spacer

Enzymes - Flavin adenine dinucleotide

Flavin adenine dinucleotide-using

Enzymes, which use Flavin adenine dinucleotide as a cofactor

Enzyme name E.C.
number
Enzyme
mechanism
CATH
domain
3D
structure
Species
information
Reference
UDP-N-acetylmuramate dehydrogenase 1.1.1.158 1.10.1060.10
1.10.45.10
see all
1hsk (PDBsum)
1mbb (PDBsum)
see all
species [IntEnz]
L-lactate dehydrogenase (cytochrome) 1.1.2.3 M0102 2oz0 (PDBsum)
1fcb (PDBsum)
see all
species [IntEnz]
D-lactate dehydrogenase (cytochrome) 1.1.2.4 species [IntEnz]
Pyranose oxidase 1.1.3.10 1tt0 (PDBsum)
1tzl (PDBsum)
see all
species [IntEnz]
Pyridoxine 4-oxidase 1.1.3.12 species [IntEnz]
Alcohol oxidase 1.1.3.13 species [IntEnz]
(S)-2-hydroxy-acid oxidase 1.1.3.15 2rdw (PDBsum)
1al7 (PDBsum)
see all
species [IntEnz]
Choline oxidase 1.1.3.17 2jbv  (PDBsum)
3nne  (PDBsum)
species [IntEnz]
4-hydroxymandelate oxidase 1.1.3.19 [IntEnz]
Glycerol-3-phosphate oxidase 1.1.3.21 2rgh  (PDBsum)
2rgo  (PDBsum)
species [IntEnz]
Thiamine oxidase 1.1.3.23 [IntEnz]
Malate oxidase 1.1.3.3 [IntEnz]
D-arabinono-1,4-lactone oxidase 1.1.3.37 species [IntEnz]
Vanillyl-alcohol oxidase 1.1.3.38 M0103 1.10.1060.10
1.10.45.10
see all
1ahv (PDBsum)
1ahz (PDBsum)
see all
species [MACiE]
Nucleoside oxidase (H(2)O(2)-forming) 1.1.3.39 [IntEnz]
Glucose oxidase 1.1.3.4 1.10.1060.10
1.10.45.10
see all
1cf3 (PDBsum)
1gal (PDBsum)
see all
species [IntEnz]
Alditol oxidase 1.1.3.41 2vfr (PDBsum)
2vfs (PDBsum)
see all
species [IntEnz]
Cholesterol oxidase 1.1.3.6 1.10.1060.10
1.10.45.10
see all
1b4v (PDBsum)
1b8s (PDBsum)
see all
species [IntEnz]
L-gulonolactone oxidase 1.1.3.8 species [IntEnz]
Malate dehydrogenase (quinone) 1.1.5.4 [IntEnz]
Glucose dehydrogenase (acceptor) 1.1.99.10 species [IntEnz]
Glucoside 3-dehydrogenase 1.1.99.13 [IntEnz]
Malate dehydrogenase (acceptor) 1.1.99.16 species [IntEnz]
Cellobiose dehydrogenase (acceptor) 1.1.99.18 1pl3 (PDBsum)
1d7b (PDBsum)
see all
species [IntEnz]
2-hydroxyglutarate dehydrogenase 1.1.99.2 species [IntEnz]
D-sorbitol dehydrogenase (acceptor) 1.1.99.21 [IntEnz]
(R)-pantolactone dehydrogenase (flavin) 1.1.99.27 [IntEnz]
Pyranose dehydrogenase (acceptor) 1.1.99.29 [IntEnz]
Gluconate 2-dehydrogenase (acceptor) 1.1.99.3 species [IntEnz]
Dehydrogluconate dehydrogenase 1.1.99.4 [KEGG]
D-2-hydroxy-acid dehydrogenase 1.1.99.6 [IntEnz]
Pyridoxine 5-dehydrogenase 1.1.99.9 [IntEnz]
o-aminophenol oxidase 1.10.3.4 [KEGG]
Ribosyldihydronicotinamide dehydrogenase (quinone) 1.10.99.2 1qr2 (PDBsum)
1sg0 (PDBsum)
see all
species [IntEnz]
NADH peroxidase 1.11.1.1 1.10.1060.10
1.10.45.10
see all
1f8w (PDBsum)
1joa (PDBsum)
see all
species [IntEnz]
Hydrogen dehydrogenase 1.12.1.2 species [IntEnz]
Coenzyme F420 hydrogenase 1.12.98.1 species [IntEnz]
2-nitropropane dioxygenase 1.13.11.32 species [IntEnz]
