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Literature for inhibitor I04.020: plasminogen activator inhibitor-1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Pharma

(Topics flags: S Structure, M Mutation, I Inhibitor, K Knockout, U Therapeutic, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Haynes,L.M., Holding,M.L., DiGiovanni,H.L., Siemieniak,D. and Ginsburg,D.
    High-throughput amino acid-level characterization of the interactions of plasminogen activator inhibitor-1 with variably divergent proteases
    Protein Sci34, e70088-e70088. PubMed  Europe PubMed DOI
    2. 2024
  2. Barrett,C.D., Moore,P.K., Moore,E.E., Moore,H.B., Chandler,J.G., Siddiqui,H., Maginot,E.R., Sauaia,A., Perez-Calatayud,A.A., Buesing,K., Wang,J., Davila-Chapa,C., Hershberger,D., Douglas,I., Pieracci,F.M. and Yaffe,M.B.
    Plasminogen Degradation by Neutrophil Elastase in Pleural Infection, Not High Plasminogen Activator Inhibitor-1 (PAI-1), is the Cause of Intrapleural Lytic Failure
    Chest PubMed  Europe PubMed DOI
  3. Gehlot,P., Brunnert,D., Kaushik,V., Yadav,A., Bage,S., Gaur,K., Saini,M., Ehrhardt,J., Manjunath,G.K., Kumar,A., Kasliwal,N., Sharma,A.K., Zygmunt,M. and Goyal,P.
    Unconventional localization of PAI-1 in PML bodies: A possible link with cellular growth of endothelial cells
    Biochem Biophys Rep39, 101793-101793. PubMed  Europe PubMed DOI
  4. Huang,Y.K., Cheng,W.C., Kuo,T.T., Yang,J.C., Wu,Y.C., Wu,H.H., Lo,C.C., Hsieh,C.Y., Wong,S.C., Lu,C.H., Wu,W.L., Liu,S.J., Li,Y.C., Lin,C.C., Shen,C.N., Hung,M.C., Lin,J.T., Yeh,C.C. and Sher,Y.P.
    Inhibition of ADAM9 promotes the selective degradation of KRAS and sensitizes pancreatic cancers to chemotherapy
    Nat Cancer5, 400-419. PubMed  Europe PubMed DOI
  5. Vrzalova,A. and Vrzal,R.
    Orchestra of ligand-activated transcription factors in the molecular symphony of SERPINE 1 / PAI-1 gene regulation
    Biochimie PubMed  Europe PubMed DOI  V
  6. Wang,X., Chen,L., Wen,B., Wang,L., Yang,F., Bao,J., Pan,X., Zhang,G., Ji,K. and Liu,H.
    Serpin family E member 1 enhances myometrium contractility by increasing ATP production during labor
    FASEB J38, e23368-e23368. PubMed  Europe PubMed DOI
    7. 2023
  7. Alfieri,M., Meo,L. and Ragno,P.
    Posttranscriptional Regulation of the Plasminogen Activation System by Non-Coding RNA in Cancer
    Int J Mol Sci24, PubMed  Europe PubMed DOI  V
  8. Chen,B.H., Lu,X.Q., Liang,X.H. and Wang,P.
    Serpin E1 mediates the induction of renal tubular degeneration and premature senescence upon diabetic insult
    Sci Rep13, 16210-16210. PubMed  Europe PubMed DOI
  9. Dai,W., Zhang,H., Lund,H., Zhang,Z., Castleberry,M., Rodriguez,M., Kuriakose,G., Gupta,S., Lewandowska,M., Powers,H.R., Valmiki,S., Zhu,J., Shapiro,A.D., Hussain,M.M., Lopez,J.A., Sorci-Thomas,M.G., Silverstein,R.L., Ginsberg,H.N., Sahoo,D., Tabas,I. and Zheng,Z.
