EC 188.8.131.52 - HIV-1 retropepsin
IntEnz Enzyme Nomenclature
human immunodeficiency virus type 1 protease
- Specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro.
Present in human immunodeficiency virus type 1. Contributes to the maturation of the viral particle, and is a target of antiviral drugs. Active enzyme is a dimer of identical 11-kDa subunits. Similar enzymes occur in other retroviruses . Type example of peptidase family A2.
Links to other databases
In: Kuo, L.C. and Shafer, J.A. (Eds.) Retroviral Proteases. Methods Enzymol. vol. 241, 1994, 1-431
Human immunodeficiency virus 1 retropepsin.In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds.) Handbook of Proteolytic Enzymes, Academic Press, London, 1998, 919-928
[EC 184.108.40.206 created 1992, modified 2000]