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Contents |
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180 a.a.
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188 a.a.
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13 a.a.
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* Residue conservation analysis
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PDB id:
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| Name: |
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Histocompatibility antigen
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Title:
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Crystal structure of the human class ii mhc protein hla-dr1 with an influenza virus peptide
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Structure:
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Class ii histocompatibility antigen (hla-dr1) (al chain). Chain: a, d. Engineered: yes. Class ii histocompatibility antigen (hla-dr1) (be chain: b, e. Engineered: yes. Enterotoxin type b precursor. Chain: c, f.
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera. Expression_system_taxid: 7106.
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Biol. unit:
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Hexamer (from
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Resolution:
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2.80Å
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R-factor:
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0.205
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R-free:
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0.304
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Authors:
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L.J.Stern
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Key ref:
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L.J.Stern
et al.
(1994).
Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide.
Nature,
368,
215-221.
PubMed id:
DOI:
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Date:
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15-Feb-94
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Release date:
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22-Jun-94
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PROCHECK
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Headers
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References
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P01903
(DRA_HUMAN) -
HLA class II histocompatibility antigen, DR alpha chain
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Seq:
Struc:
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254 a.a.
180 a.a.
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Gene Ontology (GO) functional annotation
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Cellular component
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membrane
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2 terms
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Biological process
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immune response
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2 terms
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Biochemical function
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protein binding
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1 term
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DOI no:
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Nature
368:215-221
(1994)
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PubMed id:
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Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide.
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L.J.Stern,
J.H.Brown,
T.S.Jardetzky,
J.C.Gorga,
R.G.Urban,
J.L.Strominger,
D.C.Wiley.
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ABSTRACT
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An influenza virus peptide binds to HLA-DR1 in an extended conformation with a
pronounced twist. Thirty-five per cent of the peptide surface is accessible to
solvent and potentially available for interaction with the antigen receptor on T
cells. Pockets in the peptide-binding site accommodate five of the thirteen side
chains of the bound peptide, and explain the peptide specificity of HLA-DR1.
Twelve hydrogen bonds between conserved HLA-DR1 residues and the main chain of
the peptide provide a universal mode of peptide binding, distinct from the
strategy used by class I histocompatibility proteins.
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Literature references that cite this PDB file's key reference
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| |
PubMed id
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Reference
|
|
|
|
|
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A.K.Anders,
M.J.Call,
M.S.Schulze,
K.D.Fowler,
D.A.Schubert,
N.P.Seth,
E.J.Sundberg,
and
K.W.Wucherpfennig
(2011).
HLA-DM captures partially empty HLA-DR molecules for catalyzed removal of peptide.
|
| |
Nat Immunol, 12,
54-61.
|
|
|
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|
|
|
B.A.Akhoon,
P.S.Slathia,
P.Sharma,
S.K.Gupta,
and
V.Verma
(2011).
In silico identification of novel protective VSG antigens expressed by Trypanosoma brucei and an effort for designing a highly immunogenic DNA vaccine using IL-12 as adjuvant.
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| |
Microb Pathog, 51,
77-87.
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|
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|
B.E.Hansen,
C.H.Nielsen,
H.O.Madsen,
L.P.Ryder,
B.K.Jakobsen,
and
A.Svejgaard
(2011).
The HLA-DP2 protein binds the immunodominant epitope from myelin basic protein, MBP85-99, with high affinity.
|
| |
Tissue Antigens, 77,
229-234.
|
|
|
|
|
|
|
D.Cížková,
J.Gouy de Bellocq,
S.J.Baird,
J.Piálek,
and
J.Bryja
(2011).
Genetic structure and contrasting selection pattern at two major histocompatibility complex genes in wild house mouse populations.
|
| |
Heredity, 106,
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|
J.Greenbaum,
J.Sidney,
J.Chung,
C.Brander,
B.Peters,
and
A.Sette
(2011).
Functional classification of class II human leukocyte antigen (HLA) molecules reveals seven different supertypes and a surprising degree of repertoire sharing across supertypes.
|
| |
Immunogenetics, 63,
325-335.
|
|
|
|
|
|
|
V.Srithayakumar,
S.Castillo,
R.C.Rosatte,
and
C.J.Kyle
(2011).
