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DB01093 : dimethyl sulfoxide

Approved drug dimethyl sulfoxide ... 0 targets DB01093

Generic name: dimethyl sulfoxide PDB Het Group: DMS
 
787 structures in PDB
Brand name(s): decap, deltan, demasorb, demavet, demeso, demsodrox, dermasorb, dimexide, dipirartril-tropico, dolicur, doligur, domoso, dromisol, durasorb, gamasol 90, hyadur, infiltrina, kemsol, rimso 50, sclerosol, somipront, syntexan, topsym.
Formula: C2H6Os
IUPAC Formula: Methanesulfinylmethane
PDB name: Dimethyl sulfoxide

0
There are no target proteins defined in DrugBank for this drug.
 636 
There are 636 PDB structures containing the drug molecule bound to a protein that is not specified as a target.
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Other proteins with dimethyl sulfoxide bound in the PDB

There are 164 "non-target" proteins in the PDB containing the dimethyl sulfoxide molecule bound. That is, the UniProt code for the proteins is missing or does not match any of the drug targets listed above. the drug target above. Only 10 of the 164 proteins are listed below.

Protein 1:   UniProt id: A4KCE5 ()  -  Tautomycetin biosynthetic PKS OS=Streptomyces sp. CK4412 PE=1 SV=1
UniProt id: A4KCE5    7619 a.a.  
3lcr A,B   273 a.a. 273   X-ray 2.00 Å
The PDB contains 1 entry of dimethyl sulfoxide bound to this protein
Protein 2:   UniProt id: A4SNL2 ()  -  Two-component system response regulator/GGDEF domain protein OS=Aeromonas salmonicida (strain A449) GN=ASA_2441 PE=1 SV=1
UniProt id: A4SNL2    414 a.a.  
3luf A,B   244 a.a. 240   X-ray 1.76 Å
The PDB contains 1 entry of dimethyl sulfoxide bound to this protein
Protein 3:   UniProt id: A5HZZ9 ()  -  Botulinum neurotoxin type A OS=Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A) GN=botA PE=1 SV=1
UniProt id: A5HZZ9    1296 a.a.  
4kuf A   425 a.a. 422   X-ray 1.70 Å
The PDB contains 1 entry of dimethyl sulfoxide bound to this protein
Protein 4:   UniProt id: A5K1A2 ()  -  Glycylpeptide N-tetradecanoyltransferase OS=Plasmodium vivax (strain Salvador I) GN=PVX_085815 PE=1 SV=1
UniProt id: A5K1A2    409 a.a.  
1. 2ynd A,B,C   385 a.a. 385   X-ray 1.89 Å
  2. 4cae A,B,C   384 a.a. 384   X-ray 1.46 Å
  3. 4b14 A,B,C   385 a.a. 384   X-ray 1.50 Å
  4. 4b10 A,B,C   385 a.a. 384   X-ray 1.56 Å
  5. 4b11 A,B,C   385 a.a. 384   X-ray 1.59 Å
 
The PDB contains 10 entries of dimethyl sulfoxide bound to this protein
Protein 5:   UniProt id: A7J8L3 ()  -  Orf1a polyprotein OS=Human SARS coronavirus GN=orf1ab PE=1 SV=1
UniProt id: A7J8L3    4381 a.a.  
2vj1 A,B   300 a.a. 300   X-ray 2.25 Å
The PDB contains 1 entry of dimethyl sulfoxide bound to this protein
Protein 6:   UniProt id: A7LS78 ()  -  IgA Peptidase M64 OS=Bacteroides ovatus (strain ATCC 8483 / DSM 1896 / JCM 5824 / NCTC 11153) GN=BACOVA_00663 PE=1 SV=1
UniProt id: A7LS78    424 a.a.  
3p1v A,B   406 a.a. 406   X-ray 1.93 Å
The PDB contains 1 entry of dimethyl sulfoxide bound to this protein
Protein 7:   UniProt id: A8Z540 ()  -  Possible esterase OS=Staphylococcus aureus (strain USA300 / TCH1516) GN=USA300HOU_2331 PE=1 SV=1
UniProt id: A8Z540    305 a.a.  
3d7r A,B   296 a.a. 296   X-ray 2.01 Å
The PDB contains 1 entry of dimethyl sulfoxide bound to this protein
Protein 8:   UniProt id: A9LIE0 ()  -  Polyprotein OS=Dengue virus 3 PE=4 SV=1
UniProt id: A9LIE0    3389 a.a.  
4ctk A,C   257 a.a. 257   X-ray 1.53 Å
The PDB contains 1 entry of dimethyl sulfoxide bound to this protein
Protein 9:   UniProt id: B9RU15 ()  -  Probable Histone-lysine N-methyltransferase ATXR5 OS=Ricinus communis GN=ATXR5 PE=1 SV=1
UniProt id: B9RU15    373 a.a.  
4o30 A,B   217 a.a. 217   X-ray 2.10 Å
The PDB contains 1 entry of dimethyl sulfoxide bound to this protein
Protein 10:   UniProt id: C3L5T6 ()  -  Probable nicotinate-nucleotide adenylyltransferase OS=Bacillus anthracis (strain CDC 684 / NRRL 3495) GN=nadD PE=1 SV=1
UniProt id: C3L5T6    188 a.a.  
1. 3mla A,B   188 a.a. 187   X-ray 1.75 Å
  2. 3mmx A,B,C,D,...   180 a.a. 179   X-ray 2.55 Å
The PDB contains 2 entries of dimethyl sulfoxide bound to this protein

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

Where there is more than one PDB model for a given UniProt sequence, the models are ordered by: 1. decreasing order of similarity to the UniProt sequence, 2. X-ray structures (in order of increasing resolution), NMR structures, and theoretical models. Clicking on any PDB code take you to the corresponding PDBsum page.

 

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