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CHEBI:2089 - 5-methoxytryptamine
| Formula | C11H14N2O |
| Net Charge | 0 |
| Average Mass | 190.246 |
| Monoisotopic Mass | 190.11061 |
| SMILES | COc1ccc2ncc(CCN)c2c1 |
| InChI | InChI=1S/C11H14N2O/c1-14-9-2-3-11-10(6-9)8(4-5-12)7-13-11/h2-3,6-7,13H,4-5,12H2,1H3 |
| InChIKey | JTEJPPKMYBDEMY-UHFFFAOYSA-N |
| Wikipedia |
|---|
| Species of Metabolite | Component | Source | Comments |
|---|---|---|---|
| Homo sapiens (ncbitaxon:9606) | urine (BTO:0001419) | Article (Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.) | |
| Mus musculus (ncbitaxon:10090) | - | PubMed (19425150) | Source: BioModels - MODEL1507180067 |
| Brassica napus (ncbitaxon:3708) | leaf lamina (BTO:0000719) | MetaboLights (MTBLS309) | From MetaboLights |
| Roles Classification |
|---|
| Chemical Roles: | antioxidant A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides. Bronsted base A molecular entity capable of accepting a hydron from a donor (Brønsted acid). |
| Biological Roles: | 5-hydroxytryptamine 2C receptor agonist An agonist at the 5-hydroxytryptamine 2B (5-HT2C) receptor. mouse metabolite Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus). serotonergic agonist An agent that has an affinity for serotonin receptors and is able to mimic the effects of serotonin by stimulating the physiologic activity at the cell receptors. Serotonin agonists are used as antidepressants, anxiolytics, and in the treatment of migraine disorders. human metabolite Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens). 5-hydroxytryptamine 2B receptor agonist An agonist at the 5-hydroxytryptamine 2B (5-HT2B) receptor. 5-hydroxytryptamine 2A receptor agonist An agonist at the 5-hydroxytryptamine 2A (5-HT2A) receptor. |
| Applications: | cardioprotective agent Any protective agent that is able to prevent damage to the heart. neuroprotective agent Any compound that can be used for the treatment of neurodegenerative disorders. serotonergic agonist An agent that has an affinity for serotonin receptors and is able to mimic the effects of serotonin by stimulating the physiologic activity at the cell receptors. Serotonin agonists are used as antidepressants, anxiolytics, and in the treatment of migraine disorders. radiation protective agent Any compound that is able to protect normal cells from the damage caused by radiation therapy. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| 5-methoxytryptamine (CHEBI:2089) has functional parent serotonin (CHEBI:28790) |
| 5-methoxytryptamine (CHEBI:2089) has role 5-hydroxytryptamine 2A receptor agonist (CHEBI:145982) |
| 5-methoxytryptamine (CHEBI:2089) has role 5-hydroxytryptamine 2B receptor agonist (CHEBI:142184) |
| 5-methoxytryptamine (CHEBI:2089) has role 5-hydroxytryptamine 2C receptor agonist (CHEBI:142185) |
| 5-methoxytryptamine (CHEBI:2089) has role antioxidant (CHEBI:22586) |
| 5-methoxytryptamine (CHEBI:2089) has role cardioprotective agent (CHEBI:77307) |
| 5-methoxytryptamine (CHEBI:2089) has role human metabolite (CHEBI:77746) |
| 5-methoxytryptamine (CHEBI:2089) has role mouse metabolite (CHEBI:75771) |
| 5-methoxytryptamine (CHEBI:2089) has role neuroprotective agent (CHEBI:63726) |
| 5-methoxytryptamine (CHEBI:2089) has role radiation protective agent (CHEBI:66987) |
| 5-methoxytryptamine (CHEBI:2089) has role serotonergic agonist (CHEBI:35941) |
| 5-methoxytryptamine (CHEBI:2089) is a aromatic ether (CHEBI:35618) |
| 5-methoxytryptamine (CHEBI:2089) is a primary amino compound (CHEBI:50994) |
| 5-methoxytryptamine (CHEBI:2089) is a tryptamines (CHEBI:27162) |
| 5-methoxytryptamine (CHEBI:2089) is conjugate base of 5-methoxytryptamine(1+) (CHEBI:166874) |
| Incoming Relation(s) |
| 5-methoxy-N,N-diisopropyltryptamine (CHEBI:48282) has functional parent 5-methoxytryptamine (CHEBI:2089) |
| 5-methoxytryptamine(1+) (CHEBI:166874) is conjugate acid of 5-methoxytryptamine (CHEBI:2089) |
| IUPAC Name |
|---|
| 2-(5-methoxy-1H-indol-3-yl)ethanamine |
| Synonyms | Source |
|---|---|
| 5-Methoxytryptamine | KEGG COMPOUND |
| 5-MeOT | IUPHAR |
| 3-(2-aminoethyl)-5-methoxyindole | ChemIDplus |
| 5MOT | ChemIDplus |
| 5-MT | IUPHAR |
| mexamine | NIST Chemistry WebBook |
| Manual Xrefs | Databases |
|---|---|
| C05659 | KEGG COMPOUND |
| HMDB0004095 | HMDB |
| 5-Methoxytryptamine | Wikipedia |
| LSM-4582 | LINCS |
| F5U | PDBeChem |
| C00051985 | KNApSAcK |
| FDB023311 | FooDB |
| 1767 | ChemSpider |
| WO2005009419 | Patent |
| EP1653948 | Patent |
| Citations |
|---|