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PDBsum entry 2xn9

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protein ligands metals Protein-protein interface(s) links
Immune system PDB id
2xn9
Jmol
Contents
Protein chains
199 a.a. *
242 a.a. *
215 a.a. *
178 a.a. *
188 a.a. *
13 a.a. *
Ligands
GOL ×4
Metals
_NA
Waters ×280
* Residue conservation analysis
PDB id:
2xn9
Name: Immune system
Title: Crystal structure of the ternary complex between human t cel receptor, staphylococcal enterotoxin h and human major histocompatibility complex class ii
Structure: T cell receptor alpha chain c region. Chain: a. Fragment: extracellular domain, residues 1-95. Engineered: yes. Mutation: yes. Other_details: variable domain trav27 fused to constant dom t cell receptor beta-1 chain c region. Chain: b. Fragment: extracellular domain, residues 1-130.
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell: t lymphocyte. Expressed in: escherichia coli. Expression_system_taxid: 469008. Staphylococcus aureus. Organism_taxid: 1280. Expression_system_taxid: 83333.
Resolution:
2.30Å     R-factor:   0.224     R-free:   0.272
Authors: M.Saline,K.E.J.Rodstrom,G.Fischer,V.Y.Orekhov,B.G.Karlsson, K.Lindkvist-Petersson
Key ref: M.Saline et al. (2010). The structure of superantigen complexed with TCR and MHC reveals novel insights into superantigenic T cell activation. Nat Commun, 1, 119. PubMed id: 21081917 DOI: 10.1038/ncomms1117
Date:
31-Jul-10     Release date:   24-Nov-10    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P01848  (TCA_HUMAN) -  T-cell receptor alpha chain C region
Seq:
Struc:
142 a.a.
199 a.a.*
Protein chain
Pfam   ArchSchema ?
P01850  (TRBC1_HUMAN) -  T-cell receptor beta-1 chain C region
Seq:
Struc:
177 a.a.
242 a.a.*
Protein chain
Pfam   ArchSchema ?
P0A0M0  (ETXH_STAAU) -  Enterotoxin type H
Seq:
Struc:
241 a.a.
215 a.a.
Protein chain
Pfam   ArchSchema ?
P01903  (DRA_HUMAN) -  HLA class II histocompatibility antigen, DR alpha chain
Seq:
Struc:
254 a.a.
178 a.a.
Protein chain
Pfam   ArchSchema ?
P04229  (2B11_HUMAN) -  HLA class II histocompatibility antigen, DRB1-1 beta chain
Seq:
Struc:
266 a.a.
188 a.a.
Protein chain
Pfam   ArchSchema ?
Q03909  (HEMA_I89A7) -  Hemagglutinin
Seq:
Struc:
 
Seq:
Struc:
571 a.a.
13 a.a.
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 6 residue positions (black crosses)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular region   3 terms 
  Biological process     immune response   3 terms 
  Biochemical function     metal ion binding     1 term  

 

 
DOI no: 10.1038/ncomms1117 Nat Commun 1:119 (2010)
PubMed id: 21081917  
 
 
The structure of superantigen complexed with TCR and MHC reveals novel insights into superantigenic T cell activation.
M.Saline, K.E.Rödström, G.Fischer, V.Y.Orekhov, B.G.Karlsson, K.Lindkvist-Petersson.
 
  ABSTRACT  
 
No abstract given.