Phenotypes browsing by Ontology terms :: Cellular Phenotype Database

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Browse phenotype ontology terms or, by clicking on ✎ collect link by the phenotype term, choose multiple phenotypes set from different studies or from the same study to retrieve a list of gene/reagent pairs showing all selected phenotypes

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Cell population
- Aggregated cells in population
- Cell number in population
  - Increased cell numbers
    
    J1_SyM_1 :
    
    Increased cell number ✎ collect
    - More cells in S
    - More cells in G1
    - More cells in G2M
      
      J1_SyM_1 :
      
      Increased mitotic index ✎ collect
    - More cells with projections
      - More lamellipodia cells
        
        C1_SyM_1 :
        
        Lamellipodia + high actin ratio cells ✎ collect
        
        C1_SyM_1 :
        
        Lamellipodia cells ✎ collect
    - More polyploid cells
    - More cells with decreased number of nucleoli
    - More cells with increased number of nucleoli
    - More actin filament cells
    - More mitotic metaphase cells
    - More apoptosis in population
    - Proliferating cells
      
      C1_SyM_1 :
      
      Proliferating cells ✎ collect
      
      M1_SyM_1 :
      
      Increased proliferation ✎ collect
    - More cells in M phase
    - More multinucleate cells
      
      J1_SyM_1 :
      
      Increased number of multinucleate cells ✎ collect
  - Decreased cell numbers
    
    J1_SyM_1 :
    
    Decreased cell number ✎ collect
    - Fewer cells in G1
    - Fewer cells in G2M
      
      M1_SyM_2 :
      
      Reduced mitotic index ✎ collect
    - Fewer cells in S
    - Fewer cells with projections
      - Fewer lamellipodia cells
    - Fewer actin filament cells
    - Fewer mitotic metaphase cells
    - Less apoptosis in population
    - Fewer cells in M phase
- Cell population process
  - More cells in S
  - More cells in G1
  - More cells in G2M
    
    J1_SyM_1 :
    
    Increased mitotic index ✎ collect
  - Fewer cells in G1
  - Fewer cells in G2M
    
    M1_SyM_2 :
    
    Reduced mitotic index ✎ collect
  - Fewer cells in S
  - Mitotic metaphase cells in population
    - More mitotic metaphase cells
    - Fewer mitotic metaphase cells
  - More apoptosis in population
  - Less apoptosis in population
  - Proliferating cells
    
    C1_SyM_1 :
    
    Proliferating cells ✎ collect
    
    M1_SyM_1 :
    
    Increased proliferation ✎ collect
  - More cells in M phase
  - Fewer cells in M phase
- Cells with projections
  
  C1_SyM_1 :
  
  Cells with protrusions ✎ collect
  
  C1_SyM_1 :
  
  Elongated cells with protrusions ✎ collect
- Cell viability in population
  - Increased cell viability in population
  - Decreased cell viability in population
- Cell population morphology
  - Elongated cells in population
  - Increased variability of cell size in population
    
    J1_SyM_1 :
    
    Variable cell size ✎ collect
  - Increased variability of cell shape in population
    
    J1_SyM_1 :
    
    Cell shape variable ✎ collect
  - Layered cells in population
  - Increased cell size in population
    
    C1_SyM_1 :
    
    Large cells ✎ collect
  - Increased variability of nuclear shape in population
    
    M1_SyM_1 :
    
    Dynamic changes ✎ collect
- Cell layer
  - Loss of cell monolayer
    
    J1_SyM_1 :
    
    Loss of cell monolayer ✎ collect
- No cells
Cell process
- Cell adhesion
  - Cell-matrix adhesion
  - Cell spreading
- Cell cycle
  - Cell cycle phase
    - S phase mitotic
    - G1 phase mitotic
    - G2 phase mitotic
    - Mitotic metaphase
      - Metaphase arrested
        
        C1_SyM_1 :
        
        SM phenotype (abundance of large cells with protrusions and bright nuclei) ✎ collect
        
        M1_SyM_2 :
        
        Metaphase arrest/delay ✎ collect
        
        C1_SyM_1 :
        
