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Literature for family I1 unassigned peptidases

Summary Sequences Sequence features Distribution Structure Literature Pharma

(Topics flags: S Structure, E Expression. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Zingkou,E., Bisyris,E., Pampalakis,G. and Sotiropoulou,G.<br>Dysregulated proteolytic cascades in Netherton syndrome: from molecular pathology to preclinical drug testing<br>J Pathol (2026) PubMed  Europe PubMed DOI
    2. 2025
  2. Kordaczuk,J., Sulek,M., Mak,P., Pawlikowska-Pawlega,B. and Wojda,I.<br>Serine protease inhibitor dipetalogastin-like from Galleria mellonella is involved in insect immunity<br>Sci Rep (2025) 15, 24094-24094. PubMed  Europe PubMed DOI  PMC  EPMC
  3. Lian,X., Liu,B., Li,D., Wang,X., Long,C., Feng,X., Liao,Q. and Rong,M.<br>An Elastase Inhibitor ShSPI from Centipede Attenuates Bleomycin-Induced Pulmonary Fibrosis<br>Toxins (Basel) (2025) 17 PubMed  Europe PubMed DOI  PMC  EPMC
  4. Zhao,X., Qiao,X., Gu,X., Zeng,Y., Wang,Y., Chen,M., Wang,L. and Song,L.<br>A Kazal-type serine protease inhibitor enhances antimicrobial peptide expression in the immune priming of Chinese mitten crab Eriocheir sinensis<br>Fish Shellfish Immunol (2025) 165, 110562-110562. PubMed  Europe PubMed DOI
    5. 2024
  5. Petrova,E., Lopez-Gay,J.M., Fahrner,M., Leturcq,F., de Villartay,J.P., Barbieux,C., Gonschorek,P., Tsoi,L.C., Gudjonsson,J.E., Schilling,O. and Hovnanian,A.<br>Comparative analyses of Netherton syndrome patients and Spink5 conditional knock-out mice uncover disease-relevant pathways<br>Commun Biol (2024) 7, 152-152. PubMed  Europe PubMed DOI  PMC  EPMC
  6. Shao,S., Liu,K., Du,J., Yin,C., Wang,M. and Wang,Y.<br>Functional characterization of serine proteinase inhibitor Kazal-Type in the red claw crayfish Cherax quadricarinatus<br>Fish Shellfish Immunol (2024) 148, 109525-109525. PubMed  Europe PubMed DOI
    7. 2023
  7. Chen,Y.R., Yang,H.J., Cha,J.M., Zhang,X.X. and Fan,D.<br>Expression patterns and antifungal function study of KaSPI in Mythimna separata<br>Bull Entomol Res (2023) , 1-11. PubMed  Europe PubMed DOI
    8. 2022
  8. Wang,H., Xu,L., Dou,Y. and Wang,J.<br>Bombyx batryticatus Cocoonase Inhibitor Separation, Purification, and Inhibitory Effect on the Proliferation of SMCC-7721 HeLa-Derived Cells<br>Evid Based Complement Alternat Med (2022) 2022, 4064829-4064829. PubMed  Europe PubMed DOI  PMC  EPMC
  9. Wang,N.A., Xie,F., Liu,Y.A., Jiang,X., Wei,G., Zhu,B., Wang,L. and Qian,C.<br>A Kazal-type serine protease inhibitor mediates innate immunity in wild silkworm Actias selene Hubner<br>J Biosci (2022) 47 PubMed  Europe PubMed
    10. 2021
  10. Leinweber,J., Mizurini,D.M., Francischetti,I.M.B., Fleischer,M., Hermann,D.M., Kleinschnitz,C. and Langhauser,F.<br>Elastase inhibitor agaphelin protects from acute ischemic stroke in mice by reducing thrombosis, blood-brain barrier damage, and inflammation<br>Brain Behav Immun (2021) PubMed  Europe PubMed DOI
    11. 2020
  11. Yang,L., Qiu,L.M., Fang,Q. and Ye,G.Y.<br>A venom protein, Kazal-type serine protease inhibitor, of ectoparasitoid Pachycrepoideus vindemiae inhibits the hemolymph melanization of host Drosophila melanogaster<br>Arch Insect Biochem Physiol (2020) 105, e21736-e21736. PubMed  Europe PubMed DOI
