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CHEBI:4856 - esmolol
| ChEBI ID | CHEBI:4856 |
| ChEBI Name | esmolol |
| Stars | |
| Definition | A racemate comprising equimolar amounts of (R)- and (S)-esmolol. A cardioselective and short-acting β1 receptor blocker with rapid onset but lacking intrinsic sympathomimetic and membrane-stabilising properties, it is used as the hydrochloride salt in the management of supraventricular arrhythmias, and for the control of hypertension and tachycardia during surgery. While the S enantiomer possesses all of the heart rate control, both enantiomers contribute to lowering blood pressure. |
| Secondary ChEBI ID | CHEBI:143354 |
| Last Modified | 29 September 2025 |
| Formula | |
| Net Charge | 0 |
| Average Mass | 295.379 |
| Wikipedia |
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| Roles Classification |
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| Biological Role: | beta-adrenergic antagonist An agent that binds to but does not activate β-adrenergic receptors thereby blocking the actions of endogenous or exogenous β-adrenergic agonists. β-Adrenergic antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches and anxiety. |
| Applications: | anti-arrhythmia drug A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres. beta-adrenergic antagonist An agent that binds to but does not activate β-adrenergic receptors thereby blocking the actions of endogenous or exogenous β-adrenergic agonists. β-Adrenergic antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches and anxiety. |
| ChEBI Ontology |
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| Outgoing Relation(s) |
| esmolol (CHEBI:4856) has functional parent 3-{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl}propanoic acid (CHEBI:143310) |
| esmolol (CHEBI:4856) has part (R)-esmolol (CHEBI:60074) |
| esmolol (CHEBI:4856) has part (S)-esmolol (CHEBI:60075) |
| esmolol (CHEBI:4856) has role anti-arrhythmia drug (CHEBI:38070) |
| esmolol (CHEBI:4856) has role β-adrenergic antagonist (CHEBI:35530) |
| esmolol (CHEBI:4856) is a racemate (CHEBI:60911) |
| Incoming Relation(s) |
| esmolol hydrochloride (CHEBI:4857) has part esmolol (CHEBI:4856) |
| IUPAC Name |
|---|
| rac-methyl 3-{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl}propanoate |
| INNs | Source |
|---|---|
| esmolol | ChemIDplus |
| esmolol | WHO MedNet |
| esmolol | WHO MedNet |
| esmololum | WHO MedNet |
| Synonyms | Source |
|---|---|
| Esmolol | KEGG COMPOUND |
| 3-[4-(2-Hydroxy-3-isopropylamino-propoxy)-phenyl]-propionic acid methyl ester | ChEMBL |
| ESMOLOL | ChEMBL |
| Methyl 4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)benzenepropanoate | ChemIDplus |
| (±)-esmolol | ChemIDplus |
| methyl p-(2-hydroxy-3-(isopropylamino)propoxy)hydrocinnamate | ChEBI |
| Registry Numbers | Sources |
|---|---|
| Reaxys:5287174 | Reaxys |
| CAS:103598-03-4 | KEGG COMPOUND |
| CAS:81147-92-4 | ChemIDplus |
| CAS:103598-03-4 | ChemIDplus |
| Citations |
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