_EC 2.7.7.49 RNA-directed Dna polymerase. 1,070 PDB entries  
EC 2.-.-.- Transferases. [19,022 PDB entries]
EC 2.7.-.- Transferring phosphorous-containing groups. [11,599 PDB entries]
EC 2.7.7.- Nucleotidyltransferases. [4,701 PDB entries]
EC 2.7.7.49 RNA-directed Dna polymerase. [1,070 PDB entries]    
1a30

Reaction: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
 


Deoxynucleoside triphosphate
+
DNA(n)
=
diphosphate
+
DNA(n+1)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Dna nucleotidyltransferase (RNA-directed). Reverse transcriptase. Revertase.
Comments: Catalyzes RNA-template-directed extension of the 3'-end of a Dna strand by one deoxynucleotide at a time. Cannot initiate a chain de novo. Requires a Rna or dna primer. Dna can also serve as template. See also Ec 2.7.7.7.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 1070 PDB entries in enzyme class E.C.2.7.7.49

  PDB code Protein
1a30
HIV-1 protease complexed with a tripeptide inhibitor
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: isolate hxb2. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1a43
Structure of the HIV-1 capsid protein dimerization domain at 2.6a resolution
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Cell_line: bl21. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (72 residues) CATH domain: 1.10.1200.30
1a5v
Asv integrase core domain with HIV-1 integrase inhibitor y3 cation
Source: Rous sarcoma virus (strain schmidt-rup organism_taxid: 11889. Strain: schmidt-ruppin. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: see jrnl reference
Chain: A (146 residues) CATH domain: 3.30.420.10
1a5w
Asv integrase core domain with HIV-1 integrase inhibitor y3
Source: Rous sarcoma virus (strain schmidt- ruppin). Organism_taxid: 11889. Strain: schmidt-ruppin. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: see jrnl reference
Chain: A (146 residues) CATH domain: 3.30.420.10
1a5x
Asv integrase core domain with HIV-1 integrase inhibitor y3
Source: Rous sarcoma virus (strain schmidt- ruppin). Organism_taxid: 11889. Strain: schmidt-ruppin. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: see jrnl reference
Chain: A (146 residues) CATH domain: 3.30.420.10
1a8g
HIV-1 protease in complex with sdz283-910
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1a8k
Crystallographic analysis of human immunodeficiency virus 1 with an analog of the conserved ca-p2 substrate: interactio frequently occurring glutamic acid residue at p2' position substrates
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, D, E (99 residues) CATH domain: 2.40.70.10
1a8o
HIV capsid c-terminal domain
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Cell_line: bl21. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (70 residues) CATH domain: 1.10.1200.30
1a94
Structural basis for specificity of retroviral proteases
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, D, E (99 residues) CATH domain: 2.40.70.10
1a9m
G48h mutant of HIV-1 protease in complex with a peptidic inhibitor u-89360e
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1aaf
Nucleocapsid zinc fingers detected in retroviruses: exafs st intact viruses and the solution-state structure of the nucl protein from HIV-1
Source: Human immunodeficiency virus 1. Organism_taxid: 11696. Strain: m/b_mn. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (55 residues) CATH domain: 4.10.60.10
1aaq
Hydroxyethylene isostere inhibitors of human immunodeficienc protease: structure-activity analysis using enzyme kinetics crystallography, and infected t-cell assays
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1afv
HIV-1 capsid protein (p24) complex with fab25.3
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: c-12. Cell_line: bl21. Gene: gag. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Other_details: iiib/lai isolate of HIV-1. Mus musculus.
Chains: A, B (151 residues) CATH domain: 1.10.375.10
1aid
Structure of a non-peptide inhibitor complexed with HIV-1 pr developing a cycle of structure-based drug design
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Variant: sf1 isolate. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1ajv
HIV-1 protease in complex with the cyclic sulfamide inhibitor aha006
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: bh10. Cell_line: bl21. Gene: protease. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1ajx
HIV-1 protease in complex with the cyclic urea inhibitor aha001
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: bh10. Cell_line: bl21. Gene: protease. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1ak4
Human cyclophilin a bound to the amino-terminal domain of HIV-1 capsid
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: bl21. Gene: cyclophilin. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Human immunodeficiency virus 1. Organism_taxid: 11676.
Chains: C, D (145 residues) CATH domain: 1.10.375.10
1asu
Avian sarcoma virus integrase catalytic core domain crystall 2% peg 400, 2m ammonium sulfate, hepes ph 7.5
Source: Avian sarcoma virus. Organism_taxid: 11876. Strain: schmidt-ruppin b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (162 residues) CATH domain: 3.30.420.10
1asv
Avian sarcoma virus integrase catalytic core domain
Source: Avian sarcoma virus. Organism_taxid: 11876. Strain: schmidt-ruppin b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (146 residues) CATH domain: 3.30.420.10
1asw
Avian sarcoma virus integrase catalytic core domain crystallized from 20% peg 4000, 10% isopropanol, hepes ph 7.5 using selenomethionine substituted protein; data collected at-165 degrees c
Source: Avian sarcoma virus. Organism_taxid: 11876. Strain: schmidt-ruppin b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (152 residues) CATH domain: 3.30.420.10
1aum
HIV capsid c-terminal domain (cac146)
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Cell_line: bl21. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (70 residues) CATH domain: 1.10.1200.30
1axa
Active-site mobility in human immunodeficiency virus type 1 protease as demonstrated by crystal structure of a28s mutant
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1az5
Unliganded siv protease structure in an "open" conformation
Source: Simian immunodeficiency virus. Organism_taxid: 11723. Strain: x90. Variant: siv(mac)239. Gene: siv(mac)239. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (95 residues) CATH domain: 2.40.70.10
1b11
Structure of feline immunodeficiency virus protease complexe 3-093
Source: Feline immunodeficiency virus. Organism_taxid: 11673
Chain: A (113 residues) CATH domain: 2.40.70.10
1b6j
HIV-1 protease complexed with macrocyclic peptidomimetic inh
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Other_details: cys residues replaced with aba. Synthetic: yes
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1b6k
HIV-1 protease complexed with macrocyclic peptidomimetic inhibitor 5
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Other_details: cys residues replaced with aba
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1b6l
HIV-1 protease complexed with macrocyclic peptidomimetic inhibitor 4
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Other_details: cys residues replaced with aba
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1b6m
HIV-1 protease complexed with macrocyclic peptidomimetic inh
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Other_details: cys residues replaced with aba
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1b6p
HIV-1 protease complexed with macrocyclic peptidomimetic inhibitor 7
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Other_details: cys residues replaced with aba
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1b92
Mobility of an HIV-1 integrase active site loop is correlate catalytic activity
Source: Human immunodeficiency virus. Organism_taxid: 11676. Strain: 1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: de3.
Chain: A (144 residues) CATH domain: 3.30.420.10
1b9d
Mobility of an HIV-1 integrase active site loop is correlate catalytic activity
Source: Human immunodeficiency virus. Organism_taxid: 11676. Strain: 1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: de3.
Chain: A (143 residues) CATH domain: 3.30.420.10
1b9f
Mobility of an HIV-1 integrase active site loop is correlate catalytic activity
Source: Human immunodeficiency virus type 1 (c organism_taxid: 11679. Strain: 1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: de3.
Chain: A (151 residues) CATH domain: 3.30.420.10
1baj
HIV-1 capsid protein c-terminal fragment plus gag p2 domain
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Cell_line: bl21. Gene: gag. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (71 residues) CATH domain: 1.10.1200.30
1bdl
HIV-1 (2:31-37) protease complexed with inhibitor sb203386
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: iiib. Gene: HIV-1 protease. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_variant: bmh 71-18 muts.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1bdq
HIV-1 (2:31-37, 47, 82) protease complexed with inhibitor sb203386
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: iiib. Gene: HIV-1 protease. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_variant: bmh 71-18 muts.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1bdr
HIV-1 (2: 31, 33-37) protease complexed with inhibitor sb203386
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: iiib. Gene: HIV-1 protease. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_variant: bmh 71-18 muts.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1bhl
Cacodylated catalytic domain of HIV-1 integrase
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Cell_line: bl21. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Other_details: expression clone for core, refer to pnas usa 90, pp. 3428-3432, april 1993, and pnas usa 92, pp. 6057-60 1995
Chain: A (135 residues) CATH domain: 3.30.420.10
1bi4
Catalytic domain of HIV-1 integrase
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Cell_line: bl21. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Other_details: reference, pnas usa, vol. 90, pp 3428-3432, and pnas usa 92, pp. 6057-6061. And pnas usa 92, pp. 6057-6061
Chains: A, B, C (142 residues) CATH domain: 3.30.420.10
1bis
HIV-1 integrase core domain
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: de3.
Chains: A, B (146 residues) CATH domain: 3.30.420.10
1biu
HIV-1 integrase core domain complexed with mg++
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: de3.
Chains: A, B, C (147 residues) CATH domain: 3.30.420.10
1biz
HIV-1 integrase core domain
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: de3.
Chains: A, B (147 residues) CATH domain: 3.30.420.10
1bl3
Catalytic domain of HIV-1 integrase
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Cell_line: bl21. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C (142 residues) CATH domain: 3.30.420.10
1bqm
HIV-1 rt/hby 097
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: bh10. Cell_line: 293. Atcc: atcc 1065288. Collection: atcc 1065288. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (556 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1bqn
Tyr 188 leu HIV-1 rt/hby 097
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: bh10. Cell_line: 293. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (558 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1bv7
Counteracting HIV-1 protease drug resistance: structural analysis of mutant proteases complexed with xv638 and sd146, cyclic urea amides with broad specificities
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: bh102. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1bv9
HIV-1 protease (i84v) complexed with xv638 of dupont pharmaceuticals
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: bh102. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1bve
HIV-1 protease-dmp323 complex in solution, nmr, 28 structures
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: hxb2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1bvg
HIV-1 protease-dmp323 complex in solution, nmr minimized average structure
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: hxb2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1bwa
HIV-1 protease (v82f/i84v) double mutant complexed with xv638 of dupont pharmaceuticals
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: bh102. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1bwb
HIV-1 protease (v82f/i84v) double mutant complexed with sd14 dupont pharmaceuticals
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: bh102. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1c0m
Crystal structure of rsv two-domain integrase
Source: Rous sarcoma virus. Organism_taxid: 11886. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (221 residues) CATH domains: 3.30.420.10 2.30.30.10
1c0t
Crystal structure of HIV-1 reverse transcriptase in complex bm+21.1326
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: hxb2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (491 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1c0u
Crystal structure of HIV-1 reverse transcriptase in complex bm+50.0934
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: hxb2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (539 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1c1a
Crystal structure of rsv two-domain integrase
Source: Rous sarcoma virus. Organism_taxid: 11886. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (221 residues) CATH domains: 3.30.420.10 2.30.30.10
1c1b
Crystal structure of HIV-1 reverse transcriptase in complex 186
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: hxb2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (537 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1c1c
Crystal structure of HIV-1 reverse transcriptase in complex 6123
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: hxb2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (537 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1c6v
Siv integrase (catalytic domain + DNA biding domain comprising residues 50-293) mutant with phe 185 replaced by his (f185h)
Source: Simian immunodeficiency virus. Organism_taxid: 11723. Expressed in: escherichia coli k12. Expression_system_taxid: 83333. Expression_system_variant: de3.
Chains: A, B, C, D, X (148 residues) CATH domain: 3.30.420.10
1c9r
Crystal structure of met184ile mutant of HIV-1 reverse transcriptase in complex with double stranded DNA template- primer
Source: Human immunodeficiency virus type 1. Expressed in: escherichia coli. Mus musculus. Mouse. Synthetic: yes. Synthetic: yes
Chains: A, B (558 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1cpi
Regioselective structural and functional mimicry of peptides of hydrolytically stable cyclic peptidomimetic inhibitors o protease
Source: Synthetic: yes. Other_details: chemically synthesized protein corresponding protease from the HIV-i. Synthetic: yes
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1cxq
Atomic resolution asv integrase core domain from ammonium su
Source: Avian sarcoma virus. Organism_taxid: 11876. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (143 residues) CATH domain: 3.30.420.10
1cxu
1.42a resolution asv integrase core domain from citrate
Source: Avian sarcoma virus. Organism_taxid: 11876. Strain: rous sarcoma virus, schmidt-ruppin b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (143 residues) CATH domain: 3.30.420.10
1cz9
Atomic resolution asv integrase core domain (d64n) from citr
Source: Avian sarcoma virus. Organism_taxid: 11876. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (139 residues) CATH domain: 3.30.420.10
1czb
Atomic resolution asv integrase core domain from hepes
Source: Avian sarcoma virus. Organism_taxid: 11876. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (141 residues) CATH domain: 3.30.420.10
1d0e
Crystal structures of the n-terminal fragment from moloney m leukemia virus reverse transcriptase complexed with nucleic functional implications for template-primer binding to the domain
Source: Synthetic: yes. Moloney murine leukemia virus. Organism_taxid: 11801. Gene: mmlv-rt. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (259 residues) CATH domains: 3.10.10.10 3.30.70.270
1d1u
Use of an n-terminal fragment from moloney murine leukemia virus reverse transcriptase to facilitate crystallization and analysis of a pseudo-16-mer DNA molecule containing g- a mispairs
Source: Synthetic: yes. Other_details: the sequence 5'-ctcgtg-3' was synthesized on an applied biosystems 392 DNA/RNA synthesizer. Moloney murine leukemia virus. Organism_taxid: 11801. Gene: mmlv reverse transcriptase. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (255 residues) CATH domains: 3.10.10.10 3.30.70.270
1d4h
HIV-1 protease in complex with the inhibitor bea435
Source: Human immunodeficiency virus. Organism_taxid: 12721. Strain: bh10. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1d4i
HIV-1 protease in complex with the inhibitor bea425
Source: Human immunodeficiency virus. Organism_taxid: 12721. Strain: bh10. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1d4j
HIV-1 protease in complex with the inhibitor msl370
Source: Human immunodeficiency virus. Organism_taxid: 12721. Strain: bh10. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1d4k
HIV-1 protease complexed with a macrocyclic peptidomimetic inhibitor
Source: Synthetic: yes. Other_details: sf2 isolate, chemically synthesised protein corresponds to the protease from HIV-1, with 4 mutations per monomer
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1d4l
HIV-1 protease complexed with a macrocyclic peptidomimetic inhibitor
Source: Synthetic: yes. Other_details: sf2 isolate, chemically synthesised protein corresponds to the protease from HIV-1, with 4 mutations per monomer
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1d4s
HIV-1 protease v82f/i84v double mutant/tipranavir complex
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1d4y
HIV-1 protease triple mutant/tipranavir complex
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1daz
Structural and kinetic analysis of drug resistant mutants of protease
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: C, D (99 residues) CATH domain: 2.40.70.10
1dif
HIV-1 protease in complex with a difluoroketone containing inhibitor a79285
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1dlo
Human immunodeficiency virus type 1
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: bh10 isolate. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B (556 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1dmp
Structure of HIV-1 protease complex
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: bh102 isolate. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1dtq
Crystal structure of HIV-1 reverse transcriptase in complex 1 (pett131a94)
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: bacteria. Expression_system_taxid: 2. Expression_system_taxid: 2
Chains: A, B (525 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1dtt
Crystal structure of HIV-1 reverse transcriptase in complex 2 (pett130a94)
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: bacteria. Expression_system_taxid: 2. Expression_system_taxid: 2
Chains: A, B (541 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1duc
Eiav dutpase dudp/strontium complex
Source: Equine infectious anemia virus. Organism_taxid: 11665. Cell_line: bl21. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (118 residues) CATH domain: 2.70.40.10
Bound ligand:   Het Group DUD is 55.17% similar to enzyme reactant Deoxynucleoside
1dun
Eiav dutpase native
Source: Equine infectious anemia virus. Organism_taxid: 11665. Cell_line: bl21. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (120 residues) CATH domain: 2.70.40.10
1dut
Fiv dutp pyrophosphatase
Source: Feline immunodeficiency virus. Organism_taxid: 11674. Strain: (isolate petaluma). Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: tn5.