Arginine 2-monooxygenase 1.13.12.1 [KEGG]
Nitronate monooxygenase 1.13.12.16 2gjl  (PDBsum)
2gjn  (PDBsum)
[IntEnz]
Lysine 2-monooxygenase 1.13.12.2 [IntEnz]
Lactate 2-monooxygenase 1.13.12.4 species [IntEnz]
Benzoate 1,2-dioxygenase 1.14.12.10 3e99  (PDBsum) species [KEGG]
Naphthalene 1,2-dioxygenase 1.14.12.12 M0130 2hmo  (PDBsum) species [MACiE]
Nitric oxide dioxygenase 1.14.12.17 1.10.1060.10
1.10.45.10
see all
1cqx (PDBsum)
1gvh (PDBsum)
see all
species [IntEnz]
Benzoyl-CoA 2,3-dioxygenase 1.14.12.21 [IntEnz]
Benzene 1,2-dioxygenase 1.14.12.3 3eqq  (PDBsum) species [IntEnz]
3-hydroxy-2-methylpyridinecarboxylate dioxygenase 1.14.12.4 [IntEnz]
5-pyridoxate dioxygenase 1.14.12.5 [KEGG]
Phthalate 4,5-dioxygenase 1.14.12.7 species [IntEnz]
4-sulfobenzoate 3,4-dioxygenase 1.14.12.8 [IntEnz]
Salicylate 1-monooxygenase 1.14.13.1 species [IntEnz]
2,6-dihydroxypyridine 3-monooxygenase 1.14.13.10 [KEGG]
Monocyclic monoterpene ketone monooxygenase 1.14.13.105 species [IntEnz]
Limonene 1,2-monooxygenase 1.14.13.107 species [IntEnz]
6-hydroxynicotinate 3-monooxygenase 1.14.13.114 [IntEnz]
4-hydroxyphenylacetate 1-monooxygenase 1.14.13.18 [IntEnz]
Taxifolin 8-monooxygenase 1.14.13.19 [KEGG]
4-hydroxybenzoate 3-monooxygenase 1.14.13.2 M0131 1.10.1060.10
1.10.45.10
see all
1bf3 (PDBsum)
1bgj (PDBsum)
see all
species [MACiE]
2,4-dichlorophenol 6-monooxygenase 1.14.13.20 species [IntEnz]
Cyclohexanone monooxygenase 1.14.13.22 species [IntEnz]
3-hydroxybenzoate 4-monooxygenase 1.14.13.23 [IntEnz]
3-hydroxybenzoate 6-monooxygenase 1.14.13.24 [IntEnz]
4-aminobenzoate 1-monooxygenase 1.14.13.27 [IntEnz]
4-nitrophenol 2-monooxygenase 1.14.13.29 [IntEnz]
4-hydroxyphenylacetate 3-monooxygenase 1.14.13.3 3cb0  (PDBsum) [IntEnz]
Albendazole monooxygenase 1.14.13.32 2v0m  (PDBsum) species [IntEnz]
4-hydroxybenzoate 3-monooxygenase (NAD(P)H) 1.14.13.33 [IntEnz]
Melilotate 3-monooxygenase 1.14.13.4 [IntEnz]
Anthraniloyl-CoA monooxygenase 1.14.13.40 [IntEnz]
Imidazoleacetate 4-monooxygenase 1.14.13.5 [IntEnz]
Pentachlorophenol monooxygenase 1.14.13.50 species [IntEnz]
Ketosteroid monooxygenase 1.14.13.54 [IntEnz]
Benzoyl-CoA 3-monooxygenase 1.14.13.58 [IntEnz]
L-lysine 6-monooxygenase (NADPH) 1.14.13.59 species [IntEnz]
Orcinol 2-monooxygenase 1.14.13.6 [IntEnz]
3-hydroxyphenylacetate 6-hydroxylase 1.14.13.63 [IntEnz]
4-hydroxybenzoate 1-hydroxylase 1.14.13.64 [IntEnz]
Phenol 2-monooxygenase 1.14.13.7 1.10.1060.10
1.10.45.10
see all
1foh  (PDBsum)
1pn0  (PDBsum)
species [IntEnz]
Flavin-containing monooxygenase 1.14.13.8 species [IntEnz]
4-hydroxyacetophenone monooxygenase 1.14.13.84 species [IntEnz]
Kynurenine 3-monooxygenase 1.14.13.9 species [IntEnz]
Zeaxanthin epoxidase 1.14.13.90 species [IntEnz]
Phenylacetone monooxygenase 1.14.13.92 1w4x  (PDBsum) species [IntEnz]
Alkanal monooxygenase (FMN-linked) 1.14.14.3 M0132 1xkj  (PDBsum)