        Metaphase cells ✎ collect
      - Metaphase delayed
        
        M1_SyM_2 :
        
        Metaphase arrest/delay ✎ collect
    - M phase mitotic
      - M phase arrested
    - Cell cycle arrested
    - Mitotic prophase
    - Prometaphase delayed
      
      M1_SyM_2 :
      
      Prometaphase ✎ collect
  - Cytokinesis
    - Absence of cytokinesis
  - Mitotic process
    - S phase mitotic
      - S phase arrested
    - G1 phase mitotic
      - Increased nuclei size in G1
      - Decreased nuclei size in G1
    - G2/M transition
      - Decreased nuclei size in G2/M
    - Mitosis delayed
      
      M1_SyM_1 :
      
      Mitotic delay ✎ collect
    - G2 phase mitotic
      - G2 arrested
    - Mitotic metaphase
    - Absence of mitotic process
    - Mitotic chromosome condensation
    - Mitotic chromosome decondensation
      - Absence of mitotic chromosome decondensation
    - M phase mitotic
    - Exit from mitosis
      
      P1_SyM_1 :
      
      Normal mitotic exit ✎ collect
      - Increased duration of exit from mitosis
        
        P1_SyM_1 :
        
        Prolonged mitotic exit ✎ collect
      - Decreased duration of exit from mitosis
    - Mitotic prophase
      - Increased duration of mitotic prophase
      - Decreased duration of mitotic prophase
    - Mitosis arrested
    - Absence of mitotic metaphase process
    - Mitotic metaphase plate congression
      
      M1_SyM_2 :
      
      Metaphase alignment problem ✎ collect
  - Abnormal cell cycle
- Cell death
  
  M1_SyM_2 :
  
  Cell death ✎ collect
  
  M1_SyM_1 :
  
  Cell death ✎ collect
  - Cell apoptosis
- Cell membrane organisation
  - Plasma membrane fusion occurance
- Cell growth
  - Abnormal cell growth
  - Cell growth arrested
- Chromosome segregation
  - Abnormal chromosome segregation
    
    M1_SyM_2 :
    
    Segregation problem ✎ collect
- Metabolic process
  - Apoptotic DNA fragmentation
  - Telomerase activity
    - Decreased telomerase activity
    - Increased telomerase activity
  - Mitotic chromosome condensation
    - Increased duration of mitotic chromosome condensation
    - Decreased duration of mitotic chromosome condensation
- Organelle localization
- Transport
  - Cell secretion
    - Increased rate of protein secretion
      
      E1_SyM_2 :
      
      Enhanced secretion ✎ collect
    - Decreased rate of protein secretion
      - Mild decrease in rate of protein secretion
        
        E1_SyM_1 :
        
        Mild inhibition of secretion ✎ collect
      - Strong decrease in rate of protein secretion
        
        E1_SyM_1 :
        
        Strong inhibition of secretion ✎ collect
  - Decreased rate of intracellular protein transport
    
    B1_SyM_1 :
    
    Intracellular retention of SH4(YES)-mCherry ✎ collect
    
    B1_SyM_2 :
    
    Intracellular retention of SH4(YES)-mCherry ✎ collect
    
    B1_SyM_2 :
    
    Intracellular retention of SH4(HASPB)-GFP ✎ collect
    
    B1_SyM_1 :
    
    Intracellular retention of SH4(HASPB)-GFP ✎ collect
- Cell division
  - Cytokinesis
  - Increased rate of cell division
  - Decreased rate of cell division
- Arrested process
  - G0/1 arrested
  - Cell cycle arrested
    - M phase arrested
    - G2 arrested
    - S phase arrested
    - Metaphase arrested
      
      C1_SyM_1 :
      
      SM phenotype (abundance of large cells with protrusions and bright nuclei) ✎ collect
      
      M1_SyM_2 :
      
      Metaphase arrest/delay ✎ collect
      
      C1_SyM_1 :
      
      Metaphase cells ✎ collect
    - Mitosis arrested
    - Prometaphase arrested
      
      M1_SyM_2 :
      
