Literature for family I1 unassigned peptidases

(Topics flags: S Structure, E Expression. To select only the references relevant to a single topic, click the link above. See explanation.)

2026
1. Zingkou,E., Bisyris,E., Pampalakis,G. and Sotiropoulou,G.
   Dysregulated proteolytic cascades in Netherton syndrome: from molecular pathology to preclinical drug testing
   J Pathol (2026) PubMed  Europe PubMed DOI
2025
2. Kordaczuk,J., Sulek,M., Mak,P., Pawlikowska-Pawlega,B. and Wojda,I.
   Serine protease inhibitor dipetalogastin-like from Galleria mellonella is involved in insect immunity
   Sci Rep (2025) 15, 24094-24094. PubMed  Europe PubMed DOI  PMC  EPMC
3. Lian,X., Liu,B., Li,D., Wang,X., Long,C., Feng,X., Liao,Q. and Rong,M.
   An Elastase Inhibitor ShSPI from Centipede Attenuates Bleomycin-Induced Pulmonary Fibrosis
   Toxins (Basel) (2025) 17 PubMed  Europe PubMed DOI  PMC  EPMC
4. Zhao,X., Qiao,X., Gu,X., Zeng,Y., Wang,Y., Chen,M., Wang,L. and Song,L.
   A Kazal-type serine protease inhibitor enhances antimicrobial peptide expression in the immune priming of Chinese mitten crab Eriocheir sinensis
   Fish Shellfish Immunol (2025) 165, 110562-110562. PubMed  Europe PubMed DOI
2024
5. Petrova,E., Lopez-Gay,J.M., Fahrner,M., Leturcq,F., de Villartay,J.P., Barbieux,C., Gonschorek,P., Tsoi,L.C., Gudjonsson,J.E., Schilling,O. and Hovnanian,A.
   Comparative analyses of Netherton syndrome patients and Spink5 conditional knock-out mice uncover disease-relevant pathways
   Commun Biol (2024) 7, 152-152. PubMed  Europe PubMed DOI  PMC  EPMC
6. Shao,S., Liu,K., Du,J., Yin,C., Wang,M. and Wang,Y.
   Functional characterization of serine proteinase inhibitor Kazal-Type in the red claw crayfish Cherax quadricarinatus
   Fish Shellfish Immunol (2024) 148, 109525-109525. PubMed  Europe PubMed DOI
2023
7. Chen,Y.R., Yang,H.J., Cha,J.M., Zhang,X.X. and Fan,D.
   Expression patterns and antifungal function study of KaSPI in Mythimna separata
   Bull Entomol Res (2023) , 1-11. PubMed  Europe PubMed DOI
2022
8. Wang,H., Xu,L., Dou,Y. and Wang,J.
   Bombyx batryticatus Cocoonase Inhibitor Separation, Purification, and Inhibitory Effect on the Proliferation of SMCC-7721 HeLa-Derived Cells
   Evid Based Complement Alternat Med (2022) 2022, 4064829-4064829. PubMed  Europe PubMed DOI  PMC  EPMC
9. Wang,N.A., Xie,F., Liu,Y.A., Jiang,X., Wei,G., Zhu,B., Wang,L. and Qian,C.
   A Kazal-type serine protease inhibitor mediates innate immunity in wild silkworm Actias selene Hubner
   J Biosci (2022) 47 PubMed  Europe PubMed
2021
10. Leinweber,J., Mizurini,D.M., Francischetti,I.M.B., Fleischer,M., Hermann,D.M., Kleinschnitz,C. and Langhauser,F.
    Elastase inhibitor agaphelin protects from acute ischemic stroke in mice by reducing thrombosis, blood-brain barrier damage, and inflammation
    Brain Behav Immun (2021) PubMed  Europe PubMed DOI
2020
11. Yang,L., Qiu,L.M., Fang,Q. and Ye,G.Y.
    A venom protein, Kazal-type serine protease inhibitor, of ectoparasitoid Pachycrepoideus vindemiae inhibits the hemolymph melanization of host Drosophila melanogaster