3fgc  (PDBsum)
species [IntEnz]
Alkanesulfonate monooxygenase 1.14.14.5 1nqk  (PDBsum) species [IntEnz]
Methanesulfonate monooxygenase 1.14.14.6 [IntEnz]
Tryptophan 7-halogenase 1.14.14.7 [IntEnz]
Lathosterol oxidase 1.14.21.6 species [KEGG]
Latia-luciferin monooxygenase (demethylating) 1.14.99.21 [KEGG]
Steroid 9-alpha-monooxygenase 1.14.99.24 [IntEnz]
Monoprenyl isoflavone epoxidase 1.14.99.34 [IntEnz]
Squalene monooxygenase 1.14.99.7 species [IntEnz]
Aquacobalamin reductase 1.16.1.3 1qfj  (PDBsum) species [KEGG]
Cob(II)alamin reductase 1.16.1.4 [KEGG]
Aquacobalamin reductase (NADPH) 1.16.1.5 species [KEGG]
Cyanocobalamin reductase (cyanide-eliminating) 1.16.1.6 [KEGG]
Ferric-chelate reductase 1.16.1.7 species [IntEnz]
[Methionine synthase] reductase 1.16.1.8 2qtl  (PDBsum)
2qtz  (PDBsum)
species [IntEnz]
Cob(II)yrinic acid a,c-diamide reductase 1.16.8.1 species [IntEnz]
Xanthine dehydrogenase 1.17.1.4 M0139 3eub  (PDBsum) species [MACiE]
Nicotinate dehydrogenase 1.17.1.5 3hrd  (PDBsum) [KEGG]
Xanthine oxidase 1.17.3.2 3eub  (PDBsum) species [IntEnz]
6-hydroxynicotinate dehydrogenase 1.17.3.3 [IntEnz]
4-cresol dehydrogenase (hydroxylating) 1.17.99.1 M0141 1.10.1060.10
1.10.45.10
see all
1dii (PDBsum)
1diq (PDBsum)
see all
species [MACiE]
Bile-acid 7-alpha-dehydroxylase 1.17.99.5 species [IntEnz]
Rubredoxin--NAD(+) reductase 1.18.1.1 2v3a (PDBsum)
2v3b (PDBsum)
see all
species [IntEnz]
Ferredoxin--NADP(+) reductase 1.18.1.2 M0142 1.10.1060.10
1.10.45.10
see all
1a8p (PDBsum)
1b2r (PDBsum)
see all
species [MACiE]
Rubredoxin--NAD(P)(+) reductase 1.18.1.4 [IntEnz]
Retinal dehydrogenase 1.2.1.36 1bxs  (PDBsum)
1bi9  (PDBsum)
species [IntEnz]
Phenylglyoxylate dehydrogenase (acylating) 1.2.1.58 [IntEnz]
Pyruvate dehydrogenase (cytochrome) 1.2.2.2 M0275 3ey9  (PDBsum)
3eya  (PDBsum)
species [KEGG]
Carbon-monoxide dehydrogenase (cytochrome b-561) 1.2.2.4 [IntEnz]
Aldehyde oxidase 1.2.3.1 M0105 1hlr  (PDBsum) species [IntEnz]
Pyruvate oxidase 1.2.3.3 M0274 1pow (PDBsum)
1pox (PDBsum)
see all
species [IntEnz]
Oxalate oxidase 1.2.3.4 2ete  (PDBsum) species [KEGG]
Pyruvate oxidase (CoA-acetylating) 1.2.3.6 [IntEnz]
Indole-3-acetaldehyde oxidase 1.2.3.7 [IntEnz]
Pyruvate dehydrogenase (quinone) 1.2.5.1 3ey9  (PDBsum)
3eya  (PDBsum)
[IntEnz]
Carbon-monoxide dehydrogenase (acceptor) 1.2.99.2 M0107 1.10.1060.10
1.10.45.10
see all
1ffu (PDBsum)
1ffv (PDBsum)
see all
species [MACiE]
Reticuline oxidase 1.21.3.3 3d2d (PDBsum)
3d2h (PDBsum)
see all
species [IntEnz]
Beta-cyclopiazonate dehydrogenase 1.21.99.1 [IntEnz]
Iodotyrosine deiodinase 1.22.1.1 3gb5 (PDBsum)
3gfd (PDBsum)
see all
[IntEnz]
Orotate reductase (NADH) 1.3.1.14 1.10.1060.10
1.10.45.10
see all
1ep1 (PDBsum)
1ep2 (PDBsum)
see all
[IntEnz]
Orotate reductase (NADPH) 1.3.1.15 [KEGG]
2-enoate reductase 1.3.1.31 species [IntEnz]
