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PDBsum entry 5tft
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Oxidoreductase/oxidoreductase inhibitor
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PDB id
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5tft
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PDB id:
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| Name: |
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Oxidoreductase/oxidoreductase inhibitor
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Title:
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Structure of cytochrome p450 2d6 (cyp2d6) bace1 inhibitor complex
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Structure:
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Cytochrome p450 2d6. Chain: a, b, c, d. Fragment: unp residues 34-497. Synonym: cypiid6,cholesterol 25-hydroxylase,cytochrome p450-db1, debrisoquine 4-hydroxylase. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: cyp2d6, cyp2dl1. Expressed in: escherichia coli dh5[alpha]. Expression_system_taxid: 668369.
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Resolution:
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2.71Å
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R-factor:
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0.213
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R-free:
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0.245
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Authors:
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M.H.Hsu,E.F.Johnson
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Key ref:
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C.R.Butler
et al.
(2017).
Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality.
J Med Chem,
60,
386-402.
PubMed id:
DOI:
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Date:
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26-Sep-16
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Release date:
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11-Jan-17
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PROCHECK
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Headers
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References
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P10635
(CP2D6_HUMAN) -
Cytochrome P450 2D6 from Homo sapiens
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Seq:
Struc:
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497 a.a.
467 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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*
PDB and UniProt seqs differ
at 3 residue positions (black
crosses)
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DOI no:
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J Med Chem
60:386-402
(2017)
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PubMed id:
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Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality.
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C.R.Butler,
K.Ogilvie,
L.Martinez-Alsina,
G.Barreiro,
E.M.Beck,
C.E.Nolan,
K.Atchison,
E.Benvenuti,
L.Buzon,
S.Doran,
C.Gonzales,
C.J.Helal,
X.Hou,
M.H.Hsu,
E.F.Johnson,
K.Lapham,
L.Lanyon,
K.Parris,
B.T.O'Neill,
D.Riddell,
A.Robshaw,
F.Vajdos,
M.A.Brodney.
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ABSTRACT
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Links