    12. 2019
  12. Cabrera-Munoz,A., Valiente,P.A., Rojas,L., Alonso-Del-Rivero Antigua,M. and Pires,J.R.<br>NMR structure of CmPI-II, a non-classical Kazal protease inhibitor: understanding its conformational dynamics and subtilisin A inhibition<br>J Struct Biol (2019) 206, 280-294. PubMed  Europe PubMed DOI  S
  13. Cheng,R.M., Tang,X.P., Long,A.L., Mwangi,J., Lai,R., Sun,R.P., Long,C.B. and Zhang,Z.Q.<br>Purification and characterization of a novel anti-coagulant from the leech Hirudinaria manillensis<br>Zool Res (2019) 40, 205-210. PubMed  Europe PubMed DOI
  14. Faiz,Z.M., Mardhiyyah,M.P., Mohamad,A., Hidir,A., Nurul-Hidayah,A., Wong,L., Jasmani,S. and Ikhwanuddin,M.<br>Identification and relative abundances of mRNA for a gene encoding the vWD domain and three Kazal-type domains in the ovary of giant freshwater prawns, Macrobrachium rosenbergii<br>Anim Reprod Sci (2019) 209, 106143-106143. PubMed  Europe PubMed DOI
  15. Luan,N., Zhao,Q., Duan,Z., Ji,M., Xing,M., Zhu,T., Mwangi,J., Rong,M., Liu,J. and Lai,R.<br>Identification and characterization of ShSPI, a Kazal-type elastase inhibitor from the venom of Scolopendra hainanum<br>Toxins (Basel) (2019) 11 PubMed  Europe PubMed DOI
  16. Xu,J., Yu,P., Wu,L., Liu,M. and Lu,Y.<br>Regulatory effect of two Trichinella spiralis serine protease inhibitors on the host's immune system<br>Sci Rep (2019) 9, 17045-17045. PubMed  Europe PubMed DOI  PMC  EPMC
    17. 2018
  17. Boonrawd,S., Supungul,P., Tassanakajon,A. and Rimphanitchayakit,V.<br>Antimicrobial activity of a serine proteinase inhibitor SPIPm5 from the black tiger shrimp Penaeus monodon<br>Fish Shellfish Immunol (2018) 77, 147-155. PubMed  Europe PubMed DOI
  18. Kwon,H., Yang,H., Lee,S., Nilojan,J., Bathige,S.D.N.K., Nam,B.H., Wan,Q. and Lee,J.<br>Characterization of a Kazal-type serine protease inhibitor from black rockfish Sebastes schlegelii and its possible role in hepatic immune response<br>Fish Shellfish Immunol (2018) 74, 485-490. PubMed  Europe PubMed DOI
  19. Zhou,Y., Liu,G., Cheng,X., Wang,Q., Wang,B., Wang,B., Zhang,H., He,Q. and Zhang,L.<br>Antimicrobial activity of a newly identified Kazal-type serine proteinase inhibitor, CcKPI1, from the jellyfish Cyanea capillata<br>Int J Biol Macromol (2018) 107, 1945-1955. PubMed  Europe PubMed DOI
    20. 2017
  20. Ekchaweng,K., Evangelisti,E., Schornack,S., Tian,M. and Churngchow,N.<br>The plant defense and pathogen counterdefense mediated by Hevea brasiliensis serine protease HbSPA and Phytophthora palmivora extracellular protease inhibitor PpEPI10<br>PLoS ONE (2017) 12, e0175795-e0175795. PubMed  Europe PubMed DOI  PMC  EPMC
  21. Proano-Bolanos,C., Li,R., Zhou,M., Wang,L., Xi,X., Tapia,E.E., Coloma,L.A., Chen,T. and Shaw,C.<br>Novel Kazal-type proteinase inhibitors from the skin secretion of the Splendid leaf frog, Cruziohyla calcarifer<br>EuPA Open Proteomics (2017) 15, 1-13. DOI
    22. 2016
  22. Cabrera-Munoz,A., Rojas,L., Gil,D.F., Gonzalez-Gonzalez,Y., Mansur,M., Camejo,A., Pires,J.R. and Alonso-Del-Rivero Antigua,M.<br>Heterologous expression of Cenchritis muricatus protease inhibitor II (CmPI-II) in Pichia pastoris system: purification, isotopic labeling and preliminary characterization<br>Protein Expr Purif (2016) 126, 127-136. PubMed  Europe PubMed DOI  E