      Prometaphase ✎ collect
  - Cell growth arrested
- Cell component movement
  - Cell migration
    
    M1_SyM_2 :
    
    Cell migration ✎ collect
    - Increased rate of cell migration process
      
      P2_SyM_1 :
      
      Increased cell migration and increased cell area ✎ collect
    - Decreased rate of cell migration process
    - Impaired cell migration
      
      P2_SyM_1 :
      
      Impaired cell migration with increased protrusive activity ✎ collect
      
      P2_SyM_1 :
      
      Impaired cell migration ✎ collect
    - Increased duration of cell migration process
    - Decreased duration of cell migration process
    - Increased substrate-dependent cell migration, cell extension
      
      P2_SyM_1 :
      
      Impaired cell migration with increased protrusive activity ✎ collect
    - Increased substrate-dependent cell migration
      
      P2_SyM_1 :
      
      Increased directional cell migration ✎ collect
  - Actin-mediated cell contraction
- Delayed process
  - Mitosis delayed
    
    M1_SyM_1 :
    
    Mitotic delay ✎ collect
  - Metaphase delayed
    
    M1_SyM_2 :
    
    Metaphase arrest/delay ✎ collect
  - Prometaphase delayed
    
    M1_SyM_2 :
    
    Prometaphase ✎ collect
- Absence of cell process
  - Absence of cytokinesis
  - Absence of mitotic chromosome decondensation
  - Absence of mitotic process
  - Absence of cell spreading
  - Absence of mitotic metaphase process
- Regulation of process
  - Regulation of metabolic process
    - Decreased frequency of negative regulation of NF-kappaB transcription factor activity
      
      N1_SyM_1 :
      
      Decreased oscillation ✎ collect
    - Increased frequency of negative regulation of NF-kappaB transcription factor activity
      
      N1_SyM_1 :
      
      Increased oscillation ✎ collect
  - Regulation of signal transduction
    - Cytoplasmic sequestering of NF-kappaB
      
      N1_SyM_1 :
      
      No oscillation ✎ collect
    - Abnormal release of cytoplasmic sequestered NF-kappaB
      
      N1_SyM_1 :
      
      Different oscillation pattern ✎ collect
- Increased microtubule-based processes
  
  J1_SyM_1 :
  
  Microtubule processes ✎ collect
Molecular component
- Cell DNA
  - Misshapen DNA
    
    J1_SyM_1 :
    
    Misshapen DNA ✎ collect
  - Apoptotic DNA
    
    J1_SyM_1 :
    
    Apoptotic DNA ✎ collect
Cellular development
- Cell spreading
  - Increased cell spreading
    - Mild increase of cell spreading
    - Strong increase of cell spreading
  - Decreased cell spreading
  - Absence of cell spreading
Single cell
- Cell morphology
  - Apoptotic cell shape
  - Elongated cell
    
    C1_SyM_1 :
    
    Elongated cells with protrusions ✎ collect
    
    C1_SyM_1 :
    
    Elongated cells ✎ collect
    
    J1_SyM_1 :
    
    Cell shape bipolar or elongated ✎ collect
  - Abnormal cell shape
  - Round cell
    
    C1_SyM_1 :
    
    Low eccentricity cells ✎ collect
    
    J1_SyM_1 :
    
    Cell shape round or non-adherent ✎ collect
    
    C1_SyM_1 :
    
    SM phenotype (abundance of large cells with protrusions and bright nuclei) ✎ collect
  - Arrow shaped cell
  - Triangular shaped cell
  - Increased cell size
    
    C1_SyM_1 :
    
    BL phenotype (decrease in the number of cells and increase of metaphase cells) ✎ collect
    
    J1_SyM_1 :
    
    Increased cell size ✎ collect
    
    P2_SyM_1 :
    
    Increased cell migration and increased cell area ✎ collect
    
    C1_SyM_1 :
    
    Big cells ✎ collect
  - Decreased cell size phenoptype
    
    C1_SyM_1 :
    
    Small cells ✎ collect
    
    J1_SyM_1 :
    