Chains: A, B (117 residues) CATH domain: 2.70.40.10
1dw6
Structural and kinetic analysis of drug resistant mutants of protease
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: C, D (99 residues) CATH domain: 2.40.70.10
1e0e
N-terminal zinc-binding hhcc domain of HIV-2 integrase
Source: Human immunodeficiency virus type 2 (isolate rod). HIV-2. Organism_taxid: 11720. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (46 residues) CATH domain: 1.10.10.200
1ebk
Structural and kinetic analysis of drug resistant mutants of protease
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: C, D, E, F (99 residues) CATH domain: 2.40.70.10
1ebw
HIV-1 protease in complex with the inhibitor bea322
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1eby
HIV-1 protease in complex with the inhibitor bea369
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1ebz
HIV-1 protease in complex with the inhibitor bea388
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1ec0
HIV-1 protease in complex with the inhibitor bea403
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1ec1
HIV-1 protease in complex with the inhibitor bea409
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1ec2
HIV-1 protease in complex with the inhibitor bea428
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1ec3
HIV-1 protease in complex with the inhibitor msa367
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1ecw
Crystal structure of simian immunodeficiency virus matrix antigen (siv ma) at 293k.
Source: Simian immunodeficiency virus. Organism_taxid: 11723. Strain: mac bk28. Gene: gag. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469.
Chain: A (114 residues) CATH domain: 1.10.150.90
1ed1
Crystal structure of simian immunodeficiency virus matrix antigen (siv ma) at 100k.
Source: Simian immunodeficiency virus - mac. Organism_taxid: 11711. Strain: mac bk28. Gene: gag. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469.
Chain: A (114 residues) CATH domain: 1.10.150.90
1eet
HIV-1 reverse transcriptase in complex with the inhibitor msc204
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: bh10. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (542 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1ep4
Crystal structure of HIV-1 reverse transcriptase in complex 1153
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: hxb2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (523 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1esk
Solution structure of ncp7 from HIV-1
Source: Synthetic: yes. Other_details: the protein was chemically synthesized. The sequence is naturally found in human immunodeficiency virus type 1 (HIV-1).
Chain: A (42 residues) CATH domain: 4.10.60.10
1ex4
HIV-1 integrase catalytic core and c-terminal domain
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (212 residues) CATH domains: 3.30.420.10 2.30.30.10
1exq
Crystal structure of the HIV-1 integrase catalytic core domain
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (147 residues) CATH domain: 3.30.420.10
1f6u
Nmr structure of the HIV-1 nucleocapsid protein bound to stem-loop sl2 of the psi-RNA packaging signal. Implications for genome recognition
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chain: A (56 residues) CATH domain: 4.10.60.10
1f7a
How does a symmetric dimer recognize an asymmetric substrate? a substrate complex of HIV-1 protease.
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: this peptide was chemically synthesized.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1f7d
Crystal structures of feline immunodeficiency virus dutp pyrophosphatase and its nucleotide complexes in three cryst
Source: Feline immunodeficiency virus. Organism_taxid: 11673. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
Chains: A, B (118 residues) CATH domain: 2.70.40.10
1f7k
Crystal structures of feline immunodeficiency virus dutp pyrophosphatase and its nucleotide complexes in three cryst
Source: Feline immunodeficiency virus. Organism_taxid: 11673. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
Chains: A, B (117 residues) CATH domain: 2.70.40.10
Bound ligand:   Het Group UMP is 41.38% similar to enzyme reactant Deoxynucleoside
1f7n
Crystal structures of feline immunodeficiency virus dutp pyrophosphatase and its nucleotide complexes in three cryst
Source: Feline immunodeficiency virus. Organism_taxid: 11673. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
Chains: A, B (117 residues) CATH domain: 2.70.40.10
Bound ligand:   Het Group UMP is 41.38% similar to enzyme reactant Deoxynucleoside
1f7o
Crystal structures of feline immunodeficiency virus dutp pyrophosphatase and its nucleotide complexes in three crystal forms.
Source: Feline immunodeficiency virus. Organism_taxid: 11673. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
Chains: A, B, C (116 residues) CATH domain: 2.70.40.10
1f7p
Crystal structures of feline immunodeficiency virus dutp pyrophosphatase and its nucleotide complexes in three crystal forms.
Source: Feline immunodeficiency virus. Organism_taxid: 11673. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
Chains: A, B, C (116 residues) CATH domain: 2.70.40.10
Bound ligand:   Het Group UDP is 55.00% similar to enzyme reactant Deoxynucleoside triphosphate
1f7q
Crystal structures of feline immunodeficiency virus dutp pyrophosphatase and its nucleotide complexes in three crystal forms.
Source: Feline immunodeficiency virus. Organism_taxid: 11673. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
Chains: A, B, C (116 residues) CATH domain: 2.70.40.10
Bound ligand:   Het Group DUT is 68.00% similar to enzyme reactant Deoxynucleoside triphosphate
1f7r
Crystal structures of feline immunodeficiency virus dutp pyrophosphatase and its nucleotide complexes in three cryst
Source: Feline immunodeficiency virus. Organism_taxid: 11673. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
Chain: A (133 residues) CATH domain: 2.70.40.10
Bound ligand:   Het Group UDP is 55.17% similar to enzyme reactant Deoxynucleoside
1fb7
Crystal structure of an in vivo HIV-1 protease mutant in com saquinavir: insights into the mechanisms of drug resistance
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (99 residues) CATH domain: 2.40.70.10
1fej
Structural implications of drug resistant mutants of HIV-1 p high resolution crystal structures of the mutant protease/s analog complexes
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: C, D (99 residues) CATH domain: 2.40.70.10
1ff0
Structural implications of drug resistant mutants of HIV-1 p high resolution crystal structures of the mutant protease/s analog complexes.
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: C, D (99 residues) CATH domain: 2.40.70.10
1fff
Structural implications of drug resistant mutants of HIV-1 p high resolution crystal structures of the mutant protease/s analog complexes.
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: C, D (99 residues) CATH domain: 2.40.70.10
1ffi
Structural implications of drug resistant mutants of HIV-1 p high resolution crystal structures of the mutant protease/s analog complexes
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: C, D (99 residues) CATH domain: 2.40.70.10
1fg6
Structural implications of drug resistant mutants of HIV-1 p high resolution crystal structures of the mutant protease/s analog complexes
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: C, D (99 residues) CATH domain: 2.40.70.10
1fg8
Structural implications of drug resistant mutants of HIV-1 p high resolution crystal structures of the mutant protease/s analog complexes
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: C, D (99 residues) CATH domain: 2.40.70.10
1fgc
Structural implications of drug resistant mutants of HIV-1 p high resolution crystal structures of the mutant protease/s analog complexes
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: C, D (99 residues) CATH domain: 2.40.70.10
1fiv
Structure of an inhibitor complex of proteinase from feline immunodeficiency virus
Source: Feline immunodeficiency virus. Organism_taxid: 11673. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chain: A (113 residues) CATH domain: 2.40.70.10
1fk9
Crystal structure of HIV-1 reverse transcriptase in complex 266(efavirenz)
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: hxb2 isolate. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B (520 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1fko
Crystal structure of nnrti resistant k103n mutant HIV-1 reve transcriptase in complex with dmp-266(efavirenz)
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: hxb2 isolate. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B (543 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1fkp
Crystal structure of nnrti resistant k103n mutant HIV-1 reverse transcriptase in complex with nevirapine
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: hxb2 isolate. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B (542 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1fmb
Eiav protease complexed with the inhibitor hby-793
Source: Equine infectious anemia virus. Organism_taxid: 11665. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (104 residues) CATH domain: 2.40.70.10
1fqx
Crystal structure of the complex of HIV-1 protease with a peptidomimetic inhibitor
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1g2k
HIV-1 protease with cyclic sulfamide inhibitor, aha047
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Variant: isolate lv. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1g35
Crystal structure of HIV-1 protease in complex with inhibitor, aha024
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: bh7. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1g6l
1.9a crystal structure of tethered HIV-1 protease
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (198 residues) CATH domains: 2.40.70.10 2.40.70.10
1gnm
HIV-1 protease mutant with val 82 replaced by asp (v82d) complexed with u89360e (inhibitor)
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1gnn
HIV-1 protease mutant with val 82 replaced by asn (v82n) complexed with u89360e (inhibitor)
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1gno
HIV-1 protease (wild type) complexed with u89360e (inhibitor)
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1har
2.2 angstroms resolution structure of the amino-terminal half of HIV-1 reverse transcriptase (fingers and palm subdomains)
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (196 residues) CATH domains: 3.10.10.10 3.30.70.270
1hbv
A check on rational drug design. Crystal structure of a comp HIV-1 protease with a novel gamma-turn mimetic
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: HIV-1 protease. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1hef
The crystal structures at 2.2 angstroms resolution of hydrox based inhibitors bound to human immunodeficiency virus type protease show that the inhibitors are present in two distin orientations
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chain: E (99 residues) CATH domain: 2.40.70.10
1heg
The crystal structures at 2.2 angstroms resolution of hydrox based inhibitors bound to human immunodeficiency virus type protease show that the inhibitors are present in two distin orientations
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: E (99 residues) CATH domain: 2.40.70.10
1hhp
The three-dimensional structure of the aspartyl protease fro 1 isolate bru
Source: Human immunodeficiency virus type 1 (b isolate). Organism_taxid: 11686. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (99 residues) CATH domain: 2.40.70.10
1hih
Comparative analysis of the x-ray structures of HIV-1 and HIV-2 proteases in complex with cgp 53820, a novel pseudosymmetric inhibitor
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Cell_line: s2. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1hii
Comparative analysis of the x-ray structures of HIV-1 and HIV-2 proteases in complex with cgp 53820, a novel pseudosymmetric inhibitor
Source: Human immunodeficiency virus 2. Organism_taxid: 11709. Cell_line: s2. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1hiv
Crystal structure of a complex of HIV-1 protease with a dihydroethylene-containing inhibitor: comparisons with mole modeling
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1hiw
Trimeric HIV-1 matrix protein
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: nl4-3. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: t7 promoter
Chains: A, B, C, Q, R, S (115 residues) CATH domain: 1.10.150.90
1hmv
The structure of unliganded reverse transcriptase from the human immunodeficiency virus type 1
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: HIV-1 pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F, G, H (536 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1hni
Structure of HIV-1 reverse transcriptase in a complex with t nonnucleoside inhibitor alpha-apa r 95845 at 2.8 angstroms
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (558 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1hnv
Structure of HIV-1 rt(slash)tibo r 86183 complex reveals similarity in the binding of diverse nonnucleoside inhibitors
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B (558 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1hos
Inhibition of human immunodeficiency virus-1 protease by a c symmetric phosphinate synthesis and crystallographic analys
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1hpo
HIV-1 protease triple mutant/u103265 complex
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1hps
Rational design, synthesis and crystallographic analysis of hydroxyethylene-based HIV-1 protease inhibitor containing a heterocyclic p1'-p2' amide bond isostere
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1hpv
Crystal structure of HIV-1 protease in complex with vx-478, and orally bioavailable inhibitor of the enzyme
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1hpx
HIV-1 protease complexed with the inhibitor kni-272
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: hivlai. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1hpz
Human immunodeficiency virus type 1
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: HIV-1 clone 12. Other_details: HIV-1 clone 12
Chains: A, B (556 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1hqe
Human immunodeficiency virus type 1
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: HIV-1 clone 12. Other_details: HIV-1 clone 12
Chains: A, B (554 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1hqu
Human immunodeficiency virus type 1
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: HIV-1 clone 12. Other_details: HIV-1 clone 12
Chains: A, B (556 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1hrh
Crystal structure of the ribonuclease h domain of HIV-1 reverse transcriptase
Source: Human immunodeficiency virus 1. Organism_taxid: 11676
Chains: A, B (125 residues) CATH domain: 3.30.420.10
1hsg
Crystal structure at 1.9 angstroms resolution of human immunodeficiency virus (HIV) ii protease complexed with l- 735,524, an orally bioavailable inhibitor of the HIV proteases
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: HIV-1 protease from the ny5 isolate. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1hsh
Crystal structure at 1.9 angstroms resolution of human immunodeficiency virus (HIV) ii protease complexed with l- 735,524, an orally bioavailable inhibitor of the HIV proteases
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: HIV-1 protease from the rod isolate. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (99 residues) CATH domain: 2.40.70.10
1hsi
Crystal structure at 1.9 angstroms resolution of human immunodeficiency virus (HIV) ii protease complexed with l- 735,524, an orally bioavailable inhibitor of the HIV proteases
Source: Human immunodeficiency virus 2. Organism_taxid: 11709. Gene: HIV-2 protease from the rod isolate. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1hte
X-ray crystallographic studies of a series of penicillin- derived asymmetric inhibitors of HIV-1 protease
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1htf
X-ray crystallographic studies of a series of penicillin- derived asymmetric inhibitors of HIV-1 protease
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1htg
X-ray crystallographic studies of a series of penicillin- derived asymmetric inhibitors of HIV-1 protease
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1hvh
Nonpeptide cyclic cyanoguanidines as HIV protease inhibitors
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Variant: bh102 isolate. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1hvi
Influence of stereochemistry on activity and binding modes for c2 symmetry-based diol inhibitors of HIV-1 protease
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1hvj
Influence of stereochemistry on activity and binding modes for c2 symmetry-based diol inhibitors of HIV-1 protease
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1hvk
Influence of stereochemistry on activity and binding modes for c2 symmetry-based diol inhibitors of HIV-1 protease
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1hvl
Influence of stereochemistry on activity and binding modes for c2 symmetry-based diol inhibitors of HIV-1 protease
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1hvr
Rational design of potent, bioavailable, nonpeptide cyclic u HIV protease inhibitors
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1hvs
Structural basis of drug resistance for the v82a mutant of HIV-1 protease: backbone flexibility and subsite repacking
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1hvu
Human immunodeficiency virus type 1 reverse transcriptase complexed with a 33-base nucleotide RNA pseudoknot
Source: Synthetic: yes. Human immunodeficiency virus 1. Organism_taxid: 11676. Variant: bh10 isolate. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B, D, G, J, E, H, K (554 residues)
1hwr
Molecular recognition of cyclic urea HIV protease inhibitors
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: bh102. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1hxb
HIV-1 proteinase complexed with ro 31-8959
Source: Human immunodeficiency virus type 1 (c organism_taxid: 11679. Variant: hxb-3. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1hxw
HIV-1 protease dimer complexed with a-84538
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1hys
Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract rna:dna
Source: Synthetic: yes. Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Mus musculus. House mouse. Organism_taxid: 10090.
