Ligand clusters for UniProt code P10635

Ligand clusters for P10635: Cytochrome P450 2D6 from Homo sapiens

		Top 6 (of 11) ligand clusters Cluster 1. 15 ligand types 36 ligands Cluster 2. 2 ligand types 2 ligands Cluster 3. 1 ligand type 1 ligand Cluster 4. 1 ligand type 1 ligand Cluster 5. 1 ligand type 1 ligand Cluster 6. 1 ligand type 11 ligands
Representative protein: 3tbgA

Structures

PDB		Schematic diagram
3tbgA
3tdaA
4wntA
4wnvA
4xryA
		more ...

Cluster 1 contains 15 ligand types

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Ligand		Description
		1. Ligand: GOL × 7 glycerin Glycerol PDB codes: 3tbg(A), 4wnu(A), 4wnv(A), 4xrz(A).
		2. Ligand: DMS × 1 dimethyl sulfoxide Dimethyl sulfoxide PDB code: 4wnu(A).
		3. Ligand: QDN × 1 quinidine Quinidine PDB code: 4wnu(A).
		4. Ligand: QI9 × 1 quinine Quinine PDB code: 4wnv(A).
		5. Ligand: HEM × 10 Protoporphyrin IX containing fe PDB codes: 2f9q(A), 3tbg(A), 4wnt(A), 4wnu(A), 4wnv(A), 4wnw(A), 4xry(A), 5tft(A), 5tfu(A), 6csb(A).
		6. Ligand: RTZ × 5 10-{2-[(2r)-1-Methylpiperidin-2-Yl]ethyl}-2- (Methylsulfanyl)-10h-Phenothiazine PDB codes: 3tbg(A), 4wnw(A), 6csb(A),
		7. Ligand: HEM-PN0 × 3 HEM=Protoporphyrin IX containing fe, PN0=Prinomastat. PDB codes: 3qm4(A), 3tda(A), 6csd(A).
		8. Ligand: 2CV × 1 Hega-10 PDB code: 6csb(A).
		9. Ligand: AJN × 1 Ajmalicine PDB code: 4wnt(A).
		10. Ligand: CPS × 1 3-[(3-Cholamidopropyl)dimethylammonio]-1- Propanesulfonate PDB code: 6csd(A).
		11. Ligand: HEM-SI6 × 1 HEM=Protoporphyrin IX containing fe, SI6=(4ar,6r,8as)-8a-(2,4-Difluorophenyl)-6-(1h-Pyrazol-4- Yl)-4,4a,5,6,8,8a-Hexahydropyrano[3,4- D][1,3]thiazin- 2-Amine. PDB code: 4xrz(A).
		12. Ligand: P6M × 1 (4s,6r)-4-[2,4-Difluoro-5-({[1-(Trifluoromethyl) cyclopropyl]amino}methyl)phenyl]-4,6-Dimethyl-5,6- Dihydro-4h-1,3-Thiazin-2-Amine PDB code: 5tfu(A).
		13. Ligand: P6U × 1 (4s)-4-[2,4-Difluoro-5-({[1-(Trifluoromethyl) cyclopropyl]amino}methyl)phenyl]-4-Methyl-5,6- Dihydro- 4h-1,3-Thiazin-2-Amine PDB code: 5tft(A).
		14. Ligand: SI5 × 1 (4ar,6r,8as)-8a-(2,4-Difluorophenyl)-6-(1-Methyl-1h- Pyrazol-4-Yl)-4,4a,5,6,8,8a- Hexahydropyrano[3,4-D][1, 3]thiazin-2-Amine PDB code: 4xry(A).
_Na		15. Metal: _NA × 1 PDB code: 4wnw(A).

Cluster 2 contains 2 ligand types

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Ligand		Description
		1. Ligand: GOL × 1 glycerin Glycerol PDB code: 4wnu(A).
		2. Ligand: PO4 × 1 Phosphate ion PDB code: 3tbg(A).

Cluster 3 contains 1 ligand type

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Ligand		Description
		1. Ligand: GOL × 1 glycerin Glycerol PDB code: 3tbg(A).

Cluster 4 contains 1 ligand type

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Ligand		Description
		1. Ligand: GOL × 1 glycerin Glycerol PDB code: 3tbg(A).

Cluster 5 contains 1 ligand type

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Ligand		Description
		1. Ligand: GOL × 1 glycerin Glycerol PDB code: 3tbg(A).

Cluster 6 contains 1 ligand type

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Ligand		Description
_Zn		1. Metal: _ZN × 11 PDB codes: 3tbg(A), 3tda(A), 4wnt(A), 4wnu(A), 4wnv(A), 4xry(A), 4xrz(A), 5tft(A), 5tfu(A), 6csb(A), 6csd(A).