    Decreased cell size ✎ collect
  - Geometric cell
    
    J1_SyM_1 :
    
    Cell shape geometric ✎ collect
  - Star shaped cell
    
    J1_SyM_1 :
    
    Cell shape processes or spiky or stretchy ✎ collect
  - Spiny shaped cell
  - Spread cell morphology
- Cell component number
  - Increased cell component number
    - Increased number of cell projections
      - Increased number of filopodia
        
        J1_SyM_1 :
        
        Increased number of filopodia ✎ collect
      - Increased number of lamellipodia
      - Increased number of axons
    - Increased number of focal adhesion
    - Increased number of microtubules
      
      J1_SyM_1 :
      
      Increased level of microtubules ✎ collect
    - Increased number of actin filament
      
      J1_SyM_1 :
      
      Increased level of actin ✎ collect
      
      C1_SyM_1 :
      
      Lamellipodia + high actin ratio cells ✎ collect
      
      C1_SyM_1 :
      
      High actin ratio cells ✎ collect
      
      C1_SyM_1 :
      
      Actin fiber cells ✎ collect
  - Decreased cell component number
    - Decreased number of focal adhesion
    - Decreased number of microtubules
    - Decreased number of dendritic branches phenotyope
    - Decreased number of cell projections
      - Decreased number of filopodia
        
        J1_SyM_1 :
        
        Decreased number of filopodia ✎ collect
      - Decreased number of lamellipodia
      - Decreased number of axons
    - Decreased number of nucleoli
    - Decreased number of actin filament
      
      J1_SyM_1 :
      
      Decreased level of actin ✎ collect
    - Decreased number of site of double-strand break
      
      C2_SyM_2 :
      
      Reduction in IR-induced 53BP1 foci in U2OS cells ✎ collect
      
      C2_SyM_1 :
      
      Reduction in IR-induced 53BP1 foci in HeLa cells ✎ collect
  - Absence of cellular component
    - Phagosomes absent
- Cell viability
  - Viable cell
  - Inviable cell
- Cell nucleation
  - Mononuclear cell
  - Multinucleated cell
    - Binuclear cell
      
      M1_SyM_2 :
      
      Nuclei stay together ✎ collect
      
      M1_SyM_1 :
      
      Binuclear ✎ collect
- Cell ploidy
  - Polyploid cell
- Cell movement
  - Increased cell movement
    - Increased cell movement speed
    - Increased cell movement distance
      
      P2_SyM_1 :
      
      Increased cell migration and increased cell area ✎ collect
  - Decreased cell movement
    - Decreased cell movement distance
    - Decreased cell movement speed
Cellular component
- Cell component position
  - Centrally located focal adhesion
  - Peripheral focal adhesion
  - Centered cytoskeleton
  - Centered nucleus
  - Dispersed nucleus
  - Peripheral nucleus
  - Peripheral cytoskeleton
  - Radial cytoskeleton
  - Polarized endoplasmic reticulum
  - Asymmetric lamellipodia
  - Aggregated microtubules
    
    J1_SyM_1 :
    
    Microtubule clumps ✎ collect
  - Microtubules nuclear bracket
    
    J1_SyM_1 :
    
    Microtubule nuclear bracket ✎ collect
  - Microtubules nuclear ring
    
    J1_SyM_1 :
    
    Microtubule nuclear ring ✎ collect
  - Punctate actin foci
  - Actin nuclear ring
    
    J1_SyM_1 :
    
    Nuclear actin ring ✎ collect
- Phenotypes by organelle
  - Cytoskeletal
    - Actin filament
      - Increased number of actin filament
        
        J1_SyM_1 :
        
        Increased level of actin ✎ collect
        
        C1_SyM_1 :
        
        Lamellipodia + high actin ratio cells ✎ collect
        
        C1_SyM_1 :
        
        High actin ratio cells ✎ collect
        
        C1_SyM_1 :
        
        Actin fiber cells ✎ collect
        
        Increased amount of punctate actin foci
        
        J1_SyM_1 :
        
        Increased number of actin puncta or dots ✎ collect
        
        Increased actin localised to the nucleus
        
        J1_SyM_1 :
        