    Arch Insect Biochem Physiol (2020) 105, e21736-e21736. PubMed  Europe PubMed DOI
2019
12. Cabrera-Munoz,A., Valiente,P.A., Rojas,L., Alonso-Del-Rivero Antigua,M. and Pires,J.R.
    NMR structure of CmPI-II, a non-classical Kazal protease inhibitor: understanding its conformational dynamics and subtilisin A inhibition
    J Struct Biol (2019) 206, 280-294. PubMed  Europe PubMed DOI  S
13. Cheng,R.M., Tang,X.P., Long,A.L., Mwangi,J., Lai,R., Sun,R.P., Long,C.B. and Zhang,Z.Q.
    Purification and characterization of a novel anti-coagulant from the leech Hirudinaria manillensis
    Zool Res (2019) 40, 205-210. PubMed  Europe PubMed DOI
14. Faiz,Z.M., Mardhiyyah,M.P., Mohamad,A., Hidir,A., Nurul-Hidayah,A., Wong,L., Jasmani,S. and Ikhwanuddin,M.
    Identification and relative abundances of mRNA for a gene encoding the vWD domain and three Kazal-type domains in the ovary of giant freshwater prawns, Macrobrachium rosenbergii
    Anim Reprod Sci (2019) 209, 106143-106143. PubMed  Europe PubMed DOI
15. Luan,N., Zhao,Q., Duan,Z., Ji,M., Xing,M., Zhu,T., Mwangi,J., Rong,M., Liu,J. and Lai,R.
    Identification and characterization of ShSPI, a Kazal-type elastase inhibitor from the venom of Scolopendra hainanum
    Toxins (Basel) (2019) 11 PubMed  Europe PubMed DOI
16. Xu,J., Yu,P., Wu,L., Liu,M. and Lu,Y.
    Regulatory effect of two Trichinella spiralis serine protease inhibitors on the host's immune system
    Sci Rep (2019) 9, 17045-17045. PubMed  Europe PubMed DOI  PMC  EPMC
2018
17. Boonrawd,S., Supungul,P., Tassanakajon,A. and Rimphanitchayakit,V.
    Antimicrobial activity of a serine proteinase inhibitor SPIPm5 from the black tiger shrimp Penaeus monodon
    Fish Shellfish Immunol (2018) 77, 147-155. PubMed  Europe PubMed DOI
18. Kwon,H., Yang,H., Lee,S., Nilojan,J., Bathige,S.D.N.K., Nam,B.H., Wan,Q. and Lee,J.
    Characterization of a Kazal-type serine protease inhibitor from black rockfish Sebastes schlegelii and its possible role in hepatic immune response
    Fish Shellfish Immunol (2018) 74, 485-490. PubMed  Europe PubMed DOI
19. Zhou,Y., Liu,G., Cheng,X., Wang,Q., Wang,B., Wang,B., Zhang,H., He,Q. and Zhang,L.
    Antimicrobial activity of a newly identified Kazal-type serine proteinase inhibitor, CcKPI1, from the jellyfish Cyanea capillata
    Int J Biol Macromol (2018) 107, 1945-1955. PubMed  Europe PubMed DOI
2017
20. Ekchaweng,K., Evangelisti,E., Schornack,S., Tian,M. and Churngchow,N.
    The plant defense and pathogen counterdefense mediated by Hevea brasiliensis serine protease HbSPA and Phytophthora palmivora extracellular protease inhibitor PpEPI10
    PLoS ONE (2017) 12, e0175795-e0175795. PubMed  Europe PubMed DOI  PMC  EPMC
21. Proano-Bolanos,C., Li,R., Zhou,M., Wang,L., Xi,X., Tapia,E.E., Coloma,L.A., Chen,T. and Shaw,C.
    Novel Kazal-type proteinase inhibitors from the skin secretion of the Splendid leaf frog, Cruziohyla calcarifer
    EuPA Open Proteomics (2017) 15, 1-13. DOI
2016
22. Cabrera-Munoz,A., Rojas,L., Gil,D.F., Gonzalez-Gonzalez,Y., Mansur,M., Camejo,A., Pires,J.R. and Alonso-Del-Rivero Antigua,M.
    Heterologous expression of Cenchritis muricatus protease inhibitor II (CmPI-II) in Pichia pastoris system: purification, isotopic labeling and preliminary characterization
    Protein Expr Purif (2016) 126, 127-136. PubMed  Europe PubMed DOI  E
23. Pariani,S., Contreras,M., Rossi,F.R., Sander,V., Corigliano,M.G., Simon,F., Busi,M.V., Gomez-Casati,D.F., Pieckenstain,F.L., Duschak,V.G. and Clemente,M.