2,4-dienoyl-CoA reductase (NADPH) 1.3.1.34 M0108 1ps9 (PDBsum)
1w8d (PDBsum)
see all
species [MACiE]
2-methyl-branched-chain-enoyl-CoA reductase 1.3.1.52 [IntEnz]
Dihydroorotate oxidase 1.3.3.1 M0109 2.10.240.10
3.20.20.70
2prm (PDBsum)
3i6r (PDBsum)
see all
species [IntEnz]
L-galactonolactone oxidase 1.3.3.12 [IntEnz]
Protoporphyrinogen oxidase 1.3.3.4 3.90.660.20 1sez (PDBsum)
2ivd (PDBsum)
see all
species [IntEnz]
Acyl-CoA oxidase 1.3.3.6 1.10.1060.10
1.10.45.10
see all
1is2 (PDBsum)
1w07 (PDBsum)
see all
species [IntEnz]
Dihydrouracil oxidase 1.3.3.7 [IntEnz]
Succinate dehydrogenase (ubiquinone) 1.3.5.1 M0294 1yq3 (PDBsum)
1yq4 (PDBsum)
see all
species [IntEnz]
succinate dehydrogenase 1.3.99.1 M0020 1.10.1060.10
1.10.45.10
see all
1d4c (PDBsum)
1d4d (PDBsum)
see all
species [MACiE]
Isovaleryl-CoA dehydrogenase 1.3.99.10 M0068 1.10.1060.10
1.10.45.10
see all
1ivh  (PDBsum) species [MACiE]
2-methylacyl-CoA dehydrogenase 1.3.99.12 [IntEnz]
Long-chain-acyl-CoA dehydrogenase 1.3.99.13 species [IntEnz]
Quinoline 2-oxidoreductase 1.3.99.17 species [IntEnz]
Butyryl-CoA dehydrogenase 1.3.99.2 1.10.1060.10
1.10.45.10
see all
1buc (PDBsum)
1jqi (PDBsum)
see all
species [IntEnz]
(R)-benzylsuccinyl-CoA dehydrogenase 1.3.99.21 species [IntEnz]
2-amino-4-deoxychorismate dehydrogenase 1.3.99.24 [IntEnz]
Acyl-CoA dehydrogenase 1.3.99.3 1.10.1060.10
1.10.45.10
see all
1egc (PDBsum)
1egd (PDBsum)
see all
species [IntEnz]
Glutaryl-CoA dehydrogenase 1.3.99.7 1siq (PDBsum)
1sir (PDBsum)
see all
species [IntEnz]
Glutamate synthase (NADPH) 1.4.1.13 M0304 2vdc  (PDBsum)
1ea0  (PDBsum)
species [IntEnz]
Glutamate synthase (NADH) 1.4.1.14 species [IntEnz]
D-aspartate oxidase 1.4.3.1 species [IntEnz]
Putrescine oxidase 1.4.3.10 species [IntEnz]
L-glutamate oxidase 1.4.3.11 [IntEnz]
Cyclohexylamine oxidase 1.4.3.12 [IntEnz]
L-lysine oxidase 1.4.3.14 [IntEnz]
D-glutamate(D-aspartate) oxidase 1.4.3.15 [IntEnz]
L-aspartate oxidase 1.4.3.16 1.10.1060.10
1.10.45.10
see all
1knp (PDBsum)
1knr (PDBsum)
see all
species [IntEnz]
Glycine oxidase 1.4.3.19 1.10.1060.10
1.10.45.10
see all
1ng3 (PDBsum)
1ng4 (PDBsum)
see all
species [IntEnz]
L-amino-acid oxidase 1.4.3.2 1.10.1060.10
1.10.45.10
see all
1f8r (PDBsum)
1f8s (PDBsum)
see all
species [IntEnz]
7-chloro-L-tryptophan oxidase 1.4.3.23 [IntEnz]
D-amino-acid oxidase 1.4.3.3 M0110 1.10.1060.10
1.10.45.10
see all
1aa8 (PDBsum)
1an9 (PDBsum)
see all
species [MACiE]
Monoamine oxidase 1.4.3.4 1.10.1060.10
1.10.45.10
see all
1gos (PDBsum)
1h8q (PDBsum)
see all
species [IntEnz]
Pyridoxal 5'-phosphate synthase 1.4.3.5 2a2j (PDBsum)
3hy8 (PDBsum)
see all
species [IntEnz]
D-amino acid dehydrogenase (quinone) 1.4.5.1 [IntEnz]
Glutamate synthase (ferredoxin) 1.4.7.1 M0111 3.60.20.10 1ofe (PDBsum)
1llw (PDBsum)
see all
species [KEGG]
D-amino-acid dehydrogenase 1.4.99.1 species [IntEnz]