        Increased actin over nucleus ✎ collect
        
        Increased actin localised to the cytoplasm
        
        J1_SyM_1 :
        
        Increased cytoplasmic actin ✎ collect
      - Decreased number of actin filament
        
        J1_SyM_1 :
        
        Decreased level of actin ✎ collect
      - Punctate actin foci
        
        Increased amount of punctate actin foci
        
        J1_SyM_1 :
        
        Increased number of actin puncta or dots ✎ collect
      - Actin nuclear ring
        
        J1_SyM_1 :
        
        Nuclear actin ring ✎ collect
    - Centered cytoskeleton
    - Peripheral cytoskeleton
    - Disorganized microtubules
      
      J1_SyM_1 :
      
      Microtubules disorganised ✎ collect
    - Podosome
    - Radial cytoskeleton
    - Cortical actin cytoskeleton
      - Increased cortical actin cytoskeleton mass
        
        J1_SyM_1 :
        
        Increased peripheral actin ✎ collect
      - Decreased cortical actin cytoskeleton mass
      - Disorganised cortical actin cytoskeleton
        
        J1_SyM_1 :
        
        Disorganised peripheral actin ✎ collect
    - Actin cytoskeleton
      - Increased actin cytoskeleton mass
      - Decreased actin cytoskeleton mass
    - Aggregated microtubules
      
      J1_SyM_1 :
      
      Microtubule clumps ✎ collect
    - Microtubules nuclear bracket
      
      J1_SyM_1 :
      
      Microtubule nuclear bracket ✎ collect
    - Microtubules nuclear ring
      
      J1_SyM_1 :
      
      Microtubule nuclear ring ✎ collect
    - Increased amount of stress fibers
      
      J1_SyM_1 :
      
      Increased number of actin stress fibres ✎ collect
      - Increased amount of stress fibers located in the cell cortex
        
        J1_SyM_1 :
        
        Increased number of cortical actin stress fibres ✎ collect
      - Increased amount of transverse stress fibers
        
        J1_SyM_1 :
        
        Increased number of transverse actin stress fibres ✎ collect
      - Increased amount of zig-zag stress fibers
        
        J1_SyM_1 :
        
        Increased number of zigzag actin stress fibres ✎ collect
  - Endoplasmic reticulum
    - Fragmented endoplasmic reticulum
    - Polarized endoplasmic reticulum
  - Golgi
    - Golgi morphology
      - Decreased golgi volume
      - Increased golgi volume
      - Fragmented golgi
  - Mitochondrion
    - Fragmented mitochondria
  - Nuclear
    - Increased number of nucleoli
    - Centered nucleus
    - Dispersed nucleus
    - Peripheral nucleus
    - Nuclear body
      - Increased nuclear body size
        
        G1_SyM_1 :
        
        Accumulation of GFP-RNF168 on nuclear bodies ✎ collect
      - Decreased nuclear body size
      - Bright nuclear body
        
        G1_SyM_1 :
        
        Accumulation of GFP-RNF168 on nuclear bodies ✎ collect
    - Bright nuclei
      
      C1_SyM_1 :
      
      BL phenotype (decrease in the number of cells and increase of metaphase cells) ✎ collect
      
      C1_SyM_1 :
      
      Bright nuclei ✎ collect
    - Nuclear morphology
    - Pyknotic nuclear
  - Organelle shape
  - Phagosomes
  - Site of double-strand break
    
    C2_SyM_2 :
    
    Reduction in IR-induced 53BP1 foci in U2OS cells ✎ collect
    
    C2_SyM_1 :
    
    Reduction in IR-induced 53BP1 foci in HeLa cells ✎ collect
    - Increased number of site of double-strand break
  - Cilium
    - Cilium morphology
- Cell projection
  - Decreased cilium length
  - Increased cilium length
  - Increased axon thickness
  - Decresed axon thickness
  - Increased axon length
  - Decreased axon length
  - Lamellipodium
    - Asymmetric lamellipodia
    - Increased lamellipodia width
      
      J1_SyM_1 :
      