Chains: A, B (553 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1i6j
Crystal structure of a pseudo-16-mer DNA with stacked guanines and two g-a mispairs complexed with the n- terminal fragment of moloney murine leukemia virus reverse transcriptase
Source: Synthetic: yes. Other_details: abi 392 DNA synthesizer. Moloney murine leukemia virus. Organism_taxid: 11801. Gene: virus. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (256 residues) CATH domains: 3.10.10.10 3.30.70.270
1ida
Crystal structures of HIV-2 protease in complex with inhibit containing the hydroxyethylamine dipeptide isostere
Source: Human immunodeficiency virus type 2. HIV-2. Organism_taxid: 11709. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1idb
Crystal structures of HIV-2 protease in complex with inhibit containing the hydroxyethylamine dipeptide isostere
Source: Human immunodeficiency virus 2. Organism_taxid: 11709. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1iiq
Crystal structure of HIV-1 protease complexed with a hydroxy peptidomimetic inhibitor
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1ikv
K103n mutant HIV-1 reverse transcriptase in complex with efi
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: bh10. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (556 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1ikw
Wild type HIV-1 reverse transcriptase in complex with efavir
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: bh10. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B (557 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1ikx
K103n mutant HIV-1 reverse transcriptase in complex with the inhibitor pnu142721
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: bh10. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B (557 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1iky
HIV-1 reverse transcriptase in complex with the inhibitor msc194
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: bh10. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (557 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1itg
Crystal structure of the catalytic domain of HIV-1 integrase similarity to other polynucleotidyl transferases
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: HIV-1 integrase. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (142 residues) CATH domain: 3.30.420.10
1ivp
The crystallographic structure of the protease from human immunodeficiency virus type 2 with two synthetic peptidic t state analog inhibitors
Source: Human immunodeficiency virus 2. Organism_taxid: 11709. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1ivq
The crystallographic structure of the protease from human immunodeficiency virus type 2 with two synthetic peptidic t state analog inhibitors
Source: Human immunodeficiency virus 2. Organism_taxid: 11709. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1izi
Inhibitor of HIV protease with unusual binding mode potently inhibiting multi-resistant protease mutants
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1j5o
Crystal structure of met184ile mutant of HIV-1 reverse transcriptase in complex with double stranded DNA template- primer
Source: Synthetic: yes. Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562. Mus musculus. House mouse. Organism_taxid: 10090. Organism_taxid: 10090
Chains: A, B (558 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1jkh
Crystal structure of y181c mutant HIV-1 reverse transcriptas complex with dmp-266(efavirenz)
Source: HIV-1 m:b_hxb2r. Organism_taxid: 11706. Strain: hxb2 isolate. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (551 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1jla
Crystal structure of y181c mutant HIV-1 reverse transcriptas complex with tnk-651
Source: HIV-1 m:b_hxb2r. Organism_taxid: 11706. Strain: hxb2 isolate. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B (547 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1jlb
Crystal structure of y181c mutant HIV-1 reverse transcriptase in complex with nevirapine
Source: HIV-1 m:b_hxb2r. Organism_taxid: 11706. Strain: hxb2 isolate. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B (550 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1jlc
Crystal structure of y181c mutant HIV-1 reverse transcriptase in complex with pett-2
Source: HIV-1 m:b_hxb2r. Organism_taxid: 11706. Strain: hxb2 isolate. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B (535 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1jld
Potent HIV protease inhibitors containing a novel (hydroxyet isostere
Source: Human immunodeficiency virus 2. Organism_taxid: 11709. Strain: rod isolate. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1jle
Crystal structure of y188c mutant HIV-1 reverse transcriptase
Source: HIV-1 m:b_hxb2r. Organism_taxid: 11706. Strain: hxb2 isolate. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B (526 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1jlf
Crystal structure of y188c mutant HIV-1 reverse transcriptase in complex with nevirapine
Source: HIV-1 m:b_hxb2r. Organism_taxid: 11706. Strain: hxb2 isolate. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B (539 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1jlg
Crystal structure of y188c mutant HIV-1 reverse transcriptase in complex with uc-781
Source: HIV-1 m:b_hxb2r. Organism_taxid: 11706. Strain: hxb2 isolate. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B (531 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1jlq
Crystal structure of HIV-1 reverse transcriptase in complex with 739w94
Source: HIV-1 m:b_hxb2r. Organism_taxid: 11706. Strain: hxb2 isolate. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B (534 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1jvr
Structure of the htlv-ii matrix protein, nmr, 20 structures
Source: Human t-lymphotropic virus 2. Organism_taxid: 11909. Cell_line: bl21. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (137 residues) CATH domain: 1.10.185.10
1k1t
Combining mutations in HIV-1 protease to understand mechanis resistance
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1k1u
Combining mutations in HIV-1 protease to understand mechanis resistance
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1k2b
Combining mutations in HIV-1 protease to understand mechanis resistance
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1k2c
Combining mutations in HIV-1 protease to understand mechanis resistance
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1k6c
Lack of synergy for inhibitors targeting a multi-drug resistant HIV-1 protease
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1k6p
Lack of synergy for inhibitors targeting a multi-drug resistant HIV-1 protease
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1k6t
Lack of synergy for inhibitors targeting a multi-drug resistant HIV-1 protease
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1k6v
Lack of synergy for inhibitors targeting a multi-drug resistant HIV-1 protease
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1k6y
Crystal structure of a two-domain fragment of HIV-1 integras
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (192 residues) CATH domains: 1.10.10.200 3.30.420.10
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme product diphosphate
1kj4
Substrate shape determines specificity of recognition recognition for HIV-1 protease: analysis of crystal structures of six substrate complexes
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: A, B, C, D (99 residues) CATH domain: 2.40.70.10
1kj7
Substrate shape determines specificity of recognition recognition for HIV-1 protease: analysis of crystal structures of six substrate complexes
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1kjf
Substrate shape determines specificity of recognition recognition for HIV-1 protease: analysis of crystal structures of six substrate complexes
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1kjg
Substrate shape determines specificity of recognition recognition for HIV-1 protease: analysis of crystal structures of six substrate complexes
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1kjh
Substrate shape determines specificity of recognition recognition for HIV-1 protease: analysis of crystal structures of six substrate complexes
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1klm
HIV-1 reverse transcriptase complexed with bhap u-90152
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: hxb2 isolate. Cell_line: 293. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (538 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1kzk
Je-2147-HIV protease complex
Source: Human immunodeficiency virus. Organism_taxid: 12721. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1lv1
Crystal structure analysis of the non-active site mutant of tethered HIV-1 protease to 2.1a resolution
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (198 residues) CATH domains: 2.40.70.10 2.40.70.10
1lw0
Crystal structure of t215y mutant HIV-1 reverse transcriptase in complex with nevirapine
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: HIV-1 pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (513 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
Bound ligand:   Het Group PO4 is 55.00% similar to enzyme product diphosphate
1lw2
Crystal structure of t215y mutant HIV-1 reverse transcriptase in complex with 1051u91
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: HIV-1 pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (519 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
Bound ligand:   Het Group PO4 is 55.00% similar to enzyme product diphosphate
1lwc
Crystal structure of m184v mutant HIV-1 reverse transcriptase in complex with nevirapine
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: HIV-1 pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (507 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
Bound ligand:   Het Group PO4 is 55.00% similar to enzyme product diphosphate
1lwe
Crystal structure of m41l/t215y mutant HIV-1 reverse transcriptase (rtmn) in complex with nevirapine
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: HIV-1 pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (543 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
Bound ligand:   Het Group PO4 is 55.00% similar to enzyme product diphosphate
1lwf
Crystal structure of a mutant HIV-1 reverse transcriptase (rtmq+m184v: m41l/d67n/k70r/m184v/t215y) in complex with nevirapine
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: HIV-1 pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (543 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1lzq
Crystal structure of the complex of mutant HIV-1 protease (a i84v) with an ethylenamine peptidomimetic inhibitor boc-phe psi[ch2ch2nh]-phe-glu-phe-nh2
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1m0b
HIV-1 protease in complex with an ethyleneamine inhibitor
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1m0c
Retrovirus-related pol polyprotein
Source: Gallus gallus. Chicken
Chain: A (246 residues)
1mer
HIV-1 mutant (i84v) protease complexed with dmp450
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: bh102 isolate. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1mes
HIV-1 mutant (i84v) protease complexed with dmp323
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: bh102 isolate. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1met
HIV-1 mutant (v82f) protease complexed with dmp323
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: bh102 isolate. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1meu
HIV-1 mutant (v82f, i84v) protease complexed with dmp323
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: bh102 isolate. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1mfs
Dynamical behavior of the HIV-1 nucleocapsid protein; nmr, 30 structures
Source: Human immunodeficiency virus. Organism_taxid: 12721. Strain: nl4-3. Cell_line: bl21. Gene: nc. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (55 residues) CATH domain: 4.10.60.10
1mml
Mechanistic implications from the structure of a catalytic fragment of mmlv reverse transcriptase
Source: Moloney murine leukemia virus. Organism_taxid: 11801. Gene: mmlv-rt. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (251 residues) CATH domains: 3.10.10.10 3.30.70.270
1mrw
Structure of HIV protease (mutant q7k l33i l63i) complexed w 577
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1mrx
Structure of HIV protease (mutant q7k l33i l63i v82f i84v ) with kni-577
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1msm
The HIV protease (mutant q7k l33i l63i) complexed with kni-7 inhibitor)
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1msn
The HIV protease (mutant q7k l33i l63i v82f i84v) complexed 764 (an inhibitor)
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1mt7
Viability of a drug-resistant HIV-1 protease mutant: structural insights for better antiviral therapy
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: this peptide sequence occurs naturally in gag of HIV-1
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1mt8
Viability of a drug-resistant HIV-1 protease mutant: structural insights for better antiviral therapy
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: this peptide sequence occurs naturally in gag of HIV-1
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1mt9
Viability of a drug-resistant HIV-1 protease mutant: structural insights for better antiviral therapy
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: this peptide sequence occurs naturally in gag of HIV-1
Chains: A, B (99 residues) CATH domain: 2.40.70.10
Bound ligand:   Het Group PO4 is 55.00% similar to enzyme product diphosphate
1mtb
Viability of a drug-resistant HIV-1 protease mutant: structu insights for better antiviral therapy
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1mtr
HIV-1 protease complexed with a cyclic phe-ile-val peptidomi inhibitor
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1mu2
Crystal structure of HIV-2 reverse transcriptase
Source: Human immunodeficiency virus 2. Organism_taxid: 11709. Strain: prod. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (538 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1n49
Viability of a drug-resistant HIV-1 protease variant: struct insights for better anti-viral therapy
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (99 residues) CATH domain: 2.40.70.10
1n4l
A DNA analogue of the polypurine tract of HIV-1
Source: Synthetic: yes. Moloney murine leukemia virus. Organism_taxid: 11801. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (255 residues) CATH domains: 3.10.10.10 3.30.70.270
1n5y
HIV-1 reverse transcriptase crosslinked to post- translocation aztmp-terminated DNA (complex p)
Source: Synthetic: yes. Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Mus musculus. House mouse. Organism_taxid: 10090.
Chains: A, B (558 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1n6q
HIV-1 reverse transcriptase crosslinked to pre- translocation aztmp-terminated DNA (complex n)
Source: Synthetic: yes. Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Mus musculus. House mouse. Organism_taxid: 10090.
