Structure analysis

LEU 55 PRO TRANSTHYRETIN CRYSTAL STRUCTURE

X-ray diffraction
2.7Å resolution
Source organism: Homo sapiens
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Multimeric state: homo tetramer
Accessible surface area: 19439.87 Å2
Buried surface area: 5985.15 Å2
Dissociation area: 1,305.61 Å2
Dissociation energy (ΔGdiss): 15.01 kcal/mol
Dissociation entropy (TΔSdiss): 12.71 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-136168
Assembly 2
Download    3D Visualisation
Multimeric state: homo tetramer
Accessible surface area: 19709.92 Å2
Buried surface area: 6068.47 Å2
Dissociation area: 1,322.74 Å2
Dissociation energy (ΔGdiss): 13.45 kcal/mol
Dissociation entropy (TΔSdiss): 12.72 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-136168
Assembly 3
Download    3D Visualisation
Multimeric state: homo tetramer
Accessible surface area: 19730.26 Å2
Buried surface area: 5923.69 Å2
Dissociation area: 1,275.51 Å2
Dissociation energy (ΔGdiss): 15.7 kcal/mol
Dissociation entropy (TΔSdiss): 12.7 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-136168

Macromolecules

Chains: A, B, C, D, E, F, G, H
Length: 127 amino acids
Theoretical weight: 13.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02766 (Residues: 21-147; Coverage: 100%)
Gene names: PALB, TTR
Pfam: HIUase/Transthyretin family
InterPro:
CATH: Transthyretin/hydroxyisourate hydrolase domain
SCOP: Transthyretin (synonym: prealbumin)

Search similar proteins