MHC class II DRB diversity in raccoons (Procyon lotor) reveals associations with raccoon rabies virus (Lyssavirus).
|
| |
Immunogenetics, 63,
103-113.
|
|
|
|
|
|
|
Zaheer-ul-Haq,
and
W.Khan
(2011).
Molecular and structural determinants of adamantyl susceptibility to HLA-DRs allelic variants: an in silico approach to understand the mechanism of MLEs.
|
| |
J Comput Aided Mol Des, 25,
81.
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C.Cárdenas,
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P.Conejeros,
G.Arenas,
S.Marshall,
and
F.J.Luque
(2010).
Molecular modeling of class I and II alleles of the major histocompatibility complex in Salmo salar.
|
| |
J Comput Aided Mol Des, 24,
1035-1051.
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|
|
C.K.Baumgartner,
A.Ferrante,
M.Nagaoka,
J.Gorski,
and
L.P.Malherbe
(2010).
Peptide-MHC class II complex stability governs CD4 T cell clonal selection.
|
| |
J Immunol, 184,
573-581.
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|
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|
|
|
C.Lundegaard,
I.Hoof,
O.Lund,
and
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(2010).
State of the art and challenges in sequence based T-cell epitope prediction.
|
| |
Immunome Res, 6,
S3.
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|
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D.Gómez,
P.Conejeros,
S.H.Marshall,
and
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(2010).
MHC evolution in three salmonid species: a comparison between class II alpha and beta genes.
|
| |
Immunogenetics, 62,
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|
D.S.Rosa,
S.P.Ribeiro,
and
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(2010).
CD4+ T cell epitope discovery and rational vaccine design.
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| |
Arch Immunol Ther Exp (Warsz), 58,
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|
|
|
G.King,
and
A.M.Dixon
(2010).
Evidence for role of transmembrane helix-helix interactions in the assembly of the Class II major histocompatibility complex.
|
| |
Mol Biosyst, 6,
1650-1661.
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|
|
|
|
J.M.Khan,
and
S.Ranganathan
(2010).
pDOCK: a new technique for rapid and accurate docking of peptide ligands to Major Histocompatibility Complexes.
|
| |
Immunome Res, 6,
S2.
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|
J.Sidney,
A.Steen,
C.Moore,
S.Ngo,
J.Chung,
B.Peters,
and
A.Sette
(2010).
Five HLA-DP molecules frequently expressed in the worldwide human population share a common HLA supertypic binding specificity.
|
| |
J Immunol, 184,
2492-2503.
|
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|
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|
|
|
K.Wei,
Z.Zhang,
X.Wang,
W.Zhang,
X.Xu,
F.Shen,
and
B.Yue
(2010).
Lineage pattern, trans-species polymorphism, and selection pressure among the major lineages of feline MHC-DRB peptide-binding region.
|
| |
Immunogenetics, 62,
307-317.
|
|
|
|
|
|
|
M.A.Patarroyo,
A.Bermúdez,
C.López,
G.Yepes,
and
M.E.Patarroyo
(2010).
3D analysis of the TCR/pMHCII complex formation in monkeys vaccinated with the first peptide inducing sterilizing immunity against human malaria.
|
| |
PLoS One, 5,
e9771.
|
|
|
|
|
|
|
M.J.Chen,
C.C.Chu,
M.H.Shyr,
C.L.Lin,
P.Y.Lin,
and
K.L.Yang
(2010).
Identification of a novel HLA-DQB1 allele, DQB1*0326, in a College of American Pathologists 2009 survey specimen.
|
| |
Int J Immunogenet, 37,
455-457.
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|
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|
|
M.J.Ejsmond,
W.Babik,
and
J.Radwan
(2010).
MHC allele frequency distributions under parasite-driven selection: A simulation model.
|
| |
BMC Evol Biol, 10,
332.
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|
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M.Saline,
K.E.Rödström,
G.Fischer,
V.Y.Orekhov,
B.G.Karlsson,
and
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(2010).