    Intracellular tPA-PAI-1 interaction determines VLDL assembly in hepatocytes
    Science381, eadh5207-eadh5207. PubMed  Europe PubMed DOI
  10. Li,L., Li,F., Xu,Z., Li,L., Hu,H., Li,Y., Yu,S., Wang,M. and Gao,L.
    Identification and validation of SERPINE1 as a prognostic and immunological biomarker in pan-cancer and in ccRCC
    Front Pharmacol14, 1213891-1213891. PubMed  Europe PubMed DOI
  11. Mennesson,M. and Revest,J.M.
    Glucocorticoid-Responsive Tissue Plasminogen Activator (tPA) and Its Inhibitor Plasminogen Activator Inhibitor-1 (PAI-1): Relevance in Stress-Related Psychiatric Disorders
    Int J Mol Sci24, PubMed  Europe PubMed DOI  V
  12. Rana,T., Jiang,C., Banerjee,S., Yi,N., Zmijewski,J.W., Liu,G. and Liu,R.M.
    PAI-1 Regulation of p53 Expression and Senescence in Type II Alveolar Epithelial Cells
    Cells12, PubMed  Europe PubMed DOI
  13. Wang,B., Gu,B., Zhang,T., Li,X., Wang,N., Ma,C., Xiang,L., Wang,Y., Gao,L., Yu,Y., Song,K., He,P., Wang,Y., Zhu,J. and Chen,H.
    Good or bad: Paradox of plasminogen activator inhibitor 1 (PAI-1) in digestive system tumors
    Cancer Lett559, 216117-216117. PubMed  Europe PubMed DOI  V
    14. 2022
  14. Kihn,K., Marchiori,E., Spagnolli,G., Boldrini,A., Terruzzi,L., Lawrence,D.A., Gershenson,A., Faccioli,P. and Wintrode,P.L.
    Long-range allostery mediates the regulation of plasminogen activator inhibitor-1 by cell adhesion factor vitronectin
    J Biol Chem298, 102652-102652. PubMed  Europe PubMed DOI
  15. Kim,W.T., Mun,J.Y., Baek,S.W., Kim,M.H., Yang,G.E., Jeong,M.S., Choi,S.Y., Han,J.Y., Kim,M.H. and Leem,S.H.
    Secretory SERPINE1 Expression Is Increased by Antiplatelet Therapy, Inducing MMP1 Expression and Increasing Colon Cancer Metastasis
    Int J Mol Sci23, PubMed  Europe PubMed DOI
  16. Liu,R.J., Xu,Z.P., Li,S.Y., Yu,J.J., Feng,N.H., Xu,B. and Chen,M.
    BAP1-Related ceRNA (NEAT1/miR-10a-5p/SERPINE1) Promotes Proliferation and Migration of Kidney Cancer Cells
    Front Oncol12, 852515-852515. PubMed  Europe PubMed DOI  K
  17. Minemura,C., Asai,S., Koma,A., Kase-Kato,I., Tanaka,N., Kikkawa,N., Kasamatsu,A., Yokoe,H., Hanazawa,T., Uzawa,K. and Seki,N.
    Identification of Tumor-Suppressive miR-30e-3p Targets: Involvement of SERPINE1 in the Molecular Pathogenesis of Head and Neck Squamous Cell Carcinoma
    Int J Mol Sci23, PubMed  Europe PubMed DOI
  18. Xu,C., Liu,X., Shen,J., Sun,Q., Guo,X., Yang,M. and Leng,J.
    Integrative identification of human serpin PAI-1 inhibitors from Dracaena dragon blood and molecular implications for inhibitor-induced PAI-1 allosterism
    Biotechnol Appl Biochem69, 221-229. PubMed  Europe PubMed DOI
    19. 2021
  19. Chen,T.Y., Zhou,M., Lin,M.Q., Liang,S.T., Yan,Y., Wang,S.M., Fang,C.S., Li,D. and Ruan,Y.
    Research Progress on the SERPINE1 Protein and Chronic Inflammatory Diseases of the Upper Respiratory Tract: A Literature Review
    Int Arch Allergy Immunol1-6. PubMed  Europe PubMed DOI
  20. Ismail,A.A., Shaker,B.T. and Bajou,K.
    The Plasminogen-Activator Plasmin System in Physiological and Pathophysiological Angiogenesis
    Int J Mol Sci23, PubMed  Europe PubMed DOI
  21. Sillen,M. and Declerck,P.J.
    A Narrative Review on Plasminogen Activator Inhibitor-1 and Its (Patho)Physiological Role: To Target or Not to Target?