  23. Pariani,S., Contreras,M., Rossi,F.R., Sander,V., Corigliano,M.G., Simon,F., Busi,M.V., Gomez-Casati,D.F., Pieckenstain,F.L., Duschak,V.G. and Clemente,M.<br>Characterization of a novel Kazal-type serine proteinase inhibitor of Arabidopsis thaliana<br>Biochimie (2016) 123, 85-94. PubMed  Europe PubMed DOI
    24. 2015
  24. Negulescu,H., Guo,Y., Garner,T.P., Goodwin,O.Y., Henderson,G., Laine,R.A. and Macnaughtan,M.A.<br>A Kazal-type serine protease inhibitor from the defense gland secretion of the subterranean termite Coptotermes formosanus Shiraki<br>PLoS ONE (2015) 10, e0125376- PubMed  Europe PubMed DOI  PMC  EPMC  S
  25. Qian,C., Fang,Q., Wang,L. and Ye,G.Y.<br>Molecular cloning and functional studies of two Kazal-type serine protease inhibitors specifically expressed by Nasonia vitripennis venom apparatus<br>Toxins (Basel) (2015) 7, 2888-2905. PubMed  Europe PubMed DOI
  26. Soares,T.S., Buarque,D.S., Queiroz,B.R., Gomes,C.M., Braz,G.R., Araujo,R.N., Pereira,M.H., Guarneri,A.A. and Tanaka,A.S.<br>A Kazal-type inhibitor is modulated by Trypanosoma cruzi to control microbiota inside the anterior midgut of Rhodnius prolixus<br>Biochimie (2015) 112, 41-48. PubMed  Europe PubMed DOI
    27. 2014
  27. Kopera,E., Bal,W., Lenarcic Zivkovic,M., Dvornyk,A., Kludkiewicz,B., Grzelak,K., Zhukov,I., Zagorski-Ostoja,W., Jaskolski,M. and Krzywda,S.<br>Atomic resolution structure of a protein prepared by non-enzymatic His-tag removal. Crystallographic and NMR study of GmSPI-2 inhibitor<br>PLoS ONE (2014) 9, e106936-e106936. PubMed  Europe PubMed DOI  PMC  EPMC  S
  28. Slowinska,M., Liszewska,E., Nynca,J., Bukowska,J., Hejmej,A., Bilinska,B., Szubstarski,J., Kozlowski,K., Jankowski,J. and Ciereszko,A.<br>Isolation and characterization of an ovoinhibitor, a multidomain Kazal-like inhibitor from turkey (Meleagris gallopavo) seminal plasma<br>Biol Reprod (2014) 91, 108-108. PubMed  Europe PubMed DOI
  29. Waisberg,M., Molina-Cruz,A., Mizurini,D.M., Gera,N., Sousa,B.C., Ma,D., Leal,A.C., Gomes,T., Kotsyfakis,M., Ribeiro,J.M., Lukszo,J., Reiter,K., Porcella,S.F., Oliveira,C.J., Monteiro,R.Q., Barillas-Mury,C., Pierce,S.K. and Francischetti,I.M.<br>Plasmodium falciparum infection induces expression of a mosquito salivary protein (agaphelin) that targets neutrophil function and inhibits thrombosis without impairing hemostasis<br>PLoS Pathog (2014) 10, e1004338-e1004338. PubMed  Europe PubMed DOI  PMC  EPMC
  30. Zhang,D., Ma,J. and Jiang,S.<br>Molecular characterization, expression and function analysis of a five-domain Kazal-type serine proteinase inhibitor from pearl oyster Pinctada fucata<br>Fish Shellfish Immunol (2014) 37, 115-121. PubMed  Europe PubMed DOI
    31. 2013
  31. Kodrik,D., Kludkiewicz,B., Navratil,O., Skokova Habustova,O., Horackova,V., Svobodova,Z., Vinokurov,K.S. and Sehnal,F.<br>Protease inhibitor from insect silk - activities of derivatives expressed in vitro and in transgenic potato<br>Appl Biochem Biotechnol (2013) 171, 209-224. PubMed  Europe PubMed DOI