Glycine dehydrogenase (cyanide-forming) 1.4.99.5 [IntEnz]
Methylenetetrahydrofolate reductase (NAD(P)H) 1.5.1.20 M0120 1.10.1060.10
1.10.45.10
see all
1b5t (PDBsum)
1v93 (PDBsum)
see all
species [MACiE]
FMN reductase 1.5.1.29 1t0i (PDBsum)
1zch (PDBsum)
see all
species [IntEnz]
Sarcosine oxidase 1.5.3.1 M0113 1.10.1060.10
1.10.45.10
see all
1b3m (PDBsum)
1el5 (PDBsum)
see all
species [MACiE]
Dimethylglycine oxidase 1.5.3.10 3gsi  (PDBsum) [IntEnz]
Polyamine oxidase 1.5.3.11 3.90.660.10 3cnt  (PDBsum) species [IntEnz]
N(1)-acetylpolyamine oxidase 1.5.3.13 [IntEnz]
Polyamine oxidase (propane-1,3-diamine-forming) 1.5.3.14 [IntEnz]
N(8)-acetylspermidine oxidase (propane-1,3-diamine-forming) 1.5.3.15 [IntEnz]
Spermine oxidase 1.5.3.16 [IntEnz]
Non-specific polyamine oxidase 1.5.3.17 1rsg (PDBsum)
1xpq (PDBsum)
see all
[IntEnz]
N-methyl-L-amino-acid oxidase 1.5.3.2 [KEGG]
(S)-6-hydroxynicotine oxidase 1.5.3.5 [IntEnz]
(R)-6-hydroxynicotine oxidase 1.5.3.6 species [IntEnz]
Electron-transferring-flavoprotein dehydrogenase 1.5.5.1 M0281 2gmh  (PDBsum)
2gmj  (PDBsum)
species [IntEnz]
Dimethylamine dehydrogenase 1.5.8.1 species [IntEnz]
Trimethylamine dehydrogenase 1.5.8.2 M0114 2tmd (PDBsum)
1djn (PDBsum)
see all
species [IntEnz]
Sarcosine dehydrogenase 1.5.99.1 species [IntEnz]
Cytokinin dehydrogenase 1.5.99.12 M0115 1w1o (PDBsum)
1w1q (PDBsum)
see all
species [IntEnz]
D-proline dehydrogenase 1.5.99.13 [IntEnz]
Dimethylglycine dehydrogenase 1.5.99.2 species [IntEnz]
Nicotine dehydrogenase 1.5.99.4 [IntEnz]
Spermidine dehydrogenase 1.5.99.6 [IntEnz]
Proline dehydrogenase 1.5.99.8 3e2s  (PDBsum) species [IntEnz]
NAD(P)(+) transhydrogenase (B-specific) 1.6.1.1 species [IntEnz]
Cytochrome-b5 reductase 1.6.2.2 1.10.1060.10
1.10.45.10
see all
1i7p (PDBsum)
1ib0 (PDBsum)
see all
species [IntEnz]
NADPH--hemoprotein reductase 1.6.2.4 M0117 1.10.1060.10
1.10.45.10
see all
1amo (PDBsum)
1j9z (PDBsum)
see all
species [MACiE]
NADPH--cytochrome-c2 reductase 1.6.2.5 [IntEnz]
NAD(P)H oxidase 1.6.3.1 species [IntEnz]
NAD(P)H dehydrogenase (quinone) 1.6.5.2 M0003 1.10.1060.10
1.10.45.10
see all
1d4a (PDBsum)
1dxo (PDBsum)
see all
species [MACiE]
NADH dehydrogenase (ubiquinone) 1.6.5.3 species [IntEnz]
2-hydroxy-1,4-benzoquinone reductase 1.6.5.7 [IntEnz]
NADPH dehydrogenase 1.6.99.1 M0319 1z48 (PDBsum)
1bwk (PDBsum)
see all
species [IntEnz]
NADH dehydrogenase 1.6.99.3 1ozk (PDBsum)
3f8d (PDBsum)
see all
species [KEGG]
NADPH dehydrogenase (quinone) 1.6.99.6 [KEGG]
Nitrate reductase (NADH) 1.7.1.1 1.10.1060.10
1.10.45.10
see all
1cne (PDBsum)
1cnf (PDBsum)
see all
species [IntEnz]
Nitrate reductase (NAD(P)H) 1.7.1.2 species [IntEnz]
Nitrate reductase (NADPH) 1.7.1.3 2bii  (PDBsum) species [IntEnz]
Nitrite reductase (NAD(P)H) 1.7.1.4 2jo6  (PDBsum)
2jza  (PDBsum)
species [IntEnz]
