Reactome release 45

Reactome release 45 offers a number of new topics and updates to existing pathways.

New topics in this release

• Reproduction (Fertilization)
• SUMOylation (Processing and activation of SUMO). 

Topics with new or revised events

• Apoptosis (Extrinsic Pathway for Apoptosis)
• Binding and Uptake of Ligands by Scavenger Receptors
• Cell Cycle (Nuclear Pore Complex (NPC) Disassembly)
• Disease (Assembly Of The HIV Virion and Budding and maturation of HIV virion)
• Extracellular matrix organization (Non-integrin membrane-ECM interactions and ECM proteoglycans)
• Immune System (Complement cascade, Cytosolic sensors of pathogen-associated DNA, and Fc epsilon receptor (FCERI) signaling)
• Metabolism (Metabolism of vitamins and cofactors)
• Signal transduction (The phototransduction cascade, Signaling by NOTCH2, Signaling by GPCR, and Signaling by Wnt).

With thanks to our contributors

R Belew and A Niarakis

Thanks to our reviewers

W Antonin, M Boutros, S Boyle, DT Bradley, M Dubé, EJ Fuentes, AK Garg, MX Ilagan, L Jin, P Lishko, CL Makino, N Venkatesan, C Neyen, C Pop, S Ricard-Blum, R Roncagalli, GS Salvesen, and J Wu are our external reviewers.