The structure of superantigen complexed with TCR and MHC reveals novel insights into superantigenic T cell activation.
|
| |
Nat Commun, 1,
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R.A.Ettinger,
E.A.James,
W.W.Kwok,
A.R.Thompson,
and
K.P.Pratt
(2010).
HLA-DR-restricted T-cell responses to factor VIII epitopes in a mild haemophilia A family with missense substitution A2201P.
|
| |
Haemophilia, 16,
44-55.
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|
|
|
S.Castillo,
V.Srithayakumar,
V.Meunier,
and
C.J.Kyle
(2010).
Characterization of major histocompatibility complex (MHC) DRB exon 2 and DRA exon 3 fragments in a primary terrestrial rabies vector (Procyon lotor).
|
| |
PLoS One, 5,
e12066.
|
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|
|
|
|
|
S.Dai,
G.A.Murphy,
F.Crawford,
D.G.Mack,
M.T.Falta,
P.Marrack,
J.W.Kappler,
and
A.P.Fontenot
(2010).
Crystal structure of HLA-DP2 and implications for chronic beryllium disease.
|
| |
Proc Natl Acad Sci U S A, 107,
7425-7430.
|
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|
PDB code:
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|
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S.Sadegh-Nasseri,
S.Natarajan,
C.L.Chou,
I.Z.Hartman,
K.Narayan,
and
A.Kim
(2010).
Conformational heterogeneity of MHC class II induced upon binding to different peptides is a key regulator in antigen presentation and epitope selection.
|
| |
Immunol Res, 47,
56-64.
|
|
|
|
|
|
|
V.Cecconi,
M.Moro,
S.Del Mare,
J.Sidney,
A.Bachi,
R.Longhi,
A.Sette,
M.P.Protti,
P.Dellabona,
and
G.Casorati
(2010).
The CD4+ T-cell epitope-binding register is a critical parameter when generating functional HLA-DR tetramers with promiscuous peptides.
|
| |
Eur J Immunol, 40,
1603-1616.
|
|
|
|
|
|
|
W.Jiang,
and
E.T.Boder
(2010).
High-throughput engineering and analysis of peptide binding to class II MHC.
|
| |
Proc Natl Acad Sci U S A, 107,
13258-13263.
|
|
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|
|
B.Waters,
and
D.Lillicrap
(2009).
The molecular mechanisms of immunomodulation and tolerance induction to factor VIII.
|
| |
J Thromb Haemost, 7,
1446-1456.
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|
C.Bowman,
and
O.Delrieu
(2009).
Immunogenetics of drug-induced skin blistering disorders. Part II: synthesis.
|
| |
Pharmacogenomics, 10,
779-816.
|
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|
|
|
|
|
C.C.Chu,
H.L.Lee,
and
M.Lin
(2009).
A novel HLA-DRB1 allele, DRB*1611, is identified in two Taiwanese individuals.
|
| |
Tissue Antigens, 74,
175-176.
|
|
|
|
|
|
|
C.C.Chu,
H.T.Ho,
H.L.Lee,
Y.S.Chan,
F.J.Chang,
C.L.Wang,
and
M.Lin
(2009).
Anti-"Mi a" immunization is associated with HLA-DRB1*0901.
|
| |
Transfusion, 49,
472-478.
|
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|
|
C.Picard,
C.Frassati,
A.Basire,
S.Buhler,
V.Galicher,
V.Ferrera,
D.Reviron,
J.P.Zappitelli,
P.Bailly,
and
J.Chiaroni
(2009).
Positive association of DRB1 04 and DRB1 15 alleles with Fya immunization in a Southern European population.
|
| |
Transfusion, 49,
2412-2417.
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D.Vassilakos,
A.Natoli,
M.Dahlheim,
and
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(2009).
Balancing and directional selection at exon-2 of the MHC DQB1 locus among populations of odontocete cetaceans.
|
| |
Mol Biol Evol, 26,
681-689.