  32. Maldonado-Aguayo,W., Nunez-Acuna,G., Valenzuela-Munoz,V., Chavez-Mardones,J. and Gallardo-Escarate,C.<br>Molecular characterization of two Kazal-type serine proteinase inhibitor genes in the surf clam Mesodesma donacium exposed to Vibrio anguillarum<br>Fish Shellfish Immunol (2013) 34, 1448-1454. PubMed  Europe PubMed DOI
  33. Wickramaarachchi,W.D., De Zoysa,M., Whang,I., Wan,Q. and Lee,J.<br>Kazal-type proteinase inhibitor from disk abalone (Haliotis discus discus): molecular characterization and transcriptional response upon immune stimulation<br>Fish Shellfish Immunol (2013) 35, 1039-1043. PubMed  Europe PubMed DOI
    34. 2012
  34. Li,R., Wang,H., Jiang,Y., Yu,Y., Wang,L., Zhou,M., Zhang,Y., Chen,T. and Shaw,C.<br>A novel Kazal-type trypsin inhibitor from the skin secretion of the Central American red-eyed leaf frog, Agalychnis callidryas<br>Biochimie (2012) 94, 1376-1381. PubMed  Europe PubMed DOI
  35. Qian,Y.Q., Li,Y., Yang,F., Yu,Y.Q., Yang,J.S. and Yang,W.J.<br>Two Kazal-type protease inhibitors from Macrobrachium nipponense and Eriocheir sinensis: comparative analysis of structure and activities<br>Fish Shellfish Immunol (2012) 32, 446-458. PubMed  Europe PubMed DOI
    36. 2011
  36. Reiss,K., Meyer-Hoffert,U., Fischer,J., Sperrhacke,M., Wu,Z., Dimitrieva,O., Krenek,P., Suchanova,S., Buryova,H., Brauer,R. and Sedlacek,R.<br>Expression and regulation of murine SPINK12, a potential orthologue of human LEKTI2<br>Exp Dermatol (2011) 20, 905-910. PubMed  Europe PubMed DOI
  37. Shenoy,R.T., Thangamani,S., Velazquez-Campoy,A., Ho,B., Ding,J.L. and Sivaraman,J.<br>Structural basis for dual-inhibition mechanism of a non-classical Kazal-type serine protease inhibitor from horseshoe crab in complex with subtilisin<br>PLoS ONE (2011) 6, e18838-e18838. PubMed  Europe PubMed DOI  PMC  EPMC
  38. van Hoef,V., Breugelmans,B., Spit,J., Simonet,G., Zels,S., Billen,J. and Vanden Broeck,J.<br>Functional analysis of a pancreatic secretory trypsin inhibitor-like protein in insects: silencing effects resemble the human pancreatic autodigestion phenotype<br>Insect Biochem Mol Biol (2011) 41, 688-695. PubMed  Europe PubMed DOI
  39. Zeng,Y. and Wang,W.<br>Molecular cloning and tissue-specific expression of a five-Kazal domain serine proteinase inhibitor from crayfish Procambarus clarkii hemocytes<br>Aquaculture (2011) 321, 8-12. DOI
    40. 2010
  40. Cerenius,L., Liu,H., Zhang,Y., Rimphanitchayakit,V., Tassanakajon,A., Gunnar Andersson,M., Soderhall,K. and Soderhall,I.<br>High sequence variability among hemocyte-specific Kazal-type proteinase inhibitors in decapod crustaceans<br>Dev Comp Immunol (2010) 34, 69-75. PubMed  Europe PubMed DOI
  41. Donpudsa,S., Soderhall,I., Rimphanitchayakit,V., Cerenius,L., Tassanakajon,A. and Soderhall,K.<br>Proteinase inhibitory activities of two two-domain Kazal proteinase inhibitors from the freshwater crayfish Pacifastacus leniusculus and the importance of the P(2) position in proteinase inhibitory activity<br>Fish Shellfish Immunol (2010) 29, 716-723. PubMed  Europe PubMed DOI
  42. Gonzalez-Gonzalez,Y., Gil,D., Alonso-del-Rivero,M., Besada,V., Gil,J., Araujo,M.S., Tanaka,A.S., Pons,T. and Chavez,M.D.L.A.<br>Novel protease inhibitors active against human neutrophil elastase and plasma kallikrein with therapeutic potentialities: structure-function relationships<br>Biotecnol Apl (2010) 27, 310-313.
