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Cellular Phenotype Database


Study accession ID: G1_SyM

Study title:
GFP-RNF168
Organism and cell line:
Homo sapiens
G1_SyM_1 — HeLa Kyoto
Description:
To identify factors that limit the DNA-damage-induced histone ubiquitylation, we cultured U-2-OS cells stably expressing green fluorescent protein (GFP)-RNF168 on small interfering RNA (siRNA) arrays targeting the known human ubiquitinome, and we screened for genes whose knockdown by at least two independent siRNAs increased GFP-RNF168 accumulation on the G1 nuclear bodies formed around spontaneous DNA lesions
Publication:
TRIP12 and UBR5 Suppress Spreading of Chromatin Ubiquitylation at Damaged Chromosomes
Cell. 150, 1-13
Authors:
Gudjonsson T, Altmeyer M, Savic V, Toledo L, Dinant C, Grøfte M, Bartkova J, Poulsen M, Oka Y, Bekker-Jensen S, Mailand N, Neumann B, Heriche JK, Shearer R, Saunders D, Bartek J, Lukas J, Lukas C.
Phenotypes:
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Download:
Study Description file (4.563kB)

Spreadsheet file(s):

Primary screen data:
G1_SyM_1 ZIP (96.455kB)
External URL:
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