    Int J Mol Sci22, PubMed  Europe PubMed DOI  V
  22. Song,L.T., Tada,H., Nishioka,T., Nemoto,E., Imamura,T., Potempa,J., Li,C.Y., Matsushita,K. and Sugawara,S.
    Porphyromonas gingivalis Gingipains-Mediated Degradation of Plasminogen Activator Inhibitor-1 Leads to Delayed Wound Healing Responses in Human Endothelial Cells
    J Innate Immun1-14. PubMed  Europe PubMed DOI
  23. Tziastoudi,M., Dardiotis,E., Pissas,G., Filippidis,G., Golfinopoulos,S., Siokas,V., Tachmitzi,S.V., Eleftheriadis,T., Hadjigeorgiou,G.M., Tsironi,E. and Stefanidis,I.
    Serpin Family E Member 1 Tag Single-Nucleotide Polymorphisms in Patients with Diabetic Nephropathy: An Association Study and Meta-Analysis Using a Genetic Model-Free Approach
    Genes (Basel)12, PubMed  Europe PubMed DOI
    24. 2020
  24. Chu,Y., Bucci,J.C. and Peterson,C.B.
    Dissecting molecular details and functional effects of the high-affinity copper binding site in plasminogen activator Inhibitor-1
    Protein Sci PubMed  Europe PubMed DOI
  25. Nougier,C., Benoit,R., Simon,M., Desmurs-Clavel,H., Marcotte,G., Argaud,L., David,J.S., Bonnet,A., Negrier,C. and Dargaud,Y.
    Hypofibrinolytic state and high thrombin generation may play a major role in SARS-COV2 associated thrombosis
    J Thromb Haemost PubMed  Europe PubMed DOI
  26. Sanda,T., Yoshimura,M., Hyodo,K., Ishii,H. and Yamashita,T.
    Effects of Long-term Thrombin Inhibition (Dabigatran Etexilate) on Spontaneous Thrombolytic Activity during the Progression of Atherosclerosis in ApoE(-/-)-LDLR(-/-) Double-Knockout Mice
    Korean Circ J50, 804-816. PubMed  Europe PubMed DOI  I
  27. Yang,B., Zhang,D., Qian,J. and Cheng,Y.
    Chelerythrine suppresses proliferation and metastasis of human prostate cancer cells via modulating MMP/TIMP/NF-kappaB system
    Mol Cell Biochem474, 199-208. PubMed  Europe PubMed DOI
  28. Zhang,Q., Lei,L. and Jing,D.
    Knockdown of SERPINE1 reverses resistance of triplenegative breast cancer to paclitaxel via suppression of VEGFA
    Oncol Rep44, 1875-1884. PubMed  Europe PubMed DOI
    29. 2019
  29. Jendroszek,A., Madsen,J.B., Chana-Munoz,A., Dupont,D.M., Christensen,A., Panitz,F., Fuchtbauer,E.M., Lovell,S.C. and Jensen,J.K.
    Biochemical and structural analyses suggest that plasminogen activators coevolved with their cognate protein substrates and inhibitors
    J Biol Chem294, 3794-3805. PubMed  Europe PubMed DOI
  30. Kubala,M.H. and DeClerck,Y.A.
    The plasminogen activator inhibitor-1 paradox in cancer: a mechanistic understanding
    Cancer Metastasis Rev38, 483-492. PubMed  Europe PubMed DOI
  31. Peng,S., Xue,G., Chen,S., Chen,Z., Yuan,C., Li,J. and Huang,M.
    tPA Point mutation at autolysis loop enhances resistance to PAI-1 inhibition and catalytic activity
    Thromb Haemost119, 77-86. PubMed  Europe PubMed DOI
  32. Reinke,A.A., Li,S.H., Warnock,M., Shaydakov,M.E., Guntaka,N.S., Su,E.J., Diaz,J.A., Emal,C.D. and Lawrence,D.A.
    Dual-reporter high-throughput screen for small-molecule in vivo inhibitors of plasminogen activator inhibitor type-1 yields a clinical lead candidate
    J Biol Chem294, 1464-1477. PubMed  Europe PubMed DOI
    33. 2017
  33. Iwaki,T., Nagahashi,K., Takano,K., Suzuki-Inoue,K., Kanayama,N., Umemura,K. and Urano,T.
    Mutation in a highly conserved glycine residue in strand 5B of plasminogen activator inhibitor 1 causes polymerisation
    Thromb Haemost117, 860-869. PubMed  Europe PubMed DOI  M
  34. Jendroszek,A., Sonnichsen,M.S., Munoz,A.C., Leyman,K., Christensen,A., Petersen,S.V., Wang,T., Bendixen,C., Panitz,F., Andreasen,P.A. and Jensen,J.K.
    Latency transition of plasminogen activator inhibitor type 1 is evolutionarily conserved
    Thromb Haemost117, PubMed  Europe PubMed DOI
  35. Peng,S., Xue,G., Gong,L., Fang,C., Chen,J., Yuan,C., Chen,Z., Yao,L., Furie,B. and Huang,M.
    A long-acting PAI-1 inhibitor reduces thrombus formation
    Thromb Haemost117, 1338-1347. PubMed  Europe PubMed DOI
    36. 2016
  36. Denorme,F., Wyseure,T., Peeters,M., Vandeputte,N., Gils,A., Deckmyn,H., Vanhoorelbeke,K., Declerck,P.J. and De Meyer,S.F.
    Inhibition of thrombin-activatable fibrinolysis inhibitor and plasminogen activator inhibitor-1 reduces ischemic brain damage in mice
    Stroke47, 2419-2422. PubMed  Europe PubMed DOI
  37. Gettins,P.G. and Dolmer,K.
    The high affinity binding site on plasminogen activator inhibitor-1 (PAI-1) for the low density lipoprotein receptor-related protein (LRP1) is composed of four basic residues
    J Biol Chem291, 800-812. PubMed  Europe PubMed DOI
  38. Gong,L., Liu,M., Zeng,T., Shi,X., Yuan,C., Andreasen,P.A. and Huang,M.
    Structural basis of specific inhibition of tissue-type plasminogen activator by plasminogen activators inhibitor-1
    Data Brief6, 550-555. PubMed  Europe PubMed DOI
  39. Gong,L., Proulle,V., Fang,C., Hong,Z., Lin,Z., Liu,M., Xue,G., Yuan,C., Lin,L., Furie,B., Flaumenhaft,R., Andreasen,P., Furie,B. and Huang,M.
    A specific plasminogen activator inhibitor-1 antagonist derived from inactivated urokinase
    J Cell Mol Med20, 1851-1860. PubMed  Europe PubMed DOI
  40. Ji,Y., Weng,Z., Fish,P., Goyal,N., Luo,M., Myears,S.P., Strawn,T.L., Chandrasekar,B., Wu,J. and Fay,W.P.
    Pharmacological targeting of plasminogen activator inhibitor-1 decreases vascular smooth muscle cell migration and neointima formation
    Arterioscler Thromb Vasc Biol36, 2167-2175. PubMed  Europe PubMed DOI
  41. Qureshi,T. and Peterson,C.B.
    Single fluorescence probes along the reactive center loop reveal site-specific changes during the latency transition of PAI-1
    Protein Sci25, 487-498. PubMed  Europe PubMed DOI
    42. 2015
  42. Dittmann,M., Hoffmann,H.H., Scull,M.A., Gilmore,R.H., Bell,K.L., Ciancanelli,M., Wilson,S.J., Crotta,S., Yu,Y., Flatley,B., Xiao,J.W., Casanova,J.L., Wack,A., Bieniasz,P.D. and Rice,C.M.
    A serpin shapes the extracellular environment to prevent influenza A virus maturation
    Cell160, 631-643. PubMed  Europe PubMed DOI
  43. Gong,L., Liu,M., Zeng,T., Shi,X., Yuan,C., Andreasen,P.A. and Huang,M.
    Crystal structure of the Michaelis complex between tissue-type plasminogen activator and plasminogen activators inhibitor-1
    J Biol Chem290, 25795-25804. PubMed  Europe PubMed DOI  S
  44. Horvath,C.M.
    A serpin takes a bite out of the flu
    Cell Host Microbe17, 283-284. PubMed  Europe PubMed DOI
    45. 2014
  45. Trelle,M.B., Madsen,J.B., Andreasen,P.A. and Jorgensen,T.J.
    Local transient unfolding of native state PAI-1 associated with serpin metastability
    Angew Chem Int Ed Engl53, 9751-9754. PubMed  Europe PubMed DOI
    46. 2013
  46. Declerck,P.J. and Gils,A.
    Three Decades of Research on Plasminogen Activator Inhibitor-1: A Multifaceted Serpin
    Semin Thromb Hemost39, 356-364. PubMed  Europe PubMed DOI  V
  47. Fortenberry,Y.M.
    Plasminogen activator inhibitor-1 inhibitors: a patent review (2006 - present)
    Expert Opin Ther Pat23, 801-815. PubMed  Europe PubMed DOI  V
  48. Li,S.H., Reinke,A.A., Sanders,K.L., Emal,C.D., Whisstock,J.C., Stuckey,J.A. and Lawrence,D.A.
    Mechanistic characterization and crystal structure of a small molecule inactivator bound to plasminogen activator inhibitor-1
    Proc Natl Acad Sci U S A110, E4941-E4949. PubMed  Europe PubMed DOI
    49. 2011
  49. Bernot,D., Stalin,J., Stocker,P., Bonardo,B., Scroyen,I., Alessi,M.C. and Peiretti,F.
    Plasminogen activator inhibitor 1 is an intracellular inhibitor of furin proprotein convertase
    J Cell Sci124, 1224-1230. PubMed  Europe PubMed DOI
  50. Li,S.H. and Lawrence,D.A.
    Development of inhibitors of plasminogen activator inhibitor-1
    Methods Enzymol501, 177-207. PubMed  Europe PubMed DOI  V
  51. Lin,Z., Jiang,L., Yuan,C., Jensen,J.K., Zhang,X., Luo,Z., Furie,B.C., Furie,B., Andreasen,P.A. and Huang,M.
    Structural basis for recognition of urokinase-type plasminogen activator by plasminogen activator inhibitor-1
    J Biol Chem286, 7027-7032. PubMed  Europe PubMed DOI
  52. Lobov,S. and Ranson,M.
    Molecular competition between plasminogen activator inhibitors type -1 and -2 for urokinase: implications for cellular proteolysis and adhesion in cancer
    Cancer Lett303, 118-127. PubMed  Europe PubMed DOI
  53. Thompson,L.C., Goswami,S. and Peterson,C.B.
    Metals affect the structure and activity of human plasminogen activator inhibitor-1. II. Binding affinity and conformational changes
    Protein Sci20, 366-378. PubMed  Europe PubMed DOI
    54. 2010
  54. Dewilde,M., Van De Craen,B., Compernolle,G., Madsen,J.B., Strelkov,S., Gils,A. and Declerck,P.J.
    Subtle structural differences between human and mouse PAI-1 reveal the basis for biochemical differences
    J Struct Biol171, 95-101. PubMed  Europe PubMed DOI  S
  55. Hu,H., Zhao,Y., Xiao,Y., Zhang,R. and Song,H.
    Disruption of plasminogen activator inhibitor-1 gene enhances spontaneous enlargement of mouse airspace with increasing age
    Tohoku J Exp Med222, 291-296. PubMed  Europe PubMed DOI  K
  56. Ju,H., Lim,B., Kim,M., Noh,S.M., Kim,W.H., Ihm,C., Choi,B.Y., Kim,Y.S. and Kang,C.
    SERPINE1 intron polymorphisms affecting gene expression are associated with diffuse-type gastric cancer susceptibility
    Cancer116, 4248-4255. PubMed  Europe PubMed DOI  M
  57. Madsen,J.B., Dupont,D.M., Andersen,T.B., Nielsen,A.F., Sang,L., Brix,D.M., Jensen,J.K., Broos,T., Hendrickx,M.L., Christensen,A., Kjems,J. and Andreasen,P.A.
    RNA Aptamers as conformational probes and regulatory agents for plasminogen activator inhibitor-1
    Biochemistry49, 4103-4115. PubMed  Europe PubMed DOI
  58. Park,J., Seo,J.Y. and Ha,H.
    Plasminogen activator inhibitor-1 antisense oligodeoxynucleotides abrogate mesangial fibronectin accumulation
    Korean J Physiol Pharmacol14, 385-390. PubMed  Europe PubMed DOI  K
    59. 2009
  59. Dewilde,M., Strelkov,S.V., Rabijns,A. and Declerck,P.J.
    High quality structure of cleaved PAI-1-stab
    J Struct Biol165, 126-132. PubMed  Europe PubMed DOI  S
  60. Dupont,D.M., Madsen,J.B., Kristensen,T., Bodker,J.S., Blouse,G.E., Wind,T. and Andreasen,P.A.
    Biochemical properties of plasminogen activator inhibitor-1
    Front Biosci14, 1337-1361. PubMed  Europe PubMed  V
  61. Huang,Y., Border,W.A., Lawrence,D.A. and Noble,N.A.
    Mechanisms underlying the antifibrotic properties of noninhibitory PAI-1 (PAI-1R) in experimental nephritis
    Am J Physiol Renal Physiol297, F1045-F1054. PubMed  Europe PubMed DOI
  62. Tanaka,A., Suzuki,Y., Sugihara,K., Kanayama,N. and Urano,T.
    Inactivation of plasminogen activator inhibitor type 1 by activated factor XII plays a role in the enhancement of fibrinolysis by contact factors in-vitro
    Life Sci85, 220-225. PubMed  Europe PubMed DOI
    63. 2008
  63. Bajou,K., Peng,H., Laug,W.E., Maillard,C., Noel,A., Foidart,J.M., Martial,J.A. and DeClerck,Y.A.
    Plasminogen activator inhibitor-1 protects endothelial cells from FasL-mediated apoptosis
    Cancer Cell14, 324-334. PubMed  Europe PubMed DOI
  64. Izuhara,Y., Takahashi,S., Nangaku,M., Takizawa,S., Ishida,H., Kurokawa,K., van Ypersele de Strihou,C., Hirayama,N. and Miyata,T.
    Inhibition of plasminogen activator inhibitor-1: its mechanism and effectiveness on coagulation and fibrosis
    Arterioscler Thromb Vasc Biol28, 672-677. PubMed  Europe PubMed DOI
  65. Jensen,J.K. and Gettins,P.G.
    High-resolution structure of the stable plasminogen activator inhibitor type-1 variant 14-1B in its proteinase-cleaved form: a new tool for detailed interaction studies and modeling
    Protein Sci17, 1844-1849. PubMed  Europe PubMed DOI  S
  66. Komissarov,A.A., Andreasen,P.A., Declerck,P.J., Kamikubo,Y., Zhou,A. and Gruber,A.
    Redirection of the reaction between activated protein C and a serpin to the substrate pathway
    Thromb Res122, 397-404. PubMed  Europe PubMed DOI
  67. Li,S.H., Gorlatova,N.V., Lawrence,D.A. and Schwartz,B.S.
    Structural differences between active forms of plasminogen activator inhibitor type 1 revealed by conformationally sensitive ligands
    J Biol Chem283, 18147-18157. PubMed  Europe PubMed DOI
    68. 2007
  68. Cale,J.M. and Lawrence,D.A.
    Structure-function relationships of plasminogen activator inhibitor-1 and its potential as a therapeutic agent
    Curr Drug Targets8, 971-981. PubMed  Europe PubMed DOI  V  U
  69. Eren,M., Gleaves,L.A., Atkinson,J.B., King,L.E., Declerck,P.J. and Vaughan,D.E.
    Reactive site-dependent phenotypic alterations in plasminogen activator inhibitor-1 transgenic mice
    J Thromb Haemost5, 1500-1508. PubMed  Europe PubMed DOI
  70. Wygrecka,M., Morty,R.E., Markart,P., Kanse,S.M., Andreasen,P.A., Wind,T., Guenther,A. and Preissner,K.T.
    Plasminogen activator inhibitor-1 is an inhibitor of factor VII-activating protease in patients with acute respiratory distress syndrome
    J Biol Chem282, 21671-21682. PubMed  Europe PubMed DOI
  71. Yi,J.Y. and Im,H.
    Structural factors affecting the choice between latency transition and polymerization in inhibitory serpins
    Protein Sci16, 833-841. PubMed  Europe PubMed DOI
    72. 2006
  72. [YEAR:3-10-2006]Dupont,D.M., Blouse,G.E., Hansen,M., Mathiasen,L., Kjelgaard,S., Jensen,J.K., Christensen,A., Gils,A., Declerck,P.J., Andreasen,P.A. and Wind,T.
    Evidence for a pre-latent form of the serpin plasminogen activator inhibitor-1 with a detached beta-strand 1C
    J Biol Chem281, 36071-36081. PubMed  Europe PubMed DOI
  73. Griffiths,S.L. and Grainger,D.J.
    Proposal of a novel diabetogenic mechanism involving the serpin PAI-1
    Bioessays28, 629-641. PubMed  Europe PubMed DOI
    74. 2005
  74. Boudier,C., Gils,A., Declerck,P.J. and Bieth,J.G.
    The conversion of active to latent plasminogen activator inhibitor-1 is an energetically silent event
    Biophys J88, 2848-2854. PubMed  Europe PubMed DOI
  75. Dellas,C. and Loskutoff,D.J.
    Historical analysis of PAI-1 from its discovery to its potential role in cell motility and disease
    Thromb Haemost93, 631-640. PubMed  Europe PubMed DOI  V
  76. [YEAR:15-11-2005]Hermans,P.W. and Hazelzet,J.A.
    Plasminogen activator inhibitor type 1 gene polymorphism and sepsis
    Clin Infect Dis41 Suppl 7, S453-S458. PubMed  Europe PubMed DOI
  77. [YEAR:14-1-2005]Komissarov,A.A., Andreasen,P.A., Bodker,J.S., Declerck,P.J., Anagli,J.Y. and Shore,J.D.
    Additivity in effects of vitronectin and monoclonal antibodies against alpha-helix F of plasminogen activator inhibitor-1 on its reactions with target proteinases
    J Biol Chem280, 1482-1489. PubMed  Europe PubMed DOI
  78. Na,Y.R. and Im,H.
    The length of the reactive center loop modulates the latency transition of plasminogen activator inhibitor-1
    Protein Sci14, 55-63. PubMed  Europe PubMed DOI
    79. 2004
  79. [YEAR:17-2-2004]Abbott,G.L., Blouse,G.E., Perron,M.J., Shore,J.D., Luck,L.A. and Szabo,A.G.
    19F NMR studies of plasminogen activator inhibitor-1
    Biochemistry43, 1507-1519. PubMed  Europe PubMed DOI
  80. [YEAR:15-12-2004]Brogren,H., Karlsson,L., Andersson,M., Wang,L., Erlinge,D. and Jern,S.
    Platelets synthesize large amounts of active plasminogen activator inhibitor 1
    Blood104, 3943-3948. PubMed  Europe PubMed DOI
  81. Cho,S.H., Ryu,C.H. and Oh,C.K.
    Plasminogen activator inhibitor-1 in the pathogenesis of asthma
    Exp Biol Med (Maywood)229, 138-146. PubMed  Europe PubMed
  82. Crandall,D.L., Elokdah,H., Di,L., Hennan,J.K., Gorlatova,N.V. and Lawrence,D.A.
    Characterization and comparative evaluation of a structurally unique PAI-1 inhibitor exhibiting oral in-vivo efficacy
    J Thromb Haemost2, 1422-1428. PubMed  Europe PubMed DOI
  83. Cullen,J.P., Nicholl,S.M., Sayeed,S., Sitzmann,J.V., Okada,S.S., Cahill,P.A. and Redmond,E.M.
    Plasminogen activator inhibitor-1 deficiency enhances flow-induced smooth muscle cell migration
    Thromb Res114, 57-65. PubMed  Europe PubMed DOI  I
  84. Czekay,R.P. and Loskutoff,D.J.
    Unexpected role of plasminogen activator inhibitor 1 in cell adhesion and detachment
    Exp Biol Med (Maywood)229, 1090-1096. PubMed  Europe PubMed
  85. [YEAR:7-5-2004]De Taeye,B., Compernolle,G. and Declerck,P.J.
    Site-directed targeting of plasminogen activator inhibitor-1 as an example for a novel approach in rational drug design
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