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|
|
E.F.Kikkawa,
T.T.Tsuda,
D.Sumiyama,
T.K.Naruse,
M.Fukuda,
M.Kurita,
R.P.Wilson,
Y.LeMaho,
G.D.Miller,
M.Tsuda,
K.Murata,
J.K.Kulski,
and
H.Inoko
(2009).
Trans-species polymorphism of the Mhc class II DRB-like gene in banded penguins (genus Spheniscus).
|
| |
Immunogenetics, 61,
341-352.
|
|
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|
|
|
E.Varga,
A.Petró,
R.Jáger,
and
L.Varga
(2009).
[Two faces of an illness: ankylosing spondylitis developed after rheumatoid arthritis]
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| |
Orv Hetil, 150,
2000-2003.
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J.D.Campbell,
K.F.Buckland,
S.J.McMillan,
J.Kearley,
W.L.Oldfield,
L.J.Stern,
H.Grönlund,
M.van Hage,
C.J.Reynolds,
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A.B.Kay,
D.M.Altmann,
C.M.Lloyd,
and
M.Larché
(2009).
Peptide immunotherapy in allergic asthma generates IL-10-dependent immunological tolerance associated with linked epitope suppression.
|
| |
J Exp Med, 206,
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|
|
|
K.Narayan,
K.W.Su,
C.L.Chou,
S.Khoruzhenko,
and
S.Sadegh-Nasseri
(2009).
HLA-DM mediates peptide exchange by interacting transiently and repeatedly with HLA-DR1.
|
| |
Mol Immunol, 46,
3157-3162.
|
|
|
|
|
|
|
L.E.Fallang,
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(2009).
Differences in the risk of celiac disease associated with HLA-DQ2.5 or HLA-DQ2.2 are related to sustained gluten antigen presentation.
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| |
Nat Immunol, 10,
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In vivo enhancement of peptide display by MHC class II molecules with small molecule catalysts of peptide exchange.
|
| |
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(2009).
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|
| |
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(2009).
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| |
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|
| |
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| |
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(2009).
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| |
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(2009).
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|
| |
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(2009).
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|
| |
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(2009).
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| |
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(2008).
HLA-DM mediates epitope selection by a "compare-exchange" mechanism when a potential peptide pool is available.
|
| |
PLoS ONE, 3,
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|
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(2008).
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| |
Tissue Antigens, 71,
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|
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and
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(2008).
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|
| |
Arthritis Rheum, 58,
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|
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|
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(2008).
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|
| |
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and
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(2008).
Model for the peptide-free conformation of class II MHC proteins.
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| |
PLoS ONE, 3,
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|
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|
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D.R.Flower,
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(2008).
Peptide length significantly influences in vitro affinity for MHC class II molecules.
|
| |
Immunome Res, 4,
6.
|
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(2008).
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|
| |
Mol Immunol, 45,
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(2008).
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|
| |
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Patterns of variability at the major histocompatibility class II alpha locus in Atlantic salmon contrast with those at the class I locus.
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Clin Exp Allergy, 35,
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Y.J.Cheng,
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Proc Natl Acad Sci U S A, 101,
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PDB code:
|
|
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|
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|
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|
E.E.Drouin,
L.J.Glickstein,
and
A.C.Steere
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Molecular characterization of the OspA(161-175) T cell epitope associated with treatment-resistant Lyme arthritis: differences among the three pathogenic species of Borrelia burgdorferi sensu lato.
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E.Garino,
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M.Boccadoro,
B.Bruno,
F.Bertinetto,
L.Bertola,
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M.L.Panniello,
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Tissue Antigens, 64,
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G.J.Carven,
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I.Hilgert,
M.M.Rushe,
R.F.Baggio,
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Characterization of B- and T-cell responses and HLA-DR4 binding motifs of the latex allergen Hev b 6.01 (prohevein) and its post-transcriptionally formed proteins Hev b 6.02 and Hev b 6.03.
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Allergy, 59,
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Crystallization and preliminary crystallographic analysis of Mycoplasma arthritidis-derived mitogen complexed with peptide/MHC class II antigen.
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Crystal structure of Mycoplasma arthritidis mitogen complexed with HLA-DR1 reveals a novel superantigen fold and a dimerized superantigen-MHC complex.
