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CHEBI:7789 - orphenadrine
| Formula | C18H23NO |
| Net Charge | 0 |
| Average Mass | 269.388 |
| Monoisotopic Mass | 269.17796 |
| SMILES | Cc1ccccc1C(OCCN(C)C)c1ccccc1 |
| InChI | InChI=1S/C18H23NO/c1-15-9-7-8-12-17(15)18(20-14-13-19(2)3)16-10-5-4-6-11-16/h4-12,18H,13-14H2,1-3H3 |
| InChIKey | QVYRGXJJSLMXQH-UHFFFAOYSA-N |
| Wikipedia |
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| Roles Classification |
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| Chemical Role: | Bronsted base A molecular entity capable of accepting a hydron from a donor (Brønsted acid). |
| Biological Roles: | muscarinic antagonist A drug that binds to but does not activate muscarinic cholinergic receptors, thereby blocking the actions of endogenous acetylcholine or exogenous agonists. parasympatholytic Any cholinergic antagonist that inhibits the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the muscarinic antagonists. H1-receptor antagonist H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. NMDA receptor antagonist Any substance that inhibits the action of N-methyl-D-aspartate (NMDA) receptors. They tend to induce a state known as dissociative anesthesia, marked by catalepsy, amnesia, and analgesia, while side effects can include hallucinations, nightmares, and confusion. Due to their psychotomimetic effects, many NMDA receptor antagonists are used as recreational drugs. |
| Applications: | muscarinic antagonist A drug that binds to but does not activate muscarinic cholinergic receptors, thereby blocking the actions of endogenous acetylcholine or exogenous agonists. muscle relaxant A drug used to produce muscle relaxation (excepting neuromuscular blocking agents). Its primary clinical and therapeutic use is the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. Also used for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in multiple sclerosis. parasympatholytic Any cholinergic antagonist that inhibits the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the muscarinic antagonists. antiparkinson drug A drug used in the treatment of Parkinson's disease. antidyskinesia agent Any compound which can be used to treat or alleviate the symptoms of dyskinesia. H1-receptor antagonist H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| orphenadrine (CHEBI:7789) has role antidyskinesia agent (CHEBI:66956) |
| orphenadrine (CHEBI:7789) has role antiparkinson drug (CHEBI:48407) |
| orphenadrine (CHEBI:7789) has role H1-receptor antagonist (CHEBI:37955) |
| orphenadrine (CHEBI:7789) has role muscarinic antagonist (CHEBI:48876) |
| orphenadrine (CHEBI:7789) has role muscle relaxant (CHEBI:51371) |
| orphenadrine (CHEBI:7789) has role NMDA receptor antagonist (CHEBI:60643) |
| orphenadrine (CHEBI:7789) has role parasympatholytic (CHEBI:50370) |
| orphenadrine (CHEBI:7789) is a ether (CHEBI:25698) |
| orphenadrine (CHEBI:7789) is a tertiary amino compound (CHEBI:50996) |
| Incoming Relation(s) |
| orphenadrine citrate (CHEBI:7790) has part orphenadrine (CHEBI:7789) |
| orphenadrine hydrochloride (CHEBI:60902) has part orphenadrine (CHEBI:7789) |
| IUPAC Name |
|---|
| N,N-dimethyl-2-[(2-methylphenyl)(phenyl)methoxy]ethanamine |
| INNs | Source |
|---|---|
| orfenadrina | ChemIDplus |
| orphenadrine | ChemIDplus |
| orphenadrinum | ChemIDplus |
| Synonyms | Source |
|---|---|
| 2-methyldiphenhydramine | ChemIDplus |
| 2-(phenyl-o-tolylmethoxy)ethyldimethylamine | ChemIDplus |
| Dimethyl-[2-(phenyl-o-tolyl-methoxy)-ethyl]-amine | ChEMBL |
| N,N-dimethyl-2-[(o-methyl-α-phenylbenzyl)oxy]ethylamine | NIST Chemistry WebBook |
| N,N-dimethyl-2-(α-2-tolylbenzoyloxy)ethylamine | ChemIDplus |
| o-methyldiphenhydramine | ChemIDplus |