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CHEBI:3723 - citalopram
| ChEBI ID | CHEBI:3723 |
| ChEBI Name | citalopram |
| Stars | |
| Definition | A racemate comprising equimolar amounts of (R)-citalopram and its enantiomer, escitalopram. It is used as an antidepressant, although only escitalopram is active. |
| Last Modified | 22 February 2017 |
| Formula | C20H21FN2O |
| Net Charge | 0 |
| Average Mass | 324.393 |
| Monoisotopic Mass | 324.16379 |
| Wikipedia |
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| Roles Classification |
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| Chemical Role: | environmental contaminant Any minor or unwanted substance introduced into the environment that can have undesired effects. |
| Biological Roles: | xenobiotic A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means. serotonin uptake inhibitor A compound that specifically inhibits the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent. EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor An EC 1.8.1.* (oxidoreductase acting on sulfur group of donors, NAD+ or NADP+ as acceptor) inhibitor that interferes with the action of trypanothione-disulfide reductase (EC 1.8.1.12). EC 3.4.21.26 (prolyl oligopeptidase) inhibitor Any EC 3.4.21.* (serine endopeptidase) inhibitor that interferes with the action of prolyl oligopeptidase (EC 3.4.21.26). |
| Applications: | serotonin uptake inhibitor A compound that specifically inhibits the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent. antidepressant Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| citalopram (CHEBI:3723) has part (R)-citalopram (CHEBI:36792) |
| citalopram (CHEBI:3723) has part escitalopram (CHEBI:36791) |
| citalopram (CHEBI:3723) has role antidepressant (CHEBI:35469) |
| citalopram (CHEBI:3723) has role EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor (CHEBI:77402) |
| citalopram (CHEBI:3723) has role EC 3.4.21.26 (prolyl oligopeptidase) inhibitor (CHEBI:76779) |
| citalopram (CHEBI:3723) has role environmental contaminant (CHEBI:78298) |
| citalopram (CHEBI:3723) has role serotonin uptake inhibitor (CHEBI:50949) |
| citalopram (CHEBI:3723) has role xenobiotic (CHEBI:35703) |
| citalopram (CHEBI:3723) is a racemate (CHEBI:60911) |
| IUPAC Name |
|---|
| rac-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile |
| INNs | Source |
|---|---|
| citalopram | ChemIDplus |
| citalopram | WHO MedNet |
| citalopram | WHO MedNet |
| citalopramum | ChemIDplus |
| Synonyms | Source |
|---|---|
| 1,3-dihydro-1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-5-isobenzofurancarbonitrile | ChemIDplus |
| 1-(3-(dimethylamino)propyl)-1-(p-fluorophenyl)-5-phthalancarbonitrile | ChemIDplus |
| Citalopram | KEGG COMPOUND |
| Lu 10-171 | ChemIDplus |
| Nitalapram | ChemIDplus |
| Brand Names | Source |
|---|---|
| Cipram | ChemIDplus |
| Citadur | KEGG DRUG |
| Manual Xrefs | Databases |
|---|---|
| C07572 | KEGG COMPOUND |
| Citalopram | Wikipedia |
| D07704 | KEGG DRUG |
| DB00215 | DrugBank |
| DE2657013 | Patent |
| EP0171943 | Patent |
| EP1506963 | Patent |
| HMDB0005038 | HMDB |
| US4136193 | Patent |
| Registry Numbers | Sources |
|---|---|
| Reaxys:1397373 | Reaxys |
| CAS:59729-33-8 | NIST Chemistry WebBook |
| CAS:59729-33-8 | ChemIDplus |
| CAS:59729-33-8 | KEGG COMPOUND |
| Citations |
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