EMBL-EBI | Chemical Biology | ChEBI
Example searches: iron*, InChI=1S/CH4O/c1-2/h2H,1H3, caffeine | Advanced Search
CHEBI:4636 - diphenhydramine
| Formula | C17H21NO |
| Net Charge | 0 |
| Average Mass | 255.361 |
| Monoisotopic Mass | 255.16231 |
| SMILES | CN(C)CCOC(c1ccccc1)c1ccccc1 |
| InChI | InChI=1S/C17H21NO/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16/h3-12,17H,13-14H2,1-2H3 |
| InChIKey | ZZVUWRFHKOJYTH-UHFFFAOYSA-N |
| Wikipedia |
|---|
| Roles Classification |
|---|
| Chemical Role: | Bronsted base A molecular entity capable of accepting a hydron from a donor (Brønsted acid). |
| Biological Roles: | muscarinic antagonist A drug that binds to but does not activate muscarinic cholinergic receptors, thereby blocking the actions of endogenous acetylcholine or exogenous agonists. H1-receptor antagonist H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. |
| Applications: | antiemetic A drug used to prevent nausea or vomiting. An antiemetic may act by a wide range of mechanisms: it might affect the medullary control centres (the vomiting centre and the chemoreceptive trigger zone) or affect the peripheral receptors. antiparkinson drug A drug used in the treatment of Parkinson's disease. antitussive An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration. muscarinic antagonist A drug that binds to but does not activate muscarinic cholinergic receptors, thereby blocking the actions of endogenous acetylcholine or exogenous agonists. oneirogen Any substance that produces or enhances dream-like states of consciousness. antipruritic drug A drug, usually applied topically, that relieves pruritus (itching). H1-receptor antagonist H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. anti-allergic agent A drug used to treat allergic reactions. antidyskinesia agent Any compound which can be used to treat or alleviate the symptoms of dyskinesia. local anaesthetic Any member of a group of drugs that reversibly inhibit the propagation of signals along nerves. Wide variations in potency, stability, toxicity, water-solubility and duration of action determine the route used for administration, e.g. topical, intravenous, epidural or spinal block. sedative A central nervous system depressant used to induce drowsiness or sleep or to reduce psychological excitement or anxiety. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| diphenhydramine (CHEBI:4636) has role anti-allergic agent (CHEBI:50857) |
| diphenhydramine (CHEBI:4636) has role antidyskinesia agent (CHEBI:66956) |
| diphenhydramine (CHEBI:4636) has role antiemetic (CHEBI:50919) |
| diphenhydramine (CHEBI:4636) has role antiparkinson drug (CHEBI:48407) |
| diphenhydramine (CHEBI:4636) has role antipruritic drug (CHEBI:59683) |
| diphenhydramine (CHEBI:4636) has role antitussive (CHEBI:51177) |
| diphenhydramine (CHEBI:4636) has role H1-receptor antagonist (CHEBI:37955) |
| diphenhydramine (CHEBI:4636) has role local anaesthetic (CHEBI:36333) |
| diphenhydramine (CHEBI:4636) has role muscarinic antagonist (CHEBI:48876) |
| diphenhydramine (CHEBI:4636) has role oneirogen (CHEBI:146270) |
| diphenhydramine (CHEBI:4636) has role sedative (CHEBI:35717) |
| diphenhydramine (CHEBI:4636) is a ether (CHEBI:25698) |
| diphenhydramine (CHEBI:4636) is a tertiary amino compound (CHEBI:50996) |
| Incoming Relation(s) |
| dimenhydrinate (CHEBI:4604) has part diphenhydramine (CHEBI:4636) |
| diphenhydramine hydrochloride (CHEBI:4637) has part diphenhydramine (CHEBI:4636) |
| diphenhydramine salicylate (CHEBI:34720) has part diphenhydramine (CHEBI:4636) |
| IUPAC Name |
|---|
| 2-(diphenylmethoxy)-N,N-dimethylethanamine |
| INNs | Source |
|---|---|
| difenhidramina | ChemIDplus |
| diphenhydramine | ChemIDplus |
| diphenhydraminum | ChemIDplus |
| Synonyms | Source |
|---|---|
| β-dimethylaminoethanol diphenylmethyl ether | ChemIDplus |
| 2-(benzhydryloxy)-N,N-dimethylethylamine | ChemIDplus |
| N-(2-(diphenylmethoxy)ethyl)-N,N-dimethylamine | ChemIDplus |
| α-(2-dimethylaminoethoxy)diphenylmethane | ChemIDplus |
| β-dimethylaminoethyl benzhydryl ether | ChEBI |
| 2-diphenylmethoxy-N,N-demthylethanamine | ChEBI |