EMBL-EBI | Chemical Biology | ChEBI

Example searches: iron*, InChI=1S/CH4O/c1-2/h2H,1H3, caffeine | Advanced Search

CHEBI:34650 - colistimethate sodium

Default Structure
ChEBI IDCHEBI:34650
ChEBI Namecolistimethate sodium
Stars
DefinitionA mixture where R = H or Me. Colistin in which each of the primary amino groups is converted to the corresponding aminomethanesulfonic acid sodium salt, commonly by the action of formaldehyde followed by sodium bisulfite. A polymyxin antibiotic derivative, it is used in the treatment of severe infections, particularly of multidrug-resistant Gram-negative bacteria such as Pseudomonas aeruginosa and Acinetobacter baumannii.
Secondary ChEBI IDCHEBI:597110
Last Modified3 December 2019
DownloadsMolfile
FormulaC57H102N16Na5O28S5R
Net Charge0
Average Mass (excl. R groups)1734.792
Monoisotopic Mass (excl. R groups)1733.51415
SMILES*C[C@@H](C)CCCCC(=O)N[C@@H](CCNCS(=O)(=O)[O-])C(=O)N[C@H](C(=O)N[C@@H](CCNCS(=O)(=O)[O-])C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCNCS(=O)(=O)[O-])NC(=O)[C@H](CCNCS(=O)(=O)[O-])NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCNCS(=O)(=O)[O-])NC1=O)[C@@H](C)O.[Na+].[Na+].[Na+].[Na+].[Na+]
Roles Classification
Chemical Roles:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Roles:
antibacterial agent  A substance (or active part thereof) that kills or slows the growth of bacteria.
antimicrobial agent  A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.
antimicrobial agent  A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.
antibacterial agent  A substance (or active part thereof) that kills or slows the growth of bacteria.
antimicrobial agent  A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.
Applications:
antiinfective agent  A substance used in the prophylaxis or therapy of infectious diseases.
prodrug  A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug.
ChEBI Ontology
Outgoing Relation(s)
colistimethate sodium (CHEBI:34650) has functional parent colistin (CHEBI:37943)
colistimethate sodium (CHEBI:34650) has part colistimethate(5−) (CHEBI:59661)
colistimethate sodium (CHEBI:34650) has part colistin A sodium methanesulfonate (CHEBI:59663)
colistimethate sodium (CHEBI:34650) has part colistin B sodium methanesulfonate (CHEBI:59664)
colistimethate sodium (CHEBI:34650) has role antibacterial agent (CHEBI:33282)
colistimethate sodium (CHEBI:34650) has role antiinfective agent (CHEBI:35441)
colistimethate sodium (CHEBI:34650) has role antimicrobial agent (CHEBI:33281)
colistimethate sodium (CHEBI:34650) has role prodrug (CHEBI:50266)
colistimethate sodium (CHEBI:34650) is a organic sodium salt (CHEBI:38700)
colistimethate sodium (CHEBI:34650) is a peptide antibiotic (CHEBI:25903)
colistimethate sodium (CHEBI:34650) is a polymyxin (CHEBI:59062)
INNs  Source
colistimetato de sodioWHO MedNet
colistimethate sodiqueWHO MedNet
colistimethate sodiumChemIDplus
Synonyms  Source
AlficetinChEMBL
CmsChEMBL
ColimicinaChEMBL
ColimycinChEMBL
ColimycineChEMBL
colistimethateDrugBank
Brand Names  Source
ColobreatheChEMBL
Coly-mycinChEMBL
PromixinChEMBL
Manual XrefsDatabases
C13553KEGG COMPOUND
D02049KEGG DRUG
DB01111DrugBank
Registry NumbersSources
CAS:8068-28-8ChemIDplus
CAS:8068-28-8KEGG COMPOUND
Citations