IMGT/HLA and IPD-KIR Matching Algorithms
The IPD-IMGT/HLA and IPD-KIR Databases provide a number of tools based on published matching algorithms. These have been developed in collaboration with the authors of the original papers, with the aim of providing a user friendly interface to aid in HLA matching of potential donor with a patient. New tools are being developed and APIs added to the existing tools to better enable programmatical interfaces.
DPB1 T-Cell Epitope Algorithms
Classification of HLA-DPB1 mismatches based on T-cell-epitope Groups (TCE-Groups) has been shown to identify mismatches that might be tolerated (permissive) and those that would increase risks (non-permissive) after unrelated-donor haematopoietic stem cell transplantation (HSCT). These calculators allows you to enter the HLA-DPB1 typing of a patient and donor and view the predicted T-Cell epitopes and resulting prediction of the effect of mismatching when selecting appropriate donors for HSCT recipients (Fleischhauer, 2012).
Version 1.0 of the tool was originally added to the IPD-IMGT/HLA site in 2012. This tool has been extensively used and validated in a number of studies (1-7). To faciliate ongoing studies which continue to use this algorithm, the first version of this tool will remain online.
Version 2.0 of the tool has been updated following the recent publication by Crivello et al (8). This update uses a new methodology for assessing the TCE group, and some predicted groups differ to the first version of the tool. At the current time there are no further studies published using the new algorithm.
HLA-B Leader Matching
Haematopoietic cell transplantation (HCT) from HLA-mismatched unrelated donors can cure life-threatening blood disorders, but its success may be limited by graft-versus-host disease (GVHD). The dimorphic HLA-B leader sequence informs GVHD risk in HLA-B–mismatched HCT (Petersdorf, 2020). This tool allows the patient and donor HLA-B types to be compared for mismatches in the leader sequences.HLA-B Leader Tool
KIR Ligand Calculator
Recent transplant strategies based on KIR-ligand mismatch to predict NK cell alloreactivity have resulted in less relapse, less GvHD and better overall survival in patients with Acute Myeloid Leukaemia (Ruggeri, 1999).KIR Ligand Calculator
KIR Donor B-Content Calculator
Group A and B KIR haplotypes have distinctive centromeric (Cen) and telomeric (Tel) gene-content motifs. With the goal of developing a donor selection strategy to improve transplant outcome, Cooley et al., compared the contribution of these motifs to the clinical benefit conferred by B haplotype donors (Cooley, 2010).KIR Donor B_Content Calculator
HLA Matching APIs
APIs have been developed for a number of the matching tools and documentation can be found on the following page;API Documentation
- Fleischhauer K, Shaw BE, Gooley T, et al.
Effect of T-cell-epitope matching at HLA-DPB1 in recipients of unrelated-donor haemopoietic-cell transplantation: a retrospective study.
Lancet Oncology (2012) 13:366-74
- Petersdorf EW, Stevenson P, Bengtsson M, De Santis D, Dubois V, Gooley T, Horowitz M, Hsu K, Madrigal JA, Malkki M, McKallor C, Morishima Y, Oudshoorn M, Spellman SR, Villard J, Carrington M.
HLA-B leader and survivorship after HLA-mismatched unrelated donor transplantation.
Blood (2020) 136:362-9
- Ruggeri L, Capanni M, Casucci M, Volpi I, Tosti A, Perruccio K, Urbani E, Negrin RS, Martelli MF, Velardi A.
Role of natural killer cell alloreactivity in HLA-mismatched hematopoietic stem cell transplantation.
Blood (1999) 91:333-9