EC 2.7.7.7 - DNA-directed DNA polymerase

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IntEnz Enzyme Nomenclature
EC 2.7.7.7

Names

Accepted name:
DNA-directed DNA polymerase
Other names:
DNA duplicase
DNA nucleotidyltransferase
DNA nucleotidyltransferase (DNA-directed)
DNA polymerase
DNA polymerase α
DNA polymerase β
DNA polymerase γ
DNA polymerase I
DNA polymerase II
DNA polymerase III
DNA replicase
DNA-dependent DNA polymerase
Klenow fragment
Taq DNA polymerase
Taq Pol I
Tca DNA polymerase
deoxynucleate polymerase
deoxyribonucleate nucleotidyltransferase
deoxyribonucleic acid duplicase
deoxyribonucleic acid polymerase
deoxyribonucleic duplicase
deoxyribonucleic polymerase
deoxyribonucleic polymerase I
duplicase
sequenase
Systematic name:
deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed)

Reaction

Comments:

Catalyses DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time. Cannot initiate a chain de novo. Requires a primer, which may be DNA or RNA. See also EC 2.7.7.49 RNA-directed DNA polymerase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00107 , PROSITE:PDOC00412 , PROSITE:PDOC00452
Structural data: CSA , EC2PDB
Gene Ontology: GO:0003887
CAS Registry Number: 9012-90-2
UniProtKB/Swiss-Prot: (1130) [show] [UniProt]

References

  1. Bollum, F.J.
    Calf thymus polymerase.
    J. Biol. Chem. 235: 2399-2403 (1960). [PMID: 13802334]
  2. Falaschi, A. and Kornberg, A.
    Biochemical studies of bacterial sporulation. II. Deoxy-ribonucleic acid polymerase in spores of Bacillus subtilis.
    J. Biol. Chem. 241: 1478-1482 (1966). [PMID: 4957767]
  3. Lehman, I.R., Bessman, M.J., Simms, E.S. and Kornberg, A.
    Enzymatic synthesis of deoxyribonucleic acid. I. Preparation of substrates and partial purification of an enzyme from Escherichia coli.
    J. Biol. Chem. 233: 163-170 (1958). [PMID: 13563462]
  4. Richardson, C.C., Schildkraut, C.L., Aposhian, H.V. and Kornberg, A.
    Enzymatic synthesis of deoxyribonucleic acid. XIV. Further purification and properties of deoxyribonucleic acid polymerase of Escherichia coli.
    J. Biol. Chem. 239: 222-232 (1964). [PMID: 14114848]
  5. Schachman, H.K., Adler, J., Radding, C.M., Lehman, I.R. and Kornberg, A.
    Enzymatic synthesis of deoxyribonucleic acid. VII. Synthesis of a polymer of deoxyadenylate and deoxythymidylate.
    J. Biol. Chem. 235: 3242-3249 (1960). [PMID: 13747134]
  6. Zimmerman, B.K.
    Purification and properties of deoxyribonucleic acid polymerase from Micrococcus lysodeikticus.
    J. Biol. Chem. 241: 2035-2041 (1966). [PMID: 5946628]

[EC 2.7.7.7 created 1961, modified 1981, modified 1982]