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Literature for inhibitor I04.005: protein Z-dependent peptidase inhibitor

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature

(Topics flags: S Structure, M Mutation, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Suganthi,C., Akshayaa,P., Sengupta,T. and Manoj,N.<br>Unveiling the Evolutionary History and Functional Significance of the Protein Z-Dependent Protease Inhibitor (ZPI) Across Vertebrates<br>J Mol Evol (2025) PubMed  Europe PubMed DOI
    2. 2022
  2. Huang,X., Swanson,R. and Olson,S.T.<br>Heparin activation of protein Z-dependent protease inhibitor (ZPI) allosterically blocks protein Z activation through an extended heparin-binding site<br>J Biol Chem (2022) 298, 102022-102022. PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2020
  3. Aymonnier,K., Kawecki,C., Arocas,V., Boulaftali,Y. and Bouton,M.C.<br>Serpins, New Therapeutic Targets for Hemophilia<br>Thromb Haemost (2020) PubMed  Europe PubMed DOI  V
    4. 2019
  4. Girard,T.J., Lasky,N.M., Grunz,K. and Broze GJ Jr<br>Suppressing protein Z-dependent inhibition of factor Xa improves coagulation in hemophilia A<br>J Thromb Haemost (2019) 17, 149-156. PubMed  Europe PubMed DOI
  5. Huang,X., Swanson,R., Kroh,H.K. and Bock,P.E.<br>Protein Z-dependent protease inhibitor (ZPI) is a physiologically significant inhibitor of prothrombinase function<br>J Biol Chem (2019) 294, 7644-7657. PubMed  Europe PubMed DOI
  6. Huang,X.<br>Engineering a protein Z-dependent protease inhibitor (ZPI) mutant as a novel antagonist of ZPI anticoagulant function for hemophilia treatment<br>J Thromb Haemost (2019) 17, 1655-1660. PubMed  Europe PubMed DOI
    7. 2017
  7. Karakoyun,S., Ozan Gursoy,M., Kalcik,M., Yesin,M., Gunduz,S., Ali Astarcioglu,M., Bayram,Z., Cakal,B., Bayam,E. and Ozkan,M.<br>The role of protein Z and protein Z-dependent protease inhibitor polymorphisms in the development of prosthetic heart valve thrombosis<br>J Heart Valve Dis (2017) 26, 460-466. PubMed  Europe PubMed  M
    8. 2015
  8. Huang,X., Zhou,J., Zhou,A. and Olson,S.T.<br>Thermodynamic and kinetic characterization of the protein Z-dependent protease inhibitor (ZPI)-protein Z interaction reveals an unexpected role for ZPI Lys-239<br>J Biol Chem (2015) 290, 9906-9918. PubMed  Europe PubMed DOI
  9. Yadav,D.D., De,T., Nagaraja,D. and Christopher,R.<br>Protein Z G79A polymorphism and puerperal cerebral venous thrombosis<br>Clin Appl Thromb Hemost (2015) 21, 768-771. PubMed  Europe PubMed DOI  M
    10. 2014
  10. Qureshi,S.H., Lu,Q., Manithody,C., Yang,L. and Rezaie,A.R.<br>Characterization of the protein Z-dependent protease inhibitor interactive-sites of protein Z<br>Biochim Biophys Acta (2014) 1844, 1631-1637. PubMed  Europe PubMed DOI
    11. 2012
  11. Huang,X., Yan,Y., Tu,Y., Gatti,J., Broze,G.J., Jr., Zhou,A. and Olson,S.T.<br>Structural basis for catalytic activation of protein Z-dependent protease inhibitor (ZPI) by protein Z<br>Blood (2012) 120, 1726-1733. PubMed  Europe PubMed DOI
  12. Karimi,Z., Falsafi-Zade,S. and Galehdari,H.<br>The role of Ca(2+) ions in the complex assembling of protein Z and Z-dependent protease inhibitor: a structure and dynamics investigation<br>Bioinformation (2012) 8, 407-411. PubMed  Europe PubMed DOI  PMC  EPMC