Nitrite reductase (NO-forming) 1.7.2.1 M0004 2ppf  (PDBsum) species [IntEnz]
Nitroalkane oxidase 1.7.3.1 3bw4  (PDBsum)
3d9g  (PDBsum)
[IntEnz]
3-aci-nitropropanoate oxidase 1.7.3.5 [IntEnz]
Hydroxylamine reductase 1.7.99.1 1qks  (PDBsum) species [KEGG]
CoA-glutathione reductase 1.8.1.10 [KEGG]
Trypanothione-disulfide reductase 1.8.1.12 1.10.1060.10
1.10.45.10
see all
1aog (PDBsum)
1bzl (PDBsum)
see all
species [IntEnz]
CoA-disulfide reductase 1.8.1.14 1yqz (PDBsum)
3icr (PDBsum)
see all
species [IntEnz]
Mycothione reductase 1.8.1.15 [IntEnz]
Glutathione amide reductase 1.8.1.16 [IntEnz]
Sulfite reductase (NADPH) 1.8.1.2 1.10.1060.10
1.10.45.10
see all
1ddg (PDBsum)
1ddi (PDBsum)
see all
species [IntEnz]
Dihydrolipoyl dehydrogenase 1.8.1.4 1.10.1060.10
1.10.45.10
see all
1dxl (PDBsum)
1jeh (PDBsum)
see all
species [IntEnz]
glutathione-disulfide reductase 1.8.1.7 M0006 1.10.1060.10
1.10.45.10
see all
1bwc (PDBsum)
1dnc (PDBsum)
see all
species [MACiE]
Thioredoxin-disulfide reductase 1.8.1.9 1.10.1060.10
1.10.45.10
see all
1cl0 (PDBsum)
1f6m (PDBsum)
see all
species [KEGG]
Glutathione oxidase 1.8.3.3 [IntEnz]
Prenylcysteine oxidase 1.8.3.5 species [IntEnz]
Adenylyl-sulfate reductase 1.8.99.2 M0123 [MACiE]
Methionine synthase 2.1.1.13 M0268 2o2k (PDBsum)
3bul (PDBsum)
see all
species [KEGG]
Thymidylate synthase (FAD) 2.1.1.148 1.10.1060.10
1.10.45.10
see all
1kq4 (PDBsum)
1o26 (PDBsum)
see all
species [IntEnz]
tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase 2.1.1.61 3awi (PDBsum)
3pvc (PDBsum)
see all
[PDB]
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase (FADH(2)-oxidizing) 2.1.1.74 3g5q (PDBsum)
3g5r (PDBsum)
see all
species [IntEnz]
Acetolactate synthase 2.2.1.6 M0289 1.10.1060.10
1.10.45.10
see all
1jsc (PDBsum)
1n0h (PDBsum)
see all
species [KEGG]
Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase 2.3.1.168 3rnm (PDBsum)
2ii4 (PDBsum)
see all
species [PDB]
CTP-dependent riboflavin kinase 2.7.1.161 2.40.30.30 2vbv  (PDBsum)
3cta  (PDBsum)
species [IntEnz]
Riboflavin phosphotransferase 2.7.1.42 [IntEnz]
2'-hydroxybiphenyl-2-sulfinate desulfinase 3.13.1.3 2de4  (PDBsum) species [IntEnz]
FAD diphosphatase 3.6.1.18 species [IntEnz]
Phosphopantothenoylcysteine decarboxylase 4.1.1.36 1u80 (PDBsum)
1e20 (PDBsum)
see all
species [IntEnz]
Tartronate-semialdehyde synthase 4.1.1.47 M0298 2pan  (PDBsum) species [KEGG]
(6-4)DNA photolyase 4.1.99.13 [IntEnz]
Deoxyribodipyrimidine photo-lyase 4.1.99.3 M0183 1.10.1060.10
1.10.45.10
see all
1dnp (PDBsum)
1iqr (PDBsum)
see all
species [MACiE]
4-hydroxybutanoyl-CoA dehydratase 4.2.1.120 [IntEnz]
Chorismate synthase 4.2.3.5 2qhf (PDBsum)
1qxo (PDBsum)
see all
species [IntEnz]
FAD-AMP lyase (cyclizing) 4.6.1.15 species [IntEnz]
Isopentenyl-diphosphate Delta-isomerase 5.3.3.2 M0190 2zrz (PDBsum)
3hyq (PDBsum)
see all
species [IntEnz]

