Press releases from IPD-MHC

This section hosts all the updates and news from the IPD-MHC Database.

Introducing a new species section for MHC allelic diversity in the domestic goat

With most of the major ruminant livestock species already represented on the IPD MHC Database we are now pleased to add the domestic goat, Capra hircus to the list. The development of a Caprine leukocyte antigens (CLA) section begins with assigning nomenclature to alleles at the MHC class II DRB1 locus from domesticated goats. These will be termed Cahi-DRB1 and are named in a single allelic series (Ballingall and Todd 2018). Other Loci will be added in due course and will follow the rules described in the recent report from the comparative MHC nomenclature committee (Ballingall et al. 2018, Maccari et al. 2018) in partnership with the IPD-MHC Database (Maccari et al. 2017).

  • Keith T. Ballingall and Helen Todd. An official nomenclature for MHC sequences from domestic goat (Capra hircus) HLA (2018), Published on line, DOI:10.1111/tan.13425
  • Keith T. Ballingall, Ronald E. Bontrop, Shirley A. Ellis, Unni Grimholt, John A. Hammond, Chak-Sum Ho, Jim Kaufman, Lorna J. Kennedy, Giuseppe Maccari, Donald Miller, James Robinson, Steven G.E. Marsh Comparative MHC Nomenclature: report from the ISAG/IUIS-VIC committee Immunogenetics (2018), 70, 625-632. doi.org/10.1007/s00251-018-1073-3.
  • Giuseppe Maccari, James Robinson, Ronald E. Bontrop, Nel Otting, Natasja G. de Groot, Chak-Sum Ho, Keith T. Ballingall, Steven G.E. Marsh and John A. Hammond IPD-MHC: nomenclature requirements for the non-human major histocompatibility complex in the next-generation sequencing era. Immunogenetics (2018), 70:619–623. doi.org/10.1007/s00251-018-1072-4.
  • Giuseppe Maccari, James Robinson, Keith T. Ballingall, Lisbeth A, Guethlein, Unni Grimholt, Jim Kaufman, Chak-Sum Ho, Natasja G. de Groot, Paul Flicek, Ronald E. Bontrop, John A. Hammond and Steve G.E. Marsh IPD-MHC 2.0: an improved inter-species database for the study of the major histocompatibility complex. Nucleic Acids Res. (2017), 45: D860–D864

Photo by Florian van Duyn on Unsplash

18 December 2018: New sheep DQ allelic sections

The sheep section now includes 82 full-length and partial cDNA alleles at the DQA1, DQA2, DQA2-like, DQB1, DQB2 and DQB2-like genes.

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14 February 2018: IPD-MHC Release 3.0

A new version of the IPD-MHC has been released, featuring a revised interface and improved analysis tools.

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24 October 2016: IPD-MHC Article in press

A manuscript about the IPD-MHC Database 2.0 has recently been accepted for publication on the Nucleic Acid Research 2017 database issue.

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21 October 2016: Gallus IPD-MHC Group Added

A new section dedicated to Gallus genus has been added to the IPD-MHC Database.

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21 October 2016: IPD-MHC Release 2.0

The IPD-MHC Database 2.0 has been released, including a revamped interface as well as additional analysis tools.

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