Literature for ELND007 (XA22.001 inhibitor)
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Probst,G., Aubele,D.L., Bowers,S., Dressen,D., Garofalo,A.W., Hom,R.K., Konradi,A.W., Marugg,J.L., Mattson,M.N., Neitzel,M.L., Semko,C.M., Sham,H.L., Smith,J., Sun,M., Truong,A.P., Ye,X.M., Xu,Y.Z., Dappen,M.S., Jagodzinski,J.J., Keim,P.S., Peterson,B., Latimer,L.H., Quincy,D., Wu,J., Goldbach,E., Ness,D.K., Quinn,K.P., Sauer,J.M., Wong,K., Zhang,H., Zmolek,W., Brigham,E.F., Kholodenko,D., Hu,K., Kwong,G.T., Lee,M., Liao,A., Motter,R.N., Sacayon,P., Santiago,P., Willits,C., Bard,F., Bova,M.P., Hemphill,S.S., Nguyen,L., Ruslim,L., Tanaka,K., Tanaka,P., Wallace,W., Yednock,T.A. and Basi,G.S.
Discovery of (R)-4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline (ELND006) and (R)-4-cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline (ELND007): Metabolically stable gamma-secretase inhibitors that selectively inhibit the production of amyloid-beta over notch
J Med Chem (2013) 56, 5261-5274. PubMed Europe PubMed DOI I
2013
