PDBsum entry 2rf2

Transferase

PDB id: 2rf2

Contents

Protein chains

554 a.a.

405 a.a.

Ligands

MRX

Waters ×710

References listed in PDB file

Key reference

• Title: Novel indole-3-Sulfonamides as potent HIV non-Nucleoside reverse transcriptase inhibitors (nnrtis).
• Authors: Z.Zhao, S.E.Wolkenberg, P.E.Sanderson, M.Lu, V.Munshi, G.Moyer, M.Feng, A.V.Carella, L.T.Ecto, L.J.Gabryelski, M.T.Lai, S.G.Prasad, Y.Yan, G.B.Mcgaughey, M.D.Miller, C.W.Lindsley, G.D.Hartman, J.P.Vacca, T.M.Williams.
• Ref.: Bioorg Med Chem Lett, 2008, 18, 554-559. [DOI no: 10.1016/j.bmcl.2007.11.085]
• PubMed id: 18083561

Abstract

This Letter describes the design, synthesis, and biological evaluation of novel 3-indole sulfonamides as potent non-nucleoside reverse transcriptase inhibitors (NNRTIs) with balanced profiles against common HIV RT mutants K103N and Y181C.