IPD-IMGT/HLA

DPB1 T-Cell Epitope Algorithm v3.0

Classification of HLA-DPB1 mismatches based on T-cell-epitope groups (TCE-groups) has been shown to identify mismatches that might be better tolerated (permissive) and those that would increase risks (non-permissive) after unrelated-donor haematopoietic stem cell transplantation (HSCT). This calculator allows you to enter the HLA-DPB1 typing of a patient and a donor and retrieve the predicted TCE grouping and resulting matching/mismatching when selecting appropriate donors for HSCT recipients.

Advice on the user of this tool:

• Please provide HLA-DPB1 typing at 2 field resolution, or higher. P groups are also accepted.
• All HLA-DPB1 typing provided should be at the same resolution level (2 field, 3 field, 4 field or P group)
• TCE group assignments between version 2.1 and 3.0 are the same. However, version 3.0 incorporates the assignment for TCE 3 core and non-core alleles, as well as the assessment of permissive mismatch directionality based on these classifications (see Arrieta-Bolaños et al. Blood 2024).
• Changes in the permissiveness prediction between version 2.0 and 3.0 may arise due to the implementation of bidirectional immunogenicity in version 2.1, please see DPB1 TCE version 2.1 for further details.
• This tool has been developed in collaboration with the original authors and validated with their support on a cohort of 15,000 patient donor pairs (manuscript in preparation).
• No information entered into this tool is collected or stored on our servers.