Solute carrier family 13 (IPR001898)

Short name: SLC13A/DASS

Overlapping homologous superfamilies


Family relationships


Integral membrane proteins that mediate the intake of a wide variety of molecules with the concomitant uptake of sodium ions (sodium symporters) can be grouped, on the basis of sequence and functional similarities into a number of distinct families. The SLC13 family consists mainly of dicarboxylate and sulfate transporters [PMID: 16211368, PMID: 23506872], and includes of the following proteins:

  • Mammalian sodium/sulphate cotransporter [PMID: 7690140].
  • Mammalian renal sodium/dicarboxylate cotransporter [PMID: 8967342], which transports succinate and citrate.
  • Mammalian intestinal sodium/dicarboxylate cotransporter.
  • Chlamydomonas reinhardtii putative sulphur deprivation response regulator SAC1 [PMID: 8641280].

These transporters are proteins of from 430 to 620 amino acids which are highly hydrophobic and which probably contain about 12 transmembrane regions.

GO terms

Biological Process

GO:0006814 sodium ion transport
GO:0055085 transmembrane transport

Molecular Function

GO:0005215 transporter activity

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.