› 6wtx

X-ray diffraction
3.92Å resolution

Structure of VcINDY in complex with terephthalate

Released:
DOI: 10.2210/pdb6wtx/pdb
PDB entry 6wtx coloured by chain, front view.
PDB entry 6wtx coloured by chain, side view.
PDB entry 6wtx coloured by chain, top view.
Source organism: Vibrio cholerae
Primary publication:
Structural basis for the reaction cycle of DASS dicarboxylate transporters.
Sauer DB, Trebesch N, Marden JJ, Cocco N, Song J, Koide A, Koide S, Tajkhorshid E, Wang DN
Elife 9 (2020)
PMID: 32869741

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-191988 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Citrate transporter-like domain-containing protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 449 amino acids
Theoretical weight: 48.16 KDa
Source organism: Vibrio cholerae
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9KNE0 (Residues: 14-462; Coverage: 97%)
Gene name: VC_A0025
Sequence domains: Citrate transporter

Ligands and Environments

2 bound ligands:
Ligand UB7 4 x UB7
Ligand NA 8 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P21
Unit cell:
a: 108.458Å b: 103.062Å c: 174.447Å
α: 90° β: 95.848° γ: 90°
R-values:
R R work R free
0.292 0.29 0.308
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Drosophila INDY and Mammalian INDY: Major Differences in Transport Mechanism and Structural Features despite Mostly Similar Biological Functions.
Jaramillo-Martinez et al. (2021)
1 more

2 mentions without citation

Structural basis for the reaction cycle of DASS dicarboxylate transporters.
Sauer et al. (2020)
1 more