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Structure, 12,
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PDB code:
|
|
|
|
|
|
|
|
Z.Pu,
S.B.Lovitch,
E.K.Bikoff,
and
E.R.Unanue
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T cells distinguish MHC-peptide complexes formed in separate vesicles and edited by H2-DM.
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Immunity, 20,
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Z.X.Chen,
S.G.Tsan,
C.W.Dang,
C.C.Chu,
M.Lin,
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Identification of two new HLA-DRB1 alleles: HLA-DRB1*1350 and DRB1*140502.
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Tissue Antigens, 64,
300-303.
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Z.Zavala-Ruiz,
I.Strug,
B.D.Walker,
P.J.Norris,
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L.J.Stern
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A hairpin turn in a class II MHC-bound peptide orients residues outside the binding groove for T cell recognition.
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| |
Proc Natl Acad Sci U S A, 101,
13279-13284.
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PDB codes:
|
|
|
|
|
|
|
|
Z.Zavala-Ruiz,
I.Strug,
M.W.Anderson,
J.Gorski,
and
L.J.Stern
(2004).
A polymorphic pocket at the P10 position contributes to peptide binding specificity in class II MHC proteins.
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| |
Chem Biol, 11,
1395-1402.
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PDB codes:
|
|
|
|
|
|
|
|
A.C.Steere,
B.Falk,
E.E.Drouin,
L.A.Baxter-Lowe,
J.Hammer,
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Binding of outer surface protein A and human lymphocyte function-associated antigen 1 peptides to HLA-DR molecules associated with antibiotic treatment-resistant Lyme arthritis.
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Arthritis Rheum, 48,
534-540.
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A.Dubaniewicz,
G.Moszkowska,
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Analysis of DQB1 allele frequencies in pulmonary tuberculosis: preliminary report.
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Thorax, 58,
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A.P.Fontenot,
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Chronic beryllium disease: immune-mediated destruction with implications for organ-specific autoimmunity.
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Tissue Antigens, 62,
449-458.
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C.E.Voorter,
B.G.Hepkema,
S.P.Lems,
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E.M.van den Berg-Loonen
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Identification of three new DRB1 alleles, DRB1*0107, *0425 and *13012 and confirmation of DRB4*01033.
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| |
Tissue Antigens, 61,
398-402.
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G.L.Hu,
D.K.Okita,
B.M.Diethelm-Okita,
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Recognition of coagulation factor VIII by CD4+ T cells of healthy humans.
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J Thromb Haemost, 1,
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G.S.Firestein
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Evolving concepts of rheumatoid arthritis.
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Nature, 423,
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H.Nojima,
M.Takeda-Shitaka,
Y.Kurihara,
K.Kamiya,
and
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Dynamic flexibility of a peptide-binding groove of human HLA-DR1 class II MHC molecules: normal mode analysis of the antigen peptide-class II MHC complex.
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| |
Chem Pharm Bull (Tokyo), 51,
923-928.
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I.Potolicchio,
L.Santambrogio,
and
J.L.Strominger
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Molecular interaction and enzymatic activity of macrophage migration inhibitory factor with immunorelevant peptides.
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J Biol Chem, 278,
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J.Loh,
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Metal-derivatized major histocompatibility complex: zeroing in on contact hypersensitivity.
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J Exp Med, 197,
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J.M.Lozano,
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Y.Silva,
J.L.Torres-Castellanos,
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MSP-1 malaria pseudopeptide analogs: biological and immunological significance and three-dimensional structure.
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Biol Chem, 384,
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K.W.Wucherpfennig
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MHC-linked susceptibility to type 1 diabetes: a structural perspective.
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| |
Ann N Y Acad Sci, 1005,
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M.A.Kelly,
M.L.Rayner,
C.H.Mijovic,
and
A.H.Barnett
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Molecular aspects of type 1 diabetes.
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Mol Pathol, 56,
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M.L.Diegel,
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R.Laus,
T.J.Graddis,
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Major histocompatibility complex class I-restricted presentation of protein antigens without prior intracellular processing.
