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PDBsum entry 2rf2
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Contents |
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* Residue conservation analysis
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Enzyme class 1:
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Chains A, B:
E.C.2.7.7.-
- ?????
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Enzyme class 2:
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Chains A, B:
E.C.2.7.7.49
- RNA-directed Dna polymerase.
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Reaction:
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DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate
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DNA(n)
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+
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2'-deoxyribonucleoside 5'-triphosphate
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=
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DNA(n+1)
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+
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diphosphate
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Enzyme class 3:
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Chains A, B:
E.C.2.7.7.7
- DNA-directed Dna polymerase.
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Reaction:
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DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate
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DNA(n)
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+
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2'-deoxyribonucleoside 5'-triphosphate
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=
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DNA(n+1)
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+
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diphosphate
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Enzyme class 4:
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Chains A, B:
E.C.3.1.-.-
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Enzyme class 5:
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Chains A, B:
E.C.3.1.13.2
- exoribonuclease H.
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Reaction:
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Exonucleolytic cleavage to 5'-phosphomonoester oligonucleotides in both 5'- to 3'- and 3'- to 5'-directions.
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Enzyme class 6:
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Chains A, B:
E.C.3.1.26.13
- retroviral ribonuclease H.
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Enzyme class 7:
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Chains A, B:
E.C.3.4.23.16
- HIV-1 retropepsin.
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Reaction:
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Specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro.
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Note, where more than one E.C. class is given (as above), each may
correspond to a different protein domain or, in the case of polyprotein
precursors, to a different mature protein.
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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DOI no:
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Bioorg Med Chem Lett
18:554-559
(2008)
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PubMed id:
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Novel indole-3-sulfonamides as potent HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs).
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Z.Zhao,
S.E.Wolkenberg,
P.E.Sanderson,
M.Lu,
V.Munshi,
G.Moyer,
M.Feng,
A.V.Carella,
L.T.Ecto,
L.J.Gabryelski,
M.T.Lai,
S.G.Prasad,
Y.Yan,
G.B.McGaughey,
M.D.Miller,
C.W.Lindsley,
G.D.Hartman,
J.P.Vacca,
T.M.Williams.
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ABSTRACT
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This Letter describes the design, synthesis, and biological evaluation of novel
3-indole sulfonamides as potent non-nucleoside reverse transcriptase inhibitors
(NNRTIs) with balanced profiles against common HIV RT mutants K103N and Y181C.
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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B.Zeng,
H.Wang,
L.Zou,
A.Zhang,
X.Yang,
and
Z.Guan
(2010).
Evaluation and target validation of indole derivatives as inhibitors of the AcrAB-TolC efflux pump.
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Biosci Biotechnol Biochem,
74,
2237-2241.
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H.P.Su,
Y.Yan,
G.S.Prasad,
R.F.Smith,
C.L.Daniels,
P.D.Abeywickrema,
J.C.Reid,
H.M.Loughran,
M.Kornienko,
S.Sharma,
J.A.Grobler,
B.Xu,
V.Sardana,
T.J.Allison,
P.D.Williams,
P.L.Darke,
D.J.Hazuda,
and
S.Munshi
(2010).
Structural basis for the inhibition of RNase H activity of HIV-1 reverse transcriptase by RNase H active site-directed inhibitors.
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J Virol,
84,
7625-7633.
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PDB codes:
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C.Ramalingan,
I.S.Lee,
and
Y.W.Kwak
(2009).
Novel furanylarylene arylsulfonylindolesulfonamides: synthesis and their antibacterial evaluation.
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Chem Pharm Bull (Tokyo),
57,
591-596.
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
codes are
shown on the right.
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Links
