Enzymes - Tetrahydrofolic acid
Tetrahydrofolic acid-using
Enzymes, which use Tetrahydrofolic acid as a cofactor
Further information
Methionine synthase uses THF and is a crucial enzyme for the regeneration of methionine from homocysteine. Methionine is required for the cofactor SAM, which is transformed to the toxic component homocysteine when SAM is consumed in methylation reactions. The enzyme has two isozymes, one of which depends on cobalamin and one of which does not [1].
Distribution of Tetrahydrofolic acid over enzyme reaction space (E.C.)
The E.C. tree highlights the enzymes that use the cofactor on a tree of
all known E.C. numbers. Thus, it illustrates how frequently the cofactor is
used in enzyme reactions and where these reactions are located withing the
E.C. classification hierarchy.
In addition to the E.C. numbers extracted from primary literature, this graph
also incudes the E.C. numbers that have been automatically extracted from
several data resources.
E.C. tree |
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Profile of Tetrahydrofolic acid-containing reactions
The E.C. wheel is a pie chart-based representation of the enzyme
reactions this cofactor is involved in. The reactions are identified by E.C. number.
The colouring is performed by E.C. class. The figure has four levels of circles
which correspond to the four levels of the E.C. classification hierarchy. Partial
and full E.C. numbers are displayed where space suffices. Each area within the
outer two rings corresponds to one full E.C. serial number.
In addition to the E.C. numbers extracted from primary literature, this graph
also incudes the E.C. numbers that have been automatically extracted from
several data resources.
E.C. wheel |
Legend |
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Tetrahydrofolic acid-synthesising
Enzymes involved in Tetrahydrofolic acid biosynthesis
Further information
[2]
Tetrahydrofolic acid-recycling
Enzymes involved in Tetrahydrofolic acid recycling
Tetrahydrofolic acid-binding
Enzymes binding to Tetrahydrofolic acid (mode unknown)
PROCOGNATE: proteins and cognate ligands
Protein domains that bind to this molecule
References
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