Distribution of Flavin adenine dinucleotide over enzyme reaction space (E.C.)

The E.C. tree highlights the enzymes that use the cofactor on a tree of all known E.C. numbers. Thus, it illustrates how frequently the cofactor is used in enzyme reactions and where these reactions are located withing the E.C. classification hierarchy.

In addition to the E.C. numbers extracted from primary literature, this graph also incudes the E.C. numbers that have been automatically extracted from several data resources.

E.C. tree

E.C. tree E.C. legend

Profile of Flavin adenine dinucleotide-containing reactions

The E.C. wheel is a pie chart-based representation of the enzyme reactions this cofactor is involved in. The reactions are identified by E.C. number. The colouring is performed by E.C. class. The figure has four levels of circles which correspond to the four levels of the E.C. classification hierarchy. Partial and full E.C. numbers are displayed where space suffices. Each area within the outer two rings corresponds to one full E.C. serial number.

In addition to the E.C. numbers extracted from primary literature, this graph also incudes the E.C. numbers that have been automatically extracted from several data resources.

E.C. wheel

Legend

E.C. wheel E.C. legend

Flavin adenine dinucleotide-synthesising

Enzymes involved in Flavin adenine dinucleotide biosynthesis

Enzyme name E.C.
number
Enzyme
mechanism
CATH
domain
3D
structure
Species
information
Reference
5-amino-6-(5-phosphoribosylamino)uracil reductase 1.1.1.193 2azn  (PDBsum)
3ex8  (PDBsum)
species [4]
riboflavin synthase 2.5.1.9 M0247 species [4]
Riboflavin kinase 2.7.1.26 1q9s (PDBsum)
1n07 (PDBsum)
see all
species [IntEnz]
FAD synthetase 2.7.7.2 2wsi  (PDBsum) species [IntEnz]
GTP cyclohydrolase II 3.5.4.25 [4]
diaminohydroxyphosphoribosylaminopyrimidine deaminase 3.5.4.26 3ex8  (PDBsum) species [4]
3,4-dihydroxy-2-butanone-4-phosphate synthase 4.1.99.12 [4]

Further information

The flavin biosynthetic pathway is found in plants and microorganisms [7]. The flavin-dependent enzyme glycine oxidase is involved in thiamine biosynthesis.

