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DB00908 : quinidine

Approved drug quinidine ... 4 targets DB00908

Generic name: quinidine
 
Brand name(s): apo-quinidine, biquin durules, cardioquin, chinidin, cin-quin, coccinine, conchinin, conchinine, conquinine, duraquin, kinidin, novoquinidin, pitayin, pitayine, quin-release, quinact, quinaglute, quinaglute dura-tabs, quinalan, quinate, quinatime, quindine, quinicardine, quinidex, quinidex extentabs, quinora.
Formula: C20H24N2O2
IUPAC Formula: (S)-[(2r,4s,5r)-5-Ethenyl-1-Azabicyclo[2.2.2]octan-2-Yl](6-Methoxyquinolin-4-Yl)methanol

4
There are 4 target proteins defined in DrugBank for this drug.
 3 
3 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: Q14524 (SCN5A_HUMAN)  -  Sodium channel protein type 5 subunit alpha
UniProt id: Q14524    2015 a.a.  
1. 4dck A     153 a.a. 153   X-ray 2.20 Å
  2. 4jq0 D     142 a.a. 142   X-ray 3.84 Å
  3. 2kbi A     97 a.a. 93   NMR  
  4. 2l53 B     31 a.a. 27   NMR  
  5. 4djc B     13 a.a. 11   X-ray 1.35 Å
There are no PDB entries containing quinidine bound to this target protein, although there are 5 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 2:   UniProt id: O00180 (KCNK1_HUMAN)  -  Potassium channel subfamily K member 1
UniProt id: O00180    335 a.a.  
3ukm A,B,C,D     252 a.a. 249   X-ray 3.40 Å
There are no PDB entries containing quinidine bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 3:   UniProt id: Q9Y257 (KCNK6_HUMAN)  -  Potassium channel subfamily K member 6
UniProt id: Q9Y257    313 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 4:   UniProt id: Q12809 (KCNH2_HUMAN)  -  Potassium voltage-gated channel subfamily H member 2
UniProt id: Q12809    1158 a.a.  
1. 2l0w A     135 a.a. 134   NMR  
  2. 2l1m A     135 a.a. 134   NMR  
  3. 2l4r A     135 a.a. 134   NMR  
  4. 4hp9 A     119 a.a. 119   X-ray 2.12 Å
  5. 4hqa A     110 a.a. 110   X-ray 1.96 Å
   more ...
There are no PDB entries containing quinidine bound to this target protein, although there are 8 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

 

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