Enzymes - Pyridoxal 5'-phosphate

Pyridoxal 5'-phosphate-using

Enzymes, which use Pyridoxal 5'-phosphate as a cofactor

Further information

Over 300 PLP enzymes have been identified up to the year 2000 [1].

PLP-dependant enzymes can be classified into 4 groups, based on protein fold [1]:

1. α- and γ-families (si-specific)
2. β-family (si-specific)
3. both specificities
4. re-specific

7,8-Diaminopelargonic acid synthase uses PLP and SAM as cofactor. In the E. coli enzyme PLP is covalently bound to a lysine residue. SAM uniquely acts as an amino donor. This enzyme is the second step in biotin biosynthesis [3].

Distribution of Pyridoxal 5'-phosphate over enzyme reaction space (E.C.)

The E.C. tree highlights the enzymes that use the cofactor on a tree of all known E.C. numbers. Thus, it illustrates how frequently the cofactor is used in enzyme reactions and where these reactions are located withing the E.C. classification hierarchy.

In addition to the E.C. numbers extracted from primary literature, this graph also incudes the E.C. numbers that have been automatically extracted from several data resources.

E.C. tree

Profile of Pyridoxal 5'-phosphate-containing reactions

The E.C. wheel is a pie chart-based representation of the enzyme reactions this cofactor is involved in. The reactions are identified by E.C. number. The colouring is performed by E.C. class. The figure has four levels of circles which correspond to the four levels of the E.C. classification hierarchy. Partial and full E.C. numbers are displayed where space suffices. Each area within the outer two rings corresponds to one full E.C. serial number.

In addition to the E.C. numbers extracted from primary literature, this graph also incudes the E.C. numbers that have been automatically extracted from several data resources.

E.C. wheel	Legend

Pyridoxal 5'-phosphate-synthesising

Enzymes involved in Pyridoxal 5'-phosphate biosynthesis

Further information

PLP biosynthesis [4] occurs on two alternative pathways: DXP-dependent and DXP-independent [5].

Pyridoxal 5'-phosphate-binding

Enzymes binding to Pyridoxal 5'-phosphate (mode unknown)

PROCOGNATE: proteins and cognate ligands

Protein domains that bind to this molecule

References

[1]	pubmed:11933244
[2]	pubmed:12949584
[3]	pubmed:17898893
[4]	pubmed:17898894
[5]	pubmed:17898895
[6]	pubmed:12379355