    Characterization of a novel Kazal-type serine proteinase inhibitor of Arabidopsis thaliana
    Biochimie (2016) 123, 85-94. PubMed  Europe PubMed DOI
2015
24. Negulescu,H., Guo,Y., Garner,T.P., Goodwin,O.Y., Henderson,G., Laine,R.A. and Macnaughtan,M.A.
    A Kazal-type serine protease inhibitor from the defense gland secretion of the subterranean termite Coptotermes formosanus Shiraki
    PLoS ONE (2015) 10, e0125376- PubMed  Europe PubMed DOI  PMC  EPMC  S
25. Qian,C., Fang,Q., Wang,L. and Ye,G.Y.
    Molecular cloning and functional studies of two Kazal-type serine protease inhibitors specifically expressed by Nasonia vitripennis venom apparatus
    Toxins (Basel) (2015) 7, 2888-2905. PubMed  Europe PubMed DOI
26. Soares,T.S., Buarque,D.S., Queiroz,B.R., Gomes,C.M., Braz,G.R., Araujo,R.N., Pereira,M.H., Guarneri,A.A. and Tanaka,A.S.
    A Kazal-type inhibitor is modulated by Trypanosoma cruzi to control microbiota inside the anterior midgut of Rhodnius prolixus
    Biochimie (2015) 112, 41-48. PubMed  Europe PubMed DOI
2014
27. Kopera,E., Bal,W., Lenarcic Zivkovic,M., Dvornyk,A., Kludkiewicz,B., Grzelak,K., Zhukov,I., Zagorski-Ostoja,W., Jaskolski,M. and Krzywda,S.
    Atomic resolution structure of a protein prepared by non-enzymatic His-tag removal. Crystallographic and NMR study of GmSPI-2 inhibitor
    PLoS ONE (2014) 9, e106936-e106936. PubMed  Europe PubMed DOI  PMC  EPMC  S
28. Slowinska,M., Liszewska,E., Nynca,J., Bukowska,J., Hejmej,A., Bilinska,B., Szubstarski,J., Kozlowski,K., Jankowski,J. and Ciereszko,A.
    Isolation and characterization of an ovoinhibitor, a multidomain Kazal-like inhibitor from turkey (Meleagris gallopavo) seminal plasma
    Biol Reprod (2014) 91, 108-108. PubMed  Europe PubMed DOI
29. Waisberg,M., Molina-Cruz,A., Mizurini,D.M., Gera,N., Sousa,B.C., Ma,D., Leal,A.C., Gomes,T., Kotsyfakis,M., Ribeiro,J.M., Lukszo,J., Reiter,K., Porcella,S.F., Oliveira,C.J., Monteiro,R.Q., Barillas-Mury,C., Pierce,S.K. and Francischetti,I.M.
    Plasmodium falciparum infection induces expression of a mosquito salivary protein (agaphelin) that targets neutrophil function and inhibits thrombosis without impairing hemostasis
    PLoS Pathog (2014) 10, e1004338-e1004338. PubMed  Europe PubMed DOI  PMC  EPMC
30. Zhang,D., Ma,J. and Jiang,S.
    Molecular characterization, expression and function analysis of a five-domain Kazal-type serine proteinase inhibitor from pearl oyster Pinctada fucata
    Fish Shellfish Immunol (2014) 37, 115-121. PubMed  Europe PubMed DOI
2013
31. Kodrik,D., Kludkiewicz,B., Navratil,O., Skokova Habustova,O., Horackova,V., Svobodova,Z., Vinokurov,K.S. and Sehnal,F.
    Protease inhibitor from insect silk - activities of derivatives expressed in vitro and in transgenic potato
    Appl Biochem Biotechnol (2013) 171, 209-224. PubMed  Europe PubMed DOI
32. Maldonado-Aguayo,W., Nunez-Acuna,G., Valenzuela-Munoz,V., Chavez-Mardones,J. and Gallardo-Escarate,C.
    Molecular characterization of two Kazal-type serine proteinase inhibitor genes in the surf clam Mesodesma donacium exposed to Vibrio anguillarum
    Fish Shellfish Immunol (2013) 34, 1448-1454. PubMed  Europe PubMed DOI
33. Wickramaarachchi,W.D., De Zoysa,M., Whang,I., Wan,Q. and Lee,J.
    Kazal-type proteinase inhibitor from disk abalone (Haliotis discus discus): molecular characterization and transcriptional response upon immune stimulation