Chains: A, B (558 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1nc8
High-resolution solution nmr structure of the minimal active domain of the human immunodeficiency virus type-2 nucleocapsid protein, 15 structures
Source: Human immunodeficiency virus 2. Organism_taxid: 11709
Chain: A (29 residues)
1ncp
Structural characterization of a 39 residue synthetic peptide containing the two zinc binding domains from the HIV-1 p7 nucleocapsid protein by cd and nmr spectroscopy
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Organism_taxid: 11676
Chains: N, C (17 residues)
1nh0
1.03 a structure of HIV-1 protease: inhibitor binding inside outside the active site
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1nnd
Arginine 116 is essential for nucleic acid recognition by the fingers domain of moloney murine leukemia virus reverse transcriptase
Source: Moloney murine leukemia virus. Organism_taxid: 11801. Gene: reverse transcriptase. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (251 residues) CATH domains: 3.10.10.10 3.30.70.270
1npa
Crystal structure of HIV-1 protease-hup
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1npv
Crystal structure of HIV-1 protease complexed with ldc271
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1npw
Crystal structure of HIV protease complexed with lgz479
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1o1w
Solution structure of the rnase h domain of the HIV-1 reverse transcriptase in the presence of magnesium
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Variant: strain hxb2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (138 residues) CATH domain: 3.30.420.10
1odw
Native HIV-1 proteinase
Source: Human immunodeficiency virus 1. HIV-1. Organism_taxid: 11676. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1odx
HIV-1 proteinase mutant a71t, v82a
Source: Human immunodeficiency virus 1. HIV-1. Organism_taxid: 11676. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1ody
HIV-1 protease complexed with an inhibitor lp-130
Source: HIV-1 m:b_hxb2r. Organism_taxid: 11706. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1pro
HIV-1 protease dimer complexed with a-98881
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: scs-1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1q9p
Solution structure of the mature HIV-1 protease monomer
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (95 residues) CATH domain: 2.40.70.10
1qai
Crystal structures of the n-terminal fragment from moloney m leukemia virus reverse transcriptase complexed with nucleic functional implications for template-primer binding to the domain
Source: Synthetic: yes. Moloney murine leukemia virus. Organism_taxid: 11801. Gene: mmlv-rt. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (251 residues) CATH domains: 3.10.10.10 3.30.70.270
1qaj
Crystal structures of the n-terminal fragment from moloney m leukemia virus reverse transcriptase complexed with nucleic functional implications for template-primer binding to the domain
Source: Synthetic: yes. Moloney murine leukemia virus. Organism_taxid: 11801. Gene: mmlv-rt. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (259 residues) CATH domains: 3.10.10.10 3.30.70.270
1qbr
HIV-1 protease inhibitors wiih low nanomolar potency
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: bh102. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1qbs
HIV-1 protease inhibitors wiih low nanomolar potency
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: bh102. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1qbt
HIV-1 protease inhibitors wiih low nanomolar potency
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: bh102. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1qbu
HIV-1 protease inhibitors wiih low nanomolar potency
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: bh102. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1qe1
Crystal structure of 3tc-resistant m184i mutant of HIV-1 reverse transcriptase
Source: Human immunodeficiency virus type 1 bh10. Organism_taxid: 11678. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B (556 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1qmc
C-terminal DNA-binding domain of HIV-1 integrase, nmr, 42 structures
Source: Human immunodeficiency virus type 1, HIV-1. Strain: bh10 isolate. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (52 residues) CATH domain: 2.30.30.10
1qrj
Solution structure of htlv-i capsid protein
Source: Human t-cell lymphotrophic virus type organism_taxid: 11926. Strain: atk. Gene: gag. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: hms174(de3). Other_details: t7-RNA polymerase-based expression system
Chain: A (214 residues) CATH domains: 1.10.375.10 1.10.1200.30
1qs4
Core domain of HIV-1 integrase complexed with mg++ and 1-(5- chloroindol-3-yl)-3-hydroxy-3-(2h-tetrazol-5-yl)-propenone
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B, C (150 residues) CATH domain: 3.30.420.10
1r0a
Crystal structure of HIV-1 reverse transcriptase covalently to DNA template-primer solved to 2.8 angstroms
Source: Synthetic: yes. Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Mus musculus. House mouse. Organism_taxid: 10090.
Chains: A, B (558 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1rdh
Crystallographic analyses of an active HIV-1 ribonuclease h domain show structural features that distinguish it from the inactive form
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (127 residues)
1rev
HIV-1 reverse transcriptase
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: hxb2 isolate. Cell_line: 293. Gene: HIV-1 pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (525 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1rl8
Crystal structure of the complex of resistant strain of HIV- protease(v82a mutant) with ritonavir
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: gag-pol. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1rt1
Crystal structure of HIV-1 reverse transcriptase complexed with mkc-442
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: hxb2 isolate. Cell_line: 293. Gene: HIV-1 pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (539 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1rt2
Crystal structure of HIV-1 reverse transcriptase complexed with tnk-651
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: hxb2 isolate. Cell_line: 293. Gene: HIV-1 pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (543 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1rt3
Azt drug resistant HIV-1 reverse transcriptase complexed with 1051u91
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Variant: hxb2 isolate. Cell_line: 293. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (521 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1rt4
HIV-1 reverse transcriptase complexed with uc781
Source: HIV-1 m:b_hxb2r. Organism_taxid: 11706. Strain: hxb2 isolate. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B (537 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
Bound ligand:   Het Group PO4 is 55.00% similar to enzyme product diphosphate
1rt5
HIV-1 reverse transcriptase complexed with uc10
Source: HIV-1 m:b_hxb2r. Organism_taxid: 11706. Strain: hxb2 isolate. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B (537 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
Bound ligand:   Het Group PO4 is 55.00% similar to enzyme product diphosphate
1rt6
HIV-1 reverse transcriptase complexed with uc38
Source: HIV-1 m:b_hxb2r. Organism_taxid: 11706. Strain: hxb2 isolate. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B (539 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
Bound ligand:   Het Group PO4 is 55.00% similar to enzyme product diphosphate
1rt7
HIV-1 reverse transcriptase complexed with uc84
Source: HIV-1 m:b_hxb2r. Organism_taxid: 11706. Strain: hxb2 isolate. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B (536 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
Bound ligand:   Het Group PO4 is 55.00% similar to enzyme product diphosphate
1rtd
Structure of a catalytic complex of HIV-1 reverse transcriptase: implications for nucleoside analog drug resistance
Source: Synthetic: yes. Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: bh10. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B, C, D (554 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
Bound ligand:   Het Group TTP is 66.00% similar to enzyme reactant Deoxynucleoside triphosphate
1rth
High resolution structures of HIV-1 rt from four rt- inhibitor complexes
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: hxb2 isolate. Cell_line: 293. Gene: HIV-1 pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (543 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1rti
High resolution structures of HIV-1 rt from four rt- inhibitor complexes
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: hxb2 isolate. Cell_line: 293. Gene: HIV-1 pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (543 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1rtj
Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: hxb2 isolate. Cell_line: 293. Gene: HIV-1 pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (543 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1rvl
Reverse transcriptase non-nucleoside binding site complexed with alpha-apa (r89439) (theoretical model)
Source: HIV-i (bh10 isolate)
Chain: A (47 residues)
1rvm
Reverse transcriptase non-nucleoside binding site complexed with hept (theoretical model)
Source: HIV-i (bh10 isolate)
Chain: A (47 residues)
1rvn
Reverse transcriptase non-nucleoside binding site complexed with phenyl-isoindolinone (theoretical model)
Source: HIV-i (bh10 isolate)
Chain: A (47 residues)
1rvo
Reverse transcriptase non-nucleoside binding site complexed with nevirapine (theoretical model)
Source: HIV-i (bh10 isolate)
Chain: A (47 residues)
1rvp
Reverse transcriptase non-nucleoside binding site complexed with thiazoloisoindolinone (theoretical model)
Source: HIV-i (bh10 isolate)
Chain: A (47 residues)
1rvq
Reverse transcriptase non-nucleoside binding site complexed with tibo (theoretical model)
Source: HIV-i (bh10 isolate)
Chain: A (47 residues)
1rvr
Reverse transcriptase non-nucleoside binding site complexed with imidazodipyridodiazepine (uk-129,485) (theoretical model)
Source: HIV-i (bh10 isolate)
Chain: A (47 residues)
1rw3
The crystal structure of the monomeric reverse transcriptase moloney murine leukemia virus
Source: Moloney murine leukemia virus. Organism_taxid: 11801. Gene: pol. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: ( residues)
1s1t
Crystal structure of l100i mutant HIV-1 reverse transcriptase in complex with uc-781
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (534 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
Bound ligand:   Het Group PO4 is 55.00% similar to enzyme product diphosphate
1s1u
Crystal structure of l100i mutant HIV-1 reverse transcriptase in complex with nevirapine
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (525 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1s1v
Crystal structure of l100i mutant HIV-1 reverse transcriptase in complex with tnk-651
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (534 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1s1w
Crystal structure of v106a mutant HIV-1 reverse transcriptase in complex with uc-781
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (525 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1s1x
Crystal structure of v108i mutant HIV-1 reverse transcriptase in complex with nevirapine
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (546 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1s6p
Crystal structure of human immunodeficiency virus type 1 rev transcriptase (rt) in complex with janssen-r100943
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: HIV-1 clone 12. Other_details: HIV-1 clone 12
Chains: A, B (552 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1s6q
Crystal structure of HIV-1 reverse transcriptase (rt) in com janssen-r147681
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: HIV-1 clone 12. Other_details: HIV-1 clone 12
Chains: A, B (552 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1s9e
Crystal structure of HIV-1 reverse transcriptase (rt) in complex with janssen-r129385
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: HIV-1 clone 12. Other_details: HIV-1 clone 12
Chains: A, B (552 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1s9g
Crystal structure of HIV-1 reverse transcriptase (rt) in com janssen-r120394.
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: HIV-1 clone 12. Other_details: HIV-1 clone 12
Chains: A, B (543 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1sbg
An orally-bioavailable HIV-1 protease inhibitor containing a imidazole-derived peptide bond replacement. Crystallographi pharmacokinetic analysis
Source: Human immunodeficiency virus type 1 bh organism_taxid: 11678. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1sdt
Crystal structures of HIV protease v82a and l90m mutants reveal changes in indinavir binding site.
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1sdu
Crystal structures of HIV protease v82a and l90m mutants reveal changes in indinavir binding site.
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1sdv
Crystal structures of HIV protease v82a and l90m mutants reveal changes in indinavir binding site.
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1sgu
Comparing the accumulation of active site and non-active site mutations in the HIV-1 protease
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1sh9
Comparing the accumulation of active site and non-active sit mutations in the HIV-1 protease
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1siv
Three-dimensional structure of a siv protease(slash)inhibito implications for the design of HIV-1 and HIV-2 protease inh
Source: Simian immunodeficiency virus. Organism_taxid: 11723
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1sp5
Crystal structure of HIV-1 protease complexed with a product of autoproteolysis
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: pol. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1suq
Crystal structure of HIV-1 reverse transcriptase (rt) in complex with janssen-r185545
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: bh10 isolate. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B (552 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1sv5
Crystal structure of k103n mutant HIV-1 reverse transcriptas complex with janssen-r165335
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: bh10 isolate. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B (552 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1t03
HIV-1 reverse transcriptase crosslinked to tenofovir terminated template-primer (complex p)
Source: Synthetic: yes. Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Mus musculus. House mouse. Organism_taxid: 10090.
Chains: A, B (558 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1t05
HIV-1 reverse transcriptase crosslinked to template-primer w tenofovir-diphosphate bound as the incoming nucleotide subs
Source: Synthetic: yes. Other_details: chemically modified with thiol-dgmp and enzy terminated with ddgtp. Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: bh10. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (554 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1t3r
HIV protease wild-type in complex with tmc114 inhibitor
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme product diphosphate
1t7i
The structural and thermodynamic basis for the binding of tm next-generation HIV-1 protease inhibitor.
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme product diphosphate
1t7j
Crystal structure of inhibitor amprenavir in complex with a resistant variant of HIV-1 protease (l63p/v82t/i84v)
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1t7k
Crystal structure of HIV protease complexed with arylsulfonamide azacyclic urea
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1tam
Human immunodeficiency virus, nmr, minimized average structure
Source: HIV-1 m:b_hxb2r. Organism_taxid: 11706. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (120 residues) CATH domain: 1.10.150.90
1tcw
Siv protease complexed with inhibitor sb203386
Source: Simian immunodeficiency virus. Organism_taxid: 11723. Gene: siv protease. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1tcx
HIV triple mutant protease complexed with inhibitor sb203386
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: HIV-1 protease. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1tkt
Crystal structure of HIV-1 reverse transcriptase in complex with gw426318
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: hxb2 isolate. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B (516 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
Bound ligand:   Het Group PO4 is 55.00% similar to enzyme product diphosphate
1tkx
Crystal structure of HIV-1 reverse transcriptase in complex with gw490745
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: hxb2 isolate. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B (535 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1tkz
Crystal structure of HIV-1 reverse transcriptase in complex with gw429576
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: hxb2 isolate. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B (517 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
Bound ligand:   Het Group PO4 is 55.00% similar to enzyme product diphosphate
1tl1
Crystal structure of HIV-1 reverse transcriptase in complex with gw451211
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: hxb2 isolate. Gene: name=pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B (517 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
Bound ligand:   Het Group PO4 is 55.00% similar to enzyme product diphosphate
1tl3
Crystal structure of HIV-1 reverse transcriptase in complex with gw450557
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: hxb2 isolate. Gene: name=pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B (517 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
Bound ligand:   Het Group PO4 is 55.00% similar to enzyme product diphosphate
1tsq
Crystal structure of ap2v substrate variant of nc-p1 decamer peptide in complex with v82a/d25n HIV-1 protease mutant
Source: Synthetic: yes. Synthetic: yes
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1tsu
Crystal structure of decamer ncp1 substrate peptide in complex with wild-type d25n HIV-1 protease variant
Source: Synthetic: yes. Synthetic: yes
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1tv6
HIV-1 reverse transcriptase complexed with cp-94,707
Source: Human immunodeficiency virus type 1 bh10. Organism_taxid: 11678. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (535 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1tvr
HIV-1 rt/9-cl tibo
Source: Human immunodeficiency virus type 1 (clone 12). Organism_taxid: 11679. Strain: bh10. Cell_line: 293. Atcc: accession number 1065288. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: human immunodeficiency virus type 1 (HIV-1)
Chains: A, B (558 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1u8g
Crystal structure of a HIV-1 protease in complex with peptid inhibitor ki2-phe-glu-glu-nh2
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: gag-pol. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1uph
HIV-1 myristoylated matrix
Source: Human immunodeficiency virus type 1 (clone 12). HIV-1. Organism_taxid: 11679. Strain: pnl4-3, subclone 4.20. Expressed in: escherichia coli. Expression_system_taxid: 511693. Expression_system_variant: ril codon plus.
Chain: A (132 residues) CATH domain: 1.10.150.90
1upj
HIV-1 protease complex with u095438 [3-[1-(4-bromophenyl) is hydroxycoumarin
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: bh5. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (99 residues) CATH domain: 2.40.70.10
1uwb
Tyr 181 cys HIV-1 rt/8-cl tibo
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: bh10. Cell_line: 293. Atcc: 1065288. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (558 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1vij
HIV-1 protease complexed with the inhibitor hoe/bay 793 hexagonal form
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1vik
HIV-1 protease complexed with the inhibitor hoe/bay 793 orthorhombic form
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1vrt
High resolution structures of HIV-1 rt from four rt- inhibitor complexes
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: hxb2 isolate. Cell_line: 293. Gene: HIV-1 pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (525 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1vru
High resolution structures of HIV-1 rt from four rt- inhibitor complexes
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Cell_line: 293. Gene: HIV-1 pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Strain: hxb2 isolate.
