EMBL-EBI | Chemical Biology | ChEBI
Example searches: iron*, InChI=1S/CH4O/c1-2/h2H,1H3, caffeine | Advanced Search
CHEBI:4027 - cyclophosphamide
| Formula | C7H15Cl2N2O2P |
| Net Charge | 0 |
| Average Mass | 261.089 |
| Monoisotopic Mass | 260.02482 |
| SMILES | O=P1(N(CCCl)CCCl)NCCCO1 |
| InChI | InChI=1S/C7H15Cl2N2O2P/c8-2-5-11(6-3-9)14(12)10-4-1-7-13-14/h1-7H2,(H,10,12) |
| InChIKey | CMSMOCZEIVJLDB-UHFFFAOYSA-N |
| Wikipedia |
|---|
| Roles Classification |
|---|
| Chemical Role: | environmental contaminant Any minor or unwanted substance introduced into the environment that can have undesired effects. |
| Biological Roles: | immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. antitubercular agent A substance that kills or slows the growth of Mycobacterium tuberculosis and is used in the treatment of tuberculosis. alkylating agent Highly reactive chemical that introduces alkyl radicals into biologically active molecules and thereby prevents their proper functioning. It could be used as an antineoplastic agent, but it might be very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. It could also be used as a component of poison gases. carcinogenic agent A role played by a chemical compound which is known to induce a process of carcinogenesis by corrupting normal cellular pathways, leading to the acquistion of tumoral capabilities. drug allergen Any drug which causes the onset of an allergic reaction. anti-HIV agent An antiviral agent that destroys or inhibits the replication of the human immunodeficiency virus. xenobiotic A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means. alkylating agent Highly reactive chemical that introduces alkyl radicals into biologically active molecules and thereby prevents their proper functioning. It could be used as an antineoplastic agent, but it might be very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. It could also be used as a component of poison gases. |
| Applications: | antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. antitubercular agent A substance that kills or slows the growth of Mycobacterium tuberculosis and is used in the treatment of tuberculosis. antifibrotic agent Any agent which acts to reduce fibrosis. renoprotective agent Any compound that is able to prevent damage to the kidneys. nephroprotective agent Any protective agent that is able to prevent damage to the kidney. anti-inflammatory agent Any compound that has anti-inflammatory effects. anticoagulant An agent that prevents blood clotting. anti-anaemic agent A compound which increases either the number of red cells or the amount of haemoglobin in the blood. antiemetic A drug used to prevent nausea or vomiting. An antiemetic may act by a wide range of mechanisms: it might affect the medullary control centres (the vomiting centre and the chemoreceptive trigger zone) or affect the peripheral receptors. drug allergen Any drug which causes the onset of an allergic reaction. antirheumatic drug A drug used to treat rheumatoid arthritis. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| cyclophosphamide (CHEBI:4027) has role alkylating agent (CHEBI:22333) |
| cyclophosphamide (CHEBI:4027) has role anti-anaemic agent (CHEBI:75835) |
| cyclophosphamide (CHEBI:4027) has role anti-HIV agent (CHEBI:64946) |
| cyclophosphamide (CHEBI:4027) has role anti-inflammatory agent (CHEBI:67079) |
| cyclophosphamide (CHEBI:4027) has role anticoagulant (CHEBI:50249) |
| cyclophosphamide (CHEBI:4027) has role antiemetic (CHEBI:50919) |
| cyclophosphamide (CHEBI:4027) has role antifibrotic agent (CHEBI:233423) |
| cyclophosphamide (CHEBI:4027) has role antineoplastic agent (CHEBI:35610) |
| cyclophosphamide (CHEBI:4027) has role antirheumatic drug (CHEBI:35842) |
| cyclophosphamide (CHEBI:4027) has role antitubercular agent (CHEBI:33231) |
| cyclophosphamide (CHEBI:4027) has role carcinogenic agent (CHEBI:50903) |
| cyclophosphamide (CHEBI:4027) has role drug allergen (CHEBI:88188) |
| cyclophosphamide (CHEBI:4027) has role environmental contaminant (CHEBI:78298) |
| cyclophosphamide (CHEBI:4027) has role immunosuppressive agent (CHEBI:35705) |
| cyclophosphamide (CHEBI:4027) has role nephroprotective agent (CHEBI:76595) |
| cyclophosphamide (CHEBI:4027) has role renoprotective agent (CHEBI:231911) |
| cyclophosphamide (CHEBI:4027) has role xenobiotic (CHEBI:35703) |
| cyclophosphamide (CHEBI:4027) is a nitrogen mustard (CHEBI:37598) |
| cyclophosphamide (CHEBI:4027) is a organochlorine compound (CHEBI:36683) |
| cyclophosphamide (CHEBI:4027) is a phosphorodiamide (CHEBI:35467) |
| Incoming Relation(s) |
| cyclophosphamide hydrate (CHEBI:4026) has part cyclophosphamide (CHEBI:4027) |
| IUPAC Name |
|---|
| N,N-bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide |
| Synonyms | Source |
|---|---|
| 2-[Bis(2-chloroethylamino)]-tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide | NIST Chemistry WebBook |
| B-518 | ChEMBL |
| Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester | ChemIDplus |
| Ciclofosfamide | ChEMBL |
| Cycloblastin | ChEMBL |
| (+-)-Cyclophosphamide | ChemIDplus |
| Brand Names | Source |
|---|---|
| Cytoxan | ChEMBL |
| Cytoxan (lyophilized) | ChEMBL |
| Endoxana | ChEMBL |
| Lyophilized cytoxan | ChEMBL |
| Neosar | ChEMBL |
| Manual Xrefs | Databases |
|---|---|
| 758 | DrugCentral |
| C07888 | KEGG COMPOUND |
| Cyclophosphamide | Wikipedia |
| D07760 | KEGG DRUG |
| DB00531 | DrugBank |
| HMDB0014672 | HMDB |
| LSM-4961 | LINCS |
| Citations |
|---|