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CHEBI:2639 - amiloride

ChEBI IDCHEBI:2639
ChEBI Nameamiloride
Stars
DefinitionA member of the class of pyrazines resulting from the formal monoacylation of guanidine with the carboxy group of 3,5-diamino-6-chloropyrazine-2-carboxylic acid.
Secondary ChEBI IDCHEBI:47210
Last Modified26 July 2017
DownloadsMolfile
FormulaC6H8ClN7O
Net Charge0
Average Mass229.631
Monoisotopic Mass229.04789
SMILESN=C(N)NC(=O)c1nc(Cl)c(N)nc1N
InChIInChI=1S/C6H8ClN7O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11/h(H4,8,9,13)(H4,10,11,14,15)
InChIKeyXSDQTOBWRPYKKA-UHFFFAOYSA-N
Wikipedia
Roles Classification
Chemical Role:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Role:
sodium channel blocker  An agent that inhibits sodium influx through cell membranes.
Application:
diuretic  An agent that promotes the excretion of urine through its effects on kidney function.
ChEBI Ontology
Outgoing Relation(s)
amiloride (CHEBI:2639) has role diuretic (CHEBI:35498)
amiloride (CHEBI:2639) has role sodium channel blocker (CHEBI:38633)
amiloride (CHEBI:2639) is a aromatic amine (CHEBI:33860)
amiloride (CHEBI:2639) is a guanidines (CHEBI:24436)
amiloride (CHEBI:2639) is a organochlorine compound (CHEBI:36683)
amiloride (CHEBI:2639) is a pyrazines (CHEBI:38314)
amiloride (CHEBI:2639) is conjugate base of amiloride(1+) (CHEBI:84745)
Incoming Relation(s)
5-(N-methyl-N-propyl)amiloride (CHEBI:138016) has functional parent amiloride (CHEBI:2639)
5-(N,N-hexamethylene)amiloride (CHEBI:76400) has functional parent amiloride (CHEBI:2639)
ethylisopropylamiloride (CHEBI:136538) has functional parent amiloride (CHEBI:2639)
amiloride(1+) (CHEBI:84745) is conjugate acid of amiloride (CHEBI:2639)
IUPAC Name 
3,5-diamino-N-[amino(imino)methyl]-6-chloropyrazine-2-carboxamide
INNs  Source
amilorideChEBI
amiloridaChemIDplus
amiloridumChemIDplus
amilorideWHO MedNet
Synonyms  Source
AmilorideKEGG COMPOUND
N-Amidino-3,5-diamino-6-chloropyrazinecarboxamideChemIDplus
3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamideIUPAC
Manual XrefsDatabases
C06821KEGG COMPOUND
D07447KEGG DRUG
DB00594DrugBank
BE639386Patent
US3313813Patent
AmilorideWikipedia
HMDB0014732HMDB
AMRPDBeChem
LSM-4194LINCS
158DrugCentral
CPD-10324MetaCyc
Registry NumbersSources
Beilstein:616612Beilstein
Reaxys:657410Reaxys
CAS:2609-46-3KEGG COMPOUND
CAS:2609-46-3ChemIDplus
Citations