Chains: A, B (526 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
1vsd
Asv integrase core domain with mg(ii) cofactor and hepes ligand, high mg concentration form
Source: Rous sarcoma virus (strain schmidt- ruppin). Organism_taxid: 11889. Strain: schmidt-ruppin. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: original viral DNA clone\: ju et al., J. Virol. 33:1026-1033 (1980), original expression clone\: terry et al., J. Virol. 62:2358-2365 (1988), expression
Chain: A (146 residues) CATH domain: 3.30.420.10
1vse
Asv integrase core domain with mg(ii) cofactor and hepes ligand, low mg concentration form
Source: Rous sarcoma virus (strain schmidt- ruppin). Organism_taxid: 11889. Strain: schmidt-ruppin. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: original viral DNA clone\: ju et al., J. Virol. 33:1026-1033 (1980), original expression clone\: terry et al., J. Virol. 62:2358-2365 (1988), expression
Chain: A (146 residues) CATH domain: 3.30.420.10
1vsf
Asv integrase core domain with mn(ii) cofactor and hepes ligand, high mg concentration form
Source: Rous sarcoma virus (strain schmidt- ruppin). Organism_taxid: 11889. Strain: schmidt-ruppin. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: original viral DNA clone\: ju et al., J. Virol. 33:1026-1033 (1980), original expression clone\: terry et al., J. Virol. 62:2358-2365 (1988), expression
Chain: A (146 residues) CATH domain: 3.30.420.10
1vsh
Asv integrase core domain with zn(ii) cofactors
Source: Rous sarcoma virus (strain schmidt-rup organism_taxid: 11889. Strain: schmidt-ruppin. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: original viral DNA clone: ju et al., J. Viro 33:1026-1033 (1980), original expression clone terry et al. Virol. 62:2358-2365 (1988), expression clone for core: kulk al., J. Virol. 206:448-456 (1995).
Chain: A (146 residues) CATH domain: 3.30.420.10
1vsi
Asv integrase core domain with ca(ii) cofactor
Source: Rous sarcoma virus (strain schmidt- ruppin). Organism_taxid: 11889. Strain: schmidt-ruppin. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: original viral DNA clone\: ju et al., J. Virol. 33\:1026-1033 (1980), original expression clone terry et al., J. Virol. 62\:2358-2365 (1988), expression
Chain: A (146 residues) CATH domain: 3.30.420.10
1vsj
Asv integrase core domain with cd(ii) cofactors
Source: Rous sarcoma virus (strain schmidt- ruppin). Organism_taxid: 11889. Strain: schmidt-ruppin. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: original viral DNA clone\: ju et al., J. Virol. 33\:1026-1033 (1980), original expression clone terry et al., J. Virol. 62\:2358-2365 (1988), expression
Chain: A (146 residues) CATH domain: 3.30.420.10
1vsk
Asv integrase core domain d64n mutation in citrate buffer ph 6.0
Source: Rous sarcoma virus - schmidt-ruppin b. Organism_taxid: 269447. Strain: schmidt-ruppin b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (146 residues) CATH domain: 3.30.420.10
1vsl
Asv integrase core domain d64n mutation with zinc cation
Source: Rous sarcoma virus (strain schmidt- ruppin). Organism_taxid: 11889. Strain: schmidt-ruppin. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (146 residues) CATH domain: 3.30.420.10
1vsm
Asv integrase core domain in citrate buffer ph 5.0
Source: Rous sarcoma virus (strain schmidt- ruppin). Organism_taxid: 11889. Strain: schmidt-ruppin. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (146 residues) CATH domain: 3.30.420.10
1w5v
HIV-1 protease in complex with fluoro substituted diol- based c2-symmetric inhibitor
Source: Human immunodeficiency virus. HIV-1. Organism_taxid: 12721. Variant: bh10. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1w5w
HIV-1 protease in complex with fluoro substituted diol- based c2-symmetric inhibitor
Source: Human immunodeficiency virus. HIV-1. Organism_taxid: 12721. Variant: bh10. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1w5x
HIV-1 protease in complex with fluoro substituted diol- based c2-symmetric inhibitor
Source: Human immunodeficiency virus. HIV-1. Organism_taxid: 12721. Variant: bh10. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1w5y
HIV-1 protease in complex with fluoro substituted diol- based c2-symmetric inhibitor
Source: Human immunodeficiency virus. HIV-1. Organism_taxid: 12721. Variant: bh10. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1wja
Solution structure of the n-terminal zn binding domain of HIV-1 integrase (d form), nmr, regularized mean structure
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: potential. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (47 residues) CATH domain: 1.10.10.200
1wjb
Solution structure of the n-terminal zn binding domain of HIV-1 integrase (d form), nmr, 40 structures
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: potential. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (55 residues) CATH domain: 1.10.10.200
1wjc
Solution structure of the n-terminal zn binding domain of HIV-1 integrase (e form), nmr, regularized mean structure
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: potential. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (47 residues) CATH domain: 1.10.10.200
1wjd
Solution structure of the n-terminal zn binding domain of HIV-1 integrase (e form), nmr, 38 structures
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: potential. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (55 residues) CATH domain: 1.10.10.200
1wje
Solution structure of h12c mutant of the n-terminal zn binding domain of HIV-1 integrase complexed to cadmium, nmr, minimized average structure
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Cell_line: bl21. Gene: potential. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (46 residues) CATH domain: 1.10.10.200
1wjf
Solution structure of h12c mutant of the n-terminal zn binding domain of HIV-1 integrase complexed to cadmium, nmr, 40 structures
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Cell_line: bl21. Gene: potential. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (55 residues) CATH domain: 1.10.10.200
1wkn
A plausible model of full-length integrasedna complex
Source: Human immunodeficiency virus type 1. Virus. Synthetic: yes. Synthetic: yes
Chains: A, B (270 residues)
1xl2
HIV-1 protease in complex with pyrrolidinmethanamine
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: gag-pol. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1xl5
HIV-1 protease in complex with amidhyroxysulfone
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: gag-pol. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1yt9
HIV protease with oximinoarylsulfonamide bound
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1ytg
Siv protease crystallized with peptide product
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: x90. Gene: strain sf-2. Expressed in: human immunodeficiency virus 1. Expression_system_taxid: 11676.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1yth
Siv protease crystallized with peptide product
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: x90. Gene: strain sf-2. Expressed in: bicistronic.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1yti
Siv protease crystallized with peptide product
Source: Simian immunodeficiency virus. Organism_taxid: 11723. Strain: x90. Gene: siv(mac)239. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: ptac-tac.
Chain: A (99 residues) CATH domain: 2.40.70.10
1ytj
Siv protease crystallized with peptide product
Source: Simian immunodeficiency virus. Organism_taxid: 11723. Strain: x90. Gene: siv(mac)239. Expressed in: ptac-tac.
Chain: A (99 residues) CATH domain: 2.40.70.10
1z1h
HIV-1 protease complexed with macrocyclic peptidomimetic inhibitor 3
Source: Synthetic: yes. Other_details: hiv1 protease synthesised chemically by solid phase peptide synthesis
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1z1r
HIV-1 protease complexed with macrocyclic peptidomimetic inhibitor 2
Source: Synthetic: yes. Other_details: chemically synthesised by solid phase peptide synthesis
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1z8c
Crystal structure of the complex of mutant HIV-1 protease (l v82t, i84v) with a hydroxyethylamine peptidomimetic inhibit phe-psi[r-ch(oh)ch2nh]-phe-glu-phe-nh2
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1zbg
Crystal structure of a complex of mutant HIV-1 protease (a71 i84v) with a hydroxyethylamine peptidomimetic inhibitor boc psi[r-ch(oh)ch2nh]-phe-glu-phe-nh2
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1zj7
Crystal structure of a complex of mutant HIV-1 protease (a71 i84v) with a hydroxyethylamine peptidomimetic inhibitor boc psi[s-ch(oh)ch2nh]-phe-glu-phe-nh2
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (99 residues) CATH domain: 2.40.70.10
1zlf
Crystal structure of a complex of mutant HIV-1 protease (a71 i84v) with a hydroxyethylamine peptidomimetic inhibitor
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1zp8
HIV protease with inhibitor ab-2
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (99 residues) CATH domain: 2.40.70.10
1zpa
HIV protease with scripps ab-3 inhibitor
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (99 residues) CATH domain: 2.40.70.10
1zpk
Crystal structure of the complex of mutant HIV-1 protease (a i84v) with a hydroxyethylamine peptidomimetic inhibitor boc psi[r-ch(oh)ch2nh]-phe-glu-phe-nh2
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1zsf
Crystal structure of complex of a hydroxyethylamine inhibito HIV-1 protease at 2.0a resolution
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1zsr
Crystal structure of wild type HIV-1 protease (bru isolate) hydroxyethylamine peptidomimetic inhibitor boc-phe-psi[s-ch ch2nh]-phe-glu-phe-nh2
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
1ztt
Netropsin bound to d(cttaattcgaattaag) in complex with mmlv rt catalytic fragment
Source: Synthetic: yes. Moloney murine leukemia virus. Organism_taxid: 11801. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (255 residues) CATH domains: 3.30.70.270 3.10.10.10
1ztw
D(cttaattcgaattaag) complexed with moloney murine leukemia virus reverse transcriptase catalytic fragment
Source: Synthetic: yes. Moloney murine leukemia virus. Organism_taxid: 11801. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (255 residues) CATH domains: 3.30.70.270 3.10.10.10
1ztz
Crystal structure of HIV protease- metallacarborane complex
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: gag-pol. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2a1e
High resolution structure of HIV-1 pr with ts-126
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: gag-pol. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2aid
Structure of a non-peptide inhibitor complexed with HIV-1 pr developing a cycle of structure-based drug design
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Variant: sf1 isolate. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2aoc
Crystal structure analysis of HIV-1 protease mutant i84v wit substrate analog p2-nc
Source: Human immunodeficiency virus type 1 (b isolate). Organism_taxid: 11682. Strain: bh5 isolate. Gene: pol. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2aod
Crystal structure analysis of HIV-1 protease with a substrat p2-nc
Source: Human immunodeficiency virus type 1 (b isolate). Organism_taxid: 11682. Strain: bh5 isolate. Gene: pol. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2aoe
Crystal structure analysis of HIV-1 protease mutant v82a wit substrate analog ca-p2
Source: Human immunodeficiency virus type 1 (b isolate). Organism_taxid: 11682. Strain: bh5 isolate. Gene: pol. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2aof
Crystal structure analysis of HIV-1 protease mutant v82a wit substrate analog p1-p6
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: pol. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Other_details: this sequence was chemically synthesized and analogous to the p1-p6 processing site in HIV-1.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2aog
Crystal structure analysis of HIV-1 protease mutant v82a wit substrate analog p2-nc
Source: Human immunodeficiency virus type 1 (b isolate). Organism_taxid: 11682. Strain: bh5 isolate. Gene: pol. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2aoh
Crystal structure analysis of HIV-1 protease mutant v82a wit substrate analog p6-pr
Source: Human immunodeficiency virus type 1 (b isolate). Organism_taxid: 11682. Strain: bh5 isolate. Gene: pol. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Other_details: this sequence was chemically synthesized and
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2aoi
Crystal structure analysis of HIV-1 protease with a substrat p1-p6
Source: Human immunodeficiency virus type 1 (b isolate). Organism_taxid: 11682. Strain: bh5 isolate. Gene: pol. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Other_details: this sequence was chemically synthesized and
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2aoj
Crystal structure analysis of HIV-1 protease with a substrat p6-pr
Source: Human immunodeficiency virus type 1 (b isolate). Organism_taxid: 11682. Strain: bh5 isolate. Gene: pol. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Other_details: this sequence was chemically synthesized and
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2aqu
Structure of HIV-1 protease bound to atazanavir
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2avm
Kinetics, stability, and structural changes in high resoluti structures of HIV-1 protease with drug resistant mutations i50v, and g73s
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: isolate bh5. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2avo
Kinetics, stability, and structural changes in high resoluti structures of HIV-1 protease with drug resistant mutations i50v, and g73s
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2avq
Kinetics, stability, and structural changes in high resoluti structures of HIV-1 protease with drug resistant mutations i50v, and g73s
Source: Human immunodeficiency virus type 1 (b isolate). Organism_taxid: 11682. Strain: bh5 isolate. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2avs
Kinetics, stability, and structural changes in high resolution crystal structures of HIV-1 protease with drug resistant mutations l24i, i50v, and g73s
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
Bound ligand:   Het Group PO4 is 55.00% similar to enzyme product diphosphate
2avv
Kinetics, stability, and structural changes in high resolution crystal structures of HIV-1 protease with drug resistant mutations l24i, i50v, and g73s
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, D, E (99 residues) CATH domain: 2.40.70.10
2az8
HIV-1 protease nl4-3 in complex with inhibitor, tl-3
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: r8. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: protease nl4-3
Chain: A (99 residues) CATH domain: 2.40.70.10
2az9
HIV-1 protease nl4-3 1x mutant
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: r8. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: protease nl4-3
Chain: A (99 residues) CATH domain: 2.40.70.10
2azb
HIV-1 protease nl4-3 3x mutant in complex with inhibitor, tl
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: r8. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: protease nl4-3
Chain: A (97 residues) CATH domain: 2.40.70.10
2azc
HIV-1 protease nl4-3 6x mutant
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: r8. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: protease nl4-3
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2b2a
Crystal structure of the ten domain of the telomerase reverse transcriptase
Source: Tetrahymena thermophila. Organism_taxid: 5911. Gene: tert. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C (164 residues)
2b4j
Structural basis for the recognition between HIV-1 integrase ledgf/p75
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: pol. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Homo sapiens. Human. Organism_taxid: 9606. Gene: psip1, ledgf.
Chains: A, B (135 residues) CATH domain: 3.30.420.10
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme product diphosphate
2b5j
Crystal structure of HIV-1 reverse transcriptase (rt) in complex with janssen-r165481
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: bh10 isolate. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: HIV-1 clone 12. Other_details: HIV-1 clone 12
Chains: A, B (552 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
2b6a
Crystal structure of HIV-1 reverse transcriptase (rt) in complex with thr-50
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (558 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
2b7f
Crystal structure of human t-cell leukemia virus protease, a target for anti-cancer design
Source: Human t-lymphotropic virus 1. Organism_taxid: 11908. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes
Chains: A, B, C, D, E, F (116 residues) CATH domain: 2.40.70.10
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme product diphosphate
2b7z
Structure of HIV-1 protease mutant bound to indinavir
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: B, A (99 residues) CATH domain: 2.40.70.10
2ban
Crystal structure of HIV-1 reverse transcriptase (rt) in complex with janssen-r157208
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: bh10 isolate. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: HIV-1 clone 12. Other_details: HIV-1 clone 12
Chains: A, B (552 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
2bb9
Structure of hiv1 protease and akc4p_133a complex.