    Fish Shellfish Immunol (2013) 35, 1039-1043. PubMed  Europe PubMed DOI
2012
34. Li,R., Wang,H., Jiang,Y., Yu,Y., Wang,L., Zhou,M., Zhang,Y., Chen,T. and Shaw,C.
    A novel Kazal-type trypsin inhibitor from the skin secretion of the Central American red-eyed leaf frog, Agalychnis callidryas
    Biochimie (2012) 94, 1376-1381. PubMed  Europe PubMed DOI
35. Qian,Y.Q., Li,Y., Yang,F., Yu,Y.Q., Yang,J.S. and Yang,W.J.
    Two Kazal-type protease inhibitors from Macrobrachium nipponense and Eriocheir sinensis: comparative analysis of structure and activities
    Fish Shellfish Immunol (2012) 32, 446-458. PubMed  Europe PubMed DOI
2011
36. Reiss,K., Meyer-Hoffert,U., Fischer,J., Sperrhacke,M., Wu,Z., Dimitrieva,O., Krenek,P., Suchanova,S., Buryova,H., Brauer,R. and Sedlacek,R.
    Expression and regulation of murine SPINK12, a potential orthologue of human LEKTI2
    Exp Dermatol (2011) 20, 905-910. PubMed  Europe PubMed DOI
37. Shenoy,R.T., Thangamani,S., Velazquez-Campoy,A., Ho,B., Ding,J.L. and Sivaraman,J.
    Structural basis for dual-inhibition mechanism of a non-classical Kazal-type serine protease inhibitor from horseshoe crab in complex with subtilisin
    PLoS ONE (2011) 6, e18838-e18838. PubMed  Europe PubMed DOI  PMC  EPMC
38. van Hoef,V., Breugelmans,B., Spit,J., Simonet,G., Zels,S., Billen,J. and Vanden Broeck,J.
    Functional analysis of a pancreatic secretory trypsin inhibitor-like protein in insects: silencing effects resemble the human pancreatic autodigestion phenotype
    Insect Biochem Mol Biol (2011) 41, 688-695. PubMed  Europe PubMed DOI
39. Zeng,Y. and Wang,W.
    Molecular cloning and tissue-specific expression of a five-Kazal domain serine proteinase inhibitor from crayfish Procambarus clarkii hemocytes
    Aquaculture (2011) 321, 8-12. DOI
2010
40. Cerenius,L., Liu,H., Zhang,Y., Rimphanitchayakit,V., Tassanakajon,A., Gunnar Andersson,M., Soderhall,K. and Soderhall,I.
    High sequence variability among hemocyte-specific Kazal-type proteinase inhibitors in decapod crustaceans
    Dev Comp Immunol (2010) 34, 69-75. PubMed  Europe PubMed DOI
41. Donpudsa,S., Soderhall,I., Rimphanitchayakit,V., Cerenius,L., Tassanakajon,A. and Soderhall,K.
    Proteinase inhibitory activities of two two-domain Kazal proteinase inhibitors from the freshwater crayfish Pacifastacus leniusculus and the importance of the P(2) position in proteinase inhibitory activity
    Fish Shellfish Immunol (2010) 29, 716-723. PubMed  Europe PubMed DOI
42. Gonzalez-Gonzalez,Y., Gil,D., Alonso-del-Rivero,M., Besada,V., Gil,J., Araujo,M.S., Tanaka,A.S., Pons,T. and Chavez,M.D.L.A.
    Novel protease inhibitors active against human neutrophil elastase and plasma kallikrein with therapeutic potentialities: structure-function relationships
    Biotecnol Apl (2010) 27, 310-313.
43. Li,X.C., Zhang,R.R., Sun,R.R., Lan,J.F., Zhao,X.F. and Wang,J.X.
    Three Kazal-type serine proteinase inhibitors from the red swamp crayfish Procambarus clarkii and the characterization, function analysis of hcPcSPI2
    Fish Shellfish Immunol (2010) 28, 942-951. PubMed  Europe PubMed DOI
44. Meiser,C.K., Piechura,H., Werner,T., Dittmeyer-Schafer,S., Meyer,H.E., Warscheid,B., Schaub,G.A. and Balczun,C.
    Kazal-type inhibitors in the stomach of Panstrongylus megistus (Triatominae, Reduviidae)
    Insect Biochem Mol Biol (2010) 40, 345-353. PubMed  Europe PubMed DOI
2009
45. Augustin,R., Siebert,S. and Bosch,T.C.
    Identification of a Kazal-type serine protease inhibitor with potent anti-staphylococcal activity as part of Hydra's innate immune system
    Dev Comp Immunol (2009) 33, 830-837. PubMed  Europe PubMed DOI
46. Kong,H.J., Cho,H.K., Park,E.M., Hong,G.E., Kim,Y.O., Nam,B.H., Kim,W.J., Lee,S.J., Han,H.S., Jang,I.K., Lee,C.H., Cheong,J. and Choi,T.J.
