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CHEBI:37943 - colistin

ChEBI IDCHEBI:37943
ChEBI Namecolistin
Stars
DefinitionA multi-component mixture comprising mostly of colistin A (R = Me) and B (R = H), with small amounts of colistin C and other polymyxins, produced by certain strains of Bacillus polymyxa var. colistinus. An antibiotic, it is used as its sulfate salt (for oral or topical use) or as the sodium salt of the N-methylsulfonic acid derivative (the injectable form) in the treatment of severe Gram-negative infections, partiularly those due to Pseudomonas aeruginosa.
Secondary ChEBI IDsCHEBI:34651, CHEBI:472593, CHEBI:560465, CHEBI:566816, CHEBI:596826, CHEBI:597111, CHEBI:600596, CHEBI:659853
Last Modified3 December 2019
DownloadsMolfile
FormulaC52H97N16O13R
Average Mass (excl. R groups)1154.428
Monoisotopic Mass (excl. R groups)1153.74210
SMILES*C[C@@H](C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H](C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O)[C@@H](C)O
Roles Classification
Chemical Roles:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Roles:
nephrotoxic agent  A role played by any chemical compound (natural or synthetic) exhibiting itself through the ability to induce damage to the kidneys.
antimicrobial agent  A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.
antimicrobial agent  A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.
antibacterial agent  A substance (or active part thereof) that kills or slows the growth of bacteria.
ChEBI Ontology
Outgoing Relation(s)
colistin (CHEBI:37943) has part colistin A (CHEBI:59064)
colistin (CHEBI:37943) has part colistin B (CHEBI:59673)
colistin (CHEBI:37943) has role nephrotoxic agent (CHEBI:50909)
colistin (CHEBI:37943) is a peptide antibiotic (CHEBI:25903)
colistin (CHEBI:37943) is a polymyxin (CHEBI:59062)
Incoming Relation(s)
colistimethate (CHEBI:59662) has functional parent colistin (CHEBI:37943)
colistimethate sodium (CHEBI:34650) has functional parent colistin (CHEBI:37943)
INNs  Source
colistineChemIDplus
colistinumChemIDplus
colistinaChemIDplus
Synonyms  Source
ColistinChEMBL
polymyxin EChemIDplus
Manual XrefsDatabases
C13768KEGG COMPOUND
D02138KEGG DRUG
DB00803DrugBank
Registry NumbersSources
CAS:1264-72-8KEGG COMPOUND
CAS:1264-72-8ChemIDplus
CAS:1066-17-7ChemIDplus
Citations