  43. Li,X.C., Zhang,R.R., Sun,R.R., Lan,J.F., Zhao,X.F. and Wang,J.X.<br>Three Kazal-type serine proteinase inhibitors from the red swamp crayfish Procambarus clarkii and the characterization, function analysis of hcPcSPI2<br>Fish Shellfish Immunol (2010) 28, 942-951. PubMed  Europe PubMed DOI
  44. Meiser,C.K., Piechura,H., Werner,T., Dittmeyer-Schafer,S., Meyer,H.E., Warscheid,B., Schaub,G.A. and Balczun,C.<br>Kazal-type inhibitors in the stomach of Panstrongylus megistus (Triatominae, Reduviidae)<br>Insect Biochem Mol Biol (2010) 40, 345-353. PubMed  Europe PubMed DOI
    45. 2009
  45. Augustin,R., Siebert,S. and Bosch,T.C.<br>Identification of a Kazal-type serine protease inhibitor with potent anti-staphylococcal activity as part of Hydra's innate immune system<br>Dev Comp Immunol (2009) 33, 830-837. PubMed  Europe PubMed DOI
  46. Kong,H.J., Cho,H.K., Park,E.M., Hong,G.E., Kim,Y.O., Nam,B.H., Kim,W.J., Lee,S.J., Han,H.S., Jang,I.K., Lee,C.H., Cheong,J. and Choi,T.J.<br>Molecular cloning of Kazal-type proteinase inhibitor of the shrimp Fenneropenaeus chinensis<br>Fish Shellfish Immunol (2009) 26, 109-114. PubMed  Europe PubMed DOI
  47. Li,X.C., Wang,X.W., Wang,Z.H., Zhao,X.F. and Wang,J.X.<br>A three-domain Kazal-type serine proteinase inhibitor exhibiting domain inhibitory and bacteriostatic activities from freshwater crayfish Procambarus clarkii<br>Dev Comp Immunol (2009) 33, 1229-1238. PubMed  Europe PubMed DOI
  48. Tulsidas,S.R., Thangamani,S., Ho,B., Sivaraman,J. and Ding,J.L.<br>Crystallization of a nonclassical Kazal-type Carcinoscorpius rotundicauda serine protease inhibitor, CrSPI-1, complexed with subtilisin<br>Acta Crystallograph Sect F Struct Biol Cryst Commun (2009) 65, 533-535. PubMed  Europe PubMed DOI  PMC  EPMC
    49. 2007
  49. Araujo,R.N., Campos,I.T., Tanaka,A.S., Santos,A., Gontijo,N.F., Lehane,M.J. and Pereira,M.H.<br>Brasiliensin: a novel intestinal thrombin inhibitor from Triatoma brasiliensis (Hemiptera: Reduviidae) with an important role in blood intake<br>Int J Parasitol (2007) 37, 1351-1358. PubMed  Europe PubMed DOI  PMC  EPMC
  50. Gonzalez,Y., Tanaka,A.S., Hirata,I.Y., del Rivero,M.A., Oliva,M.L., Araujo,M.S. and Chavez,M.A.<br>Purification and partial characterization of human neutrophil elastase inhibitors from the marine snail Cenchritis muricatus (Mollusca)<br>Comp Biochem Physiol A Mol Integr Physiol (2007) 146, 506-513. PubMed  Europe PubMed DOI
    51. 2006
  51. [YEAR:14-8-2006]Jalkanen,J., Kotimaki,M., Huhtaniemi,I. and Poutanen,M.<br>Novel epididymal protease inhibitors with Kazal or WAP family domain<br>Biochem Biophys Res Commun (14-8-2006) 349, 245-254. PubMed  Europe PubMed DOI
  52. [YEAR:6-7-2006]Zhu,L., Song,L., Chang,Y., Xu,W. and Wu,L.<br>Molecular cloning, characterization and expression of a novel serine proteinase inhibitor gene in bay scallops (Argopecten irradians, Lamarck 1819)<br>Fish Shellfish Immunol (6-7-2006) 20, 320-331. PubMed  Europe PubMed DOI
    53. 2005
  53. Jimenez-Vega,F. and Vargas-Albores,F.<br>A four-Kazal domain protein in Litopenaeus vannamei hemocytes<br>Dev Comp Immunol (2005) 29, 385-391. PubMed  Europe PubMed DOI
  54. [YEAR:8-8-2005]Kludkiewicz,B., Kodrik,D., Grzelak,K., Nirmala,X. and Sehnal,F.<br>Structurally unique recombinant Kazal-type proteinase inhibitor retains activity when terminally extended and glycosylated<br>Protein Expr Purif (8-8-2005) 43, 94-102. PubMed  Europe PubMed DOI
    55. 2001
  55. Nirmala,X., Kodrik,D., Zurovec,M. and Sehnal,F.<br>Insect silk contains both a Kunitz-type and a unique Kazal-type proteinase inhibitor<br>Eur J Biochem (2001) 268, 2064-2073. PubMed  Europe PubMed DOI
  56. Nirmala,X., Mita,K., Vanisree,V., Zurovec,M. and Sehnal,F.<br>Identification of four small molecular mass proteins in the silk of Bombyx mori<br>Insect Mol Biol (2001) 10, 437-445. PubMed  Europe PubMed DOI
    57. 1999
  57. Odum,L., Bundgaard,J.R. and Johnsen,A.H.<br>A Kazal-type trypsin inhibitor from the protochordate Ciona intestinalis<br>Eur J Biochem (1999) 259, 872-876. PubMed  Europe PubMed DOI

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