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| |
Scand J Immunol, 58,
1-8.
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M.T.Reding,
D.K.Okita,
B.M.Diethelm-Okita,
T.A.Anderson,
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Human CD4+ T-cell epitope repertoire on the C2 domain of coagulation factor VIII.
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| |
J Thromb Haemost, 1,
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S.L.Lam,
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V.L.Hsu
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NMR identification of left-handed polyproline type II helices.
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Biopolymers, 69,
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W.Swietnicki,
A.M.Barnie,
B.K.Dyas,
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Zinc binding and dimerization of Streptococcus pyogenes pyrogenic exotoxin C are not essential for T-cell stimulation.
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J Biol Chem, 278,
9885-9895.
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Z.Zavala-Ruiz,
E.J.Sundberg,
J.D.Stone,
D.B.DeOliveira,
I.C.Chan,
J.Svendsen,
R.A.Mariuzza,
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Exploration of the P6/P7 region of the peptide-binding site of the human class II major histocompatability complex protein HLA-DR1.
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| |
J Biol Chem, 278,
44904-44912.
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|
PDB code:
|
|
|
|
|
|
|
|
A.J.Czaja,
P.T.Donaldson,
and
A.W.Lohse
(2002).
Antibodies to soluble liver antigen/liver pancreas and HLA risk factors for type 1 autoimmune hepatitis.
|
| |
Am J Gastroenterol, 97,
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A.K.Moustakas,
and
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Molecular properties of HLA-DQ alleles conferring susceptibility to or protection from insulin-dependent diabetes mellitus: keys to the fate of islet beta-cells.
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| |
Am J Med Genet, 115,
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B.Bochicchio,
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Polyproline II structure in proteins: identification by chiroptical spectroscopies, stability, and functions.
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| |
Chirality, 14,
782-792.
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B.Catchpole,
F.J.Ward,
A.S.Hamblin,
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Autoreactivity in collagen-induced arthritis of rats: a potential role for T cell responses to self MHC peptides.
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| |
J Autoimmun, 18,
271-280.
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|
B.J.McFarland,
and
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(2002).
Binding interactions between peptides and proteins of the class II major histocompatibility complex.
|
| |
Med Res Rev, 22,
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|
|
C.Texier,
S.Pouvelle-Moratille,
C.Buhot,
F.A.Castelli,
C.Pecquet,
A.Ménez,
F.Leynadier,
and
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(2002).
Emerging principles for the design of promiscuous HLA-DR-restricted peptides: an example from the major bee venom allergen.
|
| |
Eur J Immunol, 32,
3699-3707.
|
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|
D.H.Fremont,
S.Dai,
H.Chiang,
F.Crawford,
P.Marrack,
and
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(2002).
Structural basis of cytochrome c presentation by IE(k).
|
| |
J Exp Med, 195,
1043-1052.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
E.R.Unanue
(2002).
Perspective on antigen processing and presentation.
|
| |
Immunol Rev, 185,
86.
|
|
|
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|
|
H.Noguchi,
R.Kato,
T.Hanai,
Y.Matsubara,
H.Honda,
V.Brusic,
and
T.Kobayashi
(2002).
Hidden Markov model-based prediction of antigenic peptides that interact with MHC class II molecules.
|
| |
J Biosci Bioeng, 94,
264-270.
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|
|
|
I.Parrot,
P.C.Huang,
and
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(2002).
Circular dichroism and nuclear magnetic resonance spectroscopic analysis of immunogenic gluten peptides and their analogs.
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| |
J Biol Chem, 277,
45572-45578.
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|
|
J.Hennecke,
and
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Structure of a complex of the human alpha/beta T cell receptor (TCR) HA1.7, influenza hemagglutinin peptide, and major histocompatibility complex class II molecule, HLA-DR4 (DRA*0101 and DRB1*0401): insight into TCR cross-restriction and alloreactivity.
|
| |
J Exp Med, 195,
571-581.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
K.Suzuki,
R.Inoue,
H.Sakaguchi,
M.Aoki,
Z.Kato,
H.Kaneko,
S.Matsushita,
and
N.Kondo
(2002).