  13. Yang,L., Ding,Q., Huang,X., Olson,S.T. and Rezaie,A.R.<br>Characterization of the heparin-binding site of the protein Z-dependent protease inhibitor<br>Biochemistry (2012) 51, 4078-4085. PubMed  Europe PubMed DOI
  14. Young,L.K., Birch,N.P., Browett,P.J., Coughlin,P.B., Horvath,A.J., Van de Water,N.S., Ockelford,P.A. and Harper,P.L.<br>Two missense mutations identified in venous thrombosis patients impair the inhibitory function of the protein Z dependent protease inhibitor<br>Thromb Haemost (2012) 107, 854-863. PubMed  Europe PubMed DOI  M
    15. 2011
  15. Huang,X., Rezaie,A.R., Broze,G.J., Jr. and Olson,S.T.<br>Heparin is a major activator of the anticoagulant serpin, protein Z-dependent protease inhibitor<br>J Biol Chem (2011) 286, 8740-8751. PubMed  Europe PubMed DOI
  16. Vasse,M.<br>The protein Z/protein Z-dependent protease inhibitor complex. Systemic or local control of coagulation?<br>Hamostaseologie (2011) 31, 155-164. PubMed  Europe PubMed DOI
    17. 2010
  17. Gacka,M.A., Maecki,R. and Adamiec,R.<br>Participation of protein Z-dependent protease inhibitor and protein Z system in the pathomechanism of thrombotic complications<br>Int J Angiol (2010) 19, e120-e125. PubMed  Europe PubMed DOI
  18. Huang,X., Dementiev,A., Olson,S.T. and Gettins,P.G.<br>Basis for the specificity and activation of the serpin protein Z-dependent proteinase inhibitor (ZPI) as an inhibitor of membrane-associated factor Xa<br>J Biol Chem (2010) 285, 20399-20409. PubMed  Europe PubMed DOI
    19. 2009
  19. Chandrasekaran,V., Lee,C.J., Lin,P., Duke,R.E. and Pedersen,L.G.<br>A computational modeling and molecular dynamics study of the Michaelis complex of human protein Z-dependent protease inhibitor (ZPI) and factor Xa (FXa)<br>J Mol Model (2009) 15, 897-911. PubMed  Europe PubMed DOI  PMC  EPMC
  20. Wei,Z., Yan,Y., Carrell,R.W. and Zhou,A.<br>Crystal structure of protein Z-dependent inhibitor complex shows how protein Z functions as a cofactor in the membrane inhibition of factor X<br>Blood (2009) 114, 3662-3667. PubMed  Europe PubMed DOI  S
    21. 2008
  21. Huang,X., Swanson,R., Broze,G.J., Jr. and Olson,S.T.<br>Kinetic characterization of the protein Z-dependent protease inhibitor reaction with blood coagulation factor Xa<br>J Biol Chem (2008) 283, 29770-29783. PubMed  Europe PubMed DOI  PMC  EPMC
  22. Ndonwi,M., Lu,L., Tu,Y., Phillips,M. and Broze,G., Jr.<br>Functional analysis of protein Z (Arg255His) and protein Z-dependent protease inhibitor (Lys25Arg and Ser40Gly) polymorphisms<br>Br J Haematol (2008) 143, 298-300. PubMed  Europe PubMed DOI  M
  23. Rezaie,A.R., Bae,J.S., Manithody,C., Qureshi,S.H. and Yang,L.<br>Protein Z-dependent protease inhibitor binds to the C-terminal domain of protein Z<br>J Biol Chem (2008) 283, 19922-19926. PubMed  Europe PubMed DOI  PMC  EPMC
  24. Zhang,J., Tu,Y., Lu,L., Lasky,N. and Broze,G.J., Jr.<br>Protein Z-dependent protease inhibitor deficiency produces a more severe murine phenotype than protein Z deficiency<br>Blood (2008) 111, 4973-4978. PubMed  Europe PubMed DOI  PMC  EPMC  K
    25. 2007
  25. Burggraf,S., Dorhofer,B. and Olgemoller,B.<br>Hybridization probe genotyping of the R67X nonsense polymorphism in the protein Z-dependent protease inhibitor reveals a new R67Q mutation<br>Clin Chem (2007) 53, 1385-1387. PubMed  Europe PubMed DOI  M