      Increased width of lamellae ✎ collect
    - Decreased lamellipodia width
      
      J1_SyM_1 :
      
      Decreased width of lamellae ✎ collect
    - Fan-shaped lamellipodia
      
      J1_SyM_1 :
      
      Motile lamellae ✎ collect
  - Filopodium
- Cell component morphology
  - Cell component size
    - Increased cell component size
      - Increased nuclear body size
        
        G1_SyM_1 :
        
        Accumulation of GFP-RNF168 on nuclear bodies ✎ collect
      - Increased golgi volume
      - Increased cilium length
      - Increased size of focal adhesion
        
        Increased focal adhesion area
        
        Increased focal adhesion length
      - Increased nucleus size
        
        M1_SyM_1 :
        
        Large ✎ collect
        
        C1_SyM_1 :
        
        Large nuclei ✎ collect
        
        J1_SyM_1 :
        
        Increased DNA area ✎ collect
        
        M1_SyM_2 :
        
        Large nucleus ✎ collect
        
        Increased nuclei size in G1
      - Increased thickness of dendritic branches
      - Increased axon thickness
      - Increased axon length
      - Increased lamellipodia width
        
        J1_SyM_1 :
        
        Increased width of lamellae ✎ collect
    - Decreased cell component size
      - Decreased nuclear body size
      - Decreased golgi volume
      - Decreased cilium length
      - Decreased size of focal adhesion
        
        Decreased focal adhesion area
        
        Decreased focal adhesion length
      - Decreased nucleus size
        
        M1_SyM_2 :
        
        Small nucleus ✎ collect
        
        J1_SyM_1 :
        
        Decreased DNA area ✎ collect
      - Decreased thickness of dendritic branches
      - Decresed axon thickness
      - Decreased axon length
      - Decreased lamellipodia width
        
        J1_SyM_1 :
        
        Decreased width of lamellae ✎ collect
  - Cell component shape
    - Organelle shape
      - Nucleus shape
        
        Bilobed nucleus
        
        Elongated nucleus
        
        Round nucleus
        
        Abnormal nucleus shape
        
        M1_SyM_1 :
        
        Polylobed ✎ collect
        
        M1_SyM_2 :
        
        Strange nuclear shape ✎ collect
    - Elongated focal adhesion
    - Fan-shaped lamellipodia
      
      J1_SyM_1 :
      
      Motile lamellae ✎ collect
    - Round focal adhesion
  - Cell component structure
    - Apoptopic nucleus
    - Disorganized microtubules
      
      J1_SyM_1 :
      
      Microtubules disorganised ✎ collect
    - Fragmented endoplasmic reticulum
    - Fragmented golgi
    - Fragmented mitochondria
    - Fragmented nucleus
    - Graped micronucleus
      
      M1_SyM_1 :
      
      Grape ✎ collect
    - Disorganised cortical actin cytoskeleton
      
      J1_SyM_1 :
      
      Disorganised peripheral actin ✎ collect
  - Nuclear morphology
    - Nucleus shape
    - Apoptopic nucleus
    - Deformed nucleus
    - Increased nuclear body size
      
      G1_SyM_1 :
      
      Accumulation of GFP-RNF168 on nuclear bodies ✎ collect
    - Decreased nuclear body size
    - Increased nucleus size
      
      M1_SyM_1 :
      
      Large ✎ collect
      
      C1_SyM_1 :
      
      Large nuclei ✎ collect
      
      J1_SyM_1 :
      
      Increased DNA area ✎ collect
      
      M1_SyM_2 :
      
      Large nucleus ✎ collect
    - Decreased nucleus size
      
      M1_SyM_2 :
      
      Small nucleus ✎ collect
      
      J1_SyM_1 :
      
      Decreased DNA area ✎ collect
      - Decreased nuclei size in G1
      - Decreased nuclei size in G2/M
    - Fragmented nucleus
    - Graped micronucleus
      
      M1_SyM_1 :
      
      Grape ✎ collect
  - Golgi morphology
  - Cilium morphology
    - Decreased cilium length
    - Increased cilium length