The correlation between ovomucoid-derived peptides, human leucocyte antigen class II molecules and T cell receptor-complementarity determining region 3 compositions in patients with egg-white allergy.
|
| |
Clin Exp Allergy, 32,
1223-1230.
|
|
|
|
|
|
|
M.Fridkis-Hareli,
L.Santambrogio,
J.N.Stern,
L.Fugger,
C.Brosnan,
and
J.L.Strominger
(2002).
Novel synthetic amino acid copolymers that inhibit autoantigen-specific T cell responses and suppress experimental autoimmune encephalomyelitis.
|
| |
J Clin Invest, 109,
1635-1643.
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|
|
M.J.Kogan,
I.Dalcol,
P.Gorostiza,
C.Lopez-Iglesias,
R.Pons,
M.Pons,
F.Sanz,
and
E.Giralt
(2002).
Supramolecular properties of the proline-rich gamma-Zein N-terminal domain.
|
| |
Biophys J, 83,
1194-1204.
|
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|
|
|
|
|
M.M.Mullen,
K.M.Haan,
R.Longnecker,
and
T.S.Jardetzky
(2002).
Structure of the Epstein-Barr virus gp42 protein bound to the MHC class II receptor HLA-DR1.
|
| |
Mol Cell, 9,
375-385.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
M.Panigada,
T.Sturniolo,
G.Besozzi,
M.G.Boccieri,
F.Sinigaglia,
G.G.Grassi,
and
F.Grassi
(2002).
Identification of a promiscuous T-cell epitope in Mycobacterium tuberculosis Mce proteins.
|
| |
Infect Immun, 70,
79-85.
|
|
|
|
|
|
|
O.Rötzschke,
J.M.Lau,
M.Hofstätter,
K.Falk,
and
J.L.Strominger
(2002).
A pH-sensitive histidine residue as control element for ligand release from HLA-DR molecules.
|
| |
Proc Natl Acad Sci U S A, 99,
16946-16950.
|
|
|
|
|
|
|
P.E.Adrian,
G.Rajaseger,
V.S.Mathura,
M.K.Sakharkar,
and
P.Kangueane
(2002).
Types of inter-atomic interactions at the MHC-peptide interface: identifying commonality from accumulated data.
|
| |
BMC Struct Biol, 2,
2.
|
|
|
|
|
|
|
P.Etongué-Mayer,
M.A.Langlois,
M.Ouellette,
H.Li,
S.Younes,
R.Al-Daccak,
and
W.Mourad
(2002).
Involvement of zinc in the binding of Mycoplasma arthritidis-derived mitogen to the proximity of the HLA-DR binding groove regardless of histidine 81 of the beta chain.
|
| |
Eur J Immunol, 32,
50-58.
|
|
|
|
|
|
|
S.L.Cunliffe,
J.R.Wyer,
J.K.Sutton,
M.Lucas,
G.Harcourt,
P.Klenerman,
A.J.McMichael,
and
A.D.Kelleher
(2002).
Optimization of peptide linker length in production of MHC class II/peptide tetrameric complexes increases yield and stability, and allows identification of antigen-specific CD4+T cells in peripheral blood mononuclear cells.
|
| |
Eur J Immunol, 32,
3366-3375.
|
|
|
|
|
|
|
T.D.Lockey,
S.Surman,
S.Brown,
K.S.Slobod,
C.Coleclough,
P.C.Doherty,
and
J.L.Hurwitz
(2002).
A five-residue HIV envelope helper T cell determinant: does this peptide-MHC interaction leave the binding groove half empty?
|
| |
AIDS Res Hum Retroviruses, 18,
1141-1144.
|
|
|
|
|
|
|
X.Liu,
S.Dai,
F.Crawford,
R.Fruge,
P.Marrack,
and
J.Kappler
(2002).
Alternate interactions define the binding of peptides to the MHC molecule IA(b).
|
| |
Proc Natl Acad Sci U S A, 99,
8820-8825.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
C.Texier,
S.Pouvelle-Moratille,
M.Busson,
D.Charron,
A.Ménez,
and
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