  26. Corral,J., Gonzalez-Conejero,R., Hernandez-Espinosa,D. and Vicente,V.<br>Protein Z/Z-dependent protease inhibitor (PZ/ZPI) anticoagulant system and thrombosis<br>Br J Haematol (2007) 137, 99-108. PubMed  Europe PubMed DOI  K
  27. Fabbro,D., Barillari,G. and Damante,G.<br>Mutations R67X and W303X of the protein Z-dependent protease inhibitor gene and venous thromboembolic disease: a case-control study in Italian subjects<br>J Thromb Thrombolysis (2007) 23, 77-78. PubMed  Europe PubMed DOI  M
    28. 2006
  28. [YEAR:9-3-2006]Corral,J., Gonzalez-Conejero,R., Soria,J.M., Gonzalez-Porras,J.R., Perez-Ceballos,E., Lecumberri,R., Roldan,V., Souto,J.C., Minano,A., Hernandez-Espinosa,D., Alberca,I., Fontcuberta,J. and Vicente,V.<br>A nonsense polymorphism in the protein Z-dependent protease inhibitor increases the risk for venous thrombosis<br>Blood (9-3-2006) 108, 177-183. PubMed  Europe PubMed DOI  PMC  EPMC
  29. Razzari,C., Martinelli,I., Bucciarelli,P., Viscardi,Y. and Biguzzi,E.<br>Polymorphisms of the protein Z-dependent protease inhibitor (ZPI) gene and the risk of venous thromboembolism<br>Thromb Haemost (2006) 95, 909-910. PubMed  Europe PubMed DOI  M
    30. 2005
  30. Al-Shanqeeti,A., van Hylckama Vlieg,A., Berntorp,E., Rosendaal,F.R. and Broze,G.J., Jr.<br>Protein Z and protein Z-dependent protease inhibitor. Determinants of levels and risk of venous thrombosis<br>Thromb Haemost (2005) 93, 411-413. PubMed  Europe PubMed DOI
  31. [YEAR:10-8-2005]Heeb,M.J., Cabral,K.M. and Ruan,L.<br>Down-regulation of factor IXa in the factor Xase complex by protein Z-dependent protease inhibitor<br>J Biol Chem (10-8-2005) 280, 33819-33825. PubMed  Europe PubMed DOI
  32. [YEAR:3-8-2005]Rezaie,A.R., Manithody,C. and Yang,L.<br>Identification of factor Xa residues critical for interaction with protein Z-dependent protease inhibitor: both active site and exosite interactions are required for inhibition<br>J Biol Chem (3-8-2005) 280, 32722-32728. PubMed  Europe PubMed DOI  PMC  EPMC
    33. 2004
  33. Sofi,F., Cesari,F., Fedi,S., Abbate,R. and Gensini,G.F.<br>Protein Z: "light and shade" of a new thrombotic factor<br>Clin Lab (2004) 50, 647-652. PubMed  Europe PubMed
  34. Van de Water,N., Tan,T., Ashton,F., O'Grady,A., Day,T., Browett,P., Ockelford,P. and Harper,P.<br>Mutations within the protein Z-dependent protease inhibitor gene are associated with venous thromboembolic disease: a new form of thrombophilia<br>Br J Haematol (2004) 127, 190-194. PubMed  Europe PubMed DOI  M
    35. 2001
  35. Tabatabai,A., Fiehler,R. and Broze,G.J., Jr.<br>Protein Z circulates in plasma in a complex with protein Z-dependent protease inhibitor<br>Thromb Haemost (2001) 85, 655-660. PubMed  Europe PubMed
  36. Zhang,J. and Broze,G.J., Jr.<br>Mouse protein Z-dependent protease inhibitor cDNA<br>Thromb Haemost (2001) 85, 861-865. PubMed  Europe PubMed
    37. 2000
  37. [YEAR:1-11-2000]Han,X., Fiehler,R. and Broze,G.J., Jr.<br>Characterization of the protein Z-dependent protease inhibitor<br>Blood (1-11-2000) 96, 3049-3055. PubMed  Europe PubMed
    38. 1999
  38. [YEAR:24-8-1999]Han,X., Huang,Z.F., Fiehler,R. and Broze,G.J., Jr.<br>The protein Z-dependent protease inhibitor is a serpin<br>Biochemistry (24-8-1999) 38, 11073-11078. PubMed  Europe PubMed DOI

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