Binding Site

Transthyretin, thyroxine binding site (IPR023418)

Short name: Thyroxine_BS

Description

Transthyretin (prealbumin) is a thyroid hormone-binding protein that seems to transport thyroxine (T4) from the bloodstream to the brain. It is a protein of about 130 amino acids that assembles as a homotetramer and forms an internal channel that binds thyroxine. In humans, transthyretin is mainly synthesized in the brain choroid plexus; variants of the protein are associated with distinct forms of amyloidosis.

The sequence of transthyretin is highly conserved in vertebrates. A number of uncharacterised proteins also belong to this family:

  • Escherichia coli hypothetical protein YedX.
  • Bacillus subtilis hypothetical protein YunM.
  • Caenorhabditis elegans hypothetical protein R09H10.3.
  • Caenorhabditis elegans hypothetical protein ZK697.8.

The signature pattern in this entry is located in the N-terminal extremity and starts with a lysine known to be involved in binding thyroxine binding.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns