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Literature for inhibitor I04.005: protein Z-dependent peptidase inhibitor

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Inhibits

(Topics flags: S Structure, M Mutation, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Suganthi,C., Akshayaa,P., Sengupta,T. and Manoj,N.
    Unveiling the Evolutionary History and Functional Significance of the Protein Z-Dependent Protease Inhibitor (ZPI) Across Vertebrates
    J Mol Evol (2025) PubMed  Europe PubMed DOI
    2. 2022
  2. Huang,X., Swanson,R. and Olson,S.T.
    Heparin activation of protein Z-dependent protease inhibitor (ZPI) allosterically blocks protein Z activation through an extended heparin-binding site
    J Biol Chem (2022) 298, 102022-102022. PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2020
  3. Aymonnier,K., Kawecki,C., Arocas,V., Boulaftali,Y. and Bouton,M.C.
    Serpins, New Therapeutic Targets for Hemophilia
    Thromb Haemost (2020) PubMed  Europe PubMed DOI  V
    4. 2019
  4. Girard,T.J., Lasky,N.M., Grunz,K. and Broze GJ Jr
    Suppressing protein Z-dependent inhibition of factor Xa improves coagulation in hemophilia A
    J Thromb Haemost (2019) 17, 149-156. PubMed  Europe PubMed DOI
  5. Huang,X., Swanson,R., Kroh,H.K. and Bock,P.E.
    Protein Z-dependent protease inhibitor (ZPI) is a physiologically significant inhibitor of prothrombinase function
    J Biol Chem (2019) 294, 7644-7657. PubMed  Europe PubMed DOI
  6. Huang,X.
    Engineering a protein Z-dependent protease inhibitor (ZPI) mutant as a novel antagonist of ZPI anticoagulant function for hemophilia treatment
    J Thromb Haemost (2019) 17, 1655-1660. PubMed  Europe PubMed DOI
    7. 2017
  7. Karakoyun,S., Ozan Gursoy,M., Kalcik,M., Yesin,M., Gunduz,S., Ali Astarcioglu,M., Bayram,Z., Cakal,B., Bayam,E. and Ozkan,M.
    The role of protein Z and protein Z-dependent protease inhibitor polymorphisms in the development of prosthetic heart valve thrombosis
    J Heart Valve Dis (2017) 26, 460-466. PubMed  Europe PubMed  M
    8. 2015
  8. Huang,X., Zhou,J., Zhou,A. and Olson,S.T.
    Thermodynamic and kinetic characterization of the protein Z-dependent protease inhibitor (ZPI)-protein Z interaction reveals an unexpected role for ZPI Lys-239
    J Biol Chem (2015) 290, 9906-9918. PubMed  Europe PubMed DOI
  9. Yadav,D.D., De,T., Nagaraja,D. and Christopher,R.
    Protein Z G79A polymorphism and puerperal cerebral venous thrombosis
    Clin Appl Thromb Hemost (2015) 21, 768-771. PubMed  Europe PubMed DOI  M
    10. 2014
  10. Qureshi,S.H., Lu,Q., Manithody,C., Yang,L. and Rezaie,A.R.
    Characterization of the protein Z-dependent protease inhibitor interactive-sites of protein Z
    Biochim Biophys Acta (2014) 1844, 1631-1637. PubMed  Europe PubMed DOI
    11. 2012
  11. Huang,X., Yan,Y., Tu,Y., Gatti,J., Broze,G.J., Jr., Zhou,A. and Olson,S.T.
    Structural basis for catalytic activation of protein Z-dependent protease inhibitor (ZPI) by protein Z
    Blood (2012) 120, 1726-1733. PubMed  Europe PubMed DOI
  12. Karimi,Z., Falsafi-Zade,S. and Galehdari,H.
    The role of Ca(2+) ions in the complex assembling of protein Z and Z-dependent protease inhibitor: a structure and dynamics investigation
    Bioinformation (2012) 8, 407-411. PubMed  Europe PubMed DOI  PMC  EPMC
  13. Yang,L., Ding,Q., Huang,X., Olson,S.T. and Rezaie,A.R.
    Characterization of the heparin-binding site of the protein Z-dependent protease inhibitor
    Biochemistry (2012) 51, 4078-4085. PubMed  Europe PubMed DOI
  14. Young,L.K., Birch,N.P., Browett,P.J., Coughlin,P.B., Horvath,A.J., Van de Water,N.S., Ockelford,P.A. and Harper,P.L.
    Two missense mutations identified in venous thrombosis patients impair the inhibitory function of the protein Z dependent protease inhibitor
    Thromb Haemost (2012) 107, 854-863. PubMed  Europe PubMed DOI  M
    15. 2011
  15. Huang,X., Rezaie,A.R., Broze,G.J., Jr. and Olson,S.T.
    Heparin is a major activator of the anticoagulant serpin, protein Z-dependent protease inhibitor
    J Biol Chem (2011) 286, 8740-8751. PubMed  Europe PubMed DOI
  16. Vasse,M.
    The protein Z/protein Z-dependent protease inhibitor complex. Systemic or local control of coagulation?
    Hamostaseologie (2011) 31, 155-164. PubMed  Europe PubMed DOI
    17. 2010
  17. Gacka,M.A., Maecki,R. and Adamiec,R.
    Participation of protein Z-dependent protease inhibitor and protein Z system in the pathomechanism of thrombotic complications
    Int J Angiol (2010) 19, e120-e125. PubMed  Europe PubMed DOI
  18. Huang,X., Dementiev,A., Olson,S.T. and Gettins,P.G.
    Basis for the specificity and activation of the serpin protein Z-dependent proteinase inhibitor (ZPI) as an inhibitor of membrane-associated factor Xa
    J Biol Chem (2010) 285, 20399-20409. PubMed  Europe PubMed DOI
    19. 2009
  19. Chandrasekaran,V., Lee,C.J., Lin,P., Duke,R.E. and Pedersen,L.G.
    A computational modeling and molecular dynamics study of the Michaelis complex of human protein Z-dependent protease inhibitor (ZPI) and factor Xa (FXa)
    J Mol Model (2009) 15, 897-911. PubMed  Europe PubMed DOI  PMC  EPMC
  20. Wei,Z., Yan,Y., Carrell,R.W. and Zhou,A.
    Crystal structure of protein Z-dependent inhibitor complex shows how protein Z functions as a cofactor in the membrane inhibition of factor X
    Blood (2009) 114, 3662-3667. PubMed  Europe PubMed DOI  S
    21. 2008
  21. Huang,X., Swanson,R., Broze,G.J., Jr. and Olson,S.T.
    Kinetic characterization of the protein Z-dependent protease inhibitor reaction with blood coagulation factor Xa
    J Biol Chem (2008) 283, 29770-29783. PubMed  Europe PubMed DOI  PMC  EPMC
  22. Ndonwi,M., Lu,L., Tu,Y., Phillips,M. and Broze,G., Jr.
    Functional analysis of protein Z (Arg255His) and protein Z-dependent protease inhibitor (Lys25Arg and Ser40Gly) polymorphisms
    Br J Haematol (2008) 143, 298-300. PubMed  Europe PubMed DOI  M
  23. Rezaie,A.R., Bae,J.S., Manithody,C., Qureshi,S.H. and Yang,L.
    Protein Z-dependent protease inhibitor binds to the C-terminal domain of protein Z
    J Biol Chem (2008) 283, 19922-19926. PubMed  Europe PubMed DOI  PMC  EPMC
  24. Zhang,J., Tu,Y., Lu,L., Lasky,N. and Broze,G.J., Jr.
    Protein Z-dependent protease inhibitor deficiency produces a more severe murine phenotype than protein Z deficiency
    Blood (2008) 111, 4973-4978. PubMed  Europe PubMed DOI  PMC  EPMC  K
    25. 2007
  25. Burggraf,S., Dorhofer,B. and Olgemoller,B.
    Hybridization probe genotyping of the R67X nonsense polymorphism in the protein Z-dependent protease inhibitor reveals a new R67Q mutation
