim,S.K., Lee,W., Sacchi,K.L., Shaw,K.J., Liang,A., Wu,Q. and Zhao,Z. Synthesis and biological evaluation of menthol-based derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) Bioorg Med Chem Lett (6-10-2003) 13, 3361-3365. PubMed Europe PubMed DOI
Zhou,A., Huntington,J.A., Pannu,N.S., Carrell,R.W. and Read,R.J. How vitronectin binds PAI-1 to modulate fibrinolysis and cell migration Nat Struct Biol (2003) 10, 541-544. PubMed Europe PubMed DOI S

2002

Backovic,M., Stratikos,E., Lawrence,D.A. and Gettins,P.G. Structural similarity of the covalent complexes formed between the serpin plasminogen activator inhibitor-1 and the arginine-specific proteinases trypsin, LMW u-PA, HMW u-PA, and t-PA: use of site-specific fluorescent probes of local environment Protein Sci (2002) 11, 1182-1191. PubMed Europe PubMed DOI PMC EPMC
Binder,B.R., Christ,G., Gruber,F., Grubic,N., Hufnagl,P., Krebs,M., Mihaly,J. and Prager,G.W. Plasminogen activator inhibitor 1: Physiological and pathophysiological roles News Physiol Sci (2002) 17, 56-61. PubMed Europe PubMed
[YEAR:8-10-2002]Blouse,G.E., Perron,M.J., Thompson,J.H., Day,D.E., Link,C.A. and Shore,J.D. A concerted structural transition in the plasminogen activator inhibitor-1 mechanism of inhibition Biochemistry (8-10-2002) 41, 11997-12009. PubMed Europe PubMed DOI
[YEAR:29-10-2002]Brodsky,S.V., Malinowski,K., Golightly,M., Jesty,J. and Goligorsky,M.S. Plasminogen activator inhibitor-1 promotes formation of endothelial microparticles with procoagulant potential Circulation (29-10-2002) 106, 2372-2378. PubMed Europe PubMed DOI K
Eddy,A.A. Plasminogen activator inhibitor-1 and the kidney Am J Physiol Renal Physiol (2002) 283, F209-F220. PubMed Europe PubMed DOI
[YEAR:27-4-2002]Lahlou,A., Peraldi,M.N., Thervet,E., Flahault,A., Delarue,F., Soubrier,F., Rossert,J., Hertig,A. and Rondeau,E. Chronic graft dysfunction in renal transplant patients: potential role of plasminogen activator inhibitor type 1 Transplantation (27-4-2002) 73, 1290-1295. PubMed Europe PubMed M
Lee,J.H., Lee,K.H., Lee,J.H., Kim,S., Seol,M., Park,C.J., Chi,H.S., Kang,W., Kim,S.T., Kim,W.K. and Lee,J.S. Plasminogen activator inhibitor-1 is an independent diagnostic marker as well as severity predictor of hepatic veno-occlusive disease after allogeneic bone marrow transplantation in adults conditioned with busulphan and cyclophosphamide Br J Haematol (2002) 118, 1087-1094. PubMed Europe PubMed DOI
Luttun,A., Lupu,F., Storkebaum,E., Hoylaerts,M.F., Moons,L., Crawley,J., Bono,F., Poole,A.R., Tipping,P., Herbert,J.M., Collen,D. and Carmeliet,P. Lack of plasminogen activator inhibitor-1 promotes growth and abnormal matrix remodeling of advanced atherosclerotic plaques in apolipoprotein E-deficient mice Arterioscler Thromb Vasc Biol (2002) 22, 499-505. PubMed Europe PubMed DOI
Sisson,T.H., Hanson,K.E., Subbotina,N., Patwardhan,A., Hattori,N. and Simon,R.H. Inducible lung-specific urokinase expression reduces fibrosis and mortality after lung injury in mice Am J Physiol Lung Cell Mol Physiol (2002) 283, L1023-L1032. PubMed Europe PubMed DOI
Tsikouris,J.P., Suarez,J.A. and Meyerrose,G.E. Plasminogen activator inhibitor-1: physiologic role, regulation, and the influence of common pharmacologic agents J Clin Pharmacol (2002) 42, 1187-1199. PubMed Europe PubMed DOI
Van Ness,K., Chobaz-Peclat,V., Castellucci,M., So,A. and Busso,N. Plasminogen activator inhibitor type-1 deficiency attenuates murine antigen-induced arthritis Rheumatology (Oxford) (2002) 41, 136-141. PubMed Europe PubMed
Wind,T., Hansen,M., Jensen,J.K. and Andreasen,P.A. The molecular basis for anti-proteolytic and non-proteolytic functions of plasminogen activator inhibitor type-1: Roles of the reactive centre loop, the shutter region, the flexible joint region and the small serpin fragment Biol Chem (2002) 383, 21-36. PubMed Europe PubMed DOI
Wu,Q. and Zhao,Z. Inhibition of PAI-1: a new anti-thrombotic approach Curr Drug Targets Cardiovasc Haematol Disord (2002) 2, 27-42. PubMed Europe PubMed DOI
[YEAR:12-12-2002]Yamada,Y., Izawa,H., Ichihara,S., Takatsu,F., Ishihara,H., Hirayama,H., Sone,T., Tanaka,M. and Yokota,M. Prediction of the risk of myocardial infarction from polymorphisms in candidate genes N Engl J Med (12-12-2002) 347, 1916-1923. PubMed Europe PubMed DOI M
[YEAR:22-1-2002]Yamamoto,K., Takeshita,K., Shimokawa,T., Yi,H., Isobe,K., Loskutoff,D.J. and Saito,H. Plasminogen activator inhibitor-1 is a major stress-regulated gene: implications for stress-induced thrombosis in aged individuals Proc Natl Acad Sci U S A (22-1-2002) 99, 890-895. PubMed Europe PubMed DOI PMC EPMC

2001

[YEAR:30-11-2001]Bijnens,A.P., Gils,A., Stassen,J.M., Komissarov,A.A., Knockaert,I., Brouwers,E., Shore,J.D. and Declerck,P.J. The distal hinge of the reactive site loop and its proximity: a target to modulate plasminogen activator inhibitor-1 activity J Biol Chem (30-11-2001) 276, 44912-44918. PubMed Europe PubMed DOI
Chan,J.C., Duszczyszyn,D.A., Castellino,F.J. and Ploplis,V.A. Accelerated skin wound healing in plasminogen activator inhibitor-1-deficient mice Am J Pathol (2001) 159, 1681-1688. PubMed Europe PubMed DOI PMC EPMC
[YEAR:14-8-2001]Kaikita,K., Fogo,A.B., Ma,L., Schoenhard,J.A., Brown,N.J. and Vaughan,D.E. Plasminogen activator inhibitor-1 deficiency prevents hypertension and vascular fibrosis in response to long-term nitric oxide synthase inhibition Circulation (14-8-2001) 104, 839-844. PubMed Europe PubMed
[YEAR:6-7-2001]Urano,T., Ihara,H., Umemura,K., Suzuki,Y., Oike,M., Akita,S., Tsukamoto,Y., Suzuki,I. and Takada,A. The profibrinolytic enzyme subtilisin NAT purified from Bacillus subtilis cleaves and inactivates plasminogen activator inhibitor type 1 J Biol Chem (6-7-2001) 276, 24690-24696. PubMed Europe PubMed DOI

2000

[YEAR:3-3-2000]Bijnens,A.P., Gils,A., Knockaert,I., Stassen,J.M. and Declerck,P.J. Importance of the hinge region between alpha-helix F and the main part of serpins, based upon identification of the epitope of plasminogen activator inhibitor type 1 neutralizing antibodies J Biol Chem (3-3-2000) 275, 6375-6380. PubMed Europe PubMed DOI
Floridon,C., Nielsen,O., Holund,B., Sweep,F., Sunde,L., Thomsen,S.G. and Teisner,B. Does plasminogen activator inhibitor-1 (PAI-1) control trophoblast invasion? A study of fetal and maternal tissue in intrauterine, tubal and molar pregnancies Placenta (2000) 21, 754-762. PubMed Europe PubMed DOI
[YEAR:23-6-2000]Mangs,H., Sui,G.C. and Wiman,B. PAI-1 stability: the role of histidine residues FEBS Lett (23-6-2000) 475, 192-196. PubMed Europe PubMed DOI
Morange,P.E., Lijnen,H.R., Alessi,M.C., Kopp,F., Collen,D. and Juhan-Vague,I. Influence of PAI-1 on adipose tissue growth and metabolic parameters in a murine model of diet-induced obesity Arterioscler Thromb Vasc Biol (2000) 20, 1150-1154. PubMed Europe PubMed
Nar,H., Bauer,M., Stassen,J.M., Lang,D., Gils,A. and Declerck,P.J. Plasminogen activator inhibitor 1. Structure of the native serpin, comparison to its other conformers and implications for serpin inactivation J Mol Biol (2000) 297, 683-695. PubMed Europe PubMed DOI S
Stout,T.J., Graham,H., Buckley,D.I. and Matthews,D.J. Structures of active and latent PAI-1: a possible stabilizing role for chloride ions Biochemistry (2000) 39, 8460-8469. PubMed Europe PubMed DOI S

1999

[YEAR:5-5-1999]Mikolajczyk,S.D., Millar,L.S., Kumar,A. and Saedi,M.S. Prostatic human kallikrein 2 inactivates and complexes with plasminogen activator inhibitor-1 Int J Cancer (5-5-1999) 81, 438-442. PubMed Europe PubMed DOI
[YEAR:2-11-1999]Rezaie,A.R. Role of exosites 1 and 2 in thrombin reaction with plasminogen activator inhibitor-1 in the absence and presence of cofactors Biochemistry (2-11-1999) 38, 14592-14599. PubMed Europe PubMed DOI
Sharp,A.M., Stein,P.E., Pannu,N.S., Carrell,R.W., Berkenpas,M.B., Ginsburg,D., Lawrence,D.A. and Read,R.J. The active conformation of plasminogen activator inhibitor 1, a target for drugs to control fibrinolysis and cell adhesion Structure (1999) 7, 111-118. PubMed Europe PubMed DOI S
[YEAR:15-6-1999]Zhu,Y., Carmeliet,P. and Fay,W.P. Plasminogen activator inhibitor-1 is a major determinant of arterial thrombolysis resistance Circulation (15-6-1999) 99, 3050-3055. PubMed Europe PubMed

1998

[YEAR:17-3-1998]Farrehi,P.M., Ozaki,C.K., Carmeliet,P. and Fay,W.P. Regulation of arterial thrombolysis by plasminogen activator inhibitor-1 in mice Circulation (17-3-1998) 97, 1002-1008. PubMed Europe PubMed
Xue,Y., Bjorquist,P., Inghardt,T., Linschoten,M., Musil,D., Sjolin,L. and Deinum,J. Interfering with the inhibitory mechanism of serpins: crystal structure of a complex formed between cleaved plasminogen activator inhibitor type 1 and a reactive-centre loop peptide Structure (1998) 6, 627-636. PubMed Europe PubMed S

1997

[YEAR:4-11-1997]Carmeliet,P., Moons,L., Lijnen,R., Janssens,S., Lupu,F., Collen,D. and Gerard,R.D. Inhibitory role of plasminogen activator inhibitor-1 in arterial wound healing and neointima formation: a gene targeting and gene transfer study in mice Circulation (4-11-1997) 96, 3180-3191. PubMed Europe PubMed
[YEAR:15-4-1997]Carmeliet,P., Moons,L., Dewerchin,M., Mackman,N., Luther,T., Breier,G., Ploplis,V., Muller,M., Nagy,A., Plow,E., Gerard,R., Edgington,T., Risau,W. and Collen,D. Insights in vessel development and vascular disorders using targeted inactivation and transfer of vascular endothelial growth factor, the tissue factor receptor, and the plasminogen system Ann N Y Acad Sci (15-4-1997) 811, 191-206. PubMed Europe PubMed DOI

