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CHEBI:2639 - amiloride
| Formula | C6H8ClN7O |
| Net Charge | 0 |
| Average Mass | 229.631 |
| Monoisotopic Mass | 229.04789 |
| SMILES | N=C(N)NC(=O)c1nc(Cl)c(N)nc1N |
| InChI | InChI=1S/C6H8ClN7O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11/h(H4,8,9,13)(H4,10,11,14,15) |
| InChIKey | XSDQTOBWRPYKKA-UHFFFAOYSA-N |
| Wikipedia |
|---|
| Roles Classification |
|---|
| Chemical Role: | Bronsted base A molecular entity capable of accepting a hydron from a donor (Brønsted acid). |
| Biological Roles: | immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. sodium channel blocker An agent that inhibits sodium influx through cell membranes. |
| Applications: | antihypertensive agent Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism. cardiovascular drug A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. diuretic An agent that promotes the excretion of urine through its effects on kidney function. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| amiloride (CHEBI:2639) has role antihypertensive agent (CHEBI:35674) |
| amiloride (CHEBI:2639) has role cardiovascular drug (CHEBI:35554) |
| amiloride (CHEBI:2639) has role diuretic (CHEBI:35498) |
| amiloride (CHEBI:2639) has role immunosuppressive agent (CHEBI:35705) |
| amiloride (CHEBI:2639) has role sodium channel blocker (CHEBI:38633) |
| amiloride (CHEBI:2639) is a aromatic amine (CHEBI:33860) |
| amiloride (CHEBI:2639) is a guanidines (CHEBI:24436) |
| amiloride (CHEBI:2639) is a organochlorine compound (CHEBI:36683) |
| amiloride (CHEBI:2639) is a pyrazines (CHEBI:38314) |
| amiloride (CHEBI:2639) is conjugate base of amiloride(1+) (CHEBI:84745) |
| Incoming Relation(s) |
| 5-(N-methyl-N-propyl)amiloride (CHEBI:138016) has functional parent amiloride (CHEBI:2639) |
| 5-(N,N-hexamethylene)amiloride (CHEBI:76400) has functional parent amiloride (CHEBI:2639) |
| ethylisopropylamiloride (CHEBI:136538) has functional parent amiloride (CHEBI:2639) |
| amiloride(1+) (CHEBI:84745) is conjugate acid of amiloride (CHEBI:2639) |
| IUPAC Name |
|---|
| 3,5-diamino-N-[amino(imino)methyl]-6-chloropyrazine-2-carboxamide |
| INNs | Source |
|---|---|
| amilorida | ChemIDplus |
| amiloride | ChEBI |
| amiloride | WHO MedNet |
| amiloridum | ChemIDplus |
| Synonyms | Source |
|---|---|
| 3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide | IUPAC |
| Amiclaran | ChEMBL |
| Amiloride | KEGG COMPOUND |
| N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide | ChemIDplus |
| Hydro-ride | ChEMBL |
| Registry Numbers | Sources |
|---|---|
| Beilstein:616612 | Beilstein |
| Reaxys:657410 | Reaxys |
| CAS:2609-46-3 | KEGG COMPOUND |
| CAS:2609-46-3 | ChemIDplus |
| Citations |
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