Flavin adenine dinucleotide-binding

Enzymes binding to Flavin adenine dinucleotide (mode unknown)

Enzyme name E.C.
number
Enzyme
mechanism
CATH
domain
3D
structure
Species
information
Reference
[[deleted/transferred E.C. number]] 1.1.1.204 1.10.1060.10
1.10.45.10
see all
1jro (PDBsum)
1jrp (PDBsum)
see all
[PDB]
D-lactate dehydrogenase 1.1.1.28 1.10.1060.10
1.10.45.10
see all
1f0x (PDBsum)
2dld (PDBsum)
see all
species [ProCognate]
Aryl-alcohol oxidase 1.1.3.7 3fim  (PDBsum) [PDB]
Glycerol-3-phosphate dehydrogenase 1.1.5.3 2qcu (PDBsum)
2r45 (PDBsum)
see all
species [PDB]
Phenylalanine 2-monooxygenase 1.13.12.9 2yr4 (PDBsum)
2yr5 (PDBsum)
see all
[PDB]
Methane monooxygenase 1.14.13.25 1xvg  (PDBsum)
1yew  (PDBsum)
species [ProCognate]
Nitric-oxide synthase 1.14.13.39 1.10.1060.10
1.10.45.10
see all
1f20 (PDBsum)
1tll (PDBsum)
see all
species [ProCognate]
Mercury(II) reductase 1.16.1.1 M0277 1zk7  (PDBsum)
1zx9  (PDBsum)
species [ProCognate]
Ferredoxin--NAD(+) reductase 1.18.1.3 1.10.1060.10
1.10.45.10
see all
1krh (PDBsum)
3ef6 (PDBsum)
see all
species [ProCognate]
Dihydropyrimidine dehydrogenase (NADP(+)) 1.3.1.2 1.10.1060.10
1.10.45.10
see all
1gt8 (PDBsum)
1gte (PDBsum)
see all
species [ProCognate]
4-hydroxybenzoyl-CoA reductase 1.3.99.20 1rm6  (PDBsum)
1sb3  (PDBsum)
species [ProCognate]
1-pyrroline-5-carboxylate dehydrogenase 1.5.1.12 3.20.20.220 2j5n  (PDBsum)
3e2s  (PDBsum)
species [ProCognate]
[[deleted/transferred E.C. number]] 1.6.4.2 2grs  (PDBsum) [PDB]
[[deleted/transferred E.C. number]] 1.6.4.5 2v6o (PDBsum)
2x8c (PDBsum)
see all
[PDB]
[[deleted/transferred E.C. number]] 1.6.6.1 1.10.1060.10
1.10.45.10
see all
1cnd  (PDBsum) [PDB]
2-oxopropyl-CoM reductase (carboxylating) 1.8.1.5 1.10.1060.10
1.10.45.10
see all
1mo9 (PDBsum)
1mok (PDBsum)
see all
species [ProCognate]
Thiol oxidase 1.8.3.2 1.10.1060.10
1.10.45.10
see all
1jr8 (PDBsum)
1jra (PDBsum)
see all
species [PDB]
Dihydrolipoyllysine-residue acetyltransferase 2.3.1.12 1.10.1060.10
1.10.45.10
see all
1w85 (PDBsum)
1w88 (PDBsum)
see all
species [ProCognate]
Alkylglycerone-phosphate synthase 2.5.1.26 2uuu  (PDBsum)
2uuv  (PDBsum)
species [ProCognate]
Histidine kinase 2.7.13.3 2gj3 (PDBsum)
1d06 (PDBsum)
see all
species [PDB]
Vinylacetyl-CoA Delta-isomerase 5.3.3.3 1u8v  (PDBsum) species [ProCognate]
UDP-galactopyranose mutase 5.4.99.9 1.10.1060.10
1.10.45.10
see all
1i8t (PDBsum)
1usj (PDBsum)
see all
species [ProCognate]

PROCOGNATE: proteins and cognate ligands

Protein domains that bind to this molecule

Name Link
FLAVIN-ADENINE DINUCLEOTIDEFAD-binding protein domains
DIHYDROFLAVINE-ADENINE DINUCLEOTIDEFDA-binding protein domains

References

[1] pubmed:17275397
[2] pubmed:19438712
[3] pubmed:16704345
[4] pubmed:16010344
[5] pubmed:21166638
[6] pubmed:21527346
[7] pubmed:17898895
[8] pubmed:11514662
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