    Molecular cloning of Kazal-type proteinase inhibitor of the shrimp Fenneropenaeus chinensis
    Fish Shellfish Immunol (2009) 26, 109-114. PubMed  Europe PubMed DOI
47. Li,X.C., Wang,X.W., Wang,Z.H., Zhao,X.F. and Wang,J.X.
    A three-domain Kazal-type serine proteinase inhibitor exhibiting domain inhibitory and bacteriostatic activities from freshwater crayfish Procambarus clarkii
    Dev Comp Immunol (2009) 33, 1229-1238. PubMed  Europe PubMed DOI
48. Tulsidas,S.R., Thangamani,S., Ho,B., Sivaraman,J. and Ding,J.L.
    Crystallization of a nonclassical Kazal-type Carcinoscorpius rotundicauda serine protease inhibitor, CrSPI-1, complexed with subtilisin
    Acta Crystallograph Sect F Struct Biol Cryst Commun (2009) 65, 533-535. PubMed  Europe PubMed DOI  PMC  EPMC
2007
49. Araujo,R.N., Campos,I.T., Tanaka,A.S., Santos,A., Gontijo,N.F., Lehane,M.J. and Pereira,M.H.
    Brasiliensin: a novel intestinal thrombin inhibitor from Triatoma brasiliensis (Hemiptera: Reduviidae) with an important role in blood intake
    Int J Parasitol (2007) 37, 1351-1358. PubMed  Europe PubMed DOI  PMC  EPMC
50. Gonzalez,Y., Tanaka,A.S., Hirata,I.Y., del Rivero,M.A., Oliva,M.L., Araujo,M.S. and Chavez,M.A.
    Purification and partial characterization of human neutrophil elastase inhibitors from the marine snail Cenchritis muricatus (Mollusca)
    Comp Biochem Physiol A Mol Integr Physiol (2007) 146, 506-513. PubMed  Europe PubMed DOI
2006
51. [YEAR:14-8-2006]Jalkanen,J., Kotimaki,M., Huhtaniemi,I. and Poutanen,M.
    Novel epididymal protease inhibitors with Kazal or WAP family domain
    Biochem Biophys Res Commun (14-8-2006) 349, 245-254. PubMed  Europe PubMed DOI
52. [YEAR:6-7-2006]Zhu,L., Song,L., Chang,Y., Xu,W. and Wu,L.
    Molecular cloning, characterization and expression of a novel serine proteinase inhibitor gene in bay scallops (Argopecten irradians, Lamarck 1819)
    Fish Shellfish Immunol (6-7-2006) 20, 320-331. PubMed  Europe PubMed DOI
2005
53. Jimenez-Vega,F. and Vargas-Albores,F.
    A four-Kazal domain protein in Litopenaeus vannamei hemocytes
    Dev Comp Immunol (2005) 29, 385-391. PubMed  Europe PubMed DOI
54. [YEAR:8-8-2005]Kludkiewicz,B., Kodrik,D., Grzelak,K., Nirmala,X. and Sehnal,F.
    Structurally unique recombinant Kazal-type proteinase inhibitor retains activity when terminally extended and glycosylated
    Protein Expr Purif (8-8-2005) 43, 94-102. PubMed  Europe PubMed DOI
2001
55. Nirmala,X., Kodrik,D., Zurovec,M. and Sehnal,F.
    Insect silk contains both a Kunitz-type and a unique Kazal-type proteinase inhibitor
    Eur J Biochem (2001) 268, 2064-2073. PubMed  Europe PubMed DOI
56. Nirmala,X., Mita,K., Vanisree,V., Zurovec,M. and Sehnal,F.
    Identification of four small molecular mass proteins in the silk of Bombyx mori
    Insect Mol Biol (2001) 10, 437-445. PubMed  Europe PubMed DOI
1999
57. Odum,L., Bundgaard,J.R. and Johnsen,A.H.
    A Kazal-type trypsin inhibitor from the protochordate Ciona intestinalis
    Eur J Biochem (1999) 259, 872-876. PubMed  Europe PubMed DOI