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CHEBI:136538 - ethylisopropylamiloride

Default Structure
ChEBI IDCHEBI:136538
ChEBI Nameethylisopropylamiloride
Stars
DefinitionA member of the class of pyrazines that is amiloride in which the amino substitutent of the pyrazine ring that is adjacent to the chloro substituent has been substituted by an ethyl group and by an isopropyl group.
Last Modified13 March 2017
SubmitterGareth Owen
DownloadsMolfile
FormulaC11H18ClN7O
Net Charge0
Average Mass299.766
Monoisotopic Mass299.12614
SMILESCCN(c1nc(N)c(C(=O)NC(=N)N)nc1Cl)C(C)C
InChIInChI=1S/C11H18ClN7O/c1-4-19(5(2)3)9-7(12)16-6(8(13)17-9)10(20)18-11(14)15/h5H,4H2,1-3H3,(H2,13,17)(H4,14,15,18,20)
InChIKeyQDERNBXNXJCIQK-UHFFFAOYSA-N
Roles Classification
Chemical Role:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Role:
sodium channel blocker  An agent that inhibits sodium influx through cell membranes.
Applications:
neuroprotective agent  Any compound that can be used for the treatment of neurodegenerative disorders.
anti-arrhythmia drug  A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres.
ChEBI Ontology
Outgoing Relation(s)
ethylisopropylamiloride (CHEBI:136538) has functional parent amiloride (CHEBI:2639)
ethylisopropylamiloride (CHEBI:136538) has role anti-arrhythmia drug (CHEBI:38070)
ethylisopropylamiloride (CHEBI:136538) has role neuroprotective agent (CHEBI:63726)
ethylisopropylamiloride (CHEBI:136538) has role sodium channel blocker (CHEBI:38633)
ethylisopropylamiloride (CHEBI:136538) is a aromatic amine (CHEBI:33860)
ethylisopropylamiloride (CHEBI:136538) is a guanidines (CHEBI:24436)
ethylisopropylamiloride (CHEBI:136538) is a monocarboxylic acid amide (CHEBI:29347)
ethylisopropylamiloride (CHEBI:136538) is a organochlorine compound (CHEBI:36683)
ethylisopropylamiloride (CHEBI:136538) is a pyrazines (CHEBI:38314)
ethylisopropylamiloride (CHEBI:136538) is a tertiary amino compound (CHEBI:50996)
IUPAC Name 
3-amino-N-carbamimidoyl-6-chloro-5-[ethyl(isopropyl)amino]pyrazine-2-carboxamide
Synonyms  Source
3-amino-N-(aminoiminomethyl)-6-chloro-5-(ethyl(1-methylethyl)amino)pyrazinecarboxamideChemIDplus
5-(N-ethyl-N-isopropyl)amilorideChemIDplus
5-(ethylisopropyl)amilorideChemIDplus
EIPAChemIDplus
N-amidino-3-amino-5-ethylisopropylamino-6-chloropyrazine carboxamideChemIDplus
ethyl isopropyl amilorideChemIDplus
Registry NumbersSources
CAS:1154-25-2ChemIDplus
Citations