1996

[YEAR:1-6-1996]Eitzman,D.T., Krauss,J.C., Shen,T., Cui,J. and Ginsburg Lack of plasminogen activator inhibitor-1 effect in a transgenic mouse model of metastatic melanoma Blood (1-6-1996) 87, 4718-4722. PubMed Europe PubMed
Gils,A., Knockaert,I. and Declerck,P.J. Substrate behavior of plasminogen activator inhibitor-1 is not associated with a lack of insertion of the reactive site loop Biochemistry (1996) 35, 7474-7481. PubMed Europe PubMed DOI

1995

Aertgeerts,K., De Bondt,H.L., De Ranter,C.J. and Declerck,P.J. Mechanisms contributing to the conformational and functional flexibility of plasminogen activator inhibitor-1 Nat Struct Biol (1995) 2, 891-897. PubMed Europe PubMed
Fa,M., Karolin,J., Aleshkov,S., Strandberg,L., Johansson,L.B. and Ny,T. Time-resolved polarized fluorescence spectroscopy studies of plasminogen activator inhibitor type 1: conformational changes of the reactive center upon interactions with target proteases, vitronectin and heparin Biochemistry (1995) 34, 13833-13840. PubMed Europe PubMed
Steven,F.S., Anees,M. and Booth,N.A. Selectivity of the plasminogen activator inhibitor (PAI-1) for the iso enzyme of guanidinobenzoatase on the surface of colonic carcinoma cells Anticancer Res (1995) 15, 205-210. PubMed Europe PubMed
Tucker,H.M., Mottonen,J., Goldsmith,E.J. and Gerard,R.D. Engineering of plasminogen activator inhibitor-1 to reduce the rate of latency transition Nat Struct Biol (1995) 2, 442-445. PubMed Europe PubMed

1994

Bjorquist,P., Brohlin,M., Ehnebom,J., Ericsson,M., Kristiansen,C., Pohl,G. and Deinum,J. Plasminogen activator inhibitor type-1 interacts exclusively with the proteinase domain of tissue plasminogen activator Biochim Biophys Acta (1994) 1209, 191-202. PubMed Europe PubMed

1993

Carmeliet,P., Stassen,J.M., Schoonjans,L., Ream,B., van den Oord,J.J., De Mol,M., Mulligan,R.C. and Collen,D. Plasminogen activator inhibitor-1 gene-deficient mice. II. Effects on hemostasis, thrombosis, and thrombolysis J Clin Invest (1993) 92, 2756-2760. PubMed Europe PubMed DOI PMC EPMC K
Carmeliet,P., Kieckens,L., Schoonjans,L., Ream,B., van Nuffelen,A., Prendergast,G., Cole,M., Bronson,R., Collen,D. and Mulligan,R.C. Plasminogen activator inhibitor-1 gene-deficient mice. I. Generation by homologous recombination and characterization J Clin Invest (1993) 92, 2746-2755. PubMed Europe PubMed DOI PMC EPMC K

1992

Mottonen,J., Strand,A., Symersky,J., Sweet,R.M., Danley,D.E., Geoghegan,K.F., Gerard,R.D. and Goldsmith,E.J. Structural basis of latency in plasminogen activator inhibitor-1 Nature (1992) 355, 270-273. PubMed Europe PubMed DOI S

1990

Andreasen,P.A., Georg,B., Lund,L.R., Riccio,A. and Stacey,S.N. Plasminogen activator inhibitors: hormonally regulated serpins Mol Cell Endocrinol (1990) 68, 1-19. PubMed Europe PubMed DOI

1977

[YEAR:15-8-1977]Wiman,B. and Collen,D. Purification and characterization of human antiplasmin, the fast-acting plasmin inhibitor in plasma Eur J Biochem (15-8-1977) 78, 19-26. PubMed Europe PubMed