    Clin Chem (2007) 53, 1385-1387. PubMed  Europe PubMed DOI  M
  26. Corral,J., Gonzalez-Conejero,R., Hernandez-Espinosa,D. and Vicente,V.
    Protein Z/Z-dependent protease inhibitor (PZ/ZPI) anticoagulant system and thrombosis
    Br J Haematol (2007) 137, 99-108. PubMed  Europe PubMed DOI  K
  27. Fabbro,D., Barillari,G. and Damante,G.
    Mutations R67X and W303X of the protein Z-dependent protease inhibitor gene and venous thromboembolic disease: a case-control study in Italian subjects
    J Thromb Thrombolysis (2007) 23, 77-78. PubMed  Europe PubMed DOI  M
    28. 2006
  28. [YEAR:9-3-2006]Corral,J., Gonzalez-Conejero,R., Soria,J.M., Gonzalez-Porras,J.R., Perez-Ceballos,E., Lecumberri,R., Roldan,V., Souto,J.C., Minano,A., Hernandez-Espinosa,D., Alberca,I., Fontcuberta,J. and Vicente,V.
    A nonsense polymorphism in the protein Z-dependent protease inhibitor increases the risk for venous thrombosis
    Blood (9-3-2006) 108, 177-183. PubMed  Europe PubMed DOI  PMC  EPMC
  29. Razzari,C., Martinelli,I., Bucciarelli,P., Viscardi,Y. and Biguzzi,E.
    Polymorphisms of the protein Z-dependent protease inhibitor (ZPI) gene and the risk of venous thromboembolism
    Thromb Haemost (2006) 95, 909-910. PubMed  Europe PubMed DOI  M
    30. 2005
  30. Al-Shanqeeti,A., van Hylckama Vlieg,A., Berntorp,E., Rosendaal,F.R. and Broze,G.J., Jr.
    Protein Z and protein Z-dependent protease inhibitor. Determinants of levels and risk of venous thrombosis
    Thromb Haemost (2005) 93, 411-413. PubMed  Europe PubMed DOI
  31. [YEAR:10-8-2005]Heeb,M.J., Cabral,K.M. and Ruan,L.
    Down-regulation of factor IXa in the factor Xase complex by protein Z-dependent protease inhibitor
    J Biol Chem (10-8-2005) 280, 33819-33825. PubMed  Europe PubMed DOI
  32. [YEAR:3-8-2005]Rezaie,A.R., Manithody,C. and Yang,L.
    Identification of factor Xa residues critical for interaction with protein Z-dependent protease inhibitor: both active site and exosite interactions are required for inhibition
    J Biol Chem (3-8-2005) 280, 32722-32728. PubMed  Europe PubMed DOI  PMC  EPMC
    33. 2004
  33. Sofi,F., Cesari,F., Fedi,S., Abbate,R. and Gensini,G.F.
    Protein Z: "light and shade" of a new thrombotic factor
    Clin Lab (2004) 50, 647-652. PubMed  Europe PubMed
  34. Van de Water,N., Tan,T., Ashton,F., O'Grady,A., Day,T., Browett,P., Ockelford,P. and Harper,P.
    Mutations within the protein Z-dependent protease inhibitor gene are associated with venous thromboembolic disease: a new form of thrombophilia
    Br J Haematol (2004) 127, 190-194. PubMed  Europe PubMed DOI  M
    35. 2001
  35. Tabatabai,A., Fiehler,R. and Broze,G.J., Jr.
    Protein Z circulates in plasma in a complex with protein Z-dependent protease inhibitor
    Thromb Haemost (2001) 85, 655-660. PubMed  Europe PubMed
  36. Zhang,J. and Broze,G.J., Jr.
    Mouse protein Z-dependent protease inhibitor cDNA
    Thromb Haemost (2001) 85, 861-865. PubMed  Europe PubMed
    37. 2000
  37. [YEAR:1-11-2000]Han,X., Fiehler,R. and Broze,G.J., Jr.
    Characterization of the protein Z-dependent protease inhibitor
    Blood (1-11-2000) 96, 3049-3055. PubMed  Europe PubMed
    38. 1999
  38. [YEAR:24-8-1999]Han,X., Huang,Z.F., Fiehler,R. and Broze,G.J., Jr.
    The protein Z-dependent protease inhibitor is a serpin
    Biochemistry (24-8-1999) 38, 11073-11078. PubMed  Europe PubMed DOI

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