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CHEBI:7790 - orphenadrine citrate
| Formula | C18H23NO.C6H8O7 |
| Net Charge | 0 |
| Average Mass | 461.511 |
| Monoisotopic Mass | 461.20497 |
| SMILES | Cc1ccccc1C(OCCN(C)C)c1ccccc1.O=C(O)CC(O)(CC(=O)O)C(=O)O |
| InChI | InChI=1S/C18H23NO.C6H8O7/c1-15-9-7-8-12-17(15)18(20-14-13-19(2)3)16-10-5-4-6-11-16;7-3(8)1-6(13,5(11)12)2-4(9)10/h4-12,18H,13-14H2,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12) |
| InChIKey | MMMNTDFSPSQXJP-UHFFFAOYSA-N |
| Roles Classification |
|---|
| Biological Roles: | H1-receptor antagonist H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. parasympatholytic Any cholinergic antagonist that inhibits the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the muscarinic antagonists. NMDA receptor antagonist Any substance that inhibits the action of N-methyl-D-aspartate (NMDA) receptors. They tend to induce a state known as dissociative anesthesia, marked by catalepsy, amnesia, and analgesia, while side effects can include hallucinations, nightmares, and confusion. Due to their psychotomimetic effects, many NMDA receptor antagonists are used as recreational drugs. muscarinic antagonist A drug that binds to but does not activate muscarinic cholinergic receptors, thereby blocking the actions of endogenous acetylcholine or exogenous agonists. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. |
| Applications: | H1-receptor antagonist H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. muscle relaxant A drug used to produce muscle relaxation (excepting neuromuscular blocking agents). Its primary clinical and therapeutic use is the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. Also used for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in multiple sclerosis. parasympatholytic Any cholinergic antagonist that inhibits the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the muscarinic antagonists. muscarinic antagonist A drug that binds to but does not activate muscarinic cholinergic receptors, thereby blocking the actions of endogenous acetylcholine or exogenous agonists. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| orphenadrine citrate (CHEBI:7790) has part orphenadrine (CHEBI:7789) |
| orphenadrine citrate (CHEBI:7790) has role analgesic (CHEBI:35480) |
| orphenadrine citrate (CHEBI:7790) has role H1-receptor antagonist (CHEBI:37955) |
| orphenadrine citrate (CHEBI:7790) has role muscarinic antagonist (CHEBI:48876) |
| orphenadrine citrate (CHEBI:7790) has role muscle relaxant (CHEBI:51371) |
| orphenadrine citrate (CHEBI:7790) has role NMDA receptor antagonist (CHEBI:60643) |
| orphenadrine citrate (CHEBI:7790) has role parasympatholytic (CHEBI:50370) |
| orphenadrine citrate (CHEBI:7790) is a citrate salt (CHEBI:50744) |
| IUPAC Name |
|---|
| N,N-dimethyl-2-[(2-methylphenyl)(phenyl)methoxy]ethanamine 2-hydroxypropane-1,2,3-tricarboxylate |
| Synonyms | Source |
|---|---|
| (±)-N,N-dimethyl-2-((o-methyl-α-phenylbenzyl)oxy)ethylamine citrate | ChemIDplus |
| N,N-dimethyl-2-((o-methyl-α-phenylbenzyl)oxy)ethylamine citrate | ChemIDplus |
| NSC-757238 | ChEMBL |
| Orphenadrine (citrate) | ChEMBL |
| orphenadrine dihydrogen citrate | ChemIDplus |
| Brand Names | Source |
|---|---|
| Banflex | ChEBI |
| Flexon | ChEBI |
| Norflex | KEGG DRUG |
| Orphenadrine citrate component of invagesic | ChEMBL |
| Orphenadrine citrate component of invagesic forte | ChEMBL |
| Orphenadrine citrate component of norgesic | ChEMBL |
| Citations |
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