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: gag. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2bbb
Structure of hiv1 protease and hh1_173_3a complex.
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: gag. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2be2
Crystal structure of HIV-1 reverse transcriptase (rt) in com r221239
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: isolate bh10. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: HIV-1 clone 12. Other_details: HIV-1 clone 12
Chains: A, B (552 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
2bpv
HIV-1 protease-inhibitor complex
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: HIV-1 protease from the ny5 isolate. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2bpw
HIV-1 protease-inhibitor complex
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: HIV-1 protease from the ny5 isolate. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2bpx
HIV-1 protease-inhibitor complex
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: HIV-1 protease from the ny5 isolate. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2bpy
HIV-1 protease-inhibitor complex
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: HIV-1 protease from the ny5 isolate. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2bpz
HIV-1 protease-inhibitor complex
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: HIV-1 protease from the ny5 isolate. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2e1x
Nmr structure of the HIV-2 nucleocapsid protein
Source: Synthetic: yes. Other_details: this peptide has been chemically synthesized. This sequence occurs naturally in HIV-2.
Chain: A (27 residues)
2ei9
Crystal structure of r1bm endonuclease domain
Source: Bombyx mori. Domestic silkworm. Organism_taxid: 7091. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (214 residues) CATH domain: 3.60.10.10
2f3k
Substrate envelope and drug resistance: crystal structure of r01 in complex with wild-type HIV-1 protease
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: sf2
Chains: A, B (99 residues) CATH domain: 2.40.70.10
Bound ligand:   Het Group PO4 is 55.00% similar to enzyme product diphosphate
2f80
HIV-1 protease mutant d30n complexed with inhibitor tmc114
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: bh5 isolate. Gene: pol. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2f81
HIV-1 protease mutant l90m complexed with inhibitor tmc114
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: bh5 isolate. Gene: pol. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2f8g
HIV-1 protease mutant i50v complexed with inhibitor tmc114
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: bh5 isolate. Gene: pol. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2fde
Wild type HIV protease bound with gw0385
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2fgu
X-ray crystal structure of HIV-1 protease t80s variant in co the inhibitor saquinavir used to explore the role of invari in HIV-1 protease structure, function, and viral infectivit
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: sf2. Gene: gag. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme product diphosphate
2fgv
X-ray crystal structure of HIV-1 protease t80n variant in co the inhibitor saquinavir used to explore the role of invari in HIV-1 protease structure, function, and viral infectivit
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: sf2. Gene: gag. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme product diphosphate
2fiv
Crystal structure of feline immunodeficiency virus protease with a substrate
Source: Feline immunodeficiency virus. Organism_taxid: 11673. Cell_line: bl21. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (113 residues) CATH domain: 2.40.70.10
2fjv
Rt29 bound to d(cttaattcgaattaag) in complex with mmlv rt catalytic fragment
Source: Synthetic: yes. Moloney murine leukemia virus. Organism_taxid: 11801. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (255 residues) CATH domains: 3.30.70.270 3.10.10.10
2fjw
D(cttgaatgcattcaag) in complex with mmlv rt catalytic fragment
Source: Synthetic: yes. Moloney murine leukemia virus. Organism_taxid: 11801. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (255 residues) CATH domains: 3.30.70.270 3.10.10.10
2fjx
Rt29 bound to d(cttgaatgcattcaag) in complex with mmlv rt catalytic fragment
Source: Synthetic: yes. Moloney murine leukemia virus. Organism_taxid: 11801. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (255 residues) CATH domains: 3.30.70.270 3.10.10.10
2fmb
Eiav protease complexed with an inhibitor lp-130
Source: Equine infectious anemia virus. Organism_taxid: 11665. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (104 residues) CATH domain: 2.40.70.10
2fns
Crystal structure of wild-type inactive (d25n) HIV-1 protease complexed with wild-type HIV-1 nc-p1 substrate.
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: hxb2. Gene: gag. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: this sequence of this peptide occurs naturally in human immunodeficiency virus (HIV)
Chains: A, B (99 residues) CATH domain: 2.40.70.10
Bound ligand:   Het Group PO4 is 55.00% similar to enzyme product diphosphate
2fnt
Crystal structure of a drug-resistant (v82a) inactive (d25n) HIV-1 protease complexed with ap2v variant of HIV-1 nc-p1 substrate.
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: hxb2. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: this sequence occurs naturally in drug- resistant HIV
Chains: A, B (99 residues) CATH domain: 2.40.70.10
Bound ligand:   Het Group PO4 is 55.00% similar to enzyme product diphosphate
2fvp
A structural study of the ca dinucleotide step in the integrase processing site of moloney murine leukemia virus
Source: Synthetic: yes. Moloney murine leukemia virus. Organism_taxid: 11801. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (255 residues) CATH domains: 3.30.70.270 3.10.10.10
2fvq
A structural study of the ca dinucleotide step in the integrase processing site of moloney murine leukemia virus
Source: Synthetic: yes. Moloney murine leukemia virus. Organism_taxid: 11801. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (255 residues) CATH domains: 3.30.70.270 3.10.10.10
2fvr
A structural study of the ca dinucleotide step in the integrase processing site of moloney murine leukemia virus
Source: Synthetic: yes. Moloney murine leukemia virus. Organism_taxid: 11801. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (255 residues) CATH domains: 3.30.70.270 3.10.10.10
2fvs
A structural study of the ca dinucleotide step in the integrase processing site of moloney murine leukemia virus
Source: Synthetic: yes. Moloney murine leukemia virus. Organism_taxid: 11801. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (255 residues) CATH domains: 3.30.70.270 3.10.10.10
2fxe
X-ray crystal structure of HIV-1 protease crm mutant complex atazanavir (bms-232632)
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: pol. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2g69
Structure of unliganded HIV-1 protease f53l mutant
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (99 residues) CATH domain: 2.40.70.10
2gol
Xray structure of gag278
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: isolate new york-5. Gene: gag. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B, D (102 residues) CATH domain: 1.10.150.90
2gon
Xray structure of gag133-278
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: isolate new york-5. Gene: gag. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (127 residues) CATH domain: 1.10.375.10
2h3f
Solution structure of the HIV-1 ma protein
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (131 residues) CATH domain: 1.10.150.90
2h3i
Solution structure of the HIV-1 myristoylated matrix protein
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (131 residues) CATH domain: 1.10.150.90
2h3q
Solution structure of HIV-1 myrma bound to di-c4-phosphatidy (4,5)-bisphosphate
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (131 residues) CATH domain: 1.10.150.90
Bound ligand:   Het Group PBU is 46.94% similar to enzyme reactant DNA
2h3v
Structure of the HIV-1 matrix protein bound to di-c8- phosphatidylinositol-(4,5)-bisphosphate
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (131 residues) CATH domain: 1.10.150.90
Bound ligand:   Het Group PIO is 40.00% similar to enzyme reactant DNA
2h3z
Structure of the HIV-1 matrix protein bound to di-c4- phosphatidylinositol-(4,5)-bisphosphate
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (131 residues) CATH domain: 1.10.150.90
Bound ligand:   Het Group PBU is 46.94% similar to enzyme reactant DNA
2hah
The structure of fiv 12s protease in complex with tl-3
Source: Feline immunodeficiency virus (isolate petaluma). Organism_taxid: 11674. Strain: isolate petaluma. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (112 residues) CATH domain: 2.40.70.10
2hb2
Structure of HIV protease 6x mutant in apo form
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: nl4-3. Gene: gal-pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (97 residues) CATH domain: 2.40.70.10
2hb3
Wild-type HIV-1 protease in complex with potent inhibitor gr
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: gag, pol. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2hb4
Structure of HIV protease nl4-3 in an unliganded state
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: nl4-3. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (99 residues) CATH domain: 2.40.70.10
2hb5
Crystal structure of the moloney murine leukemia virus rnase h domain
Source: Moloney murine leukemia virus. Organism_taxid: 11801. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (150 residues) CATH domain: 3.30.420.10
2hc0
Structure of HIV protease 6x mutant in complex with ab-2.
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: nl4-3. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2hmi
HIV-1 reverse transcriptase/fragment of fab 28/DNA complex
Source: Synthetic: yes. Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: bh10 isolate. Atcc: atcc 1065288. Expressed in: escherichia coli. Expression_system_taxid: 562. Mus musculus. House mouse.
Chains: A, B (558 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
2hmx
Human immunodeficiency virus type 1 matrix protein
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Cell_line: bl21. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (133 residues) CATH domain: 1.10.150.90
2hnd
Crystal structure of k101e mutant HIV-1 reverse transcriptase in complex with nevirapine
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B (523 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
Bound ligand:   Het Group PO4 is 55.00% similar to enzyme product diphosphate
2hny
Crystal structure of e138k mutant HIV-1 reverse transcriptase in complex with nevirapine
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B (523 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
Bound ligand:   Het Group PO4 is 55.00% similar to enzyme product diphosphate
2hnz
Crystal structure of e138k mutant HIV-1 reverse transcriptase in complex with pett-2
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: hxb2 isolate. Gene: gag. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B (517 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
Bound ligand:   Het Group PO4 is 55.00% similar to enzyme product diphosphate
2hpe
Comparison of the structures of HIV-2 protease complexes in three crystal space groups with an HIV-1 protease complex structure
Source: Human immunodeficiency virus 2. Organism_taxid: 11709. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2hpf
Comparison of the structures of HIV-2 protease complexes in crystal space groups with an HIV-1 protease complex structu
Source: Human immunodeficiency virus 2. Organism_taxid: 11709. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2hs1
Ultra-high resolution x-ray crystal structure of HIV-1 prote mutant with tmc114 (darunavir) inhibitor
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: gag. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2hs2
Crystal structure of m46l mutant of HIV-1 protease complexed tmc114 (darunavir)
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: gag. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2hvp
Three-dimensional structure of aspartyl protease from human immunodeficiency virus HIV-1
Source: Human immunodeficiency virus 1. Organism_taxid: 11676
Chain: A (94 residues)
2i4d
Crystal structure of wt HIV-1 protease with gs-8373
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: gag. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2i4u
HIV-1 protease with tmc-126
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: gag. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2i4v
HIV-1 protease i84v, l90m with tmc126
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: gag. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2i4w
HIV-1 protease wt with gs-8374
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: gag. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2i4x
HIV-1 protease i84v, l90m with gs-8374
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: gag. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2i5j
Crystal structure of HIV-1 reverse transcriptase (rt) in complex with dhbnh, an rnase h inhibitor
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: isolate bh10. Gene: gag. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chain: B (420 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270
2iaj
Crystal structure of k103n/y181c mutant HIV-1 reverse transc (rt) in complex with atp
Source: Human immunodeficiency virus type 1 bh organism_taxid: 11678. Strain: bh10 isolate. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chain: A (551 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
Bound ligand:   Het Group ATP is 62.50% similar to enzyme reactant Deoxynucleoside
2ic3
Crystal structure of k103n/y181c mutant HIV-1 reverse transcriptase (rt) in complex with nonnucleoside inhibitor hby 097
Source: Human immunodeficiency virus type 1 bh10. Organism_taxid: 11678. Strain: bh10 isolate. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chain: A (558 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
2idw
Crystal structure analysis of HIV-1 protease mutant v82a wit non-peptide inhibitor (uic-94017)
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: gag, pol. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme product diphosphate
2ien
Crystal structure analysis of HIV-1 protease with a potent n inhibitor (uic-94017)
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: gag, pol. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2ieo
Crystal structure analysis of HIV-1 protease mutant i84v wit non-peptide inhibitor (uic-94017)
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: gag, pol. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2itg
Catalytic domain of HIV-1 integrase: ordered active site in construct
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Cell_line: bl21. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Other_details: expression clone for core, refer to pnas usa 90, pp3428-3432, april 1993, and pnas usa, vol. 92, pp.6057 june 1995
Chain: A (160 residues) CATH domain: 3.30.420.10
2iwj
Solution structure of the zn complex of HIV-2 ncp(23-49) peptide, encompassing protein cchc-linker, distal cchc zn- binding motif and c-terminal tail.
Source: Synthetic: yes. Human immunodeficiency virus type 2. HIV-2. Organism_taxid: 11709. Variant: isolate ghana-1 subtype a
Chain: A (27 residues)
2j9j
Atomic-resolution crystal structure of chemically-synthesize protease complexed with inhibitor jg-365
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Synthetic: yes
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2j9k
Atomic-resolution crystal structure of chemically-synthesize protease complexed with inhibitor mvt-101
Source: Synthetic: yes. Human immunodeficiency virus 1. Organism_taxid: 11676. Other_details: chemically synthesized
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2je4
Atomic-resolution crystal structure of chemically-synthesize protease in complex with jg-365
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Synthetic: yes
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2jo0
The solution structure of the monomeric species of thE C terminal domain of the ca protein of HIV-1
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: gag-pol. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (87 residues) CATH domain: Unassigned
2jpr
Joint refinement of the HIV-1 ca-ntd in complex with the assembly inhibitor cap-1
Source: Human immunodeficiency virus type 1 (new york-5 isolate). Organism_taxid: 11698. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (145 residues) CATH domain: 1.10.375.10
2jyg
Solution structure of the w184a/m185a mutant of the carboxy- terminal dimerization domain of the HIV-1 capsid protein
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (84 residues) CATH domain: Unassigned
2jyl
Solution structure of a double mutant of the carboxy- terminal dimerization domain of the HIV-1 capsid protein
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (84 residues) CATH domain: Unassigned
2jys
Solution structure of simian foamy virus (mac) protease
Source: Simian foamy virus type 1. Sfvmac. Organism_taxid: 338478. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (91 residues)
2jzw
How the HIV-1 nucleocapsid protein binds and destabilises the (-)primer binding site during reverse transcription
Source: Synthetic: yes. Synthetic: yes
Chain: A (44 residues) CATH domain: Unassigned
2k4e
Solution structure of the HIV-2 unmyristoylated matrix protein
Source: Human immunodeficiency virus type 2. HIV-2. Organism_taxid: 11720. Strain: prod10. Gene: gag-pol. Expressed in: escherichia coli.
Chain: A (134 residues) CATH domain: 1.10.150.90
2k4h
Solution structure of the HIV-2 myristoylated matrix protein
Source: Human immunodeficiency virus type 2. HIV-2. Organism_taxid: 11720. Strain: prod10. Gene: gag-pol. Expressed in: escherichia coli.
