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CHEBI:4636 - diphenhydramine
| Formula | C17H21NO |
| Net Charge | 0 |
| Average Mass | 255.361 |
| Monoisotopic Mass | 255.16231 |
| SMILES | CN(C)CCOC(c1ccccc1)c1ccccc1 |
| InChI | InChI=1S/C17H21NO/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16/h3-12,17H,13-14H2,1-2H3 |
| InChIKey | ZZVUWRFHKOJYTH-UHFFFAOYSA-N |
| Wikipedia |
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| Roles Classification |
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| Chemical Role: | Bronsted base A molecular entity capable of accepting a hydron from a donor (Brønsted acid). |
| Biological Roles: | H1-receptor antagonist H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. anti-HBV agent An antiviral agent that destroys or inhibits the replication of the hepatitis B virus. muscarinic antagonist A drug that binds to but does not activate muscarinic cholinergic receptors, thereby blocking the actions of endogenous acetylcholine or exogenous agonists. |
| Applications: | antipsychotic agent Antipsychotic drugs are agents that control agitated psychotic behaviour, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. local anaesthetic Any member of a group of drugs that reversibly inhibit the propagation of signals along nerves. Wide variations in potency, stability, toxicity, water-solubility and duration of action determine the route used for administration, e.g. topical, intravenous, epidural or spinal block. H1-receptor antagonist H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. antiparkinson drug A drug used in the treatment of Parkinson's disease. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. renoprotective agent Any compound that is able to prevent damage to the kidneys. dermatologic drug A drug used to treat or prevent skin disorders or for the routine care of skin. anti-inflammatory agent Any compound that has anti-inflammatory effects. oneirogen Any substance that produces or enhances dream-like states of consciousness. sedative A central nervous system depressant used to induce drowsiness or sleep or to reduce psychological excitement or anxiety. antidyskinesia agent Any compound which can be used to treat or alleviate the symptoms of dyskinesia. anti-allergic agent A drug used to treat allergic reactions. antitussive An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration. antipruritic drug A drug, usually applied topically, that relieves pruritus (itching). antidepressant Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. antiemetic A drug used to prevent nausea or vomiting. An antiemetic may act by a wide range of mechanisms: it might affect the medullary control centres (the vomiting centre and the chemoreceptive trigger zone) or affect the peripheral receptors. antifibrotic agent Any agent which acts to reduce fibrosis. muscarinic antagonist A drug that binds to but does not activate muscarinic cholinergic receptors, thereby blocking the actions of endogenous acetylcholine or exogenous agonists. anxiolytic drug Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| diphenhydramine (CHEBI:4636) has role analgesic (CHEBI:35480) |
| diphenhydramine (CHEBI:4636) has role anti-allergic agent (CHEBI:50857) |
| diphenhydramine (CHEBI:4636) has role anti-HBV agent (CHEBI:64951) |
| diphenhydramine (CHEBI:4636) has role anti-inflammatory agent (CHEBI:67079) |
| diphenhydramine (CHEBI:4636) has role antidepressant (CHEBI:35469) |
| diphenhydramine (CHEBI:4636) has role antidyskinesia agent (CHEBI:66956) |
| diphenhydramine (CHEBI:4636) has role antiemetic (CHEBI:50919) |
| diphenhydramine (CHEBI:4636) has role antifibrotic agent (CHEBI:233423) |
| diphenhydramine (CHEBI:4636) has role antineoplastic agent (CHEBI:35610) |
| diphenhydramine (CHEBI:4636) has role antiparkinson drug (CHEBI:48407) |
| diphenhydramine (CHEBI:4636) has role antipruritic drug (CHEBI:59683) |
| diphenhydramine (CHEBI:4636) has role antipsychotic agent (CHEBI:35476) |
| diphenhydramine (CHEBI:4636) has role antitussive (CHEBI:51177) |
| diphenhydramine (CHEBI:4636) has role anxiolytic drug (CHEBI:35474) |
| diphenhydramine (CHEBI:4636) has role dermatologic drug (CHEBI:50177) |
| diphenhydramine (CHEBI:4636) has role H1-receptor antagonist (CHEBI:37955) |
| diphenhydramine (CHEBI:4636) has role immunosuppressive agent (CHEBI:35705) |
| diphenhydramine (CHEBI:4636) has role local anaesthetic (CHEBI:36333) |
| diphenhydramine (CHEBI:4636) has role muscarinic antagonist (CHEBI:48876) |
| diphenhydramine (CHEBI:4636) has role oneirogen (CHEBI:146270) |
| diphenhydramine (CHEBI:4636) has role renoprotective agent (CHEBI:231911) |
| diphenhydramine (CHEBI:4636) has role sedative (CHEBI:35717) |
| diphenhydramine (CHEBI:4636) is a ether (CHEBI:25698) |
| diphenhydramine (CHEBI:4636) is a tertiary amino compound (CHEBI:50996) |
| Incoming Relation(s) |
| dimenhydrinate (CHEBI:4604) has part diphenhydramine (CHEBI:4636) |
| diphenhydramine hydrochloride (CHEBI:4637) has part diphenhydramine (CHEBI:4636) |
| diphenhydramine salicylate (CHEBI:34720) has part diphenhydramine (CHEBI:4636) |
| IUPAC Name |
|---|
| 2-(diphenylmethoxy)-N,N-dimethylethanamine |
| INNs | Source |
|---|---|
| difenhidramina | ChemIDplus |
| diphenhydramine | ChemIDplus |
| diphenhydraminum | ChemIDplus |
| Synonyms | Source |
|---|---|
| 2-(benzhydryloxy)-N,N-dimethylethylamine | ChemIDplus |
| 2-diphenylmethoxy-N,N-demthylethanamine | ChEBI |
| Diphenhdyra | ChEMBL |
| N-(2-(diphenylmethoxy)ethyl)-N,N-dimethylamine | ChemIDplus |
| O-benzhydryldimethylaminoethanol | ChEBI |
| Restamin | ChEMBL |
| Citations |
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