Chain: A (134 residues) CATH domain: 1.10.150.90
2k4i
Solution structure of HIV-2 myrma bound to di-c4-pi(4,5)p2
Source: Human immunodeficiency virus type 2. HIV-2. Organism_taxid: 11720. Strain: prod10. Gene: gag-pol. Expressed in: escherichia coli.
Chain: A (134 residues) CATH domain: 1.10.150.90
Bound ligand:   Het Group PBU is 46.94% similar to enzyme reactant DNA
2kod
A high-resolution nmr structure of the dimeric c-terminal do HIV-1 ca
Source: HIV-1 m:b_hxb2r. HIV-1. Organism_taxid: 11706. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (88 residues) CATH domain: Unassigned
2l45
C-terminal zinc knuckle of the hivncp7 with DNA
Source: Synthetic: yes. Human immunodeficiency virus 1. HIV-1. Organism_taxid: 11676. Synthetic: yes
Chain: A (19 residues)
2l46
C-terminal zinc finger of the hivncp7 with platinated DNA
Source: Synthetic: yes. Human immunodeficiency virus 1. HIV-1. Organism_taxid: 11676. Synthetic: yes
Chain: A (19 residues)
2l4l
Structural insights into the ctar DNA recognition by the HIV nucleocapsid protein: role of sugar deoxyriboses in the bin polarity of nc
Source: Human immunodeficiency virus 1. HIV-1. Organism_taxid: 11676. Gene: gag. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chain: A (45 residues) CATH domain: Unassigned
2l6e
Nmr structure of the monomeric mutant c-terminal domain of h capsid in complex with stapled peptide inhibitor
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: gag. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes
Chain: A (94 residues) CATH domain: Unassigned
2lf4
Structure of a monomeric mutant of the HIV-1 capsid protein
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: gag. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_variant: rosetta 2.
Chain: A (232 residues) CATH domain: 1.10.375.10
2lsn
Solution structure of pfv rnase h domain
Source: Human spumaretrovirus. Sfvcpz(hu), prototype foamy virus. Organism_taxid: 11963. Gene: rnase h. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (165 residues) CATH domain: 3.30.420.10
2lya
Structure of HIV-1 myr(-) matrix protein in complex with 1,2 dioctanoyl-sn-phosphatidylcholine
Source: Human immunodeficiency virus type 1. Organism_taxid: 11698. Strain: new york-5 isolate. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (131 residues) CATH domain: 1.10.150.90
2lyb
Structure of HIV-1 myr(-) matrix protein in complex with 1,2 dioctanoyl-sn-phosphatidyl-l-serine
Source: Human immunodeficiency virus type 1. Organism_taxid: 11698. Strain: new york-5 isolate. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (131 residues) CATH domain: 1.10.150.90
2m3z
Nmr solution structure of HIV-1 nucleocapsid protein in comp an inhibitor displaying a 2 inhibitors:1 nc stoichiometry
Source: Human immunodeficiency virus type 1. HIV-1. Organism_taxid: 11698. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (55 residues) CATH domain: Unassigned
2m8l
HIV capsid dimer structure
Source: Human immunodeficiency virus type 1. HIV-1. Organism_taxid: 11698. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (221 residues) CATH domain: 1.10.375.10
2m8n
HIV-1 capsid monomer structure
Source: Human immunodeficiency virus type 1. HIV-1. Organism_taxid: 11698. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (221 residues)
2m8p
The structure of the w184am185a mutant of the HIV-1 capsid p
Source: Human immunodeficiency virus type 1. HIV-1. Organism_taxid: 11698. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (221 residues)
2m9u
Solution nmr structure of thE C-terminal domain (ctd) of mol murine leukemia virus integrase, northeast structural genom or41a
Source: Moloney murine leukemia virus isolate organism_taxid: 928306. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (89 residues) CATH domain: Unassigned
2mip
Crystal structure of human immunodeficiency virus (HIV) type protease in complex with a reduced amide inhibitor and comp with HIV-1 protease structures
Source: Human immunodeficiency virus 2. Organism_taxid: 11709. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (99 residues) CATH domain: 2.40.70.10
2mqv
Solution nmr structure of the u5-primer binding site (u5-pbs of murine leukemia virus RNA genome bound to the retroviral nucleocapsid protein
Source: Murine leukemia virus. Organism_taxid: 11786. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: in vitro transcription
Chain: A (56 residues)
2ms0
Solution nmr structure pf trnapro:mlv-nucleocapsid (1:2) com
Source: Murine leukemia virus. Organism_taxid: 11786. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: in vitro transcription
Chains: A, C (55 residues)
2ms1
Solution nmr structure of trnapro:mlv nucleocapsid protein ( complex
Source: Murine leukemia virus. Organism_taxid: 11786. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: in vitro transcription
Chain: A (55 residues)
2nmy
Crystal structure analysis of HIV-1 protease mutant v82a wit inhibitor saquinavir
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: gag. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2nmz
Crystal structure analysis of HIV-1 protease mutant v82a wit inhibitor saquinavir
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: gag. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2nnk
Crystal structure analysis of HIV-1 protease mutant i84v wit inhibitor saquinavir
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: gag. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2nnp
Crystal structure analysis of HIV-1 protease mutant i84v wit inhibitor saquinavir
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: gag. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2nph
Crystal structure of hiv1 protease in situ product complex
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: pol. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Synthetic: yes
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2nxd
Structure of HIV-1 protease d25n complexed with rt-rh analogue peptide gly-ala-asp-ile-phe Tyr-leu-asp-gly-ala
Source: HIV-1 m:b_arv2/sf2. Organism_taxid: 11685. Strain: sf2. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: this sequence was custom-designed and then purchased commercially
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2nxl
Structure of HIV-1 protease d25n complexed with the rt-rh analogue peptide gly-ala-glu-val-phe Tyr-val-asp-gly-ala
Source: HIV-1 m:b_arv2/sf2. Organism_taxid: 11685. Strain: sf2. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: this sequence was custom-designed and then purchased commercially
Chains: A, B (99 residues) CATH domain: 2.40.70.10
Bound ligand:   Het Group PO4 is 55.00% similar to enzyme product diphosphate
2nxm
Structure of HIV-1 protease d25n complexed with the rt-rh analogue peptide gly-ala-gln-thr-phe Tyr-val-asp-gly-ala
Source: HIV-1 m:b_arv2/sf2. Organism_taxid: 11685. Strain: sf2. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: this sequence was custom-designed and then purchased commercially
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2o4k
Crystal structure of HIV-1 protease (q7k) in complex with at
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: subtype b. Gene: gag-pol. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2o4l
Crystal structure of HIV-1 protease (q7k, i50v) in complex w tipranavir
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: subtype b. Gene: gag-pol. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2o4n
Crystal structure of HIV-1 protease (trm mutant) in complex tipranavir
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: subtype b. Gene: gag-pol. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2o4p
Crystal structure of HIV-1 protease (q7k) in complex with ti
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: subtype b. Gene: gag-pol. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2o4s
Crystal structure of HIV-1 protease (q7k) in complex with lo
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: subtype b. Gene: gag-pol. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2ont
A swapped dimer of the HIV-1 capsid c-terminal domain
Source: Human immunodeficiency virus type 1 (n isolate). Organism_taxid: 11698. Strain: isolate ny5 group m subtype b. Gene: gag-pol. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (73 residues) CATH domain: 1.10.1200.30
2opp
Crystal structure of HIV-1 reverse transcriptase in complex gw420867x.
Source: HIV-1 m:b_hxb2r. Organism_taxid: 11706. Strain: hxb2 isolate. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (519 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme product diphosphate
2opq
Crystal structure of l100i mutant HIV-1 reverse transcriptas complex with gw420867x.
Source: HIV-1 m:b_hxb2r. Organism_taxid: 11706. Strain: hxb2 isolate. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (516 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme product diphosphate
2opr
Crystal structure of k101e mutant HIV-1 reverse transcriptas complex with gw420867x.
Source: HIV-1 m:b_hxb2r. Organism_taxid: 11706. Strain: hxb2 isolate. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (539 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
2ops
Crystal structure of y188c mutant HIV-1 reverse transcriptas complex with gw420867x.
Source: HIV-1 m:b_hxb2r. Organism_taxid: 11706. Strain: hxb2 isolate. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (536 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme product diphosphate
2p3b
Crystal structure of the subtype b wild type HIV protease co with tl-3 inhibitor
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: gag-pol. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2pk5
Crystal structure of HIV-1 protease (q7k, l33i, l63i ) in co kni-10075
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: subtype b. Gene: gag-pol. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2pk6
Crystal structure of HIV-1 protease (q7k, l33i, l63i) in com kni-10033
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: subtype b. Gene: gag-pol. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2pqz
HIV-1 protease in complex with a pyrrolidine-based inhibitor
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2pwc
HIV-1 protease in complex with a amino decorated pyrrolidine inhibitor
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: gag-pol. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2pwm
Crystal structure of HIV-1 ca146 a92e real cell
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: nl4-3. Gene: gag-pol. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B, C, D, E, F, G, H (145 residues) CATH domain: 1.10.375.10
2pwo
Crystal structure of HIV-1 ca146 a92e psuedo cell
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: nl4-3. Gene: gag-pol. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B, C, D (144 residues) CATH domain: 1.10.375.10
2pwr
HIV-1 protease in complex with a carbamoyl decorated pyrroli inhibitor
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: gag-pol. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2pxr
Crystal structure of HIV-1 ca146 in the presence of cap-1
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: nl43
Chain: C (145 residues) CATH domain: 1.10.375.10
2pym
HIV-1 pr mutant in complex with nelfinavir
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: type b. Gene: gag-pol. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2pyn
HIV-1 pr mutant in complex with nelfinavir
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: type b. Gene: gag-pol. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2q3k
Crystal structure of lysine sulfonamide inhibitor reveals th displacement of the conserved flap water molecule in HIV-1
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: sf2. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme product diphosphate
2q63
HIV-1 pr mutant in complex with nelfinavir
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: type b. Gene: gag-pol. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2q64
HIV-1 pr mutant in complex with nelfinavir
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: type b. Gene: gag-pol. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2qak
HIV-1 pr mutant in complex with nelfinavir
Source: Human immunodeficiency virus 1. HIV-1. Strain: type b. Gene: gag-pol. Expressed in: escherichia coli.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2qci
HIV-1 protease mutant d30n with potent antiviral inhibitor grl-98065
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2qd6
HIV-1 protease mutant i50v with potent antiviral inhibitor grl-98065
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2qd7
HIV-1 protease mutant v82a with potent antiviral inhibitor g
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme product diphosphate
2qd8
HIV-1 protease mutant i84v with potent antiviral inhibitor grl-98065
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2qhc
The influence of i47a mutation on reduced susceptibility to the protease inhibitor lopinavir
Source: Human immunodeficiency virus 1. HIV-1. Organism_taxid: 11676. Strain: type b. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2qhy
Crystal structure of protease inhibitor, mit-1-ac86 in compl wild type HIV-1 protease
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: sf2. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme product diphosphate
2qhz
Crystal structure of protease inhibitor, mit-1-ac87 in compl wild type HIV-1 protease
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: sf2. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme product diphosphate
2qi0
Crystal structure of protease inhibitor, mit-1-kk80 in compl wild type HIV-1 protease
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: sf2. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme product diphosphate
2qi1
Crystal structure of protease inhibitor, mit-1-kk81 in compl wild type HIV-1 protease
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: sf2. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme product diphosphate
2qi3
Crystal structure of protease inhibitor, mit-2-ad94 in compl wild type HIV-1 protease
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: sf2. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme product diphosphate
2qi4
Crystal structure of protease inhibitor, mit-2-ad93 in compl wild type HIV-1 protease
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: sf2. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme product diphosphate
2qi5
Crystal structure of protease inhibitor, mit-2-kc08 in compl wild type HIV-1 protease
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: sf2. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme product diphosphate
2qi6
Crystal structure of protease inhibitor, mit-2-kb98 in compl wild type HIV-1 protease
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: sf2. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme product diphosphate
2qi7
Crystal structure of protease inhibitor, mit-2-ad86 in compl wild type HIV-1 protease
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: sf2. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme product diphosphate
2qnn
HIV-1 protease in complex with a multiple decorated pyrrolid inhibitor
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: gag-pol. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2qnp
HIV-1 protease in complex with a iodo decorated pyrrolidine- based inhibitor
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: gag-pol. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2qnq
HIV-1 protease in complex with a chloro decorated pyrrolidine-based inhibitor
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: gag-pol. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2r2r
D(attagttataactaat) complexed with mmlv rt catalytic fragment
Source: Moloney murine leukemia virus. Momlv. Organism_taxid: 11801. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic: yes
Chain: A (255 residues) CATH domains: 3.30.70.270 3.10.10.10
2r2s
Co(iii)bleomycinb2 bound to d(attagttataactaat) complexed with mmlv rt catalytic fragment
Source: Moloney murine leukemia virus. Momlv. Organism_taxid: 11801. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic: yes
Chain: A (255 residues) CATH domains: 3.30.70.270 3.10.10.10
2r2t
D(atttagttaactaaat) complexed with mmlv rt catalytic fragment
Source: Moloney murine leukemia virus. Momlv. Organism_taxid: 11801. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic: yes
Chain: A (255 residues) CATH domains: 3.30.70.270 3.10.10.10
2r2u
Co(iii)bleomycinb2 bithiazolE/C-terminal tail domain bound to d(atttagttaactaaat) complexed with mmlv rt catalytic fragment
Source: Moloney murine leukemia virus. Momlv. Organism_taxid: 11801. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic: yes
Chain: A (255 residues) CATH domains: 3.30.70.270 3.10.10.10
2r38
I84v HIV-1 protease mutant in complex with a carbamoyl decorated pyrrolidine-based inhibitor
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: gag-pol. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2r3t
I50v HIV-1 protease mutant in complex with a carbamoyl decorated pyrrolidine-based inhibitor
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: gag-pol. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2r3w
I84v HIV-1 protease in complex with a amino decorated pyrrolidine-based inhibitor
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: gag-pol. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2r43
I50v HIV-1 protease in complex with an amino decorated pyrro based inhibitor
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: gag-pol. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2r4g
The high resolution structure of the RNA-binding domain of t
Source: Tetrahymena thermophila. Organism_taxid: 5911. Gene: tert. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (250 residues) CATH domains: Unassigned Unassigned
2r5p
Crystal structure analysis of HIV-1 subtypE C protease complexed with indinavir
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: subtypE C. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (99 residues) CATH domain: 2.40.70.10
2r5q
Crystal structure analysis of HIV-1 subtypE C protease complexed with nelfinavir
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: subtypE C. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (99 residues) CATH domain: 2.40.70.10
2r8n
Structural analysis of the unbound form of HIV-1 subtypE C p
Source: Human immunodeficiency virus 1. Strain: subtypE C. Gene: pol. Expressed in: escherichia coli.
Chain: A (99 residues) CATH domain: 2.40.70.10
2rf2
HIV reverse transcriptase in complex with inhibitor 7e (nnrti)
Source: HIV-1 m:b_hxb2r. Organism_taxid: 11706. Strain: hxb2 isolate. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B (554 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
2rki
Crystal structure of HIV-1 reverse transcriptase (rt) in com a triazole derived nnrti
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (557 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
2upj
HIV-1 protease complex with u100313 ([3-[[3-[cyclopropyl [4- 2oxo-6-[1-(phenylmethyl)propyl]-2h-pyran-3-yl] methyl]pheny 3-oxo-propyl]carbamic acid tert-butyl ester)
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: bh5. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2uxz
Two-carbon-elongated HIV-1 protease inhibitors with a tertiary-alcohol-containing transition-state mimic
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: HIV-1 d10. Variant: d10. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2uy0
Two-carbon-elongated HIV-1 protease inhibitors with a tertiary-alcohol-containing transition-state mimic
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: HIV-1 d10. Variant: d10. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2vg5
Crystal structures of HIV-1 reverse transcriptase complexes with thiocarbamate non-nucleoside inhibitors
Source: Human immunodeficiency virus 1. HIV-1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B (551 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
2vg6
Crystal structures of HIV-1 reverse transcriptase complexes with thiocarbamate non-nucleoside inhibitors
Source: Human immunodeficiency virus 1. HIV-1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B (549 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
2vg7
Crystal structures of HIV-1 reverse transcriptase complexes with thiocarbamate non-nucleoside inhibitors
Source: Human immunodeficiency virus 1. HIV-1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B (545 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
2whh
HIV-1 protease tethered dimer q-product complex along with nucleophilic water molecule
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (198 residues) CATH domains: 2.40.70.10 2.40.70.10
2wkz
HIV-1 protease inhibitors containing a tertiary alcohol in the transition-state mimic with improved cell-based antiviral activity
Source: Human immunodeficiency virus type 1 (z2/cdc-z34 isolate). Organism_taxid: 11683. Variant: group m subtype d. Atcc: 11676. Expressed in: escherichia coli. Expression_system_taxid: 511693. Expression_system_variant: ai.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2wl0
HIV-1 protease inhibitors containing a tertiary alcohol in the transition-state mimic with improved cell-based antiviral activity
Source: Human immunodeficiency virus type 1 (z2/cdc-z34 isolate). HIV-1. Organism_taxid: 11683. Strain: HIV-1 (d10). Atcc: 11676. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2wom
Crystal structure of uk-453061 bound to HIV-1 reverse transc (k103n).
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B (558 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
2won
Crystal structure of uk-453061 bound to HIV-1 reverse transc (wild-type).
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B (558 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
2x2d
Acetyl-cypa:hiv-1 n-term capsid domain complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Human immunodeficiency virus 1. Organism_taxid: 11676
Chains: D, E (146 residues) CATH domain: 1.10.375.10
2x6n
Human foamy virus integrase - catalytic core. Manganese- bound structure.
Source: Human spumaretrovirus. Organism_taxid: 11963. Strain: hsrv2. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D, E, F (188 residues) CATH domain: 3.30.420.10
2x6s
Human foamy virus integrase - catalytic core. Magnesium- bound structure.
Source: Human spumaretrovirus. Organism_taxid: 11963. Strain: hsrv2. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D, E, F (188 residues) CATH domain: 3.30.420.10
2x74
Human foamy virus integrase - catalytic core.
Source: Human spumaretrovirus. Organism_taxid: 11963. Strain: hsrv2. Atcc: p11963. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D, E, F (187 residues) CATH domain: 3.30.420.10
2x78
Human foamy virus integrase - catalytic core.
Source: Human spumaretrovirus. Organism_taxid: 11963. Strain: hsrv2. Atcc: p11963. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (171 residues) CATH domain: 3.30.420.10
2xde
Crystal structure of the complex of pf-3450074 with an engineered HIV capsid n terminal domain
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: nl4. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (137 residues) CATH domain: 1.10.375.10
2xv6
Crystal structure of the HIV-1 capsid protein c-terminal dom (146-220) in complex with a camelid vhh.
Source: Human immunodeficiency virus 1. HIV-1. Organism_taxid: 11676. Strain: nl4-3. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: codonplus-ril. Vicugna pacos. Alpaca.
Chains: A, C (75 residues) CATH domain: Unassigned
2xxm
Crystal structure of the HIV-1 capsid protein c-terminal dom complex with a camelid vhh and the cai peptide.
Source: Human immunodeficiency virus. HIV-1. Organism_taxid: 12721. Strain: nl4-3. Expressed in: escherichia coli. Expression_system_taxid: 469008. Vicugna pacos. Alpaca. Organism_taxid: 30538.
Chain: A (73 residues) CATH domain: Unassigned
2xye
HIV-1 inhibitors with a tertiary-alcohol-containing transiti mimic and various p2 and p1 prime substituents
Source: Human immunodeficiency virus 1 (z2/cdc isolate). Organism_taxid: 11683. Strain: d10. Expressed in: escherichia coli. Expression_system_taxid: 511693. Other_details: group m subtype d
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2xyf
HIV-1 inhibitors with a tertiary-alcohol-containing transiti mimic and various p2 and p1 prime substituents
Source: Human immunodeficiency virus 1 (z2/cdc isolate). Organism_taxid: 11683. Strain: d10. Expressed in: escherichia coli. Expression_system_taxid: 511693. Other_details: group m subtype d
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2ykm
Crystal structure of HIV-1 reverse transcriptase (rt) in complex with a difluoromethylbenzoxazole (dfmb) pyrimidine thioether derivative, a non-nucleoside rt inhibitor (nnrti)
Source: Human immunodeficiency virus type 1 bh organism_taxid: 11678. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B (558 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
2ykn
Crystal structure of HIV-1 reverse transcriptase (rt) in complex with a difluoromethylbenzoxazole (dfmb) pyrimidine thioether derivative, a non-nucleoside rt inhibitor (nnrti)
Source: Human immunodeficiency virus type 1 bh organism_taxid: 11678. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B (558 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
2ynf
HIV-1 reverse transcriptase y188l mutant in complex with inh gsk560
Source: HIV-1 m\:b_hxb2r. Human immunodeficiency virus type 1 (hxb2 organism_taxid: 11706. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (557 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
2yng
HIV-1 reverse transcriptase in complex with inhibitor gsk560
Source: HIV-1 m\:b_hxb2r. Human immunodeficiency virus type 1 (hxb2 organism_taxid: 11706. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (560 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
2ynh
HIV-1 reverse transcriptase in complex with inhibitor gsk500
Source: HIV-1 m\:b_hxb2r. Human immunodeficiency virus type 1 (hxb2 organism_taxid: 11706. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (560 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
2yni
HIV-1 reverse transcriptase in complex with inhibitor gsk952
Source: HIV-1 m\:b_hxb2r. Human immunodeficiency virus type 1 (hxb2 organism_taxid: 11706. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (560 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
2z4o
Wild type HIV-1 protease with potent antiviral inhibitor grl-98065
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2z54
The influence of i47a mutation on reduced susceptibility to the protease inhibitor lopinavir
Source: Human immunodeficiency virus type 1. HIV-1. Organism_taxid: 11682. Gene: gag-pol. Expressed in: escherichia coli
Chains: A, B (99 residues) CATH domain: 2.40.70.10
2zd1
Crystal structure of HIV-1 reverse transcriptase (rt) in com tmc278 (rilpivirine), a non-nucleoside rt inhibitor
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (554 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
2ze2
Crystal structure of l100i/k103n mutant HIV-1 reverse transc (rt) in complex with tmc278 (rilpivirine), a non-nucleoside inhibitor
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (552 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
2zga
HIV-1 protease in complex with a dimethylallyl decorated pyr based inhibitor (hexagonal space group)
Source: Human immunodeficiency virus 1. HIV-1. Organism_taxid: 11676. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (99 residues) CATH domain: 2.40.70.10
2zye
Structure of HIV-1 protease in complex with potent inhibitor determined by neutron crystallography
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
3a2o
Crystal structure of HIV-1 protease complexed with kni-1689
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
3aid
A new class of HIV-1 protease inhibitor: the crystallographic structure, inhibition and chemical synthesis of an aminimide peptide isostere
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Variant: sf1 isolate. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (99 residues) CATH domain: 2.40.70.10
3ao2
Fragment-based approach to the design of ligands targeting a site on HIV-1 integrase
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: nl43. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (138 residues) CATH domain: 3.30.420.10
3av9
Crystal structures of novel allosteric peptide inhibitors of integrase in the ledgf binding site
Source: Human immunodeficiency virus type 1. HIV-1. Organism_taxid: 11698. Strain: new york-5 isolate. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Homo sapiens.
Chains: A, B (150 residues) CATH domain: 3.30.420.10
3ava
Crystal structures of novel allosteric peptide inhibitors of integrase in the ledgf binding site
Source: Human immunodeficiency virus type 1. HIV-1. Organism_taxid: 11698. Strain: new york-5 isolate. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Homo sapiens.
Chains: A, B (150 residues) CATH domain: 3.30.420.10
3avb
Crystal structures of novel allosteric peptide inhibitors of integrase in the ledgf binding site
Source: Human immunodeficiency virus type 1. HIV-1. Organism_taxid: 11698. Strain: new york-5 isolate. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Homo sapiens.
Chains: A, B (150 residues) CATH domain: 3.30.420.10
3avc
Crystal structures of novel allosteric peptide inhibitors of integrase in the ledgf binding site
Source: Human immunodeficiency virus type 1. HIV-1. Organism_taxid: 11698. Strain: new york-5 isolate. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Homo sapiens.
Chains: A, B (149 residues) CATH domain: 3.30.420.10
3avf
Crystal structures of novel allosteric peptide inhibitors of integrase in the ledgf binding site
Source: Human immunodeficiency virus type 1. HIV-1. Organism_taxid: 11698. Strain: new york-5 isolate. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Homo sapiens.
Chains: A, B (149 residues) CATH domain: 3.30.420.10
3avg
Crystal structures of novel allosteric peptide inhibitors of integrase in the ledgf binding site
Source: Human immunodeficiency virus type 1. HIV-1. Organism_taxid: 11698. Strain: new york-5 isolate. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Homo sapiens.
Chains: A, B (149 residues) CATH domain: 3.30.420.10
3avh
Crystal structures of novel allosteric peptide inhibitors of integrase in the ledgf binding site
Source: Human immunodeficiency virus type 1. HIV-1. Organism_taxid: 11698. Strain: new york-5 isolate. Gene: integrase. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Homo sapiens.
Chains: A, B (149 residues) CATH domain: 3.30.420.10
3avi
Crystal structures of novel allosteric peptide inhibitors of integrase in the ledgf binding site
Source: Human immunodeficiency virus type 1. HIV-1. Organism_taxid: 11698. Strain: new york-5 isolate. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Homo sapiens.
Chains: A, B (149 residues) CATH domain: 3.30.420.10
3avj
Crystal structures of novel allosteric peptide inhibitors of integrase in the ledgf binding site
Source: Human immunodeficiency virus type 1. HIV-1. Organism_taxid: 11698. Strain: new york-5 isolate. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Homo sapiens.
Chains: A, B (149 residues) CATH domain: 3.30.420.10
3avk
Crystal structures of novel allosteric peptide inhibitors of integrase in the ledgf binding site
Source: Human immunodeficiency virus type 1. HIV-1. Organism_taxid: 11698. Strain: new york-5 isolate. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Homo sapiens.
Chains: A, B (149 residues) CATH domain: 3.30.420.10
3avl
Crystal structures of novel allosteric peptide inhibitors of integrase in the ledgf binding site
Source: Human immunodeficiency virus type 1. HIV-1. Organism_taxid: 11698. Strain: new york-5 isolate. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Homo sapiens.
Chains: A, B (149 residues) CATH domain: 3.30.420.10
3avm
Crystal structures of novel allosteric peptide inhibitors of integrase in the ledgf binding site
Source: Human immunodeficiency virus type 1. HIV-1. Organism_taxid: 11698. Strain: new york-5 isolate. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Homo sapiens.
Chains: A, B (149 residues) CATH domain: 3.30.420.10
3avn
Crystal structures of novel allosteric peptide inhibitors of integrase in the ledgf binding site
Source: Human immunodeficiency virus type 1. HIV-1. Organism_taxid: 11698. Strain: new york-5 isolate. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Homo sapiens.
Chains: A, B (149 residues) CATH domain: 3.30.420.10
3b7v
HIV-1 protease complexed with gem-diol-amine tetrahedral int nlltqi
Source: Human immunodeficiency virus type 1 bh organism_taxid: 11678. Strain: bh5 isolate. Gene: gag-pol. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
3b80
HIV-1 protease mutant i54v complexed with gem-diol-amine int nlltqi
Source: Human immunodeficiency virus type 1 bh organism_taxid: 11678. Strain: bh5 isolate. Gene: gag-pol. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
3bc4
I84v HIV-1 protease in complex with a pyrrolidine diester
Source: Human immunodeficiency virus type 1. Viruses. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (99 residues) CATH domain: 2.40.70.10
3bgb
HIV-1 protease in complex with a isobutyl decorated oligoamine
Source: Human immunodeficiency virus type 1. Viruses. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
3bgc
HIV-1 protease in complex with a benzyl decorated oligoamine
Source: Human immunodeficiency virus type 1. Viruses. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
3bgr
Crystal structure of k103n/y181c mutant HIV-1 reverse transc (rt) in complex with tmc278 (rilpivirine), a non-nucleoside inhibitor
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (554 residues) CATH domains: 3.10.10.10 3.30.70.270 3.30.70.270 3.30.70.270 3.30.420.10
3bhe
HIV-1 protease in complex with a three armed pyrrolidine derivative
Source: Human immunodeficiency virus type 1 (bru isolate). Organism_taxid: 11686. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (99 residues) CATH domain: 2.40.70.10
3bva
Cystal structure of HIV-1 active site mutant d25n and p2-nc inhibitor
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: gag-pol. Expressed in: escherichia coli. Expression_system_taxid: 562